LOCUS       NM_004174               5555 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 9 member A3 (SLC9A3), transcript
            variant 1, mRNA.
ACCESSION   NM_004174
VERSION     NM_004174.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5555)
  AUTHORS   Qu,D., Schurmann,P., Rothamel,T., Flessner,J., Rehberg,D., Dork,T.
            and Klintschar,M.
  TITLE     Revisiting the association of sudden infant death syndrome (SIDS)
            with polymorphisms of NHE3 and IL13
  JOURNAL   Int J Legal Med 138 (3), 743-749 (2024)
   PUBMED   38091065
  REMARK    GeneRIF: Revisiting the association of sudden infant death syndrome
            (SIDS) with polymorphisms of NHE3 and IL13.
REFERENCE   2  (bases 1 to 5555)
  AUTHORS   Dominguez Rieg,J.A. and Rieg,T.
  TITLE     New functions and roles of the Na+-H+-exchanger NHE3
  JOURNAL   Pflugers Arch 476 (4), 505-516 (2024)
   PUBMED   38448727
  REMARK    GeneRIF: New functions and roles of the Na[+]-H[+]-exchanger NHE3.
            Review article
REFERENCE   3  (bases 1 to 5555)
  AUTHORS   Han,Y., Bagchi,P. and Yun,C.C.
  TITLE     Regulation of the intestinal Na+/H+ exchanger NHE3 by AMP-activated
            kinase is dependent on phosphorylation of NHE3 at S555 and S563
  JOURNAL   Am J Physiol Cell Physiol 326 (1), C50-C59 (2024)
   PUBMED   38047302
  REMARK    GeneRIF: Regulation of the intestinal Na[+]/H[+] exchanger NHE3 by
            AMP-activated kinase is dependent on phosphorylation of NHE3 at
            S555 and S563.
REFERENCE   4  (bases 1 to 5555)
  AUTHORS   Anbazhagan,A.N., Priyamvada,S., Kumar,A., Jayawardena,D.,
            Borthakur,A., Gill,R.K., Alrefai,W.A., Dudeja,P.K. and Saksena,S.
  TITLE     Downregulation of NHE-3 (SLC9A3) expression by MicroRNAs in
            intestinal epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 323 (6), C1720-C1727 (2022)
   PUBMED   36189974
  REMARK    GeneRIF: Downregulation of NHE-3 (SLC9A3) expression by MicroRNAs
            in intestinal epithelial cells.
REFERENCE   5  (bases 1 to 5555)
  AUTHORS   Xue,J., Dominguez Rieg,J.A., Thomas,L., White,J.R. and Rieg,T.
  TITLE     Intestine-Specific NHE3 Deletion in Adulthood Causes Microbial
            Dysbiosis
  JOURNAL   Front Cell Infect Microbiol 12, 896309 (2022)
   PUBMED   35719363
  REMARK    GeneRIF: Intestine-Specific NHE3 Deletion in Adulthood Causes
            Microbial Dysbiosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5555)
  AUTHORS   Dudeja,P.K., Rao,D.D., Syed,I., Joshi,V., Dahdal,R.Y., Gardner,C.,
            Risk,M.C., Schmidt,L., Bavishi,D., Kim,K.E., Harig,J.M.,
            Goldstein,J.L., Layden,T.J. and Ramaswamy,K.
  TITLE     Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1,
            NHE-2, and NHE-3 mRNA
  JOURNAL   Am J Physiol 271 (3 Pt 1), G483-G493 (1996)
   PUBMED   8843774
REFERENCE   7  (bases 1 to 5555)
  AUTHORS   Colombani,V., Silviani,V., Marteau,C., Lerique,B., Cartouzou,G. and
            Gerolami,A.
  TITLE     Presence of the NHE3 isoform of the Na+/H+ exchanger in human
            gallbladder
  JOURNAL   Clin Sci (Lond) 91 (2), 209-212 (1996)
   PUBMED   8795445
REFERENCE   8  (bases 1 to 5555)
  AUTHORS   Brant,S.R., Yun,C.H., Donowitz,M. and Tse,C.M.
  TITLE     Cloning, tissue distribution, and functional analysis of the human
            Na+/N+ exchanger isoform, NHE3
  JOURNAL   Am J Physiol 269 (1 Pt 1), C198-C206 (1995)
   PUBMED   7631746
REFERENCE   9  (bases 1 to 5555)
  AUTHORS   Brant,S.R., Bernstein,M., Wasmuth,J.J., Taylor,E.W.,
            McPherson,J.D., Li,X., Walker,S., Pouyssegur,J., Donowitz,M.,
            Tse,C.M. et al.
  TITLE     Physical and genetic mapping of a human apical epithelial Na+/H+
            exchanger (NHE3) isoform to chromosome 5p15.3
  JOURNAL   Genomics 15 (3), 668-672 (1993)
   PUBMED   8096830
REFERENCE   10 (bases 1 to 5555)
  AUTHORS   Orlowski,J., Kandasamy,R.A. and Shull,G.E.
  TITLE     Molecular cloning of putative members of the Na/H exchanger gene
            family. cDNA cloning, deduced amino acid sequence, and mRNA tissue
            expression of the rat Na/H exchanger NHE-1 and two structurally
            related proteins
  JOURNAL   J Biol Chem 267 (13), 9331-9339 (1992)
   PUBMED   1577762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106772.3, BC011555.1,
            BC101669.1, BP270851.1 and AC010442.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004174.3.
            
            Summary: The protein encoded by this gene is an epithelial brush
            border Na/H exchanger that uses an inward sodium ion gradient to
            expel acids from the cell. Defects in this gene are a cause of
            congenital secretory sodium diarrhea. Pseudogenes of this gene
            exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U28043.1, BC101669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264938.8/ ENSP00000264938.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC106772.3         102448-102462
            16-119              BC011555.1         1-104
            120-1569            BC101669.1         1-1450
            1570-1774           BP270851.1         186-390
            1775-2521           BC101669.1         1656-2402
            2522-2522           AC010442.7         27446-27446
            2523-2655           BC101669.1         2404-2536
            2656-5555           AC010442.7         29080-31979
FEATURES             Location/Qualifiers
     source          1..5555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..5555
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /note="solute carrier family 9 member A3"
                     /db_xref="GeneID:6550"
                     /db_xref="HGNC:HGNC:11073"
                     /db_xref="MIM:182307"
     exon            1..338
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2632
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Na(+)/H(+) exchanger 3; solute carrier family 9
                     (sodium/hydrogen exchanger), member 3; solute carrier
                     family 9, subfamily A (NHE3, cation proton antiporter 3),
                     member 3"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 3 isoform 1 precursor"
                     /protein_id="NP_004165.2"
                     /db_xref="CCDS:CCDS3855.1"
                     /db_xref="GeneID:6550"
                     /db_xref="HGNC:HGNC:11073"
                     /db_xref="MIM:182307"
                     /translation="MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQV
                     VTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAA
                     DHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGL
                     SLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESL
                     LNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVT
                     RFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATT
                     VRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWL
                     LNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVI
                     FQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWS
                     HFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDN
                     VVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYL
                     YKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYK
                     RERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASV
                     TKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTF
                     CRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM"
     exon            339..641
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..802
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..881
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1059
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1280
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1483
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1573
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1644
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1774
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1887
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2017
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2194
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2267
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2378
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2628
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..5555
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5482..5487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /note="hexamer: ATTAAA"
     polyA_site      5501
                     /gene="SLC9A3"
                     /gene_synonym="DIAR8; NHE-3; NHE3"
                     /note="major polyA site"
ORIGIN      
        1 ggactgtagc cggtaccggc accggagcgc gccgggtcct cgccgggtcc cagccccgcg
       61 cgtcggccca gcccagccgg gaccccccgc gacatgcgcg tcccagccct gcgctgagca
      121 ggcggcaatg tggggactcg gggcccgggg ccccgaccgg gggctgctgc tggcgctggc
      181 gctgggcggg ctggcgcggg ccgggggcgt cgaggtggag cccggcggcg cgcacggcga
      241 gagcgggggc ttccaggtgg tcaccttcga gtgggcccac gtgcaggatc cctacgtcat
      301 cgcgctctgg atcctcgtgg ccagcttggc caagatcggg ttccacctgt cccacaaggt
      361 caccagcgtg gttcccgaga gcgccctgct catcgtgctg ggcctggtgc tgggcggcat
      421 cgtctgggcg gccgaccaca tcgcgtcctt cacactgacg cccaccgtct tcttcttcta
      481 cctgctgccc cccatcgtgc tggacgccgg ctacttcatg cccaaccgcc tcttcttcgg
      541 caacctgggg accatcctgt tgtacgccgt cgtgggtacc gtgtggaacg cggccaccac
      601 cgggctgtcc ctctacggcg tcttcctcag tgggctcatg ggcgacctgc agattgggct
      661 gctggacttc ctcctgtttg gcagcctcat ggcggctgtg gacccggtgg ccgtcctggc
      721 cgtgtttgag gaggtccatg tcaacgaggt cctgttcatc atcgtcttcg gggagtcgct
      781 gctgaacgac gcagtcaccg tggttctgta caatgtgttt gaatctttcg tggcgctggg
      841 aggtgacaac gtgactggcg tggactgcgt gaagggcata gtgtccttct tcgtggtgag
      901 cctggggggc acgctggtgg gggtggtctt cgccttcctg ctgtcgctgg tgacgcgctt
      961 caccaagcat gtgcgtatca tcgagcccgg cttcgtgttc atcatctcct acctgtccta
     1021 cctgacgtcc gagatgctgt cgctgtcggc catcctcgcc atcaccttct gtggcatctg
     1081 ctgtcagaag tatgtgaagg ccaacatctc ggagcagtcg gccaccaccg tgcgctacac
     1141 catgaagatg ctggccagca gcgccgagac catcatcttc atgttcctgg gtatctcggc
     1201 cgtgaacccg ttcatctgga cctggaacac ggccttcgtg ctcctgacgc tggtcttcat
     1261 ctccgtgtac cgggccatcg gtgtggtcct gcagacctgg cttctgaacc gctaccgcat
     1321 ggtgcagctg gagcccattg accaggtggt cctgtcctac gggggcctgc gcggggccgt
     1381 ggcctttgcc ctggtggtgc ttctggatgg agacaaggtc aaggagaaga acctgttcgt
     1441 cagcaccacc atcatcgtag tgttcttcac cgtcatcttc cagggcctga ccatcaagcc
     1501 tctggtgcag tggctgaagg tgaagaggag cgagcaccgg gaacctcggc tcaacgagaa
     1561 gctgcacggg cgcgctttcg accacatcct ctcggccatc gaggacatat ccggacagat
     1621 cgggcacaat tatctcagag acaagtggtc ccacttcgac aggaagttcc tcagcagggt
     1681 cctcatgaga cggtcggccc agaagtctcg agaccggatc ctgaatgtct tccacgagct
     1741 gaacctgaag gatgccatca gctacgtggc tgagggagag cgccgcgggt ccctggcctt
     1801 catccgctcc cccagcaccg acaacgtggt caacgtggac ttcacgccac gatcgtccac
     1861 cgtggaggcc tctgtctcct acctcctgag agaaaatgtc agcgctgtct gcctggacat
     1921 gcagtctctg gagcagcgac ggcggagcat ccgggacgcg gaggacatgg tcacgcacca
     1981 cacgctacag cagtacctgt acaagccgcg gcaggagtac aagcatctgt acagccgaca
     2041 cgagctcacg cccacggagg acgagaaaca ggaccgggaa atcttccaca ggaccatgcg
     2101 gaagcgcctg gagtccttca agtcgaccaa gctggggctc aaccagaaca agaaggcggc
     2161 caagctgtac aagcgggagc gtgcccagaa gcggagaaac agcagcatcc ccaatgggaa
     2221 gctgcccatg gagagccctg cgcagaattt caccatcaag gagaaagact tggaactttc
     2281 agacaccgag gagcccccca actatgatga ggagatgagt ggggggatcg agttcctggc
     2341 tagtgtcacc aaggacacag cgtccgactc ccctgcagga attgacaacc ctgtgttttc
     2401 tccggacgag gccctggacc gcagcctcct ggccaggctg ccgccctggc tgtctcccgg
     2461 ggagacggtg gtcccctcgc agagggcccg cacgcagatt ccctactctc ccggcacctt
     2521 ctgccgcctg atgcccttcc gcctcagcag caagtccgtg gactccttcc tgcaggcaga
     2581 cggccccgag gagcggcccc ccgccgccct ccccgagtcc acacacatgt gacaccggct
     2641 ccgacacgcc gctaaccggc cgctcgtccc cgcgccacgg tccgcccacc gccgccgccg
     2701 ctgtcccaga gaaaccccag atccccgcgc ggctacagcg accgcgagcc ccgagccccg
     2761 cctcgcccac gccagcgcct gcgcagaact ccgagagtgc cgcgcctgcg cccgcagagc
     2821 cgcccgaggg cgagccgggg gcggggcctg cgccgggggc ggggccggag cgccgagggc
     2881 tgccgagtgc gcacgcgcgt tcggcggcgg cgcgccgcgt gcacagccgg cgctcgttcc
     2941 agcggcctcg cgcgcgccgc cgccccgcgc tgctgaagct ggcgtcgctg ccgccctcgt
     3001 gccacgcacc gccgcacgcg ctggagcagg aggagacgcc gctgtgacgc cgccggcggg
     3061 aagggtccgc gcgccatggc tggccgctcg cgccctttcc caccgctgcc gggaaaccga
     3121 ggctcgcccc aaacggattt gcgtgaaacc agcccaaggt tccgggcccc cccaaccgag
     3181 ccccgcgccc ggggactgac tcggggaccg actcagggac ctcccgagcg ccaggactca
     3241 gggcccgacc tgcagcggct gcaggcccag cgcccgcaag cggcctgggc cgagcgccgt
     3301 ttccaggccc tcgccaggtc tttgaactgc aggtaaagtg gcaggaacgt cttccgtctg
     3361 ctcagcgttt ggggatttag actcctaaag ccagtacctg ccccgtttcc cccccaggtt
     3421 ccgtcctgcc cgcgcccggt ctcagggtgg cggccccgga cacggcccgt ccccacagac
     3481 gaggtctccg gcctgagctg tcgcacctgg cgcggaggtc gcccggggtg ccctggctgg
     3541 gtgagaggtg gcctggcggg cggagcttgc caagaatcac ggccagtcct taagtggatg
     3601 gtggggccca gcagctgctc tgtccccctt aacaaaccag ggggcatgga ggggcccagg
     3661 gcaccgcccc cctaccaggc tcaggccctc caaggagaac ctgctgagac ccctgagcct
     3721 gtcctagacc ccggacccct gacccttccc accccttcca gcgtcccagg gcgaggcctt
     3781 ggacagagct cctggtcctc tgcagggaga ccatccagcc caagctctgg gaggcacagt
     3841 ccattgagtg ggcggaggcc gcgggtgctg agccggggag ggtgctcgga gtccatccat
     3901 ccctcagacg gcaagtccca cagggtccaa cccacctgaa acctgcctgc acggtggaag
     3961 tggtggaggt ggacactcct aggggctttt ctaaagctag actcgcagct ccttgctcag
     4021 gaaaattaaa ctattcacgt ttcagatcaa gtgttgacag tcaccagtca ggaggagttc
     4081 ttaaagagtt ttatgttgac tgaatattgc acattgagtc cccattgagt ccctggtggg
     4141 aaaagtccac aatttcccat tgatagcttt ttactgttgt gaaaaaggga agcgtcagcc
     4201 acacaaaagc ctgcatgacc gctgcttcgg agaagctctc gaccctaact gcagtcactg
     4261 ttacttggat cagatcaagc gcagtgactt tttgggattc agtggttatt ctccacactt
     4321 cgtagccatt tcaaccaact ctgagcacaa aatgcagcca tcctctatgc agcaagccct
     4381 gcccagtcag tgaccctact ggacagatcc aaggccagcc ctggttccct gctgcagcca
     4441 ccgtcctgac gttcatcgga gcaggccggg gcctggcctt cccggcacaa gtggctgttc
     4501 tgacaggccc ccagtttgtc ccatctgaac tgctgggagg tttccgggtg gccagaggag
     4561 caaagctgcc ttccaagtgc ctgtctgtgc ctgggagaac agagcaggag cgtcgtgcgg
     4621 tccaccgcgc aatgcatggc gattccaggc gctgaacaac tcccctggac ccttgggcct
     4681 gcatctgact cccagctgca gagtcagaag ctgagtccag gcaactgctt ggccactccc
     4741 gatcgctcct ccctggacac ccggttacca aagtcagcaa agaagatgcg gtaatcgccg
     4801 cctgatctcc acatggtgaa cacaacactc ccaccaacac ctccttgact ggtcggtctt
     4861 cagcaccggg ggtgggcagg caggtgttct gtgttgacga gaattgcaca ggctaaacac
     4921 aaacacggaa ccagagtgag aacacctcac tcacggcagc ccaggctgct ccctaccagg
     4981 tgacggagcg cgccggggct gtgggtgcca ggggctgagt gctagggact cgtcatgagt
     5041 ggggatcccc acgttcctgt cactgctgtc aaacagaagg taaacagtct tatgaatgta
     5101 tttccttagg aaaacttgta aaaactttta ttaggatatc tatttaatac tgaactttgg
     5161 cctactttgt gatagactat aaacaaattg aggaaatcac tatttctcac ttctgtattt
     5221 tctcaaaaat aattttgtta cagagttcaa tatactgtgt accattgatc ttctattgtg
     5281 aaagcaaaga atttcatcaa aatattttaa attatgagtg aaaattgtgt atgttaattt
     5341 tgcagctata atattaatca aatttcgtgt aattctaatc acaaaatgac gtgccttaag
     5401 tgcccctcca gctgtgggtt ggcagtgtcc agacagggag ggcccatcac cgaaatcctg
     5461 aacgattact agaccaattc tattaaaaac atttcaaggc attttgggtg caaactttgt
     5521 ttataaaaga gaaatatcca cctatgagaa tttaa
//
