LOCUS       NM_139173               1845 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 9 member B1 (SLC9B1), transcript
            variant 1, mRNA.
ACCESSION   NM_139173
VERSION     NM_139173.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Knight,A.K., Conneely,K.N., Kilaru,V., Cobb,D., Payne,J.L.,
            Meilman,S., Corwin,E.J., Kaminsky,Z.A., Dunlop,A.L. and Smith,A.K.
  TITLE     SLC9B1 methylation predicts fetal intolerance of labor
  JOURNAL   Epigenetics 13 (1), 33-39 (2018)
   PUBMED   29235940
  REMARK    GeneRIF: DNA methylation patterns in maternal blood at four CpG
            sites in SLC9B1 are predictive of fetal intolerance of labor during
            the late second and early third trimester.
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Kumar,P.L. and James,P.F.
  TITLE     Identification and characterization of
            methylation-dependent/independent DNA regulatory elements in the
            human SLC9B1 gene
  JOURNAL   Gene 561 (2), 235-248 (2015)
   PUBMED   25701605
  REMARK    GeneRIF: Results identified multiple cis-acting DNA regulatory
            elements in the 5 end of the SLC9B1 gene and shown that DNA
            methylation at these elements could provide mechanisms by which
            SLC9B1 expression is restricted to male germ cells.
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Ye,G., Chen,C., Han,D., Xiong,X., Kong,Y., Wan,B. and Yu,L.
  TITLE     Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain
            containing 1) gene expressed specifically in testis
  JOURNAL   Mol Biol Rep 33 (3), 175-180 (2006)
   PUBMED   16850186
  REMARK    GeneRIF: cloning and characterization of a novel NHEDC1 (Na+/H+
            exchanger like domain containing 1) gene; it was mapped to
            chromosome 4p24; molecular weight of NHEDC1 is about 56 KDa; it is
            exclusively expressed in the testis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097485.2 and AC083826.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_139173.3.
            
            Summary: The protein encoded by this gene is a sodium/hydrogen
            exchanger and transmembrane protein. Highly conserved orthologs of
            this gene have been found in other mammalian species. The
            expression of this gene may be limited to testis. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ003059.1, BC136966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000296422.12/
                                                  ENSP00000296422.7
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC097485.2         311-417             c
            108-177             AC083826.7         99595-99664         c
            178-319             AC083826.7         97752-97893         c
            320-490             AC083826.7         57209-57379         c
            491-633             AC083826.7         54599-54741         c
            634-761             AC083826.7         53145-53272         c
            762-937             AC083826.7         40076-40251         c
            938-1044            AC083826.7         19383-19489         c
            1045-1194           AC083826.7         18391-18540         c
            1195-1303           AC083826.7         14488-14596         c
            1304-1440           AC083826.7         13466-13602         c
            1441-1845           AC083826.7         8880-9284           c
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1845
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /note="solute carrier family 9 member B1"
                     /db_xref="GeneID:150159"
                     /db_xref="HGNC:HGNC:24244"
                     /db_xref="MIM:611527"
     exon            1..107
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..177
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1656
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium/hydrogen exchanger 9B1; solute carrier family 9,
                     subfamily B (cation proton antiporter 2), member 1;
                     sodium/hydrogen exchanger-like domain-containing protein
                     1; NHE domain-containing protein 1; Na(+)/H(+)
                     exchanger-like domain-containing protein 1; solute carrier
                     family 9, subfamily B (NHA1, cation proton antiporter 1),
                     member 1; testicular tissue protein Li 127"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 9B1 isoform 1"
                     /protein_id="NP_631912.3"
                     /db_xref="CCDS:CCDS34041.1"
                     /db_xref="GeneID:150159"
                     /db_xref="HGNC:HGNC:24244"
                     /db_xref="MIM:611527"
                     /translation="MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTE
                     EIKPQTKKETYISCPLRGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIF
                     YSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIA
                     LTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLG
                     FVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSS
                     GGILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGS
                     QRIGLHGSGGLCTLVLSFIAGTKWSQEKMKVQKIITTVWDIFQPLLFGLVGAEVSVSS
                     LESNIVGISVATLSLALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPL
                     ALETARVSAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPKMLTRHYDPSKIKLQ
                     LSTLEHH"
     exon            178..319
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..490
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..633
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..761
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..937
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1044
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1194
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1303
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1440
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1845
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1652..1657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1671
                     /gene="SLC9B1"
                     /gene_synonym="NHA1; NHEDC1"
                     /note="major polyA site"
ORIGIN      
        1 gctttcgcgt caccaccctg cccacctggg tggcgcgtgg cttacgcaac ggtcactggg
       61 ctcctgggcc gctcccgggc cagcgagggc tgcgaaagaa gttgtagcat gcataccaca
      121 gaatcaaaaa atgaacattt ggaggatgaa aacttccaaa catctacaac tcctcagagt
      181 ctcattgatc ctaataatac tgcacaggaa gaaactaaaa ctgtcttatc agatacagaa
      241 gaaataaaac cacagacaaa aaaggagaca tacatttctt gtcctctaag aggagtattg
      301 aatgtaatta ttacaaatgg agttatactg tttgtgatat ggtgtatgac ctggtcaatc
      361 ttaggctctg aagctctccc tggtggaaat ttatttgggt tgttcattat tttttatagt
      421 gccattattg ggggaaaaat tttacaactc attagaatac ctttagtgcc tccacttcca
      481 cctcttcttg ggatgttact ggctggtttt acgattagga atgttccatt catcaatgaa
      541 catgtccatg ttcctaacac atggtcttca attttaagaa gcattgccct taccattatt
      601 ctaataagag ctgggcttgg actcgatcca caggctttga ggcatttgaa ggtcgtttgt
      661 ttcagattgg ctgtaggtcc atgccttatg gaggcaagtg cagctgctgt tttttcacac
      721 ttcattatga aatttccctg gcaatgggca tttctattag gttttgttct aggtgctgtc
      781 tctcctgctg ttgttgtccc ttacatgatg gtgctgcaag aaaatggata tggtgttgag
      841 gaaggcattc caaccttatt aatggctgct agcagtatgg atgacattct ggctatcact
      901 ggattcaata catgcttgag catagtcttt tcctcaggtg gtatacttaa taacgccata
      961 gcctctataa ggaacgtatg tattagtctg ctggcaggaa ttgttttggg attttttgtt
     1021 cgatattttc caagtgaaga ccagaaaaaa cttacattga agagaggatt ccttgttttg
     1081 actatgtgtg tttctgccgt cttaggcagc caacgtattg gtttacatgg atctggagga
     1141 ttatgcacac tagtgttgag tttcattgca gggacaaaat ggtcccaaga aaagatgaaa
     1201 gtccaaaaga ttattacgac tgtatgggat atttttcaac cacttctttt tggtttagtt
     1261 ggagcagaag tatctgtttc atcgcttgaa tcaaatattg ttggcatatc tgttgccact
     1321 ctaagtttgg cattatgtgt tcgaatttta accacatatc tattgatgtg ctttgctggt
     1381 tttagtttta aggagaaaat atttattgct ttagcatgga tgcccaaagc tacagtacag
     1441 gctgtgttag gtcctctggc tctagaaaca gcaagagtct ccgcacccca cttggaacca
     1501 tatgcgaagg atgtgatgac agtagcattt ttagccatct tgatcacagc tccaaatgga
     1561 gctctactta tgggcattct ggggcctaaa atgcttacac gccattatga tccaagcaaa
     1621 ataaaactgc agttgtcaac attagaacat cattaaaaag tttacctgtc atcatctgcc
     1681 tgcttctttt aatgaattat ttcacatgac agaagaattt taaagtagaa atatgtgggg
     1741 actgtacaga gaatccagga tttagtaaac atgtgatttc agtacagggc ttttcttgga
     1801 ctttttactc caaagttaat ttaataaaaa taatattaaa tggaa
//
