LOCUS       NM_182932               5133 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 8 member A3 (SLC8A3), transcript
            variant d, mRNA.
ACCESSION   NM_182932
VERSION     NM_182932.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5133)
  AUTHORS   Trendafilova,T., Adhikari,K., Schmid,A.B., Patel,R., Polgar,E.,
            Chisholm,K.I., Middleton,S.J., Boyle,K., Dickie,A.C.,
            Semizoglou,E., Perez-Sanchez,J., Bell,A.M.,
            Ramirez-Aristeguieta,L.M., Khoury,S., Ivanov,A., Wildner,H.,
            Ferris,E., Chacon-Duque,J.C., Sokolow,S., Saad Boghdady,M.A.,
            Herchuelz,A., Faux,P., Poletti,G., Gallo,C., Rothhammer,F.,
            Bedoya,G., Zeilhofer,H.U., Diatchenko,L., McMahon,S.B., Todd,A.J.,
            Dickenson,A.H., Ruiz-Linares,A. and Bennett,D.L.
  TITLE     Sodium-calcium exchanger-3 regulates pain 'wind-up': From human
            psychophysics to spinal mechanisms
  JOURNAL   Neuron 110 (16), 2571-2587 (2022)
   PUBMED   35705078
  REMARK    GeneRIF: Sodium-calcium exchanger-3 regulates pain ''wind-up'':
            From human psychophysics to spinal mechanisms.
REFERENCE   2  (bases 1 to 5133)
  AUTHORS   Xia,Z., Wang,C. and Zhang,H.
  TITLE     The downregulation of NCXs is positively correlated with the
            prognosis of stage II-IV colon cancer
  JOURNAL   World J Surg Oncol 19 (1), 177 (2021)
   PUBMED   34127021
  REMARK    GeneRIF: The downregulation of NCXs is positively correlated with
            the prognosis of stage II-IV colon cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5133)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5133)
  AUTHORS   Liu,T., Zhao,J., Ibarra,C., Garcia,M.U., Uhlen,P. and Nister,M.
  TITLE     Glycosylation controls sodium-calcium exchanger 3 sub-cellular
            localization during cell cycle
  JOURNAL   Eur J Cell Biol 97 (3), 190-203 (2018)
   PUBMED   29526322
  REMARK    GeneRIF: These results...suggest that cells can use a dynamic
            Ca(2+) signaling toolkit in which the NCX3 sub-cellular
            localization changes in synchrony with the cell cycle
REFERENCE   5  (bases 1 to 5133)
  AUTHORS   Khananshvili,D.
  TITLE     Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains
            of Mammalian NCX Isoform/Splice Variants
  JOURNAL   Adv Exp Med Biol 981, 41-58 (2017)
   PUBMED   29594857
  REMARK    GeneRIF: Structure-Dynamic Coupling Through Ca(2+)-Binding
            Regulatory Domains of Mammalian NCX Isoform/Splice Variants
            Review article
REFERENCE   6  (bases 1 to 5133)
  AUTHORS   Gabellini,N., Bortoluzzi,S., Danieli,G.A. and Carafoli,E.
  TITLE     The gene promoter of human Na+/Ca2+ exchanger isoform 3 (SLC8A3) is
            controlled by cAMP and calcium
  JOURNAL   Ann N Y Acad Sci 976, 282-284 (2002)
   PUBMED   12502570
  REMARK    GeneRIF: The gene promoter of the human isoform of this protein is
            controlled by cAMP and calcium.
REFERENCE   7  (bases 1 to 5133)
  AUTHORS   Gabellini,N., Bortoluzzi,S., Danieli,G.A. and Carafoli,E.
  TITLE     The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3
            isoforms
  JOURNAL   Gene 298 (1), 1-7 (2002)
   PUBMED   12406570
REFERENCE   8  (bases 1 to 5133)
  AUTHORS   Blaustein,M.P. and Lederer,W.J.
  TITLE     Sodium/calcium exchange: its physiological implications
  JOURNAL   Physiol Rev 79 (3), 763-854 (1999)
   PUBMED   10390518
  REMARK    Review article
REFERENCE   9  (bases 1 to 5133)
  AUTHORS   Matsuda,T., Takuma,K. and Baba,A.
  TITLE     Na(+)-Ca2+ exchanger: physiology and pharmacology
  JOURNAL   Jpn J Pharmacol 74 (1), 1-20 (1997)
   PUBMED   9195292
  REMARK    Review article
REFERENCE   10 (bases 1 to 5133)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF510501.1, BX098112.1 and
            AL135747.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_182932.2.
            
            Summary: This gene encodes a member of the sodium/calcium exchanger
            integral membrane protein family. Na+/Ca2+ exchange proteins are
            involved in maintaining Ca2+ homeostasis in a wide variety of cell
            types. The protein is regulated by intracellular calcium ions and
            is found in both the plasma membrane and intracellular organellar
            membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic
            manner. Alternative splicing has been observed for this gene and
            multiple variants have been described. [provided by RefSeq, Aug
            2013].
            
            Transcript Variant: This variant (d, also known as NCX3.2), lacks
            an alternate in-frame exon in the mid coding region, compared to
            variant c. The encoded isoform (D) is shorter than isoform C.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF510501.1, BC036783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356921.7/ ENSP00000349392.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5124              AF510501.1         120-5243
            5125-5131           BX098112.1         322-328
            5132-5133           AL135747.4         33575-33576
FEATURES             Location/Qualifiers
     source          1..5133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5133
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="solute carrier family 8 member A3"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
     exon            1..573
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..2419
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             636..3401
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="isoform D precursor is encoded by transcript
                     variant d; sodium/calcium exchanger SLC8A3;
                     Na(+)/Ca(2+)-exchange protein 3; sodium/calcium exchanger
                     3; solute carrier family 8 (sodium/calcium exchanger),
                     member 3"
                     /codon_start=1
                     /product="sodium/calcium exchanger 3 isoform D precursor"
                     /protein_id="NP_891977.1"
                     /db_xref="CCDS:CCDS9800.1"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
                     /translation="MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQN
                     NESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASI
                     EVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF
                     IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLY
                     MILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIE
                     TEGDHPKGIEMDGKMMNSHFLDGNLVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQ
                     LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE
                     DFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE
                     GTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL
                     PRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF
                     RTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWM
                     ERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTN
                     LALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACV
                     PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDT
                     FASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLA
                     FSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEA
                     YCYIKGF"
     exon            2420..2523
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2648
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2748
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..3024
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..5133
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5102..5107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="hexamer: AATAAA"
     polyA_site      5133
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgcgc gtcccctctg cgcgcggcga ggccgagacg tctcccgcgg tgacagcgtg
       61 caaggcggag acccggcgcg ctcccagccc agggaaagcc caggcgacgc gaccgcaagc
      121 ccgagcccag gtccctcgga gccgccaggg cgcgccgggc tgcttgcctt cctgcccctt
      181 cctgcaggaa tcccccgccg cccgcggccg ggactccggg cctctcccgg gcgtagattc
      241 cagtcaccgc tctgggtcgg ggtttccctc tttctgaaat ccgtgcggaa ggacccctcc
      301 cggggcccct cgccctggcc ccagacaccc tccctcccag accccgcgct ccagatgcgc
      361 tgccccgcag ctccctgaca gctgcgagcc cacgaacccc ggcgggaggg cggcggcggc
      421 ggactgacat gccccggacg cggctgcggc cggcgggcag cccgcggggg cgatgagccg
      481 ctgcgaccgg tgaggcgccg ggcggcgggg gcatcgcgta ccttcctcac ccccctccct
      541 tgcccactcc gctcgggagg ccgagaggaa acggtctctg gcctatcagg aggacaactg
      601 gtgctgcaat agaagccagt ggctaagtct cgtgtatggc gtggttaagg ttgcagcctc
      661 tcacctctgc cttcctccat tttgggctgg ttacctttgt gctcttcctg aatggtcttc
      721 gagcagaggc tggtggctca ggggacgtgc caagcacagg gcagaacaat gagtcctgtt
      781 cagggtcatc ggactgcaag gagggtgtca tcctgccaat ctggtacccg gagaaccctt
      841 cccttgggga caagattgcc agggtcattg tctattttgt ggccctgata tacatgttcc
      901 ttggggtgtc catcattgct gaccgcttca tggcatctat tgaagtcatc acctctcaag
      961 agagggaggt gacaattaag aaacccaatg gagaaaccag cacaaccact attcgggtct
     1021 ggaatgaaac tgtctccaac ctgaccctta tggccctggg ttcctctgct cctgagatac
     1081 tcctctcttt aattgaggtg tgtggtcatg ggttcattgc tggtgatctg ggaccttcta
     1141 ccattgtagg gagtgcagcc ttcaacatgt tcatcatcat tggcatctgt gtctacgtga
     1201 tcccagacgg agagactcgc aagatcaagc atctacgagt cttcttcatc accgctgctt
     1261 ggagtatctt tgcctacatc tggctctata tgattctggc agtcttctcc cctggtgtgg
     1321 tccaggtttg ggaaggcctc ctcactctct tcttctttcc agtgtgtgtc cttctggcct
     1381 gggtggcaga taaacgactg ctcttctaca aatacatgca caaaaagtac cgcacagaca
     1441 aacaccgagg aattatcata gagacagagg gtgaccaccc taagggcatt gagatggatg
     1501 ggaaaatgat gaattcccat tttctagatg ggaacctggt gcccctggaa gggaaggaag
     1561 tggatgagtc ccgcagagag atgatccgga ttctcaagga tctgaagcaa aaacacccag
     1621 agaaggactt agatcagctg gtggagatgg ccaattacta tgctctttcc caccaacaga
     1681 agagccgtgc cttctaccgt atccaagcca ctcgtatgat gactggtgca ggcaatatcc
     1741 tgaagaaaca tgcagcagaa caagccaaga aggcctccag catgagcgag gtgcacaccg
     1801 atgagcctga ggactttatt tccaaggtct tctttgaccc atgttcttac cagtgcctgg
     1861 agaactgtgg ggctgtactc ctgacagtgg tgaggaaagg gggagacatg tcaaagacca
     1921 tgtatgtgga ctacaaaaca gaggatggtt ctgccaatgc aggggctgac tatgagttca
     1981 cagagggcac ggtggttctg aagccaggag agacccagaa ggagttctcc gtgggcataa
     2041 ttgatgacga catttttgag gaggatgaac acttctttgt aaggttgagc aatgtccgca
     2101 tagaggagga gcagccagag gaggggatgc ctccagcaat attcaacagt cttcccttgc
     2161 ctcgggctgt cctagcctcc ccttgtgtgg ccacagttac catcttggat gatgaccatg
     2221 caggcatctt cacttttgaa tgtgatacta ttcatgtcag tgagagtatt ggtgttatgg
     2281 aggtcaaggt tctgcggaca tcaggtgccc ggggtacagt catcgtcccc tttaggacag
     2341 tagaagggac agccaagggt ggcggtgagg actttgaaga cacatatggg gagttggaat
     2401 tcaagaatga tgaaactgtg aaaaccataa gggttaaaat agtagatgag gaggaatacg
     2461 aaaggcaaga gaatttcttc attgcccttg gtgaaccgaa atggatggaa cgtggaatat
     2521 cagatgtgac agacaggaag ctgactatgg aagaagagga ggccaagagg atagcagaga
     2581 tgggaaagcc agtattgggt gaacacccca aactagaagt catcattgaa gagtcctatg
     2641 agttcaagac tacggtggac aaactgatca agaagacaaa cctggccttg gttgtgggga
     2701 cccattcctg gagggaccag ttcatggagg ccatcaccgt cagtgcagca ggggatgagg
     2761 atgaggatga atccggggag gagaggctgc cctcctgctt tgactacgtc atgcacttcc
     2821 tgactgtctt ctggaaggtg ctgtttgcct gtgtgccccc cacagagtac tgccacggct
     2881 gggcctgctt cgccgtctcc atcctcatca ttggcatgct caccgccatc attggggacc
     2941 tggcctcgca cttcggctgc accattggtc tcaaagattc agtcacagct gttgttttcg
     3001 tggcatttgg cacctctgtc ccagatacgt ttgccagcaa agctgctgcc ctccaggatg
     3061 tatatgcaga cgcctccatt ggcaacgtga cgggcagcaa cgccgtcaat gtcttcctgg
     3121 gcatcggcct ggcctggtcc gtggccgcca tctactgggc tctgcaggga caggagttcc
     3181 acgtgtcggc cggcacactg gccttctccg tcaccctctt caccatcttt gcatttgtct
     3241 gcatcagcgt gctcttgtac cgaaggcggc cgcacctggg aggggagctt ggtggccccc
     3301 gtggctgcaa gctcgccaca acatggctct ttgtgagcct gtggctcctc tacatactct
     3361 ttgccacact agaggcctat tgctacatca aggggttcta agccacacaa cagagcctcc
     3421 agcagggcag gcctaggact tctcctaaga gaagggcact tccccaccag tgatctctcc
     3481 cgactgcact gccctggaga ggcagcatca ggacctaagc cccaggaact tcacccaact
     3541 taggccctgg caattaactg aaagggcaaa gtcttaatca atcaaacaat ggaggaatca
     3601 ccgactttac acagtattta attgaataca aacaagcaac agcaacaaat ccacctccac
     3661 cccatctccc cctcatatcc ctgacccaaa gcaaaggtca gagcctttcg cctccttcta
     3721 ttccatcttt tgattattcc tttgcctctc atttctttgg aagcagggtt tctcctctct
     3781 gcccaattcc atatgtccct attatctcac tcagctgaca agacgtgaaa atgagtcaca
     3841 ttcatgtggc tggggtgggg ttcttttttc attgtaatca ttattgtggt tgctttcgtt
     3901 ttgccattag gttttgctta ttattttgtt ttgtcttttt tttctgaagt gagtgaaaaa
     3961 ggtgccacaa aggaattcca ggtccgagcc aacagagaga aacatgaatt tttagacaca
     4021 tgctctcctg ccacctcttg gctccatcaa gatccagttc cccatctcac tgttttctct
     4081 gagttcttgg gaggagtgat ggtgttgggg tagaaataag ctcactcacc cacgcagggt
     4141 actaaagatc ttacaggagc ttcaactgga gcaggaggag ctttttatgc ttatgttgaa
     4201 tcaagtcaga tacaaaaagc aattgtccct ctttgcccaa gcctttccaa ttctgtgtgt
     4261 cttgttgtgt cagtgtccac ttgtgtatcc ttctgcagga agacccgcca aatagaagag
     4321 atgggacaaa aataggaatg gtgtgtgacg acaaagggct actggaagaa caaaagggat
     4381 acaggccttc ttgattatct ttggctttgt acctgaggca ggagagaaga gatgtccaac
     4441 cagtgagatc tttaagagaa aagtttgtat tttaaatgtc aatgtgcctg agaaatgtca
     4501 gcttcaccac gctcttgctt cctaatgctc tatacaaaga gggctgacta tatttcttga
     4561 agtggtgtaa aaacttagag attttataag agaaccaggg gctcccttca cctctcctgg
     4621 tccctcaggt cacatatgaa agcattttta caagatagga actggaattc ctcatttctc
     4681 ccatgttcct gcttgttctt aaacttcatg aagctatttt tccagcctat ggggtagttc
     4741 ttgctccagt aagaggaatc ttagttgtca taatcccttg gagcctgggt ttttggagaa
     4801 agagatctcc gtgccctaca gaccttttct caacgaatgt gggaaggacc tggctttaaa
     4861 acacgcacac aaacacacaa ataaacagac ataagatgtc atcacgaaac tgcccacgga
     4921 tctttaggct ttctgcattg acataaatac attttctaag gggggggggg aagaaattaa
     4981 aaaacacctg ttaattttaa acacattttt taagaaaaaa ataattaaaa aagaaacagt
     5041 gctcatgtca taagctatgt tgacagttgc cagtggaaat gttgggttgg ttcaaaaaaa
     5101 aaataaaagc tatactatat ctctctacat aca
//
