LOCUS       NM_183002               5151 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 8 member A3 (SLC8A3), transcript
            variant c, mRNA.
ACCESSION   NM_183002
VERSION     NM_183002.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5151)
  AUTHORS   Trendafilova,T., Adhikari,K., Schmid,A.B., Patel,R., Polgar,E.,
            Chisholm,K.I., Middleton,S.J., Boyle,K., Dickie,A.C.,
            Semizoglou,E., Perez-Sanchez,J., Bell,A.M.,
            Ramirez-Aristeguieta,L.M., Khoury,S., Ivanov,A., Wildner,H.,
            Ferris,E., Chacon-Duque,J.C., Sokolow,S., Saad Boghdady,M.A.,
            Herchuelz,A., Faux,P., Poletti,G., Gallo,C., Rothhammer,F.,
            Bedoya,G., Zeilhofer,H.U., Diatchenko,L., McMahon,S.B., Todd,A.J.,
            Dickenson,A.H., Ruiz-Linares,A. and Bennett,D.L.
  TITLE     Sodium-calcium exchanger-3 regulates pain 'wind-up': From human
            psychophysics to spinal mechanisms
  JOURNAL   Neuron 110 (16), 2571-2587 (2022)
   PUBMED   35705078
  REMARK    GeneRIF: Sodium-calcium exchanger-3 regulates pain ''wind-up'':
            From human psychophysics to spinal mechanisms.
REFERENCE   2  (bases 1 to 5151)
  AUTHORS   Xia,Z., Wang,C. and Zhang,H.
  TITLE     The downregulation of NCXs is positively correlated with the
            prognosis of stage II-IV colon cancer
  JOURNAL   World J Surg Oncol 19 (1), 177 (2021)
   PUBMED   34127021
  REMARK    GeneRIF: The downregulation of NCXs is positively correlated with
            the prognosis of stage II-IV colon cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5151)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5151)
  AUTHORS   Liu,T., Zhao,J., Ibarra,C., Garcia,M.U., Uhlen,P. and Nister,M.
  TITLE     Glycosylation controls sodium-calcium exchanger 3 sub-cellular
            localization during cell cycle
  JOURNAL   Eur J Cell Biol 97 (3), 190-203 (2018)
   PUBMED   29526322
  REMARK    GeneRIF: These results...suggest that cells can use a dynamic
            Ca(2+) signaling toolkit in which the NCX3 sub-cellular
            localization changes in synchrony with the cell cycle
REFERENCE   5  (bases 1 to 5151)
  AUTHORS   Khananshvili,D.
  TITLE     Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains
            of Mammalian NCX Isoform/Splice Variants
  JOURNAL   Adv Exp Med Biol 981, 41-58 (2017)
   PUBMED   29594857
  REMARK    GeneRIF: Structure-Dynamic Coupling Through Ca(2+)-Binding
            Regulatory Domains of Mammalian NCX Isoform/Splice Variants
            Review article
REFERENCE   6  (bases 1 to 5151)
  AUTHORS   Gabellini,N., Bortoluzzi,S., Danieli,G.A. and Carafoli,E.
  TITLE     The gene promoter of human Na+/Ca2+ exchanger isoform 3 (SLC8A3) is
            controlled by cAMP and calcium
  JOURNAL   Ann N Y Acad Sci 976, 282-284 (2002)
   PUBMED   12502570
  REMARK    GeneRIF: The gene promoter of the human isoform of this protein is
            controlled by cAMP and calcium.
REFERENCE   7  (bases 1 to 5151)
  AUTHORS   Gabellini,N., Bortoluzzi,S., Danieli,G.A. and Carafoli,E.
  TITLE     The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3
            isoforms
  JOURNAL   Gene 298 (1), 1-7 (2002)
   PUBMED   12406570
REFERENCE   8  (bases 1 to 5151)
  AUTHORS   Blaustein,M.P. and Lederer,W.J.
  TITLE     Sodium/calcium exchange: its physiological implications
  JOURNAL   Physiol Rev 79 (3), 763-854 (1999)
   PUBMED   10390518
  REMARK    Review article
REFERENCE   9  (bases 1 to 5151)
  AUTHORS   Matsuda,T., Takuma,K. and Baba,A.
  TITLE     Na(+)-Ca2+ exchanger: physiology and pharmacology
  JOURNAL   Jpn J Pharmacol 74 (1), 1-20 (1997)
   PUBMED   9195292
  REMARK    Review article
REFERENCE   10 (bases 1 to 5151)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF510502.1, BX098112.1 and
            AL135747.4.
            
            On Jun 2, 2019 this sequence version replaced NM_183002.2.
            
            Summary: This gene encodes a member of the sodium/calcium exchanger
            integral membrane protein family. Na+/Ca2+ exchange proteins are
            involved in maintaining Ca2+ homeostasis in a wide variety of cell
            types. The protein is regulated by intracellular calcium ions and
            is found in both the plasma membrane and intracellular organellar
            membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic
            manner. Alternative splicing has been observed for this gene and
            multiple variants have been described. [provided by RefSeq, Aug
            2013].
            
            Transcript Variant: This variant (c, also known as NCX3.3), encodes
            the longest isoform (C).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF510502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5142              AF510502.1         120-5261
            5143-5149           BX098112.1         322-328
            5150-5151           AL135747.4         33575-33576
FEATURES             Location/Qualifiers
     source          1..5151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5151
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="solute carrier family 8 member A3"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
     exon            1..573
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..2419
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             636..3419
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="isoform C precursor is encoded by transcript
                     variant c; sodium/calcium exchanger SLC8A3;
                     Na(+)/Ca(2+)-exchange protein 3; sodium/calcium exchanger
                     3; solute carrier family 8 (sodium/calcium exchanger),
                     member 3"
                     /codon_start=1
                     /product="sodium/calcium exchanger 3 isoform C precursor"
                     /protein_id="NP_892114.1"
                     /db_xref="CCDS:CCDS35498.1"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
                     /translation="MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQN
                     NESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASI
                     EVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF
                     IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLY
                     MILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIE
                     TEGDHPKGIEMDGKMMNSHFLDGNLVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQ
                     LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE
                     DFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE
                     GTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL
                     PRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF
                     RTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWM
                     ERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDK
                     LIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWK
                     VLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFG
                     TSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHV
                     SAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYIL
                     FATLEAYCYIKGF"
     exon            2420..2523
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2541
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2666
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2766
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..3042
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..5151
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5120..5125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="hexamer: AATAAA"
     polyA_site      5151
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgcgc gtcccctctg cgcgcggcga ggccgagacg tctcccgcgg tgacagcgtg
       61 caaggcggag acccggcgcg ctcccagccc agggaaagcc caggcgacgc gaccgcaagc
      121 ccgagcccag gtccctcgga gccgccaggg cgcgccgggc tgcttgcctt cctgcccctt
      181 cctgcaggaa tcccccgccg cccgcggccg ggactccggg cctctcccgg gcgtagattc
      241 cagtcaccgc tctgggtcgg ggtttccctc tttctgaaat ccgtgcggaa ggacccctcc
      301 cggggcccct cgccctggcc ccagacaccc tccctcccag accccgcgct ccagatgcgc
      361 tgccccgcag ctccctgaca gctgcgagcc cacgaacccc ggcgggaggg cggcggcggc
      421 ggactgacat gccccggacg cggctgcggc cggcgggcag cccgcggggg cgatgagccg
      481 ctgcgaccgg tgaggcgccg ggcggcgggg gcatcgcgta ccttcctcac ccccctccct
      541 tgcccactcc gctcgggagg ccgagaggaa acggtctctg gcctatcagg aggacaactg
      601 gtgctgcaat agaagccagt ggctaagtct cgtgtatggc gtggttaagg ttgcagcctc
      661 tcacctctgc cttcctccat tttgggctgg ttacctttgt gctcttcctg aatggtcttc
      721 gagcagaggc tggtggctca ggggacgtgc caagcacagg gcagaacaat gagtcctgtt
      781 cagggtcatc ggactgcaag gagggtgtca tcctgccaat ctggtacccg gagaaccctt
      841 cccttgggga caagattgcc agggtcattg tctattttgt ggccctgata tacatgttcc
      901 ttggggtgtc catcattgct gaccgcttca tggcatctat tgaagtcatc acctctcaag
      961 agagggaggt gacaattaag aaacccaatg gagaaaccag cacaaccact attcgggtct
     1021 ggaatgaaac tgtctccaac ctgaccctta tggccctggg ttcctctgct cctgagatac
     1081 tcctctcttt aattgaggtg tgtggtcatg ggttcattgc tggtgatctg ggaccttcta
     1141 ccattgtagg gagtgcagcc ttcaacatgt tcatcatcat tggcatctgt gtctacgtga
     1201 tcccagacgg agagactcgc aagatcaagc atctacgagt cttcttcatc accgctgctt
     1261 ggagtatctt tgcctacatc tggctctata tgattctggc agtcttctcc cctggtgtgg
     1321 tccaggtttg ggaaggcctc ctcactctct tcttctttcc agtgtgtgtc cttctggcct
     1381 gggtggcaga taaacgactg ctcttctaca aatacatgca caaaaagtac cgcacagaca
     1441 aacaccgagg aattatcata gagacagagg gtgaccaccc taagggcatt gagatggatg
     1501 ggaaaatgat gaattcccat tttctagatg ggaacctggt gcccctggaa gggaaggaag
     1561 tggatgagtc ccgcagagag atgatccgga ttctcaagga tctgaagcaa aaacacccag
     1621 agaaggactt agatcagctg gtggagatgg ccaattacta tgctctttcc caccaacaga
     1681 agagccgtgc cttctaccgt atccaagcca ctcgtatgat gactggtgca ggcaatatcc
     1741 tgaagaaaca tgcagcagaa caagccaaga aggcctccag catgagcgag gtgcacaccg
     1801 atgagcctga ggactttatt tccaaggtct tctttgaccc atgttcttac cagtgcctgg
     1861 agaactgtgg ggctgtactc ctgacagtgg tgaggaaagg gggagacatg tcaaagacca
     1921 tgtatgtgga ctacaaaaca gaggatggtt ctgccaatgc aggggctgac tatgagttca
     1981 cagagggcac ggtggttctg aagccaggag agacccagaa ggagttctcc gtgggcataa
     2041 ttgatgacga catttttgag gaggatgaac acttctttgt aaggttgagc aatgtccgca
     2101 tagaggagga gcagccagag gaggggatgc ctccagcaat attcaacagt cttcccttgc
     2161 ctcgggctgt cctagcctcc ccttgtgtgg ccacagttac catcttggat gatgaccatg
     2221 caggcatctt cacttttgaa tgtgatacta ttcatgtcag tgagagtatt ggtgttatgg
     2281 aggtcaaggt tctgcggaca tcaggtgccc ggggtacagt catcgtcccc tttaggacag
     2341 tagaagggac agccaagggt ggcggtgagg actttgaaga cacatatggg gagttggaat
     2401 tcaagaatga tgaaactgtg aaaaccataa gggttaaaat agtagatgag gaggaatacg
     2461 aaaggcaaga gaatttcttc attgcccttg gtgaaccgaa atggatggaa cgtggaatat
     2521 cagcgctcct gttatctcca gatgtgacag acaggaagct gactatggaa gaagaggagg
     2581 ccaagaggat agcagagatg ggaaagccag tattgggtga acaccccaaa ctagaagtca
     2641 tcattgaaga gtcctatgag ttcaagacta cggtggacaa actgatcaag aagacaaacc
     2701 tggccttggt tgtggggacc cattcctgga gggaccagtt catggaggcc atcaccgtca
     2761 gtgcagcagg ggatgaggat gaggatgaat ccggggagga gaggctgccc tcctgctttg
     2821 actacgtcat gcacttcctg actgtcttct ggaaggtgct gtttgcctgt gtgcccccca
     2881 cagagtactg ccacggctgg gcctgcttcg ccgtctccat cctcatcatt ggcatgctca
     2941 ccgccatcat tggggacctg gcctcgcact tcggctgcac cattggtctc aaagattcag
     3001 tcacagctgt tgttttcgtg gcatttggca cctctgtccc agatacgttt gccagcaaag
     3061 ctgctgccct ccaggatgta tatgcagacg cctccattgg caacgtgacg ggcagcaacg
     3121 ccgtcaatgt cttcctgggc atcggcctgg cctggtccgt ggccgccatc tactgggctc
     3181 tgcagggaca ggagttccac gtgtcggccg gcacactggc cttctccgtc accctcttca
     3241 ccatctttgc atttgtctgc atcagcgtgc tcttgtaccg aaggcggccg cacctgggag
     3301 gggagcttgg tggcccccgt ggctgcaagc tcgccacaac atggctcttt gtgagcctgt
     3361 ggctcctcta catactcttt gccacactag aggcctattg ctacatcaag gggttctaag
     3421 ccacacaaca gagcctccag cagggcaggc ctaggacttc tcctaagaga agggcacttc
     3481 cccaccagtg atctctcccg actgcactgc cctggagagg cagcatcagg acctaagccc
     3541 caggaacttc acccaactta ggccctggca attaactgaa agggcaaagt cttaatcaat
     3601 caaacaatgg aggaatcacc gactttacac agtatttaat tgaatacaaa caagcaacag
     3661 caacaaatcc acctccaccc catctccccc tcatatccct gacccaaagc aaaggtcaga
     3721 gcctttcgcc tccttctatt ccatcttttg attattcctt tgcctctcat ttctttggaa
     3781 gcagggtttc tcctctctgc ccaattccat atgtccctat tatctcactc agctgacaag
     3841 acgtgaaaat gagtcacatt catgtggctg gggtggggtt cttttttcat tgtaatcatt
     3901 attgtggttg ctttcgtttt gccattaggt tttgcttatt attttgtttt gtcttttttt
     3961 tctgaagtga gtgaaaaagg tgccacaaag gaattccagg tccgagccaa cagagagaaa
     4021 catgaatttt tagacacatg ctctcctgcc acctcttggc tccatcaaga tccagttccc
     4081 catctcactg ttttctctga gttcttggga ggagtgatgg tgttggggta gaaataagct
     4141 cactcaccca cgcagggtac taaagatctt acaggagctt caactggagc aggaggagct
     4201 ttttatgctt atgttgaatc aagtcagata caaaaagcaa ttgtccctct ttgcccaagc
     4261 ctttccaatt ctgtgtgtct tgttgtgtca gtgtccactt gtgtatcctt ctgcaggaag
     4321 acccgccaaa tagaagagat gggacaaaaa taggaatggt gtgtgacgac aaagggctac
     4381 tggaagaaca aaagggatac aggccttctt gattatcttt ggctttgtac ctgaggcagg
     4441 agagaagaga tgtccaacca gtgagatctt taagagaaaa gtttgtattt taaatgtcaa
     4501 tgtgcctgag aaatgtcagc ttcaccacgc tcttgcttcc taatgctcta tacaaagagg
     4561 gctgactata tttcttgaag tggtgtaaaa acttagagat tttataagag aaccaggggc
     4621 tcccttcacc tctcctggtc cctcaggtca catatgaaag catttttaca agataggaac
     4681 tggaattcct catttctccc atgttcctgc ttgttcttaa acttcatgaa gctatttttc
     4741 cagcctatgg ggtagttctt gctccagtaa gaggaatctt agttgtcata atcccttgga
     4801 gcctgggttt ttggagaaag agatctccgt gccctacaga ccttttctca acgaatgtgg
     4861 gaaggacctg gctttaaaac acgcacacaa acacacaaat aaacagacat aagatgtcat
     4921 cacgaaactg cccacggatc tttaggcttt ctgcattgac ataaatacat tttctaaggg
     4981 ggggggggaa gaaattaaaa aacacctgtt aattttaaac acatttttta agaaaaaaat
     5041 aattaaaaaa gaaacagtgc tcatgtcata agctatgttg acagttgcca gtggaaatgt
     5101 tgggttggtt caaaaaaaaa ataaaagcta tactatatct ctctacatac a
//
