LOCUS       NM_003047               4737 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens solute carrier family 9 member A1 (SLC9A1), transcript
            variant 1, mRNA.
ACCESSION   NM_003047
VERSION     NM_003047.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4737)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4737)
  AUTHORS   Hayashi,Y., Miyoshi,S., Watanabe,I., Yano,N., Nagashio,K.,
            Kaneko,M., Kaminota,T., Sanada,T., Hosokawa,Y., Kitani,T.,
            Mitani,S., Choudhury,M.E., Yano,H., Tanaka,J. and Hato,N.
  TITLE     Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity
            of head and neck squamous cell carcinoma
  JOURNAL   Auris Nasus Larynx 51 (3), 472-480 (2024)
   PUBMED   38520980
  REMARK    GeneRIF: Simultaneous disturbance of NHE1 and LOXL2 decreases
            tumorigenicity of head and neck squamous cell carcinoma.
REFERENCE   3  (bases 1 to 4737)
  AUTHORS   Li,X. and Fliegel,L.
  TITLE     Permissive role of Na+/H+ exchanger isoform 1 in migration and
            invasion of triple-negative basal-like breast cancer cells
  JOURNAL   Mol Cell Biochem 477 (4), 1207-1216 (2022)
   PUBMED   35084672
  REMARK    GeneRIF: Permissive role of Na(+)/H(+) exchanger isoform 1 in
            migration and invasion of triple-negative basal-like breast cancer
            cells.
REFERENCE   4  (bases 1 to 4737)
  AUTHORS   Zhu,X., Ma,K., Zhou,K., Pan,X., Liu,J., Nurnberg,B., Alesutan,I.,
            Volkl,J. and Lang,F.
  TITLE     Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced
            Osteogenic Signaling and Calcification in Human Aortic Smooth
            Muscle Cells
  JOURNAL   Kidney Blood Press Res 47 (6), 399-409 (2022)
   PUBMED   35339998
  REMARK    GeneRIF: Requirement of Na+/H+ Exchanger NHE1 for
            Vasopressin-Induced Osteogenic Signaling and Calcification in Human
            Aortic Smooth Muscle Cells.
REFERENCE   5  (bases 1 to 4737)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   6  (bases 1 to 4737)
  AUTHORS   Tse,C.M., Ma,A.I., Yang,V.W., Watson,A.J., Levine,S.,
            Montrose,M.H., Potter,J., Sardet,C., Pouyssegur,J. and Donowitz,M.
  TITLE     Molecular cloning and expression of a cDNA encoding the rabbit
            ileal villus cell basolateral membrane Na+/H+ exchanger
  JOURNAL   EMBO J 10 (8), 1957-1967 (1991)
   PUBMED   1712287
REFERENCE   7  (bases 1 to 4737)
  AUTHORS   Dudley,C.R., Giuffra,L.A., Tippett,P., Kidd,K.K. and Reeders,S.T.
  TITLE     The Na+/H+ antiporter: a 'melt' polymorphism allows regional
            mapping to the short arm of chromosome 1
  JOURNAL   Hum Genet 86 (1), 79-83 (1990)
   PUBMED   1979310
REFERENCE   8  (bases 1 to 4737)
  AUTHORS   Sardet,C., Counillon,L., Franchi,A. and Pouyssegur,J.
  TITLE     Growth factors induce phosphorylation of the Na+/H+ antiporter,
            glycoprotein of 110 kD
  JOURNAL   Science 247 (4943), 723-726 (1990)
   PUBMED   2154036
REFERENCE   9  (bases 1 to 4737)
  AUTHORS   Sardet,C., Franchi,A. and Pouyssegur,J.
  TITLE     Molecular cloning, primary structure, and expression of the human
            growth factor-activatable Na+/H+ antiporter
  JOURNAL   Cell 56 (2), 271-280 (1989)
   PUBMED   2536298
REFERENCE   10 (bases 1 to 4737)
  AUTHORS   Mattei,M.G., Sardet,C., Franchi,A. and Pouyssegur,J.
  TITLE     The human amiloride-sensitive Na+/H+ antiporter: localization to
            chromosome 1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 48 (1), 6-8 (1988)
   PUBMED   2846238
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA853045.1, DA313453.1,
            AK314190.1, AF141357.1, AL137860.22 and BQ775318.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003047.4.
            
            Summary: This gene encodes a Na+/H+ antiporter that is a member of
            the solute carrier family 9. The encoded protein is a plasma
            membrane transporter that is expressed in the kidney and intestine.
            This protein plays a central role in regulating pH homeostasis,
            cell migration and cell volume. This protein may also be involved
            in tumor growth. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S68616.1, M96066.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263980.8/ ENSP00000263980.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               DA853045.1         6-158
            154-690             DA313453.1         2-538
            691-748             AK314190.1         91-148
            749-3286            AF141357.1         1-2538
            3287-4281           AL137860.22        53194-54188
            4282-4737           BQ775318.1         16-471              c
FEATURES             Location/Qualifiers
     source          1..4737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4737
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /note="solute carrier family 9 member A1"
                     /db_xref="GeneID:6548"
                     /db_xref="HGNC:HGNC:11071"
                     /db_xref="MIM:107310"
     exon            1..1143
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     CDS             792..3239
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /note="solute carrier family 9, subfamily A (NHE1, cation
                     proton antiporter 1), member 1; solute carrier family 9
                     (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+,
                     amiloride sensitive); Na-Li countertransporter; Na(+)/H(+)
                     exchanger 1; protein phosphatase 1, regulatory subunit
                     143"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 1"
                     /protein_id="NP_003038.2"
                     /db_xref="CCDS:CCDS295.1"
                     /db_xref="GeneID:6548"
                     /db_xref="HGNC:HGNC:11071"
                     /db_xref="MIM:107310"
                     /translation="MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTAS
                     TIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTP
                     FEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDV
                     FFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQ
                     INNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHL
                     FEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFV
                     FLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSET
                     LIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQF
                     IIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAV
                     KKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGE
                     RSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALS
                     KDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINN
                     YLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGK
                     VLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDP
                     GPHPEPGEGEPFFPKGQ"
     exon            1144..1604
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1855
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2073
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2276
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2366
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2437
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2611
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2726
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2828
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2901
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..4737
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4711..4716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /note="hexamer: AATAAA"
     polyA_site      4737
                     /gene="SLC9A1"
                     /gene_synonym="APNH; LIKNS; NHE-1; NHE1; PPP1R143"
                     /note="major polyA site"
ORIGIN      
        1 agtctgctgc cgccggggcc ggggctaggg ttagttctgg agctggacca ggaggagctg
       61 cagctgggcc ggggcggagc gccgcgtcgc gccagggccg cgaggagggg cgtgttgctg
      121 ctggcccacc gcgagccgcc cccagcccgc gccgaggcgc cttcccgcca ggccgcctgc
      181 cttccgcctc tttccatttc cccggaatct cagcccggcg cgcctggacc cctgcccctc
      241 tctgggtgga gaagctcccg gccgcttccc ggtttcactc cttctcagcc tgggctccca
      301 gccccctctc tccttttcct ggactggctc tcaccccctt cggtcccctt cctttagctc
      361 aggctcccta ccccttcctt tagcccacag cccagagtcc cagctcctca gtcactttcc
      421 tcagccaaag gtcccagcct tccttcttcc tttcctttgc actatcccta tcctgcccct
      481 tcctctatcc ctagggctca gtttcccaca tccgtcctcc cccttcccag gcccggagtt
      541 ccagaccttt tggtctcctt tcgtggtcgt tcctgggtcc ttgccccctt tccccacttt
      601 ggagttccag attgcaaacc cagcctccct ccacccccag aaaattgctt ccatggaaat
      661 gcctctctaa aacatgaact tttcctagag actacgccag tctctcttcc cacttgctga
      721 ccctttgcta cctatgtgcc cggttttact ctcatttggg taaggtcgag gctggctctg
      781 gaagcagcac catggttctg cggtctggca tctgtggcct ctctccacat cggatcttcc
      841 cttccttact cgtggtggtt gctttggtgg ggctgctgcc tgttctcagg agccatggcc
      901 tccagctcag cccaactgcc agcaccattc gaagctcaga gccaccacga gaacgctcga
      961 ttggggatgt caccaccgct ccaccggagg tcaccccaga gagccgccct gttaatcatt
     1021 ccgtcactga tcatggcatg aagccgcgca aggcctttcc agtcctgggc atcgactaca
     1081 cacacgtgcg cacccccttc gagatctccc tctggatcct tctggcctgc ctcatgaaga
     1141 taggtttcca tgtgatcccc actatctcaa gcatcgtccc ggagagctgc ctgctgatcg
     1201 tggtggggct gctggtgggg ggcctgatca agggtgtagg cgagacaccc cccttcctgc
     1261 agtccgacgt cttcttcctc ttcctgctgc cgcccatcat cctggatgcg ggctacttcc
     1321 tgccactgcg gcagttcaca gaaaacctgg gcaccatcct gatctttgcc gtggtgggca
     1381 cgctgtggaa cgccttcttc ctgggcggcc tcatgtacgc cgtgtgcctg gtgggcggtg
     1441 agcagatcaa caacatcggc ctcctggaca acctgctctt cggcagcatc atctcggccg
     1501 tggaccccgt ggcggttctg gctgtctttg aggaaattca catcaatgag ctgctgcaca
     1561 tccttgtttt tggggagtcc ttgctcaatg acgccgtcac tgtggtcctg tatcacctct
     1621 ttgaggagtt tgccaactac gaacacgtgg gcatcgtgga catcttcctc ggcttcctga
     1681 gcttcttcgt ggtggccctg ggcggggtgc ttgtgggcgt ggtctacggg gtcatcgcag
     1741 ccttcacctc ccgatttacc tcccacatcc gggtcatcga gccgctcttc gtcttcctct
     1801 acagctacat ggcctacttg tcagccgagc tcttccacct gtcaggcatc atggcgctca
     1861 tagcctcagg agtggtgatg cgcccctatg tggaggccaa catctcccac aagtcccaca
     1921 ccaccatcaa atacttcctg aagatgtgga gcagcgtcag cgagaccctc atcttcatct
     1981 tcctcggcgt ctccacggtg gccggctccc accactggaa ctggaccttc gtcatcagca
     2041 ccctgctctt ctgcctcatc gcccgcgtgc tgggggtgct gggcctgacc tggttcatca
     2101 acaagttccg tatcgtgaag ctgaccccca aggaccagtt catcatcgcc tatgggggcc
     2161 tgcgaggggc catcgccttc tctctgggct acctcctgga caagaagcac ttccccatgt
     2221 gtgacctgtt cctcactgcc atcatcactg tcatcttctt caccgtcttt gtgcagggca
     2281 tgaccattcg gcccctggta gacctgttgg ctgtgaagaa aaagcaagag acgaagcgct
     2341 ccatcaacga agagatccac acacagttcc tggaccacct tctgacaggc atcgaagaca
     2401 tctgtggcca ctacggtcac caccactgga aggacaagct caaccggttt aataagaaat
     2461 atgtgaagaa gtgtctgata gctggcgagc gctccaagga gccccagctc attgccttct
     2521 accacaagat ggagatgaag caggccatcg agctggtgga gagcgggggc atgggcaaga
     2581 tcccctctgc cgtctccacc gtctccatgc agaacatcca ccccaagtcc ctgccttccg
     2641 agcgcatcct gccagcactg tccaaggaca aggaggagga gatccgcaaa atcctgagga
     2701 acaacttgca gaagaccagg cagcggctgc ggtcctacaa cagacacacg ctggtggcag
     2761 acccctacga ggaagcctgg aaccagatgc tgctccggag gcagaaggcc cggcagctgg
     2821 agcagaagat caacaactac ctgacggtgc cagcccacaa gctggactca cccaccatgt
     2881 ctcgggcccg catcggctca gacccactgg cctatgagcc gaaggaggac ctgcctgtca
     2941 tcaccatcga cccggcttcc ccgcagtcac ccgagtctgt ggacctggtg aatgaagagc
     3001 tgaagggcaa agtcttaggg ttgagccggg atcctgcaaa ggtggctgag gaggacgagg
     3061 acgacgatgg gggcatcatg atgcggagca aggagacttc gtccccagga accgacgatg
     3121 tcttcacccc cgcgcccagt gacagcccca gctcccagag gatacagcgc tgcctcagtg
     3181 acccaggccc acaccctgag cctggggagg gagaaccgtt cttccccaag gggcagtaac
     3241 accagggcca gcaggcagcg cctgtcccct cacagactct tccaccagag caggggctgc
     3301 tgggggctcc ccttgccctt cctgacccgg attggccctg cccctccccc taccgcatgg
     3361 cagctgggcc cacagccccc accccagcac agctcctccc ctgccgcctc ccgggaagca
     3421 tcctccccac cagagctgcc tccccaatcc atttggcaga actgctgggg ctggtgaggc
     3481 cggccctgcc cctccctaga tccaggcttc tcccggacct ggactagggc ctcggaggct
     3541 cctccctctg cctcatcctc ctcctcattc agaccaatct tagtttctaa ccaaagagtc
     3601 tctggctcag ctgtggtccc acccaggaag ggagggagct gaggcctccc ttgagtaggc
     3661 cctgctttat caggggacaa accaggggta ccaggcacat ggctggggga gggactgctg
     3721 acccaccaag gtctcacact cctcctgcca gctctgtcac cctggccacc acccaacctg
     3781 tccttactca gagctgcggg ctgagggcat ctctgagtgt ctctgcctgg agcaggggtg
     3841 gtttctacgg tgacagtgac gtgactcaga gcttttcgaa ctgtgctccc acggggacca
     3901 ctgggcccct caggggaagc tgctagggga aggactggcc gtggctccag aatgtgctgc
     3961 ctttttaagt tttgtttgtt cacactccta tatatgattg tttgcacaga gggcgctcct
     4021 gtttttaaaa cattttgaaa acccctggct gaacagtgct ctgcctctaa ctccctcctc
     4081 acactccaga attacccttc ctcatctgtg cctgtctgtc caacccctcc cccacgtctc
     4141 tctgcctgct gggctcttaa ctgttgctcg aagactgtga catcagaagt aactcccact
     4201 cctaatcaag agtctctcca gcctcacaga tgctggcctc ttggcacctg cctagctctt
     4261 gggcctgacc tccagtcctg ctggcctgct cttacttccc ccaccctggg tttggcccct
     4321 ggaacctttc ccttgtgtgt accacaccct gcctgctgtg gagcccattg tggaggcggt
     4381 gggggggaga aggcctcccc tgaggatccc ctgtcccctg gggctggtgg attgggcaga
     4441 atcctgggcc cccagagacc tttgcccaca cacactcctt ccccttgtcc ctggggcact
     4501 cccccaggat tgtgcaatag tcagagtgtc cctttttgca ggggactggg ccatgggtcc
     4561 tcggcccatc tgtccatcct cctctccatg caagtgctgt ttgggcagga gtcaccatgc
     4621 aagggtgaca tcgacaacca cgtaccaagc caccgcagct gctgccactc tgctgcctgt
     4681 acagaagaaa ctgaatcttt ttcatattct aataaatcaa tgtgagtttt taataga
//
