LOCUS       NM_183061               4119 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens solute carrier family 9 member C1 (SLC9C1), transcript
            variant 1, mRNA.
ACCESSION   NM_183061 XM_210562
VERSION     NM_183061.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4119)
  AUTHORS   Cavarocchi,E., Whitfield,M., Chargui,A., Stouvenel,L., Lores,P.,
            Coutton,C., Arnoult,C., Santulli,P., Patrat,C., Thierry-Mieg,N.,
            Ray,P.F., Dulioust,E. and Toure,A.
  TITLE     The sodium/proton exchanger SLC9C1 (sNHE) is essential for human
            sperm motility and fertility
  JOURNAL   Clin Genet 99 (5), 684-693 (2021)
   PUBMED   33462806
  REMARK    GeneRIF: The sodium/proton exchanger SLC9C1 (sNHE) is essential for
            human sperm motility and fertility.
REFERENCE   2  (bases 1 to 4119)
  AUTHORS   Sun,Y.M., Su,Y., Li,J., Tian,Y. and Wang,L.F.
  TITLE     Role of the Na(+)/H(+) exchanger on the development of diabetes
            mellitus and its chronic complications
  JOURNAL   Biochem Biophys Res Commun 427 (2), 229-231 (2012)
   PUBMED   23000155
  REMARK    GeneRIF: this review outlines the contribution of NHE to chronic
            complications of diabetes mellitus, such as diabetic nephropathy;
            diabetic cardiomyopathy.[review]
            Review article
REFERENCE   3  (bases 1 to 4119)
  AUTHORS   Wang,D., King,S.M., Quill,T.A., Doolittle,L.K. and Garbers,D.L.
  TITLE     A new sperm-specific Na+/H+ exchanger required for sperm motility
            and fertility
  JOURNAL   Nat Cell Biol 5 (12), 1117-1122 (2003)
   PUBMED   14634667
REFERENCE   4  (bases 1 to 4119)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK128084.1, BC044801.1 and AC128688.4.
            
            On Nov 22, 2018 this sequence version replaced NM_183061.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305815.10/ ENSP00000306627.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               AK128084.1         43-474
            433-1089            BC044801.1         444-1100
            1090-1254           AK128084.1         1132-1296
            1255-4112           BC044801.1         1122-3979
            4113-4119           AC128688.4         53821-53827
FEATURES             Location/Qualifiers
     source          1..4119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..4119
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /note="solute carrier family 9 member C1"
                     /db_xref="GeneID:285335"
                     /db_xref="HGNC:HGNC:31401"
                     /db_xref="MIM:612738"
     exon            1..124
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            125..299
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3745
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sperm-specific sodium proton exchanger; sodium/hydrogen
                     exchanger 10; sperm-specific Na(+)/H(+) exchanger; solute
                     carrier family 9, member 10; solute carrier family 9,
                     subfamily C (Na+-transporting carboxylic acid
                     decarboxylase), member 1"
                     /codon_start=1
                     /product="solute carrier family 9 member C1 isoform 1"
                     /protein_id="NP_898884.1"
                     /db_xref="CCDS:CCDS33817.1"
                     /db_xref="GeneID:285335"
                     /db_xref="HGNC:HGNC:31401"
                     /db_xref="MIM:612738"
                     /translation="MAGIFKEFFFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVP
                     VILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQK
                     LFWQILLISIPGFLVNYILVLWHLASVNQLLLKPTQWLLFSAILVSSDPMLTAAAIRD
                     LGLSRSLISLINGESLMTSVISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIA
                     SFLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICELVGMSGIFTLAIVGLL
                     LNSTSFKAAIEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLYIEFVDIYYSLNIY
                     LTLIVLRFLTLLLISPVLSRVGHEFSWRWIFIMVCSEMKGMPNINMALLLAYSDLYFG
                     SDKEKSQILFHGVLVCLITLVVNRFILPVAVTILGLRDATSTKYKSVCCTFQHFQELT
                     KSAASALKFDKDLANADWNMIEKAITLENPYMLNEEETTEHQKVKCPHCNKEIDEIFN
                     TEAMELANRRLLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGKCMSLDTIKN
                     YSESQKTVTFARKLLLNWVYNTRKEKEGPSKYFFFRICHTIVFTEEFEHVGYLVILMN
                     IFPFIISWISQLNVIYHSELKHTNYCFLTLYILEALLKIAAMRKDFFSHAWNIFELAI
                     TLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRILRIFKLIAPKLLQIIDKRMSH
                     QKTFWYGILKGYVQGEADIMTIIDQITSSKQIKQMLLKQVIRNMEHAIKELGYLEYDH
                     PEIAVTVKTKEEINVMLNMATEILKAFGLKGIISKTEGAGINKLIMAKKKEVLDSQSI
                     IRPLTVEEVLYHIPWLDKNKDYINFIQEKAKVVTFDCGNDIFEEGDEPKGIYIIISGM
                     VKLEKSKPGLGIDQMVESKEKDFPIIDTDYMLSGEIIGEINCLTNEPMKYSATCKTVV
                     ETCFIPKTHLYDAFEQCSPLIKQKMWLKLGLAITARKIREHLSYEDWNYNMQLKLSNI
                     YVVDIPMSTKTDIYDENLIYVILIHGAVEDCLLRKTYRAPFLIPITCHQIQSIEDFTK
                     VVIIQTPINMKTFRRNIRKFVPKHKSYLTPGLIGSVGTLEEGIQEERNVKEDGAHSAA
                     TARSPQPCSLLGTKFNCKESPRINLRKVRKE"
     exon            300..400
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            401..529
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            530..695
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            696..824
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            825..986
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1089
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1233
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1408
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1490
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1657
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1783
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1881
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2001
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2197
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2383
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2533
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2585
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2734
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2860
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2959
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3130
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3262
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3448
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3575
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3628
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3735
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..4119
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4092..4097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /note="hexamer: AATAAA"
     regulatory      4102..4107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /note="hexamer: ATTAAA"
     polyA_site      4112
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
                     /note="major polyA site"
     polyA_site      4119
                     /gene="SLC9C1"
                     /gene_synonym="NHE; NHE-10; SLC9A10; sperm-NHE"
ORIGIN      
        1 gagtttggag caagtaactg tcagtgaggt tgcagttggt ctgggctgtt tggctgtgag
       61 cgaaatagct gccccccact tctcacttgc acaccacggg atactcctcc tgaggctccg
      121 gatgattcag atggactgtg aaaaacaaca agatggatga tcatatggag attgcttcta
      181 acataaatct gcataaaaat ttttctgaaa catggctgga atatttaagg agtttttttt
      241 cagtactgag gacctccctg aagtcattct aacattgtct ttgatcagct ccattggagc
      301 atttttgaac cggcacttgg aagactttcc aattcctgtc cctgtgatat tatttttact
      361 tggatgcagt tttgaagtat taagctttac atcttcacag gtccaaagat acgcaaacgc
      421 catacaatgg atgagtccag acttattttt tcgtatattt acaccagtag ttttctttac
      481 tactgcattt gacatggata cgtacatgct tcaaaagtta ttttggcaga tacttttaat
      541 ttcaattccc ggctttttgg ttaattatat cttagttctt tggcatctgg catctgtaaa
      601 tcaattactt ttgaagccta cccaatggtt attattttca gctatccttg tgagttcaga
      661 tcccatgcta accgcagctg ctataagaga ccttgggctt tctagaagcc tcatcagttt
      721 aattaatgga gaaagtctga tgacctctgt tatatcatta attacattta ctagtattat
      781 ggattttgac caaagactac aaagtaaaag aaaccatacc ttagctgaag agatcgtggg
      841 tggaatttgt tcatatatta tagcaagttt cttgtttgga attctaagtt caaaactgat
      901 tcaattttgg atgtcaactg tttttggtga tgatgtcaat catataagtc tcatcttttc
      961 aattctgtat ctcatctttt atatttgtga gttagttgga atgtcaggaa tatttactct
     1021 ggccattgtg ggacttcttt taaattctac aagttttaaa gcagcaattg aagaaacact
     1081 tcttcttgaa ttctggactt ttctatcacg tattgctttt ctcatggtgt ttactttctt
     1141 tggacttcta attcctgcac atacatattt gtatatagaa tttgttgata tatactattc
     1201 attaaatatc tacttaacat tgattgtttt aagatttctg acccttcttt taataagccc
     1261 tgttttgtct cgagttggtc atgagttcag ttggcgctgg atattcataa tggtctgtag
     1321 tgaaatgaag gggatgccta atataaacat ggcccttctg cttgcctact ctgatcttta
     1381 ttttggatct gacaaagaaa aatctcaaat attatttcat ggagtgttag tatgcctaat
     1441 aacccttgtt gtcaatagat ttattttgcc agtggcagtt actatactag gtcttcgtga
     1501 tgccacatca acaaaatata aatcggtttg ttgcacattt caacactttc aagagctaac
     1561 caagtctgca gcctctgccc ttaaatttga caaagatctt gctaatgctg attggaacat
     1621 gattgagaaa gcaattacac ttgaaaaccc atacatgttg aacgaagaag aaacaacaga
     1681 acatcagaag gtgaaatgtc cacactgtaa caaggaaata gatgagatct ttaacactga
     1741 agcaatggag ctggccaaca ggcgtctctt gtcagcacaa atagcaagct accagagaca
     1801 atacaggaat gagattctgt cccagagtgc tgtccaggtg ttggttggtg cagcagaaag
     1861 ttttggtgag aagaagggaa aatgtatgag tcttgataca ataaagaatt attctgaaag
     1921 ccaaaaaaca gttacctttg ctagaaaact actacttaat tgggtgtata ataccagaaa
     1981 ggaaaaagag ggcccatcaa aatacttctt ttttcgtata tgccatacaa tagtatttac
     2041 tgaggaattt gaacatgttg gataccttgt gatattaatg aatatatttc cctttataat
     2101 ctcttggata tcccagttaa atgtaatcta ccacagcgaa ttaaaacaca ctaactactg
     2161 ttttcttaca ctttatattc tagaggcact acttaagata gcagcaatga ggaaggactt
     2221 tttttcacat gcctggaaca tattcgagtt agcaattaca ttaattggca tcttacatgt
     2281 aatacttatt gaaatagaca ccattaagta tatttttaat gagactgaag taatagtctt
     2341 tataaaagtt gttcaatttt ttcgtatact acgcattttc aagctcatag caccaaagtt
     2401 gctgcaaata atagataaaa gaatgagtca tcagaagacc ttttggtatg gaatactaaa
     2461 aggctatgtc caaggcgaag cagacataat gaccataatt gatcagatta caagttctaa
     2521 acagattaaa cagatgttat taaagcaagt gataaggaat atggaacatg ctataaaaga
     2581 gctaggctac ttagagtatg atcacccaga aattgctgtc actgtgaaaa caaaggaaga
     2641 aattaatgtt atgctcaata tggctacaga aattcttaag gcttttggct taaaaggaat
     2701 tattagtaaa actgaaggtg ctggaattaa taagttaatc atggccaaaa agaaagaggt
     2761 gcttgattct caatctatta tcaggcctct tactgttgaa gaagttctat atcatattcc
     2821 gtggctagat aaaaacaaag attatataaa cttcattcag gaaaaagcca aagttgtaac
     2881 atttgattgt ggaaatgata tatttgaaga aggtgatgag cccaaaggaa tctatatcat
     2941 tatttcaggc atggtaaagc ttgaaaaatc aaagccaggt ttagggattg atcaaatggt
     3001 ggagtcaaag gagaaagatt ttccgataat tgacacagac tatatgctca gtggagaaat
     3061 aataggagag ataaactgct taactaatga acctatgaaa tattctgcca cctgcaaaac
     3121 tgtagtggag acatgtttta ttcccaaaac tcacttgtat gatgcttttg agcaatgctc
     3181 tcctctcatt aaacaaaaaa tgtggctaaa acttggactc gctattacag ccagaaaaat
     3241 cagagaacac ttatcttatg aggattggaa ctacaatatg caactaaagc tctctaatat
     3301 ttatgtagta gatataccaa tgagtaccaa aactgatatt tatgatgaaa atctaatcta
     3361 tgttatcctc atacatggag ctgtagaaga ttgtctgtta cgaaaaactt atagagcacc
     3421 tttcttaatt cctataacat gccatcagat acaaagtatt gaagatttca caaaagtagt
     3481 gattattcaa actccgatta acatgaaaac attcagaagg aatattagaa agtttgttcc
     3541 taaacataaa agttatctta caccaggatt aataggttca gttggaacat tggaagaagg
     3601 cattcaagaa gaaagaaatg ttaaggagga tggagcacac agtgccgcca ctgccaggag
     3661 tccccagcct tgctccctgc tggggacaaa gttcaactgt aaggagtccc ctagaataaa
     3721 cctaaggaaa gtcaggaaag agtaagactg ttaagaagac cgaagcatgt attaatgctg
     3781 tggctatgag aggcctcctg ctgcagaaac acacttccct acatcaagaa ggagtaactt
     3841 caggttggat cctgtgtgga tgatcttggt gctaagcaga aaagaaattt ggaccttgaa
     3901 accagcagtt caacatatat actttttgca aaatttcctt gatttaaaat atttgttatt
     3961 ttaaatatac aaaacatttt agaaaatctt agagtaaatt ttagtcttaa agccagaaaa
     4021 taagtttata gccatctaga tattttgcat attgctctta cagcaataat ggtttggttc
     4081 actttatgaa aaataaaatg tattaaaata tagtttaaa
//
