LOCUS       NM_001386879            7114 bp    mRNA    linear   PRI 12-MAR-2025
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            1A2 (SLCO1A2), transcript variant 4, mRNA.
ACCESSION   NM_001386879 XM_011520818
VERSION     NM_001386879.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7114)
  AUTHORS   Flogel,S., Tust,M., Boussettaoui,S., Fischer,D. and Grundemann,D.
  TITLE     Enhancing transporter activity in heterologous expression systems
            with SAHA: a 2500-times more potent and odorless alternative to
            butyrate
  JOURNAL   FEBS Open Bio (2025) In press
   PUBMED   40052353
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 7114)
  AUTHORS   Kataoka,H., Akiyoshi,T., Uchida,Y., Imaoka,A., Terasaki,T. and
            Ohtani,H.
  TITLE     The Effects of N-Glycosylation on the Expression and Transport
            Activity of OATP1A2 and OATP2B1
  JOURNAL   J Pharm Sci 113 (5), 1376-1384 (2024)
   PUBMED   38432624
  REMARK    GeneRIF: The Effects of N-Glycosylation on the Expression and
            Transport Activity of OATP1A2 and OATP2B1.
REFERENCE   3  (bases 1 to 7114)
  AUTHORS   Han,H., Akiyoshi,T., Morita,T., Kataoka,H., Katayama,K., Yajima,K.,
            Imaoka,A. and Ohtani,H.
  TITLE     Comparison of the transport kinetics of fexofenadine and its pH
            dependency among OATP1A2 genetic variants
  JOURNAL   Drug Metab Pharmacokinet 47, 100470 (2022)
   PUBMED   36116173
  REMARK    GeneRIF: Comparison of the transport kinetics of fexofenadine and
            its pH dependency among OATP1A2 genetic variants.
REFERENCE   4  (bases 1 to 7114)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   5  (bases 1 to 7114)
  AUTHORS   Zheng,X., Zhang,J.V., Bai,Y., Wang,J., Jiang,M., Zeng,S. and
            Wang,L.
  TITLE     Upregulation of OATP1A2 in human oesophageal squamous cell
            carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis
  JOURNAL   Xenobiotica 51 (12), 1453-1462 (2021)
   PUBMED   34823432
  REMARK    GeneRIF: Upregulation of OATP1A2 in human oesophageal squamous cell
            carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis.
REFERENCE   6  (bases 1 to 7114)
  AUTHORS   Kullak-Ublick,G.A., Fisch,T., Oswald,M., Hagenbuch,B., Meier,P.J.,
            Beuers,U. and Paumgartner,G.
  TITLE     Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier
            protein in human liver and brain
  JOURNAL   FEBS Lett 424 (3), 173-176 (1998)
   PUBMED   9539145
REFERENCE   7  (bases 1 to 7114)
  AUTHORS   Meier,P.J., Eckhardt,U., Schroeder,A., Hagenbuch,B. and Stieger,B.
  TITLE     Substrate specificity of sinusoidal bile acid and organic anion
            uptake systems in rat and human liver
  JOURNAL   Hepatology 26 (6), 1667-1677 (1997)
   PUBMED   9398014
  REMARK    Review article
REFERENCE   8  (bases 1 to 7114)
  AUTHORS   Kullak-Ublick,G.A., Beuers,U., Fahney,C., Hagenbuch,B., Meier,P.J.
            and Paumgartner,G.
  TITLE     Identification and functional characterization of the promoter
            region of the human organic anion transporting polypeptide gene
  JOURNAL   Hepatology 26 (4), 991-997 (1997)
   PUBMED   9328325
REFERENCE   9  (bases 1 to 7114)
  AUTHORS   Kullak-Ublick,G.A., Beuers,U., Meier,P.J., Domdey,H. and
            Paumgartner,G.
  TITLE     Assignment of the human organic anion transporting polypeptide
            (OATP) gene to chromosome 12p12 by fluorescence in situ
            hybridization
  JOURNAL   J Hepatol 25 (6), 985-987 (1996)
   PUBMED   9007731
REFERENCE   10 (bases 1 to 7114)
  AUTHORS   Kullak-Ublick,G.A., Hagenbuch,B., Stieger,B., Schteingart,C.D.,
            Hofmann,A.F., Wolkoff,A.W. and Meier,P.J.
  TITLE     Molecular and functional characterization of an organic anion
            transporting polypeptide cloned from human liver
  JOURNAL   Gastroenterology 109 (4), 1274-1282 (1995)
   PUBMED   7557095
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022224.22.
            
            On Sep 16, 2020 this sequence version replaced XM_011520818.1.
            
            Summary: This gene encodes a sodium-independent transporter which
            mediates cellular uptake of organic ions in the liver. Its
            substrates include bile acids, bromosulphophthalein, and some
            steroidal compounds. The protein is a member of the SLC21A family
            of solute carriers. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.108149.1,
                                           SRR1803611.264476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683939.1/ ENSP00000508235.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC022224.22        33816-33906
            92-213              AC022224.22        34024-34145
            214-355             AC022224.22        49810-49951
            356-488             AC022224.22        54052-54184
            489-595             AC022224.22        61745-61851
            596-742             AC022224.22        64160-64306
            743-841             AC022224.22        67464-67562
            842-1063            AC022224.22        68164-68385
            1064-1228           AC022224.22        71165-71329
            1229-1424           AC022224.22        72941-73136
            1425-1590           AC022224.22        74623-74788
            1591-1763           AC022224.22        76397-76569
            1764-1828           AC022224.22        93309-93373
            1829-1946           AC022224.22        94147-94264
            1947-7114           AC022224.22        98966-104133
FEATURES             Location/Qualifiers
     source          1..7114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..7114
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="solute carrier organic anion transporter family
                     member 1A2"
                     /db_xref="GeneID:6579"
                     /db_xref="HGNC:HGNC:10956"
                     /db_xref="MIM:602883"
     exon            1..91
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            92..213
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2166
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="isoform 1 is encoded by transcript variant 4;
                     organic anion transporting polypeptide A; solute carrier
                     family 21 (organic anion transporter), member 3;
                     sodium-independent organic anion transporter; OATP-1;
                     solute carrier family 21 member 3; organic
                     anion-transporting polypeptide 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1A2 isoform 1"
                     /protein_id="NP_001373808.1"
                     /db_xref="CCDS:CCDS8686.1"
                     /db_xref="GeneID:6579"
                     /db_xref="HGNC:HGNC:10956"
                     /db_xref="MIM:602883"
                     /translation="MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSML
                     TQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFL
                     KSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVY
                     VLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCA
                     NVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLE
                     TNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVN
                     MISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGC
                     WLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIW
                     DPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDKGPDCSL
                     MLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIY
                     FGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLR
                     KCHLPGENASSGTELIETKVKGKENECKDIYQKSTVLKDDELKTKL"
     exon            214..355
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            356..488
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..595
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            596..742
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            743..841
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1063
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1228
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1424
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1590
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1763
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1828
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1946
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..7114
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="hexamer: AATAAA"
     polyA_site      2320
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="major polyA site"
     regulatory      2805..2810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="hexamer: ATTAAA"
     polyA_site      2824
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="major polyA site"
     regulatory      7092..7097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="hexamer: AATAAA"
     polyA_site      7114
                     /gene="SLCO1A2"
                     /gene_synonym="OATP; OATP-A; OATP1A2; SLC21A3"
                     /note="major polyA site"
ORIGIN      
        1 aaagttattt gatgtacctt ttgaaataga aaaccaacaa ctaaatcttc tctaacacca
       61 tgattttcta atctgtatta aagcgttcca gggtagaagt aagacatatc aagatttaaa
      121 acataaatag cttggaacac cctgaagagc aacatgggag aaactgagaa aagaattgaa
      181 acccatagaa taagatgtct ttccaagttg aagatgtttc tgttggcaat aacatgtgca
      241 tttgtatcca aaacactgtc tggatcttat atgaattcca tgctcacaca aatagagaga
      301 caattcaaca tcccaacatc tctagttgga ttcattaatg gaagctttga gattggaaat
      361 cttttgttga ttatatttgt gagttatttt ggaaccaaac tgcatagacc tataatgatt
      421 ggcattggat gtgtggttat gggcttaggc tgtttcttaa aatcactacc tcatttcctc
      481 atgaaccaat atgaatatga atctacagtt tcagtttcag gcaacttgtc ctcaaacagt
      541 ttcttgtgta tggaaaatgg aacccagatt ttaagaccaa cgcaggatcc atcagagtgt
      601 acaaaggaag ttaaatcatt aatgtgggtg tacgtcctag taggcaatat tgtacgtgga
      661 atgggtgaaa ctcccatcct gcctttgggt atttcctata tagaagattt tgccaaattt
      721 gaaaattctc ctttatatat tgggcttgta gaaacaggag ctattattgg tcctttgatt
      781 ggacttttgt tggcatcatt ctgtgcaaat gtttatgttg acactggatt tgtgaacaca
      841 gatgatctga tcataactcc cactgacact cgttgggtcg gtgcatggtg gtttggcttt
      901 ctgatttgtg caggagttaa cgtgctcact gccattcctt ttttcttttt gcccaacaca
      961 cttccaaagg aaggactaga gactaatgct gacatcatta aaaatgaaaa tgaagacaaa
     1021 caaaaagaag aggtcaagaa ggaaaaatat ggaatcacta aagattttct acctttcatg
     1081 aaaagtcttt cctgcaatcc aatttatatg cttttcatac ttgtaagtgt gatacagttc
     1141 aatgcattcg ttaacatgat ctccttcatg cctaaatacc tagaacagca atatggaata
     1201 tcatcttcag atgcaatctt tctaatgggt atttataact tacctccaat atgtattgga
     1261 tatataattg gtggtttaat tatgaagaag ttcaagatta ctgtcaaaca agctgcccac
     1321 ataggatgtt ggttatcctt acttgagtat cttctctatt ttttatcttt tctcatgact
     1381 tgtgaaaatt cttcagttgt tggaataaat acctcttatg aaggaattcc acaagattta
     1441 tatgtggaaa atgacatctt tgctgattgc aatgtggatt gcaactgtcc atctaaaata
     1501 tgggatcctg tgtgtggaaa caatggcttg tcatatctgt cagcttgtct tgctggttgt
     1561 gagacatcca ttggaacggg aataaacatg gtgttccaaa attgcagctg tattcaaaca
     1621 tcaggaaatt catctgcagt tcttgggctg tgcgacaaag gacctgactg ttccttgatg
     1681 ctccagtact tcctaatctt gtcagcgatg agcagtttca tttattcttt ggctgccata
     1741 cctggatata tggttctctt gaggtgtatg aaatctgaag agaagtccct tggtgtggga
     1801 ttacatacat tttgcacaag agtatttgct ggcattcctg cacctatata ttttggcgct
     1861 ttaatggatt ccacatgttt acactgggga actttgaaat gtggtgagtc aggggcatgc
     1921 aggatatatg attccaccac cttcagatac atctacctcg gattgccggc agcactaaga
     1981 ggatcaagct ttgttccagc cttaatcatc ttaattcttt tgaggaagtg tcatctacct
     2041 ggtgaaaatg cctcttcagg aacagagctt atagagacaa aagtcaaagg gaaggaaaat
     2101 gagtgcaaag atatatacca aaagtccacg gttttgaaag atgatgaatt gaaaactaaa
     2161 ttgtaattgt cctattatat tacttttttc agaattagag aacatgctgt acaacttaat
     2221 tgttttaaaa atcagtagag atataataga taactttttc ttgtctttaa gaacctaaaa
     2281 aacctcttaa ctcaaaataa taaaatgttc actaatgata tttctaaggt atcagtgaca
     2341 cttgagtttt cctaggaggg acatcaataa cagcccccta aagaagattc ttagagccag
     2401 ctttattttt atgttgaaac agcaatttcc cttaattcat cgaagtaagg gtgtacttcc
     2461 tacatctcct tctactaata cttctaaaaa ttttctgtta tgaaaaccta tttaattcca
     2521 ctaaatttgt tctttgatat tggaattatt cagatgccta aattctcatt ctgttatgtg
     2581 aagatttaaa tattttattc aagtttatcg cttccatgtg agagaagcct acatcttctt
     2641 attctattta ggaatcgttc tttaactctt cttattcatt ctaggcatga ctcctatata
     2701 atagattact cataaatata ccctcctact ttcaattttt tcttttcttt attactcata
     2761 catttgctca atttgtacag aatactgaca aacttaagca ggttattaaa catcatgagg
     2821 caaagattgt tggatttttt ttcagtaatt caaatccagt gactaaagtt tttcttacaa
     2881 acaagtgtct gaatcaaagg atgaaaggac aatattataa aaactccagt tcttaaaggc
     2941 tgtttgtaat gtcagatatt gtcaaagaac cactttctaa gattcaggac tctttagacc
     3001 gatgtttata tcacccattg tgtcctaagg tagaacacaa acactaattt tcccaaaata
     3061 atcttagaca atagcttctg ttatgaaaca gaggttagta aaggctaagg tacatattaa
     3121 aagctaaatc tacttatatt attattttgt aaattatgga taaaattaaa aattgaagga
     3181 ttttagacat agaagaggac ttattgatta atatagggct tctggtaaaa gagaatagaa
     3241 tgaacagaca aatacctgtt tgtctactcc ttactctcct tcctgttgaa atgacagtca
     3301 atatataaga atgacataaa tccctaatgg atgaagagaa tggagtaagg aagggtggga
     3361 gaagtgggtg tcaatacact atggttattt atgtgtacta taaatggagt gagagtgtct
     3421 gcagggatac aacagagtgg aggaagctga aatacagaat atacctagaa ggagcctgga
     3481 atggaagtgt gaaactgagt tgccagttca aagtgtgagt tggtagctgg acagaaagca
     3541 ggccagttaa ctgaaggact ttgtacagat gctttacagg ttaatatgat ttcctaaatg
     3601 atcagatgca tcatatgaaa aaagaaagca aatgagaaga gaaaggctgt atagaacagg
     3661 tttaggggga aggatgaaaa gttaagtttc agtttcatga agtttgagac ttcaactctg
     3721 ggcatataaa aaataaccaa ggttcaaacc aagactggct ttgaaacaag agagaggaac
     3781 taaaatcatt ggaaaggggg agtttaactt tgatgtaggt atgactgcag cagtgagata
     3841 tcgtattaag atctgatgac atgaaatttg gagccacttc ctttgtggtg ggaggaagtg
     3901 aggagaatgg cctggaaact aaaacaagga gaagagactt acctatattc acagagcagc
     3961 aagaaaaagt aaacagccac tgcatgagaa ggtttcaggg gaatcagatt ttgctgagtg
     4021 tgcgatggtg aagagaatgc tcatttctga actggaatct gagctaaaaa gaagcaaata
     4081 ggatatatat ggaagttaga cttatggaaa ttagaagaag gggaatgaga gatagtttgg
     4141 aattctgtgg ctatttaggt gactgacata aatgggggca gaggacataa tgaggttagt
     4201 tcttacggat tcaaggcaga tagtgttggt gaaacagtga gtgtcaaaat taggcgaggt
     4261 ggtgactggg ctccctgatg acctcttgtc gtggagcaaa actgaataag caaaaactta
     4321 ctcaagctcc tgaggcccat tcatcatccc tattgataga tttgaggtga tctgagaaag
     4381 ctgagtcttg ctttgtggac aattcaccca cttgaactcc ctcaatggag catcataggc
     4441 ccagagagac atggctatgg acttagtacc ttggcatcac ttttatcccc tcatggagga
     4501 gatggcattt tactctgaaa acatagggtt ctcctttgac acttcttggt gggagaaagc
     4561 aggtcagaga aagtgggtgt tggagtgctt tgggatccct catgacctct tttgttggta
     4621 tacatgaagc ctgggagttt agttcttatt ctgagcactt gtactactct catgagggta
     4681 gagataatgg catagcggac agacatggag aagagaaaca agagaacagg tagtgagaag
     4741 tcgagagtca gtaattttct tacttaatat tgtggggatc ttacttaata cataaagtta
     4801 atgaaactag aaatagtggt ttaatatatt acttataatt caaaaattaa cctatattta
     4861 cagatgctta cacagtttct ttgtgaatcc acctatggtt ttattttaat taatttttta
     4921 ttgcaaagca atgaaatgtt gctttgtgga gccagatagc attacagcag gtaaatgggt
     4981 ttctgctaga tctccacatt attggggaga tgctcgaaga cctcagaata tacacaccct
     5041 taaggttcaa gggctggggt tgagctctcc ataaggaact tttcctcctc ccagaagggc
     5101 gatcattgtg tatatagaca tggagacaga accagaatga cttctgtggg tggaaatagt
     5161 gccatcagaa tcatttatta ttatgaaata aatattattt atctacattg aaaaaatact
     5221 actcctccta aaatcattaa cttttcctca gatgatttta agaaatttga gtaatagcac
     5281 acgaagtggt aaagaccctt agtctttctg gtatattaga aaagcctttt aatcagtctc
     5341 tggaaggaca ctagggattg cagctgaata aatatattaa gaataacaaa tcagttcaac
     5401 aaggagtaga gtctgaagtg ggattttccg tggaaattct cttatgtctg tactaacaat
     5461 aagaaagaca agacaaagac taagtaatta aagaaaagct cgaaatgttt tgtaaccaaa
     5521 agcttgaaat gttatgtaac cagaatgtta tgtaaccaga gctgttagat cagatactgg
     5581 ctgattcata ggtgaacgtc ctctttgtgg gtcctctcat gcatccccat tttcagaatg
     5641 taaataattt ggctttgtag cccttccaaa aagggtacta tcccacttct cctggcataa
     5701 atcatacatt gactgaacgt tcaccatcta aaaatcactc atgctccttg aaccaaggtg
     5761 attatcagag acagctcctg gtagaagagg ttgtagatgt taaaagagta tgatttctat
     5821 ataagaaaat atagaaattg acagaatggt tcttatttac tgggcctgga gaattcctgt
     5881 tctggcattc ttagatccct caaatttatt accaagggga aaaggaaaaa gaggcaagta
     5941 ggcagtaggg taagctgttg tttgcttgcc aaggaactgg agagtgcagg tttcaagaca
     6001 ccttgaggaa attctcctga gcccttagcc aagagaagag agcagaaaat gcttttctgt
     6061 agaatcccaa gaggcataaa agaggatgag taactgggtc ctgtgccaag ttcccaaccc
     6121 ctaagccttc ccaacatgga gaaactacac cagtgtttaa aagtttctag gttggaggaa
     6181 caaacttgag catcaagggc agatgatttg ttaacacagt cctgtgcaga gggctccttc
     6241 agaaggcatc ccctgtgacc caaacacagt gagcaccttc tactttctgg ccttatgcca
     6301 tcaatgcatc cagctgcaat ctatcctcaa acctggaatc catctcttga cttcccagcc
     6361 agaccacctt ccatcccttc actgtgtccc accctgccca gaatgcatgc tgttctccca
     6421 gagtctcatg gaaataaggc cttgcactga aataggctgt gggaaacaaa aggataagca
     6481 ggtctggacc agtctgtaat ggtagcaggt gaaaacaact tacggaaaaa cacatgaatt
     6541 cattaggaaa taaggtgaca gatccccagc tgctgaagaa ctagaatgtc tattacactc
     6601 atacaattga tgttttattt taatacacca gagctaccac acaaaacttc cttccatgtg
     6661 aaaggctcca gataaaattc tgccatccct cctctcctca tgtcctcctg ctcagaccca
     6721 ccttcatgcc cctaaaccaa tctgcatcat gcctgtttca gagagtcatg ggaagatggg
     6781 cagtgcctcc attgtcacca ttccccacac ctctgcacac ttctgcccct tcccctctag
     6841 acgccacaac ttcacagtct tactgttgta aatattcctg cacagttagt aatgatcaaa
     6901 tgatcctgtg gtcagaggcc tctttggcag tgtcttctta cccttaagaa aggtcatgaa
     6961 atccagaagg ggcaaccttt ccaggagagc tttggagtca tttctgtgtg agacactatt
     7021 gcataatcct gtaagattgc ttttatattt aaggaatgat gttacttaac aaatgaacaa
     7081 aaaaaattgc aaataaattt tttaacaatg ttta
//
