LOCUS       NM_001358345            3510 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens solute carrier family 8 member B1 (SLC8B1), transcript
            variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001358345 XM_011538749
VERSION     NM_001358345.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3510)
  AUTHORS   Katoshevski,T., Bar,L., Tikochinsky,E., Harel,S., Ben-Kasus
            Nissim,T., Bogeski,I., Hershfinkel,M., Attali,B. and Sekler,I.
  TITLE     CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca2+
            via Mitochondrial NCLX
  JOURNAL   Cells 11 (24), 3990 (2022)
   PUBMED   36552754
  REMARK    GeneRIF: CKII Control of Axonal Plasticity Is Mediated by
            Mitochondrial Ca[2+] via Mitochondrial NCLX.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3510)
  AUTHORS   Takeuchi,A. and Matsuoka,S.
  TITLE     Spatial and Functional Crosstalk between the Mitochondrial Na+-Ca2+
            Exchanger NCLX and the Sarcoplasmic Reticulum Ca2+ Pump SERCA in
            Cardiomyocytes
  JOURNAL   Int J Mol Sci 23 (14), 7948 (2022)
   PUBMED   35887296
  REMARK    GeneRIF: Spatial and Functional Crosstalk between the Mitochondrial
            Na(+)-Ca(2+) Exchanger NCLX and the Sarcoplasmic Reticulum Ca(2+)
            Pump SERCA in Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3510)
  AUTHORS   Hagenston,A.M., Yan,J., Bas-Orth,C., Tan,Y., Sekler,I. and
            Bading,H.
  TITLE     Disrupted expression of mitochondrial NCLX sensitizes neuroglial
            networks to excitotoxic stimuli and renders synaptic activity toxic
  JOURNAL   J Biol Chem 298 (2), 101508 (2022)
   PUBMED   34942149
  REMARK    GeneRIF: Disrupted expression of mitochondrial NCLX sensitizes
            neuroglial networks to excitotoxic stimuli and renders synaptic
            activity toxic.
REFERENCE   4  (bases 1 to 3510)
  AUTHORS   Takeuchi,A. and Matsuoka,S.
  TITLE     Physiological and Pathophysiological Roles of Mitochondrial
            Na+-Ca2+ Exchanger, NCLX, in Hearts
  JOURNAL   Biomolecules 11 (12), 1876 (2021)
   PUBMED   34944520
  REMARK    GeneRIF: Physiological and Pathophysiological Roles of
            Mitochondrial Na(+)-Ca(2+) Exchanger, NCLX, in Hearts.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3510)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 3510)
  AUTHORS   Khananshvili,D.
  TITLE     The SLC8 gene family of sodium-calcium exchangers (NCX) -
            structure, function, and regulation in health and disease
  JOURNAL   Mol Aspects Med 34 (2-3), 220-235 (2013)
   PUBMED   23506867
  REMARK    Review article
REFERENCE   7  (bases 1 to 3510)
  AUTHORS   Nita,I.I., Hershfinkel,M., Fishman,D., Ozeri,E., Rutter,G.A.,
            Sensi,S.L., Khananshvili,D., Lewis,E.C. and Sekler,I.
  TITLE     The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent
            Ca2+ signalling linked to insulin secretion
  JOURNAL   PLoS One 7 (10), e46649 (2012)
   PUBMED   23056385
REFERENCE   8  (bases 1 to 3510)
  AUTHORS   Palty,R., Silverman,W.F., Hershfinkel,M., Caporale,T., Sensi,S.L.,
            Parnis,J., Nolte,C., Fishman,D., Shoshan-Barmatz,V., Herrmann,S.,
            Khananshvili,D. and Sekler,I.
  TITLE     NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
  JOURNAL   Proc Natl Acad Sci U S A 107 (1), 436-441 (2010)
   PUBMED   20018762
REFERENCE   9  (bases 1 to 3510)
  AUTHORS   Palty,R., Ohana,E., Hershfinkel,M., Volokita,M., Elgazar,V.,
            Beharier,O., Silverman,W.F., Argaman,M. and Sekler,I.
  TITLE     Lithium-calcium exchange is mediated by a distinct
            potassium-independent sodium-calcium exchanger
  JOURNAL   J Biol Chem 279 (24), 25234-25240 (2004)
   PUBMED   15060069
  REMARK    GeneRIF: NCLX catalyzes active Li(+)/Ca(2+) exchange.
REFERENCE   10 (bases 1 to 3510)
  AUTHORS   Cai,X. and Lytton,J.
  TITLE     Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+
            exchanger gene family, NCKX6
  JOURNAL   J Biol Chem 279 (7), 5867-5876 (2004)
   PUBMED   14625281
  REMARK    GeneRIF: NCKX6 is a novel member of the Na+/Ca2+ exchanger
            superfamily
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010178.40 and BM980568.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001358345.1.
            
            Summary: SLC24A6 belongs to a family of potassium-dependent
            sodium/calcium exchangers that maintain cellular calcium
            homeostasis through the electrogenic countertransport of 4 sodium
            ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004
            [PubMed 14625281]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 3
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1444803.1,
                                           SRR7346977.1458028.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000680972.1/ ENSP00000506377.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-667               AC010178.40        93730-94396
            668-905             AC010178.40        95879-96116
            906-1058            AC010178.40        107491-107643
            1059-1111           AC010178.40        107731-107783
            1112-1169           AC010178.40        107932-107989
            1170-1275           AC010178.40        108153-108258
            1276-1443           AC010178.40        108341-108508
            1444-1551           AC010178.40        109768-109875
            1552-1611           AC010178.40        111838-111897
            1612-1742           AC010178.40        112183-112313
            1743-1884           AC010178.40        113363-113504
            1885-2006           AC010178.40        118484-118605
            2007-2160           AC010178.40        120995-121148
            2161-2241           AC010178.40        122264-122344
            2242-2306           AC010178.40        124454-124518
            2307-3469           AC010178.40        128865-130027
            3470-3510           BM980568.1         23-63               c
FEATURES             Location/Qualifiers
     source          1..3510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..3510
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /note="solute carrier family 8 member B1"
                     /db_xref="GeneID:80024"
                     /db_xref="HGNC:HGNC:26175"
                     /db_xref="MIM:609841"
     exon            1..667
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            668..905
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     CDS             750..2504
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; solute carrier family 24 member 6;
                     Na(+)/K(+)/Ca(2+)-exchange protein 6; mitochondrial
                     sodium/calcium exchanger protein; solute carrier family 24
                     (sodium/potassium/calcium exchanger), member 6;
                     sodium/calcium exchanger protein, mitochondrial;
                     sodium/potassium/calcium exchanger 6, mitochondrial;
                     solute carrier family 8 (sodium/lithium/calcium
                     exchanger), member B1; solute carrier family 24
                     (sodium/lithium/calcium exchanger), member 6"
                     /codon_start=1
                     /product="mitochondrial sodium/calcium exchanger protein
                     isoform 1 precursor"
                     /protein_id="NP_001345274.1"
                     /db_xref="CCDS:CCDS31909.1"
                     /db_xref="GeneID:80024"
                     /db_xref="HGNC:HGNC:26175"
                     /db_xref="MIM:609841"
                     /translation="MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASG
                     VNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTL
                     YVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVA
                     FSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFL
                     MLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEED
                     RVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPV
                     EFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWV
                     VVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVV
                     FRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCL
                     LQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLN
                     FLVVALLTEFGVIHLKSM"
     exon            906..1058
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1111
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1169
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1275
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1443
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1551
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1611
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1742
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1884
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2006
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2160
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2241
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2306
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..3510
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3073..3078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /note="hexamer: AATAAA"
     polyA_site      3098
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
     regulatory      3486..3491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /note="hexamer: AATAAA"
     polyA_site      3510
                     /gene="SLC8B1"
                     /gene_synonym="NCKX6; NCLX; SLC24A6"
                     /note="major polyA site"
ORIGIN      
        1 gcacccggac tggcggcttc gctggcgcaa ggtcggtccg gcggccaggg acctggaagg
       61 ctgcgaggcc ctgcgaggtc gaggttcgga gtttgctggt cccaggcccg gcccgaggta
      121 agaaagagcc gcctccccgc acggccggag gacccgggcg ccccgagttc gacttctcag
      181 cctccgtccg gacgggaaac ggagcacgga gatgttcctg aggtctcttt cctgggaagc
      241 gcagccccga tttcccgccc ctgtccctta gcaggtcggc gaccatccga gcgctgggca
      301 tcggcccacg cgtacagaag gcgctcaata aatgctcact agtgaatcag taaaataaat
      361 cggcagcaaa gagagacgag acgcatgctg atcttcaggt gttggggaca tcagggacgc
      421 gaacatttat tgagctctta ttgtataccg cgtcggccag catttgtgtc catttcacac
      481 atgaggaata agaggcccag agaggtgaag tgacttcctt aaggccacac agatagtaag
      541 tggccgagac gaatttgaaa ccaggggtgt cctgtttgaa cttggtgcca aatagagtaa
      601 ctcggactcc agttggaggg gttcgggaga accatagaag aggaagggcc gtgtcttccg
      661 tggacaggcc accggagccg ccagctgttt ggaactgagc tactgcagaa agggaagtgg
      721 agagtaaggg ccaggccccg tgggggcaga tggccggcag aaggctgaat ctgcgctggg
      781 cactgagtgt gctttgtgtg ctgctaatgg cggagacagt gtctgggact aggggctcgt
      841 ctacaggagc tcacattagc ccccagtttc cagcttcagg tgtgaaccag acccccgtgg
      901 tagactgccg caaggtgtgt ggcctgaatg tctctgaccg ctgtgacttc atccggacca
      961 accctgactg ccacagtgat ggggggtacc tggactacct ggaaggcatc ttctgccact
     1021 tccctcccag cctcctccct ctggctgtca ctctctacgt ttcctggctg ctctacctgt
     1081 ttctgattct gggagtcacc gcagccaagt ttttctgccc caacttgtcg gccatttcta
     1141 ccacactgaa gctctcccac aacgtggcag gcgtcacctt cctggcattt gggaatggtg
     1201 cacctgacat cttcagtgcc ctggtggcct tctctgaccc gcacacagcc ggcctggccc
     1261 ttggggcact gtttggcgct ggcgtgctgg ttaccacagt ggtggccgga ggcattacca
     1321 tcctacaccc cttcatggct gcctccaggc ccttcttcag ggacatcgtt ttctacatgg
     1381 tggctgtgtt cctgaccttc ctcatgctct tccgtggcag ggtcaccctg gcatgggctc
     1441 tgggttacct gggcttgtat gtgttctatg tggtcactgt gattctctgc acctggatct
     1501 accaacggca acggagagga tctctgttct gccccatgcc agttactcca gagatcctct
     1561 cagactccga ggaggaccgg gtatcttcta ataccaacag ctatgactac ggtgatgagt
     1621 accggccgct gttcttctac caggagacca cggctcagat cctggtccgg gccctcaatc
     1681 ccctggatta catgaagtgg agaaggaaat cagcatactg gaaagccctc aaggtgttca
     1741 agctgcctgt ggagttcctg ctgctcctca cagtccccgt cgtggacccg gacaaggatg
     1801 accagaactg gaaacggccc ctcaactgtc tgcatctggt tatcagcccc ctggttgtgg
     1861 tcctgaccct gcagtcgggg acctatggtg tctatgagat aggcggcctc gttcccgtct
     1921 gggtcgtggt ggtgatcgca ggcacagcct tggcttcagt gacctttttt gccacatctg
     1981 acagccagcc ccccaggctt cactggctct ttgctttcct gggctttctg accagcgccc
     2041 tgtggatcaa cgcggccgcc acagaggtgg tgaacatctt gcggtccctg ggtgtggtct
     2101 tccggctgag caacactgtg ctggggctca cgctgctggc ctgggggaac agcattggag
     2161 atgccttctc ggatttcaca ctggctcgcc agggctaccc acggatggcg ttctccgcct
     2221 gctttggcgg catcatcttc aacatcctcg tgggtgtggg gctgggctgc ctgctccaga
     2281 tctcccgaag ccacacagaa gtgaagctgg agccagacgg actgctggtg tgggtcctgg
     2341 caggcgccct ggggctcagc ctcgtcttct ccctggtctc agtcccattg cagtgcttcc
     2401 agctcagcag agtctatggc ttctgcctgc tcctcttcta cctgaacttc cttgtcgtgg
     2461 ccctcctcac tgaatttgga gtgattcacc tgaaaagcat gtgactgaag ccgcttagtg
     2521 ctgtggcctc actgcaggca ggagccccgc ccctcctgcc gggggaggcc cagggaccgg
     2581 agcatttctg caaggccctt gtgggcacga gagtgcggcc cttgctgctg gagatctgag
     2641 gtcactgctg tgagctggga gaactgctgt gtacctcttg ctgccagcac ccaacagcct
     2701 tgccgtgggg accttggaaa cctggctttg ctctggacaa agggttccag agagaagcta
     2761 gaagtccccc ttgaatgacc cccagagccc ctctgagaag ggctggagtt tgggggaagg
     2821 ggatggctgg atgtgctcca ggccatgctg gaggtacccc cgaggcacag gcactgcccg
     2881 ttccccttgc ctgggcttca ggccttctgg caccttctca ggacacaagt ggctgcccaa
     2941 ccctgactca gagaatgagg gtggcttgga cccctgggaa tcaggccgcc gagggctgag
     3001 ctccagagcc gcaccatctg ccacaaacag aattcgagac atacttaatt ttgaatttct
     3061 ccttgccacg ttaataaagc caaaagcagc gggtgctatt cgtggcaaca cacttcactg
     3121 aacccacttg cttccaaaac gatgccagcc cgaggcactg ctacgccagc agctgccaca
     3181 tgggatggtg gctcaggcgc tccctccagg attctgcccc tgcctgtcca cagactcctt
     3241 tgtgctggaa cctgggctcc tccagctgcc aggcaggagt cggtaggact gtgcctgtgc
     3301 ctccctcagc ggggccctgg gcggggttcc aaggcctgcg agctgggaaa ggacagatga
     3361 ggggacctcg tgccttcttg ctgtcatgca atgaccccgc cttatgttgc cgaaataagc
     3421 aactcttagg tttgcctgac tgccttatgc tggtaaagaa aagggattca actgtctctt
     3481 ttccaaataa aaaaaaagtc aaaatttcaa
//
