LOCUS       NM_173653               3564 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens solute carrier family 9 member A9 (SLC9A9), mRNA.
ACCESSION   NM_173653
VERSION     NM_173653.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3564)
  AUTHORS   Prasad,H.
  TITLE     Genes for endosomal pH regulators NHE6 and NHE9 are dysregulated in
            the substantia nigra in Parkinson's disease
  JOURNAL   Gene 927, 148737 (2024)
   PUBMED   38945311
  REMARK    GeneRIF: Genes for endosomal pH regulators NHE6 and NHE9 are
            dysregulated in the substantia nigra in Parkinson's disease.
REFERENCE   2  (bases 1 to 3564)
  AUTHORS   Winklemann,I., Matsuoka,R., Meier,P.F., Shutin,D., Zhang,C.,
            Orellana,L., Sexton,R., Landreh,M., Robinson,C.V., Beckstein,O. and
            Drew,D.
  TITLE     Structure and elevator mechanism of the mammalian sodium/proton
            exchanger NHE9
  JOURNAL   EMBO J 39 (24), e105908 (2020)
   PUBMED   33118634
  REMARK    GeneRIF: Structure and elevator mechanism of the mammalian
            sodium/proton exchanger NHE9.
REFERENCE   3  (bases 1 to 3564)
  AUTHORS   Patak,J., Faraone,S.V. and Zhang-James,Y.
  TITLE     Sodium hydrogen exchanger 9 NHE9 (SLC9A9) and its emerging roles in
            neuropsychiatric comorbidity
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 183 (5), 289-305 (2020)
   PUBMED   32400953
  REMARK    GeneRIF: Sodium hydrogen exchanger 9 NHE9 (SLC9A9) and its emerging
            roles in neuropsychiatric comorbidity.
REFERENCE   4  (bases 1 to 3564)
  AUTHORS   Zhang-James,Y., Vaudel,M., Mjaavatten,O., Berven,F.S., Haavik,J.
            and Faraone,S.V.
  TITLE     Effect of disease-associated SLC9A9 mutations on protein-protein
            interaction networks: implications for molecular mechanisms for
            ADHD and autism
  JOURNAL   Atten Defic Hyperact Disord 11 (1), 91-105 (2019)
   PUBMED   30927234
  REMARK    GeneRIF: results provide a detailed understanding of the functions
            of protein NHE9 and its disrupted interactions, possibly underlying
            Attention Deficit Hyperactivity Disorder and Autism Spectrum
            Disorders.
REFERENCE   5  (bases 1 to 3564)
  AUTHORS   Gomez Zubieta,D.M., Hamood,M.A., Beydoun,R., Pall,A.E. and
            Kondapalli,K.C.
  TITLE     MicroRNA-135a regulates NHE9 to inhibit proliferation and migration
            of glioblastoma cells
  JOURNAL   Cell Commun Signal 15 (1), 55 (2017)
   PUBMED   29268774
  REMARK    GeneRIF: downregulation of miR-135a as a potential mechanism
            underlying the high NHE9 expression observed in subset of
            glioblastomas
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3564)
  AUTHORS   Lasky-Su,J., Neale,B.M., Franke,B., Anney,R.J., Zhou,K.,
            Maller,J.B., Vasquez,A.A., Chen,W., Asherson,P., Buitelaar,J.,
            Banaschewski,T., Ebstein,R., Gill,M., Miranda,A., Mulas,F.,
            Oades,R.D., Roeyers,H., Rothenberger,A., Sergeant,J.,
            Sonuga-Barke,E., Steinhausen,H.C., Taylor,E., Daly,M., Laird,N.,
            Lange,C. and Faraone,S.V.
  TITLE     Genome-wide association scan of quantitative traits for attention
            deficit hyperactivity disorder identifies novel associations and
            confirms candidate gene associations
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1345-1354 (2008)
   PUBMED   18821565
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3564)
  AUTHORS   Ng,D., Hu,N., Hu,Y., Wang,C., Giffen,C., Tang,Z.Z., Han,X.Y.,
            Yang,H.H., Lee,M.P., Goldstein,A.M. and Taylor,P.R.
  TITLE     Replication of a genome-wide case-control study of esophageal
            squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (7), 1610-1615 (2008)
   PUBMED   18649358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3564)
  AUTHORS   Ohgaki,R., Fukura,N., Matsushita,M., Mitsui,K. and Kanazawa,H.
  TITLE     Cell surface levels of organellar Na+/H+ exchanger isoform 6 are
            regulated by interaction with RACK1
  JOURNAL   J Biol Chem 283 (7), 4417-4429 (2008)
   PUBMED   18057008
REFERENCE   9  (bases 1 to 3564)
  AUTHORS   Nakamura,N., Tanaka,S., Teko,Y., Mitsui,K. and Kanazawa,H.
  TITLE     Four Na+/H+ exchanger isoforms are distributed to Golgi and
            post-Golgi compartments and are involved in organelle pH regulation
  JOURNAL   J Biol Chem 280 (2), 1561-1572 (2005)
   PUBMED   15522866
REFERENCE   10 (bases 1 to 3564)
  AUTHORS   de Silva,M.G., Elliott,K., Dahl,H.H., Fitzpatrick,E., Wilcox,S.,
            Delatycki,M., Williamson,R., Efron,D., Lynch,M. and Forrest,S.
  TITLE     Disruption of a novel member of a sodium/hydrogen exchanger family
            and DOCK3 is associated with an attention deficit hyperactivity
            disorder-like phenotype
  JOURNAL   J Med Genet 40 (10), 733-740 (2003)
   PUBMED   14569117
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB285312.1, AY254100.1,
            AB089794.1, AL832304.1 and AI252807.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_173653.3.
            
            Summary: This gene encodes a sodium/proton exchanger that is a
            member of the solute carrier 9 protein family. The encoded protein
            localizes the to the late recycling endosomes and may play an
            important role in maintaining cation homeostasis. Mutations in this
            gene are associated with autism susceptibility 16 and
            attention-deficit/hyperactivity disorder. [provided by RefSeq, Mar
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.66041.1,
                                           SRR1803616.250688.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316549.11/ ENSP00000320246.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DB285312.1         65-86
            23-146              AY254100.1         1-124
            147-2084            AB089794.1         1-1938
            2085-3552           AL832304.1         2013-3480
            3553-3564           AI252807.1         21-32               c
FEATURES             Location/Qualifiers
     source          1..3564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3564
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /note="solute carrier family 9 member A9"
                     /db_xref="GeneID:285195"
                     /db_xref="HGNC:HGNC:20653"
                     /db_xref="MIM:608396"
     exon            1..321
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2084
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /note="sodium/proton exchanger NHE9; Na(+)/H(+) exchanger
                     9; putative protein product of Nbla00118; solute carrier
                     family 9, subfamily A (NHE9, cation proton antiporter 9),
                     member 9; solute carrier family 9 (sodium/hydrogen
                     exchanger)"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 9"
                     /protein_id="NP_775924.1"
                     /db_xref="CCDS:CCDS33872.1"
                     /db_xref="GeneID:285195"
                     /db_xref="HGNC:HGNC:20653"
                     /db_xref="MIM:608396"
                     /translation="MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNH
                     RFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVYDCVKLTFSPSTLLVNITDQVY
                     EYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLG
                     SILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATDPVT
                     VLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDAAAFFQSVG
                     NFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTG
                     IVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIF
                     NALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAI
                     RNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQ
                     EANNLDKNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSP
                     QAYGEQLKEDDVECIVNQDELAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEG
                     DLGLGGYELKLEQTLGQSQLN"
     exon            322..524
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            525..602
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            603..679
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            680..795
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            796..901
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1040
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1146
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1235
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1349
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1461
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1615
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1670
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1750
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1856
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..3564
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /note="hexamer: AATAAA"
     polyA_site      3564
                     /gene="SLC9A9"
                     /gene_synonym="AUTS16; NHE9"
                     /note="major polyA site"
ORIGIN      
        1 aagccagggc agaatgcttg tgaagtagca actaaagtgg cagtgtttct tctgaaattc
       61 tcaggcagtc agactgtctt aggcaaatct tgataaaata gcctttatcc aggtttttat
      121 ctaaggaatc ccaagaagac tggggaatgg agagacagtc aagggttatg tcagaaaagg
      181 atgagtatca gtttcaacat cagggagcgg tggagctgct tgtcttcaat tttttgctca
      241 tccttaccat tttgacaatc tggttattta aaaatcatcg attccgcttc ttgcatgaaa
      301 ctggaggagc aatggtgtat ggccttataa tgggactaat tttacgatat gctacagcac
      361 caactgatat tgaaagtgga actgtctatg actgtgtaaa actaactttc agtccatcaa
      421 ctctgctggt taatatcact gaccaagttt atgaatataa atacaaaaga gaaataagtc
      481 agcacaacat caatcctcat caaggaaatg ctatacttga aaagatgaca tttgatccag
      541 aaatcttctt caatgtttta ctgccaccaa ttatatttca tgcaggatat agtctaaaga
      601 agagacactt ttttcaaaac ttaggatcta ttttaacgta tgccttcttg ggaactgcca
      661 tctcctgcat cgtcataggg ttaattatgt atggttttgt gaaggctatg atacatgctg
      721 gccagctgaa aaatggagac tttcatttca ctgactgttt attttttggt tcactgatgt
      781 ctgctacaga tccagtgaca gtgctggcca ttttccatga actgcacgtc gaccctgacc
      841 tgtacacact cttgtttgga gagagtgtgt tgaatgatgc agtggccata gtccttacat
      901 attctatatc catttacagt cccaaggaga atccaaatgc atttgatgcc gcagcattct
      961 tccagtctgt ggggaatttc ctgggaatct tcgctggctc atttgcaatg gggtctgcgt
     1021 atgccatcat cacagcactg ttgaccaaat ttaccaagct gtgtgagttc ccgatgctgg
     1081 aaaccggcct gtttttcctg ctttcttgga gtgccttcct gtctgccgag gctgccggcc
     1141 taacagggat agttgctgtt ctcttctgtg gagtcacaca agcacattat acctacaaca
     1201 atctgtcttc ggattccaaa ataagaacta aacagttgtt tgaatttatg aactttttgg
     1261 cggagaacgt catcttctgt tacatgggcc tggcactgtt cacgttccag aatcatatct
     1321 ttaatgctct ttttatactt ggagcctttc tagcaatttt tgttgccaga gcctgcaaca
     1381 tatatcccct ctccttcctc ctgaatctag gccgaaaaca gaagatcccc tggaactttc
     1441 agcacatgat gatgttttca ggtttgcgag gagcgatcgc atttgcctta gctattcgga
     1501 acacagaatc tcagcccaaa caaatgatgt ttaccactac gctgctcctc gtgttcttca
     1561 ctgtctgggt atttggagga ggaacaaccc ccatgttgac ttggcttcag atcagagttg
     1621 gcgtggacct ggatgaaaat ctgaaggagg acccctcctc acaacaccag gaagcaaata
     1681 acttggataa aaacatgacg aaagcagaga gtgctcggct cttcagaatg tggtatagct
     1741 ttgaccacaa gtatctgaaa ccaattttaa cccactctgg tcctccgctg actacaacat
     1801 tacctgaatg gtgtggtccg atttccaggc tgcttaccag tcctcaagcc tatggggaac
     1861 agctaaaaga ggatgatgtg gaatgcattg taaaccagga tgaactagcc ataaattacc
     1921 aggagcaagc ctcctcaccc tgcagtcctc ctgcaaggct aggtctggac cagaaagctt
     1981 caccccagac gccaggcaag gaaaacattt atgagggaga cctcggcctg ggaggctatg
     2041 aactcaagct tgagcaaact ttgggtcaat cccagttgaa ttaattggca tgaagagtac
     2101 agatgtaatc acaagtaatg caagactcac tgaggaatac aagccaagct gatgaggcag
     2161 tacaggggag aggctggaaa acatattaag agcataaatt ggagagaatc aaagccttgt
     2221 cacatggatc ctctggtgcc tgaagaaatg agattttatt atccctctct attatgcaaa
     2281 tgaatttagt tttttgacag cagccattct gattactgga ttggctgggg tggggatgga
     2341 ggtatcagga gtctagctgc tggaggatgg gacagctgtg ctgggtcttc agggcatttc
     2401 tgctgcgaat gcggctctcc aggcccttca cttctattct ggattttatt ccctccatta
     2461 aggagagttt aaaaataaaa gaaagcttct gagagtaaac attttgctcc taagctgaag
     2521 ggaatgccca gctatttagt aagtgataag tttcttattt tgaggacttg actcccattt
     2581 gctctcagtg accccagggc agagcccaga gaagtgttcc gtacccactg ctgatggttt
     2641 cccagagccc acactgagtt gaagaaccta ttgttcttct tggcatcctt cttatgctac
     2701 ttctcccatc gctcaaaggg gttgcctatg gctgggtgtg ccctgcccta aatgcagcac
     2761 cactttcaag cttagtagga ccattccaag aaaaccaggt ttcttctccc cataccacgt
     2821 tgtgcctgaa gaacaagcct tcccgtcctt gcctgcatgt gagtcacttc ttggctgtgc
     2881 agcaggtccc cccctccccg cgatatgctg gagggtagga ttctgcagcc tgtgttgctc
     2941 tctacctggc agcagactgt gcaggagccc caacctgtcc tccaattcca gcattcacag
     3001 ctgatgagca gtgcaggagc agggcgagag gaacagagcc aatgatgtgt gggttacact
     3061 gaggagccaa ggacagggcc tcaggtctcc cccttacaag gcgtggctca tggcctgcat
     3121 tccagagacc aacatgatag cttttaattc agctgcatga cctgtgcctt ttaagccata
     3181 aagatacctc aagcctagca cctcttgaaa tccagatgtt catattagac tcgaaaaaat
     3241 aggctccagg cctaggtgcc caggctatga tgagtctgct tttgaaggag gtagggaatg
     3301 acatcttcct tggacccaaa gcttaaaagt aatgtatgct ttgctgacca ctgtttgtta
     3361 ggccttaaac aacattcact gtggtggtat caggcacact gctatgtgca tcaattattt
     3421 ttttgctttc caaacagaat ctctggggca caagttttac actcaagcta agtataactt
     3481 tgtcatttca ggtaaatatg acaagtggtg gagcatgaag ttttctaatt tgacttaatc
     3541 ctaataaatt tttgttacaa agta
//
