LOCUS       NM_006446               2787 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            1B1 (SLCO1B1), mRNA.
ACCESSION   NM_006446
VERSION     NM_006446.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Hamalainen,K., Hirvensalo,P., Neuvonen,M., Tornio,A., Backman,J.T.,
            Lehtonen,M. and Niemi,M.
  TITLE     Non-targeted metabolomics for the identification of plasma
            metabolites associated with organic anion transporting polypeptide
            1B1 function
  JOURNAL   Clin Transl Sci 17 (3), e13773 (2024)
   PUBMED   38515340
  REMARK    GeneRIF: Non-targeted metabolomics for the identification of plasma
            metabolites associated with organic anion transporting polypeptide
            1B1 function.
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Bosco,G., Di Giacomo Barbagallo,F., Di Marco,M., Miano,N.,
            Scilletta,S., Spampinato,S., Vitale,A., Di Bella,F., Montalbano,M.,
            Di Mauro,S., Filippello,A., Scamporrino,A., Milluzzo,A., Di
            Pino,A., Frittitta,L., Purrello,F., Piro,S. and Scicali,R.
  TITLE     The impact of SLCO1B1 rs4149056 on LDL-C target achievement after
            lipid lowering therapy optimization in men and women with familial
            hypercholesterolemia
  JOURNAL   Front Endocrinol (Lausanne) 15, 1346152 (2024)
   PUBMED   38405139
  REMARK    GeneRIF: The impact of SLCO1B1 rs4149056 on LDL-C target
            achievement after lipid lowering therapy optimization in men and
            women with familial hypercholesterolemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Fan,J., He,H.Y., Li,H.H., Wu,P.L., Tang,L., Deng,B.Y., Dong,W.H.
            and Wang,J.H.
  TITLE     Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1
            polymorphisms and susceptibility to neonatal severe
            hyperbilirubinemia in Chinese Han population
  JOURNAL   BMC Pediatr 24 (1), 82 (2024)
   PUBMED   38279097
  REMARK    GeneRIF: Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and
            HMOX1 polymorphisms and susceptibility to neonatal severe
            hyperbilirubinemia in Chinese Han population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Jung,D., Hagenbuch,B., Gresh,L., Pontoglio,M., Meier,P.J. and
            Kullak-Ublick,G.A.
  TITLE     Characterization of the human OATP-C (SLC21A6) gene promoter and
            regulation of liver-specific OATP genes by hepatocyte nuclear
            factor 1 alpha
  JOURNAL   J Biol Chem 276 (40), 37206-37214 (2001)
   PUBMED   11483603
  REMARK    GeneRIF: The promoter of SLC21A6 gene was characterized and
            regulated by HNF 1alpha.
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Konig,J., Cui,Y., Nies,A.T. and Keppler,D.
  TITLE     Localization and genomic organization of a new hepatocellular
            organic anion transporting polypeptide
  JOURNAL   J Biol Chem 275 (30), 23161-23168 (2000)
   PUBMED   10779507
REFERENCE   6  (bases 1 to 2787)
  AUTHORS   Tamai,I., Nezu,J., Uchino,H., Sai,Y., Oku,A., Shimane,M. and
            Tsuji,A.
  TITLE     Molecular identification and characterization of novel members of
            the human organic anion transporter (OATP) family
  JOURNAL   Biochem Biophys Res Commun 273 (1), 251-260 (2000)
   PUBMED   10873595
REFERENCE   7  (bases 1 to 2787)
  AUTHORS   Konig,J., Cui,Y., Nies,A.T. and Keppler,D.
  TITLE     A novel human organic anion transporting polypeptide localized to
            the basolateral hepatocyte membrane
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 278 (1), G156-G164 (2000)
   PUBMED   10644574
REFERENCE   8  (bases 1 to 2787)
  AUTHORS   Hsiang,B., Zhu,Y., Wang,Z., Wu,Y., Sasseville,V., Yang,W.P. and
            Kirchgessner,T.G.
  TITLE     A novel human hepatic organic anion transporting polypeptide
            (OATP2). Identification of a liver-specific human organic anion
            transporting polypeptide and identification of rat and human
            hydroxymethylglutaryl-CoA reductase inhibitor transporters
  JOURNAL   J Biol Chem 274 (52), 37161-37168 (1999)
   PUBMED   10601278
REFERENCE   9  (bases 1 to 2787)
  AUTHORS   Abe,T., Kakyo,M., Tokui,T., Nakagomi,R., Nishio,T., Nakai,D.,
            Nomura,H., Unno,M., Suzuki,M., Naitoh,T., Matsuno,S. and Yawo,H.
  TITLE     Identification of a novel gene family encoding human liver-specific
            organic anion transporter LST-1
  JOURNAL   J Biol Chem 274 (24), 17159-17163 (1999)
   PUBMED   10358072
REFERENCE   10 (bases 1 to 2787)
  AUTHORS   Jirsa,M., Knisely,A.S., Schinkel,A. and Kmoch,S.
  TITLE     Rotor Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23236639
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020696.1, AF205071.2 and
            AC022335.8.
            
            On May 17, 2019 this sequence version replaced NM_006446.4.
            
            Summary: This gene encodes a liver-specific member of the organic
            anion transporter family. The encoded protein is a transmembrane
            receptor that mediates the sodium-independent uptake of numerous
            endogenous compounds including bilirubin, 17-beta-glucuronosyl
            estradiol and leukotriene C4. This protein is also involved in the
            removal of drug compounds such as statins, bromosulfophthalein and
            rifampin from the blood into the hepatocytes. Polymorphisms in the
            gene encoding this protein are associated with impaired transporter
            function. [provided by RefSeq, Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205071.2, SRR5189664.74711.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256958.3/ ENSP00000256958.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BC020696.1         2-10
            10-491              AF205071.2         1-482
            492-492             AC022335.8         82644-82644         c
            493-2787            AF205071.2         484-2778
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..2787
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /note="solute carrier organic anion transporter family
                     member 1B1"
                     /db_xref="GeneID:10599"
                     /db_xref="HGNC:HGNC:10959"
                     /db_xref="MIM:604843"
     exon            1..43
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            44..188
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2180
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /note="solute carrier family 21 (organic anion
                     transporter), member 6; sodium-independent organic
                     anion-transporting polypeptide 2; liver-specific organic
                     anion transporter 1; OATP-2; organic anion transporter
                     SLC21A6"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1B1"
                     /protein_id="NP_006437.3"
                     /db_xref="CCDS:CCDS8685.1"
                     /db_xref="GeneID:10599"
                     /db_xref="HGNC:HGNC:10959"
                     /db_xref="MIM:604843"
                     /translation="MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLG
                     AIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCF
                     IMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGK
                     GCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMI
                     GPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPF
                     FFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILT
                     NPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFL
                     GGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTS
                     HRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLE
                     VTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPE
                     LKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRV
                     YLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPS
                     AGADSETHC"
     exon            189..330
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            331..463
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            464..585
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            586..732
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            733..831
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1074
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1239
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1435
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1601
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1786
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1851
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1969
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2787
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2763..2768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /note="hexamer: AATAAA"
     polyA_site      2787
                     /gene="SLCO1B1"
                     /gene_synonym="HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2;
                     OATPC; SLC21A6"
                     /note="major polyA site"
ORIGIN      
        1 aaagggtgga cttgttgcag ttgctgtagg attctaaatc caggtgattg tttcaaactg
       61 agcatcaaca acaaaaacat ttgtatgata tctatatttc aatcatggac caaaatcaac
      121 atttgaataa aacagcagag gcacaacctt cagagaataa gaaaacaaga tactgcaatg
      181 gattgaagat gttcttggca gctctgtcac tcagctttat tgctaagaca ctaggtgcaa
      241 ttattatgaa aagttccatc attcatatag aacggagatt tgagatatcc tcttctcttg
      301 ttggttttat tgacggaagc tttgaaattg gaaatttgct tgtgattgta tttgtgagtt
      361 actttggatc caaactacat agaccaaagt taattggaat cggttgtttc attatgggaa
      421 ttggaggtgt tttgactgct ttgccacatt tcttcatggg atattacagg tattctaaag
      481 aaactaatat caattcatca gaaaattcaa catcgacctt atccacttgt ttaattaatc
      541 aaattttatc actcaataga gcatcacctg agatagtggg aaaaggttgt ttaaaggaat
      601 ctgggtcata catgtggata tatgtgttca tgggtaatat gcttcgtgga ataggggaga
      661 ctcccatagt accattgggg ctttcttaca ttgatgattt cgctaaagaa ggacattctt
      721 ctttgtattt aggtatattg aatgcaatag caatgattgg tccaatcatt ggctttaccc
      781 tgggatctct gttttctaaa atgtacgtgg atattggata tgtagatcta agcactatca
      841 ggataactcc tactgattct cgatgggttg gagcttggtg gcttaatttc cttgtgtctg
      901 gactattctc cattatttct tccataccat tctttttctt gccccaaact ccaaataaac
      961 cacaaaaaga aagaaaagct tcactgtctt tgcatgtgct ggaaacaaat gatgaaaagg
     1021 atcaaacagc taatttgacc aatcaaggaa aaaatattac caaaaatgtg actggttttt
     1081 tccagtcttt taaaagcatc cttactaatc ccctgtatgt tatgtttgtg cttttgacgt
     1141 tgttacaagt aagcagctat attggtgctt ttacttatgt cttcaaatac gtagagcaac
     1201 agtatggtca gccttcatct aaggctaaca tcttattggg agtcataacc atacctattt
     1261 ttgcaagtgg aatgttttta ggaggatata tcattaaaaa attcaaactg aacaccgttg
     1321 gaattgccaa attctcatgt tttactgctg tgatgtcatt gtccttttac ctattatatt
     1381 ttttcatact ctgtgaaaac aaatcagttg ccggactaac catgacctat gatggaaata
     1441 atccagtgac atctcataga gatgtaccac tttcttattg caactcagac tgcaattgtg
     1501 atgaaagtca atgggaacca gtctgtggaa acaatggaat aacttacatc tcaccctgtc
     1561 tagcaggttg caaatcttca agtggcaata aaaagcctat agtgttttac aactgcagtt
     1621 gtttggaagt aactggtctc cagaacagaa attactcagc ccatttgggt gaatgcccaa
     1681 gagatgatgc ttgtacaagg aaattttact tttttgttgc aatacaagtc ttgaatttat
     1741 ttttctctgc acttggaggc acctcacatg tcatgctgat tgttaaaatt gttcaacctg
     1801 aattgaaatc acttgcactg ggtttccact caatggttat acgagcacta ggaggaattc
     1861 tagctccaat atattttggg gctctgattg atacaacgtg tataaagtgg tccaccaaca
     1921 actgtggcac acgtgggtca tgtaggacat ataattccac atcattttca agggtctact
     1981 tgggcttgtc ttcaatgtta agagtctcat cacttgtttt atatattata ttaatttatg
     2041 ccatgaagaa aaaatatcaa gagaaagata tcaatgcatc agaaaatgga agtgtcatgg
     2101 atgaagcaaa cttagaatcc ttaaataaaa ataaacattt tgtcccttct gctggggcag
     2161 atagtgaaac acattgttaa ggggagaaaa aaagccactt ctgcttctgt gtttccaaac
     2221 agcattgcat tgattcagta agatgttatt tttgaggagt tcctggtcct ttcactaaga
     2281 atttccacat cttttatggt ggaagtataa ataagcctat gaacttataa taaaacaaac
     2341 tgtaggtaga aaaaatgaga gtactcattg ttacattata gctacatatt tgtggttaag
     2401 gttagactat atgatccata caaattaaag tgagagacat ggttactgtg taataaaaga
     2461 aaaaatactt gttcaggtaa ttctaattct taataaaaca aatgagtatc atacaggtag
     2521 aggttaaaaa ggaggagcta gattcatatc ctaagtaaag agaaatgcct agtgtctatt
     2581 ttattaaaca aacaaacaca gagtttgaac tataatacta aggcctgaag tctagcttgg
     2641 atatatgcta caataatatc tgttactcac ataaaattat atatttcaca gactttatca
     2701 atgtataatt aacaattatc ttgtttaagt aaatttagaa tacatttaag tattgtggaa
     2761 gaaataaaga cattccaata tttgcaa
//
