LOCUS       NM_178527               4410 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens solute carrier family 9 member C2 (putative) (SLC9C2),
            mRNA.
ACCESSION   NM_178527
VERSION     NM_178527.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4410)
  AUTHORS   Fuster,D.G. and Alexander,R.T.
  TITLE     Traditional and emerging roles for the SLC9 Na+/H+ exchangers
  JOURNAL   Pflugers Arch 466 (1), 61-76 (2014)
   PUBMED   24337822
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB071569.1, AK128104.1, BC042592.1 and AL139142.10.
            
            On Nov 22, 2018 this sequence version replaced NM_178527.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128104.1, BC042592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367714.4/ ENSP00000356687.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               DB071569.1         23-546
            525-2156            AK128104.1         547-2178
            2157-3202           BC042592.1         2126-3171
            3203-4405           AK128104.1         3225-4427
            4406-4410           AL139142.10        26327-26331         c
FEATURES             Location/Qualifiers
     source          1..4410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..4410
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /note="solute carrier family 9 member C2 (putative)"
                     /db_xref="GeneID:284525"
                     /db_xref="HGNC:HGNC:28664"
                     /db_xref="MIM:620338"
     exon            1..322
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            323..528
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..3776
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /note="NHE-11; Na(+)/H(+) exchanger 11; solute carrier
                     family 9, member 11"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 11"
                     /protein_id="NP_848622.2"
                     /db_xref="CCDS:CCDS1308.1"
                     /db_xref="GeneID:284525"
                     /db_xref="HGNC:HGNC:28664"
                     /db_xref="MIM:620338"
                     /translation="MSSYFWAQNESNRPDLLCGQPADYLVEEKHFTTLVCFIVVLGGL
                     LKMCLKNCEVIVLTILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLIIF
                     MVALDVEFYTLKKMFWQVLLTGLISFSTASIIIGYVVIKFNKDSWDLQSCLLFSITLG
                     IIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRGNRIHFSIFRDLHVG
                     IELSYDILGSIIFGYWCAKIIQCILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGT
                     LALAAVGLNLDSLTFKPKIELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHT
                     IPFIFILFTTVNLVRLLTILLVSPILMHSNYEYNWRWGVVITWSGIKGVFNLLWAPDV
                     YNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNATQ
                     HIQEIVQNTITLFKTEKILTNVNWTLVEDKTRIEYIPFSHVSHNDMKTESTTDEALME
                     EARLHVAAIQMSSFEKQRNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTR
                     SWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPM
                     IIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLEFFILVIG
                     IIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIKKRLS
                     LMYSITKGYIKSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDV
                     VIALKTKQAIRNVIAKALKNLTFLCSRGIIDKHEVIEINKVLLKKLKALNNFPKAIPP
                     PTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEMPQGIYLIISGMAIL
                     HSLSPTFGIESNQRCDRGSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETSLQACF
                     ISLEDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVET
                     LSSYSDMIIDNMTMKFVIIVYGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLII
                     QASELTQRNSNTNVMASVNTVFEQPGKNINGRQKMS"
     exon            529..629
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            630..758
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            759..924
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1041
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1203
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1303
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1447
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1616
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1698
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1862
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1958
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2056
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2176
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2375
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2564
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2714
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2766
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2915
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3041
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3140
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3308
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3440
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3626
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3711
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3772
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..4410
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4380..4385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /note="hexamer: AATAAA"
     polyA_site      4410
                     /gene="SLC9C2"
                     /gene_synonym="NHE11; SLC9A11"
                     /note="major polyA site"
ORIGIN      
        1 agttggtagt actgtccctg gcaaacagac gcataactgt gcattgttct ttgggatttt
       61 gagagccttc atctcaattt caactttaaa gcagcttaat ctttaaggaa catatctctg
      121 atctgggtaa tttgtagaac ttaatttgag ggtcattaca tgtgaggata gcaggagttg
      181 aagatgccaa ggacctgaag ggctactgga gggacaggtg aagtgatttg aagatgtagc
      241 attttgaatc tctttctggc ccatcctctg cttcacacca gaatcattgt gacctgtaga
      301 cctgcaaaac aaaggaccaa aggttagcat gcagaagtga aagtgtcaat aataaccaaa
      361 ccactccatc aagttaggtc tggggaaaag cagcagcaaa aatgagttct tacttctggg
      421 cacaaaatga aagtaacaga cctgatttac tctgcgggca gccagctgac taccttgttg
      481 aagagaaaca tttcacaacg cttgtatgct tcattgttgt tttgggaggg cttttgaaga
      541 tgtgtttaaa gaattgtgaa gtcattgttt tgacgattct ttctctatca ggattcgtga
      601 taggacacat ggcctacaat tctgttgagg tgcaccaaat tgtctaccct cttctaagaa
      661 catcaagttt ttcactttat tcttactttt cacctttaat tatatttatg gttgctttgg
      721 atgtagaatt ttatacactc aagaaaatgt tttggcaggt cttgttaact ggattaatta
      781 gcttttctac agcaagcatc ataattggat atgtcgttat aaaattcaat aaagattcat
      841 gggatttgca atcttgccta ctctttagca tcacccttgg cattatagat cctcttcgtt
      901 ctgtgaattc actaaaaact attggcattt ctaaaatata cattgatctc attagaggag
      961 aatcattgat catttgtagc atcgcatcaa ttttttttgg aaattttcgg ggcaacagaa
     1021 tccacttttc tatttttaga gatttacatg taggcattga actcagctat gacattttgg
     1081 gaagcataat atttggatat tggtgtgcaa aaatcattca gtgtatattg gctgacgttt
     1141 ttagcaatat gctgactaat atcattctct gcttttcaat ggtgtacatg actttctata
     1201 ttgtggaatt tttaggaatg tcaggcactc ttgccttagc cgctgtagga ctgaatttag
     1261 attctttaac ttttaaaccg aagatcgaac ttgtaattac taagttctta agaatttttt
     1321 catctgtata tgaacattta atatatgctt tctttggcat tgtgattgga tgtggagaac
     1381 tcagccacta tgaatttcac actatacctt tcatattcat tttatttaca acagtgaatt
     1441 tggtaaggtt gcttactatt ttgttagtga gccctatttt gatgcattca aattatgaat
     1501 ataattggcg atggggagtt gtaatcacgt ggtctggaat taaaggagtt tttaatttac
     1561 tctgggctcc tgatgtttat aatctcgctg aacgaaaagt ggaagtacca caaatgttta
     1621 tactctatgt acaagtaata tcattattga caatgggaat aaattcatac gtgatgactc
     1681 agtcagccag gaagttagat ttgtgtgttc tttccctccc aagacaaatg atcttgcaaa
     1741 atgccactca gcacatacag gagatagtac agaacacaat aactttattt aaaacagaaa
     1801 aaattttgac aaatgttaac tggaccttag tagaagataa aacgaggatc gaatacattc
     1861 ctttttccca cgtttcacat aatgatatga agacagaatc cacaacagat gaagctttaa
     1921 tggaggaagc cagattgcat gtagctgcaa tacaaatgag tagctttgaa aaacagcgta
     1981 acaatggaat tcttgaaata gaggcagccc ggatattaat tggtgcagca aaatgctatt
     2041 actccatcca aggaaaattc atgagtattt atgatgtttc aacttatatg agaactagaa
     2101 gttggcttat aaagtttaaa aatgttttaa ctttcttgga atattgtata gaaaagatac
     2161 attttattcc acctgagagt aatacatttc tgacttttat atttcacata gtattttctg
     2221 aagaatttga atatacagga cagattataa atttgatata tatttatcct atgataatac
     2281 atctgtggcc aatggcaaga ggtttaaatg tatcagcact gatatcaata aactactatt
     2341 ttatgttttt atatgtatta gaatcaacat tgaagataat aattttgaaa aggaaatatt
     2401 ttcaacaatg ttggaatact ttggaatttt ttatcctggt tattggaatc attgatatct
     2461 tttgtgtata ctttgtgaaa ttgagaccag acaacttggc tcttatacag cttacagtaa
     2521 taatgggata tttaagaata attaggtttc ttcctctctt caagataata gtaccaatac
     2581 tgataagaat tgcagatgtg cagatcaaaa agcgcctcag cttgatgtat agtattacaa
     2641 aaggctatat caaaagtcaa gaagatgcca aacttctaat aaaacaaata gctgtctgtg
     2701 aatcaatata tcagaaacta tgtgaaattt tggaaaccaa caaacaggat gctgtcaaag
     2761 aattagtact catggagcat gagggtcgtg atgttgtcat tgctttgaag actaaacagg
     2821 caatccggaa tgtgattgct aaagctctaa aaaatctcac cttcctttgt tcaagaggca
     2881 ttattgataa gcatgaagtc attgagataa ataaggtact tcttaaaaaa ttaaaagcac
     2941 taaataactt tccaaaggca atcccacccc caactcctga catatacctt cacaacatca
     3001 tttggctgga aggtaaagat gttctcattg acttcttcaa ggaaagagcc aaacttgcct
     3061 gttttgactc tggagatacc atttgtaaag gaggtgaaat gccacaagga atctacttaa
     3121 ttatttcagg aatggcaatt ttgcatagtt tatctcctac ctttggaata gagagtaatc
     3181 aaaggtgtga tagagggtcc agagacatgt ttacagagtt ctgtactact ggggacataa
     3241 ttggagagct aagctgtctg cttaagcgtg aaattgaata taccgtcatc tgtgaaacta
     3301 gtttacaggc ctgctttatc tccctggagg atttatatga aggctttgat gccttctggc
     3361 catctctgga atataaaata tggctaaagc ttgctctcag tactgcctat cagtattttg
     3421 aatcaagtct tattgatgag gacttaaggt ttcagaactg tgtgatgttc aatcaagcat
     3481 atgtggaaac tttatcaagc tatagtgaca tgattattga taatatgacc atgaaatttg
     3541 ttatcattgt gtatggcagt gtaattgata ctaagacaga ggaaccatat tttgcacctt
     3601 gcattatacc tacaacctgt gagcaggttc agggaacttc tgatttaagc aagctgctga
     3661 taatccaagc atctgagctt acccaaagaa atagtaacac caatgtcatg gcctcagtca
     3721 acacggtctt tgaacaacca ggaaagaata taaatggaag acaaaagatg agttgaaaac
     3781 tggataccat tttagaaaag ggtattaatg atacaaatat gatgtgtgga gtcaggttaa
     3841 agaccaaact actttcctcg ctcaaatact aaaggattat ctgcaaggag tttacttaga
     3901 agctactgaa acaggttact gctgcattta gtttataagc aatggatgga cttctgtaaa
     3961 acttcttaat tttaagtagt tgcattatat ttgggatgtt aaaaaagtct tcaggataat
     4021 ataaaataca ctgaaacata tgtcctacca aatgaaaccc tgtttccagc taagagcaaa
     4081 ttttaacata gtgcattata aaaagtgttg tataactgat atgttactct ctaaagcata
     4141 gaacctgtaa ttttcatttg tgaaattgtt ataattagtg cctccctaat attttcccga
     4201 gtatagctat tctccccttc ccagtttggt aaatattgaa aaacagaatt atattccaca
     4261 atcttagtaa ctttcagtaa gtaagtaact tttgctttca gtgaaattta ggagaaatta
     4321 atattctcat attgcatagt actgtttgat gtcacctttc attttatttt taaaaatcaa
     4381 ataaagttga gttttatggt tgtctattta
//
