LOCUS       NM_015063               4959 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens solute carrier family 8 member A2 (SLC8A2), mRNA.
ACCESSION   NM_015063 XM_375633
VERSION     NM_015063.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4959)
  AUTHORS   Liu,H., Yu,J., Yang,L., He,P. and Li,Z.
  TITLE     NCX2 Regulates Intracellular Calcium Homeostasis and Translocation
            of HIF-1alpha into the Nucleus to Inhibit Glioma Invasion
  JOURNAL   Biochem Genet 61 (3), 979-994 (2023)
   PUBMED   36334237
  REMARK    GeneRIF: NCX2 Regulates Intracellular Calcium Homeostasis and
            Translocation of HIF-1alpha into the Nucleus to Inhibit Glioma
            Invasion.
REFERENCE   2  (bases 1 to 4959)
  AUTHORS   Xia,Z., Wang,C. and Zhang,H.
  TITLE     The downregulation of NCXs is positively correlated with the
            prognosis of stage II-IV colon cancer
  JOURNAL   World J Surg Oncol 19 (1), 177 (2021)
   PUBMED   34127021
  REMARK    GeneRIF: The downregulation of NCXs is positively correlated with
            the prognosis of stage II-IV colon cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4959)
  AUTHORS   Valsecchi,V., Anzilotti,S., Serani,A., Laudati,G., Brancaccio,P.,
            Guida,N., Cuomo,O., Pignataro,G. and Annunziato,L.
  TITLE     miR-206 Reduces the Severity of Motor Neuron Degeneration in the
            Facial Nuclei of the Brainstem in a Mouse Model of SMA
  JOURNAL   Mol Ther 28 (4), 1154-1166 (2020)
   PUBMED   32075715
  REMARK    GeneRIF: miR-206 Reduces the Severity of Motor Neuron Degeneration
            in the Facial Nuclei of the Brainstem in a Mouse Model of SMA.
REFERENCE   4  (bases 1 to 4959)
  AUTHORS   Huai,C., Wei,Y., Li,M., Zhang,X., Wu,H., Qiu,X., Shen,L., Chen,L.,
            Zhou,W., Zhang,N., Zhu,G., Zhang,Y., Zhang,Z., He,L. and Qin,S.
  TITLE     Genome-Wide Analysis of DNA Methylation and Antituberculosis
            Drug-Induced Liver Injury in the Han Chinese Population
  JOURNAL   Clin Pharmacol Ther 106 (6), 1389-1397 (2019)
   PUBMED   31247120
  REMARK    GeneRIF: Methylation on SLC8A2 is associated with the development
            of anti-tuberculosis drug-induced liver injury.
REFERENCE   5  (bases 1 to 4959)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   6  (bases 1 to 4959)
  AUTHORS   Qu,M., Jiao,H., Zhao,J., Ren,Z.P., Smits,A., Kere,J. and Nister,M.
  TITLE     Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3
            in human gliomas
  JOURNAL   Neuropathol Appl Neurobiol 36 (3), 198-210 (2010)
   PUBMED   20132488
  REMARK    GeneRIF: The aim of this study was to investigate if NCX2 might be
            a tumour suppressor gene involved in glioma. Results indicate that
            DNA methylation may play a key role in the transcriptional
            silencing of NCX2.
REFERENCE   7  (bases 1 to 4959)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4959)
  AUTHORS   Pulina,M.V., Rizzuto,R., Brini,M. and Carafoli,E.
  TITLE     Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers
            with the 14-3-3 proteins
  JOURNAL   J Biol Chem 281 (28), 19645-19654 (2006)
   PUBMED   16679322
  REMARK    GeneRIF: plasma membrane Na+/Ca2+ exchangers have inhibitory
            interactions with the 14-3-3 proteins
REFERENCE   9  (bases 1 to 4959)
  AUTHORS   Katanosaka,Y., Iwata,Y., Kobayashi,Y., Shibasaki,F., Wakabayashi,S.
            and Shigekawa,M.
  TITLE     Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated
            hypertrophic cardiomyocytes
  JOURNAL   J Biol Chem 280 (7), 5764-5772 (2005)
   PUBMED   15557343
REFERENCE   10 (bases 1 to 4959)
  AUTHORS   Li,Z., Matsuoka,S., Hryshko,L.V., Nicoll,D.A., Bersohn,M.M.,
            Burke,E.P., Lifton,R.P. and Philipson,K.D.
  TITLE     Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+
            exchanger
  JOURNAL   J Biol Chem 269 (26), 17434-17439 (1994)
   PUBMED   8021246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC401065.1, AB029010.1 and AC073548.5.
            
            On Nov 22, 2018 this sequence version replaced NM_015063.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic and transcript sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029010.1, AK302552.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000236877.11/ ENSP00000236877.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DC401065.1         158-185
            29-3042             AB029010.1         1-3014
            3043-4954           AC073548.5         73496-75407         c
            4955-4959           AC073548.5         73491-73495         c
FEATURES             Location/Qualifiers
     source          1..4959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..4959
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /note="solute carrier family 8 member A2"
                     /db_xref="GeneID:6543"
                     /db_xref="HGNC:HGNC:11069"
                     /db_xref="MIM:601901"
     exon            1..105
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            106..796
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2887
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /note="Na+/Ca2+-exchanging protein Nac2; sodium/calcium
                     exchanger 2; Na(+)/Ca(2+)-exchange protein 2; solute
                     carrier family 8 (sodium/calcium exchanger), member 2;
                     solute carrier family 8 member 2"
                     /codon_start=1
                     /product="sodium/calcium exchanger 2 precursor"
                     /protein_id="NP_055878.1"
                     /db_xref="CCDS:CCDS33065.1"
                     /db_xref="GeneID:6543"
                     /db_xref="HGNC:HGNC:11069"
                     /db_xref="MIM:601901"
                     /translation="MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQ
                     GSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS
                     KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGEL
                     GPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAV
                     FSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDP
                     PKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQL
                     VGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDG
                     ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGT
                     LVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVA
                     PLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTA
                     RGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISAL
                     LLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNL
                     ALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACV
                     PPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDT
                     FASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLA
                     FSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEA
                     YCHIRGF"
     exon            797..1461
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1884
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1988
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2006
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2131
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2231
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2510
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..4959
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4287..4292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /note="hexamer: CATAAA"
     polyA_site      4315
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /note="major polyA site"
     regulatory      4931..4936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
                     /note="hexamer: AATAAA"
     polyA_site      4959
                     /gene="SLC8A2"
                     /gene_synonym="NCX2"
ORIGIN      
        1 agtctcaggc ttttctctct ctcaatctct ctctctcttt cgggcggagt cgcccaccac
       61 tgccagccca gcgctggggg gacctgctcc aggctgtagc cgcaggaccc caccaccccc
      121 catggctccc ctggccttgg tgggggtcac actcctcctg gcggctcccc catgctccgg
      181 ggcagccacc ccaaccccct ccctgccgcc tcccccggcc aatgacagcg acaccagcac
      241 agggggctgc caggggtcct accgctgcca gccgggggtg ctgctgcccg tgtgggagcc
      301 cgacgacccg tcgctgggtg acaaggcggc acgggcagtg gtgtactttg tggccatggt
      361 ctacatgttt ctgggagtgt ccatcatcgc cgaccgtttc atggcggcca tcgaggtcat
      421 cacgtcaaaa gagaaggaga tcaccatcac caaggccaac ggtgagacca gcgtgggcac
      481 cgttcgcatc tggaatgaga cggtgtccaa cctcacgctc atggccctgg gctcctccgc
      541 acctgagatc ctgctgtcag tcatcgaagt ctgcggccac aacttccagg cgggtgagct
      601 gggcccaggc accatcgtgg gcagcgctgc cttcaacatg tttgtggtca tcgccgtgtg
      661 catctacgtc atcccagccg gcgagagccg caagatcaag cacctgagag tcttctttgt
      721 cactgcctct tggagcatct tcgcctatgt ctggctttat ctcatccttg ctgttttttc
      781 ccccggtgtg gtccaggtgt gggaggcgct gctgaccctg gtcttcttcc cggtgtgcgt
      841 ggtattcgcc tggatggccg acaagcggct gctcttctac aagtacgtgt acaagcgcta
      901 ccgcaccgac ccacgcagcg gcatcatcat aggcgccgag ggcgaccccc cgaagagcat
      961 cgagctggac ggcacgttcg tgggcgccga ggccccaggt gagctgggcg gcctgggccc
     1021 gggccccgcc gaggcgcgcg agctggacgc cagccgccgc gaggtcatcc agatcctcaa
     1081 ggacctcaag cagaagcacc cggacaagga tctggagcag ctggtgggca tcgccaacta
     1141 ctacgcgctg ctgcaccagc agaagagccg cgccttctac cgcatccagg ccacgcggct
     1201 gatgaccggc gccgggaacg tgctgcgcag acacgcggcg gacgcctcgc gcagggcggc
     1261 gccggccgag ggcgcgggcg aggacgaaga cgacggcgcc agccgcatct tcttcgagcc
     1321 tagcctctac cactgcctgg agaactgcgg ctccgtgctg ctgtccgtca cgtgccaggg
     1381 cggcgagggc aacagcacct tctacgtgga ctaccgcact gaggacggct ctgccaaggc
     1441 gggctccgac tacgagtaca gcgagggcac gctggtgttc aaaccaggcg agacgcagaa
     1501 ggagctgcgc atcggcatca tcgacgacga catcttcgag gaggacgagc atttcttcgt
     1561 gcggctgctg aacctgcgcg tgggcgacgc gcagggcatg ttcgagccgg acggcggcgg
     1621 gcggcccaag gggcggctgg tggcgccgct gctggccacc gtcaccatcc tggacgacga
     1681 ccacgcaggc atcttctcct tccaggaccg cctgctgcac gtgagcgagt gcatgggcac
     1741 cgtggacgtg cgcgtcgtgc gcagctcggg cgcgcgcggc accgtgcgcc ttccctaccg
     1801 cacggtggac ggcacggcgc gcggcggcgg cgtgcactac gaggacgcgt gcggagagct
     1861 ggagtttggc gacgacgaga ccatgaaaac tcttcaggtg aagatagttg atgacgagga
     1921 atatgagaaa aaggataatt tcttcattga gctgggccag ccccagtggc ttaagcgagg
     1981 gatttcagct ctgctactca atcaagggga tggggacagg aagctaacag ccgaggagga
     2041 ggaggctcgg aggatagcag agatgggcaa gccagttctt ggggagaact gccggctgga
     2101 ggtcatcatc gaggagtcat atgattttaa gaacacggtg gataaactca tcaagaaaac
     2161 gaacttggcc ttggtaattg ggacccattc atggagggag cagtttttag aggcaattac
     2221 ggtgagcgca ggggacgagg aggaggagga ggacgggtcc cgggaggagc ggctgccgtc
     2281 gtgctttgac tacgtgatgc acttcctgac ggtgttctgg aaggtgctct tcgcctgtgt
     2341 gccccccacc gagtactgcc acggctgggc ctgctttggt gtctccatcc tggtcatcgg
     2401 cctgctcacc gccctcattg gggacctcgc ctcccacttc ggctgcaccg ttggcctcaa
     2461 ggactctgtc aatgctgttg tcttcgttgc cctgggcacc tccatccctg acacgttcgc
     2521 cagcaaggtg gcggcgctgc aggaccagtg cgccgacgcg tccatcggca acgtgaccgg
     2581 ctccaacgcg gtgaacgtgt tccttggcct gggcgtcgcc tggtctgtgg ccgccgtgta
     2641 ctgggcggtg cagggccgcc ccttcgaggt gcgcactggc acgctggcct tctccgtcac
     2701 gctcttcacc gtcttcgcct tcgtgggcat tgccgtgctg ctgtaccggc gccggccgca
     2761 catcggcggc gagctgggcg gcccgcgcgg acccaagctc gccaccaccg cgctcttcct
     2821 gggcctctgg ctcctgtaca tcctcttcgc cagcctggag gcgtactgcc acatccgggg
     2881 cttctagggc ctcgcgcaga gactcgtccc caccgcccgc ccggggctag ggactcggct
     2941 gcacctgctc ttggaccctg gtctcctttt ccccccagac tcggcctcct ctcctgggac
     3001 tcggcctccc ttctccgccc cctcccctgg ctttgattgc cctgttctgt gtccccagta
     3061 gctcagcctt ccctcttcct ctcgggagcc tccccggttc ctcccctgcg gtgaccccaa
     3121 ctccagccca tcctgttggt gaccgtctat atccctgggg aaatttccac cccagtcccc
     3181 tccccaggga accaccccca gtaaccatcc tggggagttt aaggtctctc tccttggtca
     3241 cccagcctgg ctttgccccc aaagtctccc ttcccctagt gacccccccc ccacttcacc
     3301 ccatgtccca gagcctcaga acccaccctc cctgggggac cctcgaagga ggctgtcaga
     3361 ggccgtctca gctcccagcc cttcccccca gccctcaggg agctccgctc agccccggcg
     3421 gggaggagcg ggtgggtgtg cgcgcaagga ggccgcacac cgttccttcc aatccctcca
     3481 ctcgggttct tgggaggaca ctcattctcc aggctcggag acgaggggag aagtttgggg
     3541 tttcagtccc agggcttagc cggaggaagc acattttgaa cctgcaactt cagacattcc
     3601 agctccccca ctcgccctcc actacctctg agagcccagc cacgccttgg agggaggggc
     3661 ttgtgtgtgt atatagtgtg tttgggggag gggggacgcg ggagggtgca tgtcttggga
     3721 aaagggggtg acagacaact tttgagaggg cagcagactc cctcagccat gagaaccagc
     3781 tttggggagg aggccgggaa tcaaagcgag tccagttgat ctcccctgac aatctggaag
     3841 gttccttttg ccctcagtgc cagccaatcc gggcaggacc ctcgaagagg agaccgaggg
     3901 tcccagagga ccaatgctac aagccagcaa atgctgccac atctctgcct gatggggggt
     3961 ggggatgggt ggggggatgg gactgggcca agggatctgg gtgggcattt ttaactttgg
     4021 aggccttcca tctgtcggta ggccatctgc attttcttac tgttgatgtt tcctgcccaa
     4081 aggacacatt tgggcagtgc cacccactcc ttgggcccct aggatgaccc aactaccccc
     4141 ataactttct gcttcccaca ggttttcagc attctatcgt cctgttgtgc tcagccccaa
     4201 catcccagac ccgttaccca ctacccttct ctcccccagc tcatcatcag tcgctgtctc
     4261 ttttctgtga tttctgtaaa agttgccata aaactttgaa attctgcctg aaaaacagtc
     4321 ccgtgggaag ctgggattca ggaggagggg gctaataagg tctctgactg agatttgggc
     4381 aactgttaaa ccaagtaatc tgggtttttg cggcccgcgg tcgtctgcgg gacacaccca
     4441 catatagcag cagcgccggg gtccagccgc caagctcttc cactcgccac gcccccatca
     4501 gtaatgagct tccactagcc acgcccccat ccgtcagcct agctcttcca ctagccacac
     4561 ccccatccat cagtcatggg cttccacaag ccacgcacct ccactctcca tgcccccatt
     4621 cgtcagtcgt gggtttccac taaccacgcc cccattcatc agccaagctc ctccacttgc
     4681 tacgcccgca tccgtcaatt acgggtttcc actaaccacg cccccattca tcagcctagc
     4741 tcttccacta atcacacccc cacttatcag tcgtgcttca gccacgcctt cctgcttcag
     4801 tcaggggctt ccactagcca cgcccccatg catgagccac aaactgtttc tctttatggg
     4861 catcctggga acacaaaaga gagacgttca tttgcctgag ccaaagagct ggggttgatg
     4921 gggtttccta aataaagcaa gtaattttct cagatccta
//
