LOCUS       NM_021097              21116 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens solute carrier family 8 member A1 (SLC8A1), transcript
            variant A, mRNA.
ACCESSION   NM_021097 XM_006712081
VERSION     NM_021097.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 21116)
  AUTHORS   Montero-Calle,A., Garranzo-Asensio,M., Poves,C., Sanz,R.,
            Dziakova,J., Pelaez-Garcia,A., de Los Rios,V., Martinez-Useros,J.,
            Fernandez-Acenero,M.J. and Barderas,R.
  TITLE     In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples
            from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key
            Proteins Associated with the Disease
  JOURNAL   J Proteome Res 23 (11), 4802-4820 (2024)
   PUBMED   39441737
  REMARK    GeneRIF: In-Depth Proteomic Analysis of Paraffin-Embedded Tissue
            Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1
            as Key Proteins Associated with the Disease.
REFERENCE   2  (bases 1 to 21116)
  AUTHORS   Dong,Y., Yu,Z., Li,Y., Huang,B., Bai,Q., Gao,Y., Chen,Q., Li,N.,
            He,L. and Zhao,Y.
  TITLE     Structural insight into the allosteric inhibition of human
            sodium-calcium exchanger NCX1 by XIP and SEA0400
  JOURNAL   EMBO J 43 (1), 14-31 (2024)
   PUBMED   38177313
  REMARK    GeneRIF: Structural insight into the allosteric inhibition of human
            sodium-calcium exchanger NCX1 by XIP and SEA0400.
REFERENCE   3  (bases 1 to 21116)
  AUTHORS   Proteau,S., Krossa,I., Husser,C., Gueguinou,M., Sella,F., Bille,K.,
            Irondelle,M., Dalmasso,M., Barouillet,T., Cheli,Y., Pisibon,C.,
            Arrighi,N., Nahon-Esteve,S., Martel,A., Gastaud,L., Lassalle,S.,
            Mignen,O., Brest,P., Mazure,N.M., Bost,F., Baillif,S.,
            Landreville,S., Turcotte,S., Hasson,D., Carcamo,S., Vandier,C.,
            Bernstein,E., Yvan-Charvet,L., Levesque,M.P., Ballotti,R.,
            Bertolotto,C. and Strub,T.
  TITLE     LKB1-SIK2 loss drives uveal melanoma proliferation and
            hypersensitivity to SLC8A1 and ROS inhibition
  JOURNAL   EMBO Mol Med 15 (12), e17719 (2023)
   PUBMED   37966164
  REMARK    GeneRIF: LKB1-SIK2 loss drives uveal melanoma proliferation and
            hypersensitivity to SLC8A1 and ROS inhibition.
            Erratum:[EMBO Mol Med. 2024 Sep;16(9):2262-2267. doi:
            10.1038/s44321-024-00114-1.. PMID: 39164473]
REFERENCE   4  (bases 1 to 21116)
  AUTHORS   Xue,J., Zeng,W., Han,Y., John,S., Ottolia,M. and Jiang,Y.
  TITLE     Structural mechanisms of the human cardiac sodium-calcium exchanger
            NCX1
  JOURNAL   Nat Commun 14 (1), 6181 (2023)
   PUBMED   37794011
  REMARK    GeneRIF: Structural mechanisms of the human cardiac sodium-calcium
            exchanger NCX1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 21116)
  AUTHORS   Lai,X., Lu,S., Jiang,J., Zhang,H., Yang,Q., Liu,Y., Li,L., Li,S.,
            Dai,S., Chen,Y., Chen,Y., Liu,J. and Li,Y.
  TITLE     Association of polymorphisms of calcium reabsorption genes SLC12A1,
            KCNJ1 and SLC8A1 with colorectal adenoma
  JOURNAL   J Cancer Res Clin Oncol 149 (11), 8335-8344 (2023)
   PUBMED   37074453
  REMARK    GeneRIF: Association of polymorphisms of calcium reabsorption genes
            SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.
REFERENCE   6  (bases 1 to 21116)
  AUTHORS   McDaniel,L.D., Lederer,W.J., Kofuji,P., Schulze,D.H., Kieval,R. and
            Schultz,R.A.
  TITLE     Mapping of the human cardiac Na+/Ca2+ exchanger gene (NCX1) by
            fluorescent in situ hybridization to chromosome region 2p22-->p23
  JOURNAL   Cytogenet Cell Genet 63 (3), 192-193 (1993)
   PUBMED   8485996
REFERENCE   7  (bases 1 to 21116)
  AUTHORS   Kofuji,P., Hadley,R.W., Kieval,R.S., Lederer,W.J. and Schulze,D.H.
  TITLE     Expression of the Na-Ca exchanger in diverse tissues: a study using
            the cloned human cardiac Na-Ca exchanger
  JOURNAL   Am J Physiol 263 (6 Pt 1), C1241-C1249 (1992)
   PUBMED   1476165
REFERENCE   8  (bases 1 to 21116)
  AUTHORS   Komuro,I., Wenninger,K.E., Philipson,K.D. and Izumo,S.
  TITLE     Molecular cloning and characterization of the human cardiac
            Na+/Ca2+ exchanger cDNA
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4769-4773 (1992)
   PUBMED   1374913
REFERENCE   9  (bases 1 to 21116)
  AUTHORS   Shieh,B.H., Xia,Y., Sparkes,R.S., Klisak,I., Lusis,A.J.,
            Nicoll,D.A. and Philipson,K.D.
  TITLE     Mapping of the gene for the cardiac sarcolemmal Na(+)-Ca2+
            exchanger to human chromosome 2p21-p23
  JOURNAL   Genomics 12 (3), 616-617 (1992)
   PUBMED   1559714
REFERENCE   10 (bases 1 to 21116)
  AUTHORS   Colvin,R.A., Bennett,J.W., Colvin,S.L., Allen,R.A., Martinez,J. and
            Miner,G.D.
  TITLE     Na+/Ca2+ exchange activity is increased in Alzheimer's disease
            brain tissues
  JOURNAL   Brain Res 543 (1), 139-147 (1991)
   PUBMED   1647256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007877.3, AC106048.5, AC007281.3, AC007377.3 and AC007254.3.
            
            On Mar 31, 2021 this sequence version replaced NM_021097.4.
            
            Summary: In cardiac myocytes, Ca(2+) concentrations alternate
            between high levels during contraction and low levels during
            relaxation. The increase in Ca(2+) concentration during contraction
            is primarily due to release of Ca(2+) from intracellular stores.
            However, some Ca(2+) also enters the cell through the sarcolemma
            (plasma membrane). During relaxation, Ca(2+) is sequestered within
            the intracellular stores. To prevent overloading of intracellular
            stores, the Ca(2+) that entered across the sarcolemma must be
            extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary
            mechanism by which the Ca(2+) is extruded from the cell during
            relaxation. In the heart, the exchanger may play a key role in
            digitalis action. The exchanger is the dominant mechanism in
            returning the cardiac myocyte to its resting state following
            excitation.[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M96368.1, BC098285.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN03267756 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000332839.9/ ENSP00000332931.4
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC007877.3         143239-143337
            100-187             AC106048.5         8507-8594           c
            188-2019            AC007281.3         15094-16925
            2020-2126           AC007377.3         87567-87673
            2127-2147           AC007377.3         90779-90799
            2148-2165           AC007377.3         91218-91235
            2166-2180           AC007377.3         91340-91354
            2181-2249           AC007377.3         95711-95779
            2250-2380           AC007377.3         101076-101206
            2381-2480           AC007377.3         105196-105295
            2481-2756           AC007377.3         126384-126659
            2757-21116          AC007254.3         6337-24696
FEATURES             Location/Qualifiers
     source          1..21116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..21116
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /note="solute carrier family 8 member A1"
                     /db_xref="GeneID:6546"
                     /db_xref="HGNC:HGNC:11068"
                     /db_xref="MIM:182305"
     exon            1..187
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..2019
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3133
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /note="isoform A precursor is encoded by transcript
                     variant A; Na+/Ca++ exchanger; sodium/calcium exchanger 1;
                     Na+/Ca2+ exchanger; Na(+)/Ca(2+)-exchange protein 1;
                     solute carrier family 8 (sodium/calcium exchanger), member
                     1; solute carrier family 8 member 1"
                     /codon_start=1
                     /product="sodium/calcium exchanger 1 isoform A precursor"
                     /protein_id="NP_066920.1"
                     /db_xref="CCDS:CCDS1806.1"
                     /db_xref="GeneID:6546"
                     /db_xref="HGNC:HGNC:11068"
                     /db_xref="MIM:182305"
                     /translation="MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGN
                     ETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSS
                     IEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHN
                     FTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWL
                     YIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMII
                     EHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELK
                     QKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVS
                     MHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT
                     ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDG
                     ILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGA
                     RGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFL
                     EIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEY
                     DDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVG
                     TNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYW
                     NGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVA
                     ATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLF
                     TIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKG
                     F"
     exon            2020..2126
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2147
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2165
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2180
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2249
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2380
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2480
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2756
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..21116
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      20577..20582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /note="hexamer: AATAAA"
     polyA_site      20601
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /note="major polyA site"
     regulatory      20800..20805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /note="hexamer: AATAAA"
     polyA_site      20819
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
     regulatory      20863..20868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /note="hexamer: ATTATA"
     polyA_site      20884
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
     regulatory      21094..21099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
                     /note="hexamer: TATAAA"
     polyA_site      21116
                     /gene="SLC8A1"
                     /gene_synonym="NCX1"
ORIGIN      
        1 gccgcggctc ccgctcgcgc cggcgctgca cggtagtcag cccgccgccg ccgcctgctt
       61 tgtgcttccc acagaagatg ggagcgacct cttcctgatc gggagctgtt taaaaggagg
      121 gagtgcgccg tattttctac tagcgtggag gaacggagga agaatccatt cacactcccc
      181 aaaccagtag gttgtgacag ttggaagtgt catgtacaac atgcggcgat taagtctttc
      241 acccaccttt tcaatgggat ttcatctgtt agttactgtg agtctcttat tttcccatgt
      301 ggaccatgta attgctgaga cagaaatgga aggagaagga aatgaaactg gtgaatgtac
      361 tggatcatat tactgtaaga aaggggtgat tttgcccatt tgggaacccc aagacccttc
      421 ttttggggac aaaattgcta gagctactgt gtattttgtg gccatggtct acatgtttct
      481 tggagtctct atcatagctg atcggttcat gtcctctata gaagtcatca catctcaaga
      541 aaaagaaata accataaaga aacccaatgg agagaccacc aagacaactg tgaggatctg
      601 gaatgaaaca gtttctaacc tgaccttgat ggccctggga tcttctgctc ctgagattct
      661 cctttcagta attgaagtgt gtggccataa cttcactgca ggagacctcg gtcctagcac
      721 catcgtggga agtgctgcat tcaatatgtt catcattatt gcactctgtg tttatgtggt
      781 gcctgacgga gagacaagga agattaagca tttgcgtgtc ttctttgtga cagcagcctg
      841 gagcatcttt gcctacacct ggctttacat tattttgtct gtcatatctc ctggtgttgt
      901 ggaggtctgg gaaggtttgc ttactttctt cttctttccc atctgtgttg tgttcgcttg
      961 ggtagcggat aggagacttc tgttttacaa gtatgtctac aagaggtatc gagctggcaa
     1021 gcagaggggg atgattattg aacatgaagg agacaggcca tcttctaaga ctgaaattga
     1081 aatggacggg aaagtggtca attctcatgt tgaaaatttc ttagatggtg ctctggttct
     1141 ggaggtggat gagagggacc aagatgatga agaagctagg cgagaaatgg ctaggattct
     1201 gaaggaactt aagcagaagc atccagataa agaaatagag caattaatag aattagctaa
     1261 ctaccaagtc ctaagtcagc agcaaaaaag tagagcattt tatcgcattc aagctactcg
     1321 cctcatgact ggagctggca acattttaaa gaggcatgca gctgaccaag caaggaaggc
     1381 tgtcagcatg cacgaggtca acactgaagt gactgaaaat gaccctgtta gtaagatctt
     1441 ctttgaacaa gggacatatc agtgtctgga gaactgtggt actgtggccc ttaccattat
     1501 ccgcagaggt ggtgatttga ctaacactgt gtttgttgac ttcagaacag aggatggcac
     1561 agcaaatgct gggtctgatt atgaatttac tgaaggaact gtggtgttta agcctggtga
     1621 tacccagaag gaaatcagag tgggtatcat agatgatgat atctttgagg aggatgaaaa
     1681 tttccttgtg catctcagca atgtcaaagt atcttctgaa gcttcagaag atggcatact
     1741 ggaagccaat catgtttcta cacttgcttg cctcggatct ccctccactg ccactgtaac
     1801 tatttttgat gatgaccacg caggcatttt tacttttgag gaacctgtga ctcatgtgag
     1861 tgagagcatt ggcatcatgg aggtgaaagt attgagaaca tctggagctc gaggaaatgt
     1921 tatcgttcca tataaaacca tcgaagggac tgccagaggt ggaggggagg attttgagga
     1981 cacttgtgga gagctcgaat tccagaatga tgaaattgtc aaaacaatat cagtcaaggt
     2041 aattgatgat gaggagtatg agaaaaacaa gaccttcttc cttgagattg gagagccccg
     2101 cctggtggag atgagtgaga agaaagccct gttattgaat gagcttggtg gcttcacaat
     2161 aacaggaaaa tacctgtttg gccaacctgt cttcaggaag gttcatgcta gagaacatcc
     2221 gattctctct actgtaatca ccattgcaga cgaatatgat gacaagcagc cactgaccag
     2281 caaagaggaa gaggagaggc gcattgcaga aatggggcgc cccatcctgg gagagcacac
     2341 caagttggaa gtgatcattg aagaatccta tgaattcaag agtactgtgg acaaactcat
     2401 taagaagaca aacctggccc ttgtggttgg gactaacagc tggagagaac agttcattga
     2461 agctatcact gtcagtgctg gggaagatga tgacgacgat gaatgtgggg aagagaagct
     2521 gccctcctgt ttcgattacg tgatgcactt tctgactgtg ttctggaagg tcctgtttgc
     2581 cttcgtcccc cctactgaat actggaatgg ctgggcgtgt ttcattgtct ccatcctcat
     2641 gattggccta ctgacagctt tcattggaga cctggcttcc cactttggct gcaccattgg
     2701 cctgaaagat tctgtgactg cagtcgtgtt cgtcgcactt ggaacatcag tgccagacac
     2761 atttgccagc aaagtggcag ccacccagga ccagtatgca gacgcctcca taggtaacgt
     2821 cacgggcagc aacgcggtga atgtcttcct gggaatcggt gtggcctggt ccatcgctgc
     2881 catctaccac gcagccaatg gggaacagtt caaagtgtcc cctggcacac tagctttctc
     2941 tgtcactctc ttcaccattt ttgctttcat caatgtgggg gtgctgctgt atcggcggag
     3001 gccagaaatc ggaggtgagc tgggtgggcc ccggactgcc aagctcctca catcctgcct
     3061 ctttgtgctc ctatggctct tgtacatttt cttctcctcc ctggaggcct actgccacat
     3121 aaaaggcttc taaaggaact atcagatata gtaaatttat atatatacat atatatacat
     3181 aaaaattatg tataatggac agaggaaact gacatttgtc atgttcactt acctgctgat
     3241 ggaatccagc ttcaagagca tactctgtac tagggccgaa gtaaaaaacc atcacctccc
     3301 attcccaggg gcatcatcat gttcaacaag gcatggaggc agggccatct ttgcagctca
     3361 gtctagaagg gctgcactct ctccaggttg ataaatcctt aaggctttga tttgttttgt
     3421 ttttggtttt gttttcagtg gagctgggga ggtagttaat gtttggcttt atttttgtta
     3481 ttttgttttg ttttgttttt ttgggagagt cagggttgtt gcttttcttt gtggaaagtg
     3541 aaaccatcca aatgtaaatg ggttttggta aaaatttaaa tcattagtat tccccctcac
     3601 ctcccccaat cactttaaaa cttattttgg attaagaaaa aatctgggca tggaagaaga
     3661 aagaagcatg tcttcatcgt attaccaaag ttcatgctta tctccggaat gtgagtggag
     3721 gtgaagctgc ctccaagaag aagcataaaa gtggaatgga gccaggaaat ccgatggttc
     3781 tagaaatagt ctgatattta aacatgtgat acctggcagt ctcgtttaac aggtacaagg
     3841 aaaacgtgcc tagattccca ggaacgtgca aaatcctttc tttcttatct ctttagctct
     3901 ggactgtgat tggcaaggtc cttcttccag cattcagccc agctaagccc ccaggtgccc
     3961 catcccaacc ctgttcctcc tgtccacctg ccatccccta tgcaaacagt aagaataacc
     4021 ccattcaaaa agcacatcat cgttttccat ttgcattaac atgtgtctca gtcccatgtt
     4081 gccgttgctt gggattgtct gtcagtttta ttttcaaagg catccatggc ttgcacaatc
     4141 ctgttccagt catgactgaa catttgctcc ttcttcatgt gccgttcgga aatgttgttg
     4201 tgatacctgt tacacagtgc atggtgaaaa acaaataaaa caaaacaaag agtatctgta
     4261 tatagtagag tatagtacat actgttctcc catttggcaa tgttgattgg acattgaaga
     4321 cataagtgag ttttcttttc acctgagttg ttacttttgt gctgttattg agtttgatta
     4381 attactaggg ataaaaggag aaaatggatt attgttcacg gttctgcaca ttcatttcta
     4441 agaagcaata actgtcatgt ggggagaagt taaagctatt gagaggatag caggcaaact
     4501 acaaagatct tcatggaaaa ttagccatgt ggaacacatc agaggcctct aaaaatcacc
     4561 cattaattca ggaaggccaa ggagaaaggc cttatagaga cgttgatatg ttggatgtgc
     4621 ctaggctttc agagccaccc tttccacaac acccctccct gcaaagtatt tatttcacat
     4681 ctgcactgtc tggcacagat ggtagatagt gctggtttgt tcattttatt tttttactta
     4741 aaaggctatt ttgagccctg tttctttcac tgtccagtct agtcctcttt gattatatca
     4801 gtagttgctg agtaagaaag aagccagggt gaccaacggg cctttaaaag tgttgtctcc
     4861 tctacttatg ctgaaagaga aggcaattaa ataagactag tacctcccag gaggattgga
     4921 ctgggatatt tttaaccctt taaaaagaat agctgtttct atgttaaaat accaaagaac
     4981 atggataaac ccaacattcc aaagtagtga gtccactaat gagaaaaata atagaatgac
     5041 tttggtcacc tctcggagac ttctgtgtct ataaggaatc ccaggctgga gacattccta
     5101 gccctctgta ttgattcaaa aatacttaat aaattaaagc tgttgagact tattttttct
     5161 tctgtcactc agtaaccatg atccttcctc atttaataaa catttggtga ctgaatgagt
     5221 aattaaatgc tggttaccca cttaatgtgc caggtagtat gatactttct ggggactaag
     5281 ccatgaacaa aacagtctag atccctgccc tcagaagggt tacagtttat gtgattacta
     5341 ttttcatgag taaaagtgaa gaaagccata tggaaagatt tttatcttgc aagaaaaaac
     5401 aattatgaaa ctcttttaac ataaacacac tgaaactgta tcaaagcaat tgtccaaatt
     5461 gtatttatac ccaagaattt ctttaactaa gagagcataa ggcatatgtt tggaaaacca
     5521 ccctctttat ctttgaccga cttgcagata aatatatctc tccattttaa accaagaagg
     5581 gcaatcatgt tggtgatcca gatcactgag aaagcccagt gtatcccatc ttttatcttt
     5641 gttggcaatg gaacttttct atggcccaca ctttacaatt ctttgtcatt ctaacccatc
     5701 cttcccatcc ttattttttt tttttttgag aattgctaaa tggaaagcta gcctagaagc
     5761 accaagtaaa tatattcaag gaatataagt tgtttaaaca ttagaaaaat ttttgcactc
     5821 attttttagc tgtattagga atgtcaataa tcctgtagca aattttcaca gagaacttta
     5881 agaaattctt gcattggtcg atttcaattt gaaagctttt tggtttgttt gctttttaaa
     5941 ttttcatgtt ctaggaaact atgattctgg ttgttcagga ttgttattat tatagttgtg
     6001 taaaattatt ttattttgtg tgtattgtgc acagcttggg gggggggcgg gaaatgcact
     6061 aattgtgctc ttccttataa atggtacata ttactgacac agacaaataa agtttctaat
     6121 tgtttctgat ttaatcacta gtgatacagc atattctgta tgaaatgttt tctcctttct
     6181 cattgtcatc tacttcattt tttgttttca tgttttgaag aaataaaaac caaaatggta
     6241 ttattgtgca actggtatca tcatccaaag aaaaaaacag acaccaagta ttcaaactct
     6301 tgcaaacgtc aacccttcgg tcatgcaatg ttctcttttt aatgtcccag gagaacacag
     6361 tgtcagaata tttgtctgtc ctacagtgct gagatatatg ttggacattc ctccatttca
     6421 ctgatttttt ttacgttgct tagtatgact ctatctacat cctttcctgc atccaggatc
     6481 ataagcccat aaacagttac atgtcagaca actttttagc atgcagagta ttacatcaaa
     6541 tcagtcgatc ccaaaaaatt ccaatcccaa aattgatggt agtacagttt cttcccaagg
     6601 ggatgtttaa gtaaatttct cttttagttt catatgttat attcctcttg tagaacttct
     6661 gcctcgcatt aacgatttct gtctatatct tattaacttc atatatcata tagtcaaaac
     6721 agtatagaag gaagtgatgt cagaaatgga ataagcattt gtggggaaaa aatgtgacct
     6781 ctaaggtttg tgtacttatt tgaagttgac atattagtgg acttagttct tactataata
     6841 gaatctgtcc acatgtacaa gtaaatgcta ctttattgat ccgatcatct ttaaaatttt
     6901 ctttagtatt cctcattata ttctttatat ggtcatatgt ggtatacttt catgtatgaa
     6961 tgaaggaatt atttaaatat tttatagtat caaactgtca atatgtctct tgagtaccag
     7021 cctttggttt aacacaaaat gagcagccaa cctctatttc tttatatagc aaaaagatta
     7081 attcaatgac cagagctcct tgaccgtcta acaacctttc agaaaaattc tgtgacctga
     7141 taattatcag tttcttacaa gcaaatttta atgggttcaa atttcctgat tccatccttc
     7201 aaccagtgag tgttttataa aattttgctt tttgtagttc atagcctaat agcactaatt
     7261 ttttgttgct tttcaaacat aaaattttta caaaatattg ttttagaaac cctgcaaaaa
     7321 ttctgatgca tgcctttccc ctgtggcctc actattaatg aaagctcacc actcacattg
     7381 cattttccac aggggtcttg attcattggt gattccacag caaaaggtcc ctgatcctaa
     7441 actgtcaaaa taaagtagcg agactgatat acatctgata actttgtgga agcaattaga
     7501 aaattttctc tggtagatga tgatgccctc catcctctaa tagtggcaga actttgcctt
     7561 ctcaagagaa taaatcagcc cctttaagac ttcttttaat atttttgggc tggggatatg
     7621 gagtctctct gttgattctg actttctgac tatgattttg ggcagttgca tgcagagcaa
     7681 gttctgagtg tagtttcata atctcaagaa cgtttggcca ttttatgatt gacagcatgt
     7741 aatattggat ctcacctgac ctacaactgg cattcagctt ttatcattgt aatcacttca
     7801 cttggccaag gcagttggta aaactgagca aagttaaata taaattccaa tcattaaatt
     7861 ggtgagtgca ttatgcagaa gatacagaat cctatttcag aaaaagaaac atgctattat
     7921 aagtggattc cttagatttt gttcagctct acctacggag ttttgctaat agaatgtagt
     7981 tctgctattc ttttttacca ttatgtactc accacttcta accatcttgt tgtcttccca
     8041 tcacgcagta catttcaaaa tgctgggcgg tcccgatggt attacaccca caaggacagc
     8101 ataggaaggg taaacaattg aaatagatat ttcatgttgg gagcttaatt aggccatgat
     8161 taatcgtctc tcaaagcaga gactgtctta tctataaaag gagcaaccac tgagaggtgg
     8221 aactcccaaa ggaaagcact gcaggtttcc agcccacaag aaatggtacg tatttcactt
     8281 tctttgactt tttccctgcc tgtcaagatg tccaaatgta ctcagaggct gtccacattt
     8341 tcagttttgt caaaggttct ctgattcaat tttgtaagaa acatttaaat cagtggttat
     8401 gtaaattatt gtttattttg ttttactttt aggaaagagc attactgtat aacttcaaaa
     8461 agcaatatga cttagtagtt aaaattatga cccatatttt ttcaggaaga cttgcttgcc
     8521 caaaattgtc ttgtctatct gttatcaatg tagtcattca tagctgcctc agtggttcac
     8581 attttttaga attatgcttc cctagcattt tttcaaagag ttggagagtt ttccccatgg
     8641 gaataaacag tcttaatatt tcctttccct aatttcagcc tttgcagttc ttcggtgact
     8701 actcccatta tatccaacta cccttagtga tgctcactat tacctcccgg caatagggaa
     8761 agagcttatg ctataaagtg attgctcaag acatgttttt ctgaaagtga acttatcata
     8821 ggagaaatca aatataatga cattccacct agataagagt cactaggaca tagtatggaa
     8881 tctttgtaaa tgagcgggac agatcatacc tacagttaca catataatag tgttgtttat
     8941 tttatacctc ttgaatcata tttattatgc ttcagtgctg cccatcgacc tagcctttta
     9001 ttctatcaat atgtaggtgt ggattgggaa tgagaaccga cattcacatc cctgatgctc
     9061 atgagggttt ctacaaaggt ggagtatgta aacatagaaa aacgtaacag atagcttcca
     9121 tgcctctaag aaatatgagt gggtcaaatg cttctctgtg ggtactattt ttctgctatg
     9181 caaatggtag aaaagttcac attaatagcc aaacagacca agagagaaat tagctaactt
     9241 cactgttaat ctgtctactt tgacagttaa gatatagccc agccctccta atttgttgac
     9301 tgcaaagaca gatacgccta gttaaatcca agaatgcact gggggacggg gggataaagt
     9361 tactagaata attatacaac cctccgtact aagattgctt attcgccaag aagaatcctg
     9421 cccagagatt ttcagagaca tttccttaca ttcccaacct tcttttaatt tacacaactt
     9481 tttaattaga ccccttgaag ccacatagta aaacaagaga tgaattatct aaggagaact
     9541 tttggccctc cctctaatgt gaagatcaca tacttgactg tatttcccat tctttccaaa
     9601 tggaaagaac agtccaatta agtaaccaac tatgtaacca ctttttgacg taattccacc
     9661 taaaaaacaa agagtgaact aaattgtaca aacattaaac ctaacagtga tatgaccaga
     9721 tggctagttt tgagaaaaat aatattttct gtagatacct tgctctccct tcctgtactc
     9781 atcctaatgc tcaagtttga gaaatactcc aaggaagaaa tcttgaaaga ttgtacattc
     9841 aaataatgct catgtaattg agtaatatgg catttgggat gagaataaga gcgtatttaa
     9901 aaataagaga attggcacaa aaatgtgtta actaggattt tattacaaat tgccctaaga
     9961 tatttgcaag ttattatatt taagtgaaat aaatcccagt ttccagaaac aacagtacaa
    10021 tttatattcg caggttttat atgaaaatca aagttgggca tacatacttt ttggctttgg
    10081 caaccaaaga aaagcatgtt tttggcacac gtttccaaat tattgagtta tttgtagaat
    10141 acattggacc tgtacaggta tctcattaaa attaccttca ataatttccc tttcttcctt
    10201 taagccatca agtttctaaa ttttacaact tcacagttta gcaatttcat ttatgaaagg
    10261 ctgattccat tttgatgttg atttttacat ttcagaattt ttcatatata aatatttgat
    10321 gcattagatg ggatactgag cttgagtctg gcccaaatga accacaaggc ccagactgat
    10381 ctatcagtag ttagaaggct tctaatacac tggctttcta atgtacagta aatactagcg
    10441 ttgttttcaa tattctttct tttgactaaa agtttccatt ccaactggtg aaaaattttt
    10501 aaaaaatatt tataatgata gttagagaac tgtttatatg aggatcagac attgtttcag
    10561 cactggatct cctctgtccc ctctcttgct acagcataca gcccagagac acacatgtaa
    10621 aagtaggtga tctctgtaaa cttcagctgc atttctgtat gtctaggatt gtcctagtat
    10681 cagatatcct ttgagaaaga gttggagagg catggaagga agcatattcc tgacctcccc
    10741 cctttttagc taaagataca aattcagagc tgtttgaaaa gggcttagaa taatattaat
    10801 taaacatatt ctataataca aagagaagta cttttttaaa atacatttat ttttctttct
    10861 tttttagcag gcatttctga cagaaaatct ttagggccaa ttagagtttc tttctgactt
    10921 ttaattgccc tctgcctttt gggaaagtgt tgaaaaaagc tctggaaaaa aatatgctgg
    10981 tcaaggtcga accctgggga attaaaaaca tgagattttt atattttccc tccaaacata
    11041 gcactgagca ggcaggttcc catgcctgtt gttaatcggc attttctttt tttttttttt
    11101 ttttttgaga cggagtctcg ctctgtcgcc caggctggag tgcagtggcg ggatctcggc
    11161 tcactgcaag ctccacctcc cgggttcacg aatcggcatt ttctaaacac gtgttttggt
    11221 gtgctgggag cagaggagta ggaggcccac ccagtcccac cacacatacc gggacatctt
    11281 tgaccacatg ggtcctctgc cgttcgtatt ttagcttaga tgttcttaac tgaactaact
    11341 tccaattttc atatacactg atcatcttgt ccctagcatt ttccctccaa gatcctgcta
    11401 acaggcaaac tagccctttc aaacagttgg tacctgagat ttctcagagc tctcttatca
    11461 agagtaagga gtgagattgc agaaggggca gtaatgtcaa taccaagtta ttggaaacta
    11521 cttaaccagc cactgcatta catactggag cccgtctagg acacttgccc ttggaaatgg
    11581 tggaaagact ttgttttatt tctatttcat caacagaact tttgtagcat tgaatctaag
    11641 caaaggataa catcatatta taatggaaag ttatttttaa ctacaactgt tattgttaaa
    11701 tttagaagaa aatattgtct ttgaagtttc agtccaaaac tctaaggaga acaaggtttt
    11761 tactgccatc ggtaatcctg tgagaaattt gacactccag atcttatttg agacagataa
    11821 gtctatgata aatatatgta tgagacttaa aatattcttg atattctcag gttgttctca
    11881 caaattctgc atagatttag ttgttttttt ttttatgaga acctttctta tcaaaaagga
    11941 ttgaaaattt ttccaacaac tggttgttaa atgagtctag cacccaaaga agctgtgagc
    12001 agttggttct accagtgact cttctaggag ctctttccag gttggtctcg aactcctgac
    12061 ctcaggtgat ccgcctgccc tggcttccca aagtgctggt attacaggca tgagccactt
    12121 tgcccagcct gatagttctg actcaatccc tagacacatt cttcagaaac aactgtacat
    12181 ggtgagagaa aagtgaaaag gaaaaaagtt ttccttcctt caaaatacac taaatttgct
    12241 tatcaccttt aaaatttgga ctgaatgttt aaactttaaa cacaaagcaa agggagatgc
    12301 tcttaaatgt gaaatctgaa gcaaagattg catttttgca aagctatcca gaagatgtgt
    12361 taattattga gacatgggat tcattaacac atcagcgccc aaccactgcc tctcctgccc
    12421 ccattcacac attatccaca atcaaataag cagctaagca ggggaaacct atcactgtta
    12481 atgtcataat cacatcacca ctgaattacc agatgtggtc aggaactagg caaagtaggt
    12541 gggaccaatc ctaggactgg ggccatacca caacctcagc tcagcccctt gtcggatacg
    12601 gtttctgaat ttagtacaat gccagaagta ttttttttct ttcagctgtg aaccagcctg
    12661 ttttgtttga caagcctttc cagattcatg cagctcaatc acgtgcttgt tgccagtttg
    12721 agagtgaacc tattatttca aacttgttgc cgtgaccaat ttttacaaaa ctgaaagtag
    12781 cactgtgagg tggattggac ctagtgatga ggtgtctaca cttgcatcct tttcttccaa
    12841 gagaatattc tgacactcca actctagaag tcatgtcatt agtaaaatga aaataataat
    12901 tgcttaatca ctgtttagaa ttagttcata cttcttcaga gcttgaagcc tccacgactc
    12961 aacatcagat ccatggatag tattactata cctttaccca aagactggat ttattttgta
    13021 aaaatatcag aatgggtctg ggtcccttta aagcaactga caaggtattt aacaacattt
    13081 taaaacaatg aagaaaggat gattctgcag aggctgctgg gttacagagg agggcagagc
    13141 ttttgtcaga ctctcttgat gttttgctct tcctggtaag tttttatcta tcatggttcc
    13201 cagtggaata ttctccatac acattctgtg ggaggatatt gacatggctc tagactctgc
    13261 cttttatttt ctaattctcc ttggagaatt agaacaggca ttccagaact tgtaatatag
    13321 aggggaagaa agaaaaaatg gcagatgcct cattgatgga tccacaagtt ttgtacaaaa
    13381 gcacacacca ttctgattgt ctctatatta acattgtact caccaaacag ctttctaaag
    13441 gtgactggaa caagataaat atcaactgga taattaccta aggaaaaaga ataaaaaaga
    13501 aatcaaacca aaaaaaaagc aaaaaattgg tcagtttagc aagcgtgttt tccaggatca
    13561 taggctcata aactatacag tcaagagagt gaaacaattt taaaatcaaa agttagagcc
    13621 ttttatattt cttcagatgt acaatttcat aaatcaagca tttattttgt gcaaagtatt
    13681 atattaggta ccctaaatgg tatataaaga attcaaaaca gagtaattta agaaaattaa
    13741 cactagtctt tgatttagtc aggaagagtc cacttatggc attctaatta aattaacctt
    13801 ccattttggt ctacatttta tcaatttgag attgcttaat ggggccattt tgaaacctat
    13861 caagaaactt tcctctaaca gaaatagaaa tattaatttt cttaatttca cattctgtct
    13921 tccactaata agataaatgg attcagaccc aacacacaca tccagagatt accatgagcc
    13981 aagacctgtg taagtttgat atagggtctt ttattcaaca tttcaagttg ggaaaatctt
    14041 attacaaaga tcatttgcct caccattgct gaattctttt actaggtgtt gatgctaatt
    14101 catcactgga ttttcttaac tctgcctgtt gctcttttgg actttgaggc atgtggttct
    14161 atttcagtga gttacaactc cagctctcat cttttaacag caaactagag aacatctcac
    14221 tcttcatctc tgaggacaca gtgttctctt cattttaaca tcaaaaagtc accagagaga
    14281 agacccaaag gcttttctct ttggaaaagg aatctttaat tgtttcagag ggtgaggaat
    14341 cttcagctct ctctggactt gattgtcctc atcattaaat gggaagactt tacctttagc
    14401 ttgattttcc agaacacatc aagccccgta tggtcagtgt ttccctgtta tcatccactt
    14461 atgtgtatgg gttgaaggta ctttaagttg tgagccagct gctgcccata ttgggtcacc
    14521 aatgcacttg tcaagcccat gtaaccacat gaagtttgat agaaatataa acatttattt
    14581 tgaaataatt ccatgtgcac ggttggaaaa acagtctccc ttccctgaga ggaatgagta
    14641 atttctccct tttcaagaag tgtacagtag aaaatgtaat gagattggaa tggattccaa
    14701 atcagtgacc tttttaaggc tgaaaccact attttaaatg aaaactttaa gttcatacag
    14761 tttcttatag taattctact tttatttttt agtcagtgtg cttaatcttt taggaaaaaa
    14821 aactaaccag ttatttttta ctaaagtatg tgaattacaa acaggatgtg caatgaccag
    14881 gcagaaagat atttaaaggt gtaattattc taaaggaaga tgagaaaaaa ttcatctgct
    14941 acagattcaa ctgtctttta aatgcctccc ttgtcatgga gtaaatgact actcaaaagg
    15001 atttcacaaa agacttaaat ctcaccctta gcaatcaacc ggtcggccac agctcagatg
    15061 cctcattagc aaaatgaaat tgcacaacag acgaaacata gcaaaagaat gtagacattt
    15121 ccatggggtg gaagaaaaga agaaagaaaa agcaaccata gtgaactctg cttgcataaa
    15181 caaagaatgt tttagtggaa taaatgtaag ctttctcttg aaggaatccc agttagaatg
    15241 tcattggaaa cggcaaaact atttcagctt catagcagta atatattcca actttattac
    15301 cactgaggca caaagctaaa tttgtcaggg ggaaaggtaa gcaaaaatta ctgacattgc
    15361 aaccgataaa atgatcttgt gagactcaat attgagaaag aaaattaaaa tagctaatat
    15421 ttctgttata attccagtga ttactaagac ttctgccaag ggataaaatt acttttcctt
    15481 ctctcattat aaatttctat atagagctat tttaatgcag taaggactgt attttcatat
    15541 tttaataaat ccctcacgtt gaatttgccc cccatttcag atttgattag gaaatactaa
    15601 attgagaagg caggtttttc catcttttta aaaacaagta tgcaccataa gcattttcag
    15661 cggatgtctg ccttaagcaa tcttggtaga gctgtcaatc agtggcaggt gcttgtttaa
    15721 ggaagagaac ctgtgaatag atttagcctt tcttcctcac agacagctgc tcattcacac
    15781 acgctcatct cgtcttcctc aacttcttgc accaatcccg cctcttggat tgacccacat
    15841 ccacctagca gttgaacaaa ctgcagattc taattacatg tcccgacagt tgctcaactt
    15901 aatttttcac caactgaatt tcatgcattg ccccttgatg ttccttccct ctgttcactc
    15961 ttttctataa gtccttgcat ttgatatact ttaaaatgga tttgactagg aaaaaaaaaa
    16021 aaaccaagtc agcaaaccct tgtgttcatt caagaaattg tgaacaaatt tagctgttat
    16081 ggtaataatc ctgaggtgag agagaaaata tcacctaggt gacaagagat cattttaacg
    16141 ctattactaa aatagtattc tatgaataga ggccatagaa ttttctacaa atagacttgt
    16201 agggactcac attttgaatc atattttact tataggtttg ctgtatatac tgattaaact
    16261 tctgaaccta aagattctct ataattaaac tagcacaaat ataatctgtc ccttacccac
    16321 attgtaagaa tgtctggtgg gggaaatcca atattgacct tcacattcca catggaaaat
    16381 ctttgtcccc agagtgcaat tagggtgatt aaaaataagc cgcttttgtg agtctcaagt
    16441 ttgttcccca aacaagcagc atcagcaact ggaaatttgt tagacatgca aattatccag
    16501 tcccacctga gacttcagcc cagatctatg aatcaaaaat tttggagtga ccctggcaat
    16561 atggacttta ataagcccct aggatggttc tgatgcatgc tcaaatttga gaatcattga
    16621 tctatgacac agcattctga gtggccaaga atgaacaatg tcacccactg cttaattatg
    16681 ctttccctta agaaaaggtt taaatgctta aaaggtaggt tctttataaa gataatgcat
    16741 tcagatatat gggagatatg tccaccattc agacttaaaa tataatttta agggacatta
    16801 atccttatgt ctttttctgg cataactgag tctgaggcag cctctccagt cagagatttc
    16861 taatcagctt atctagttct tttaaaaccc cacagctgat ctactttgcc tgacttcccc
    16921 ggggcctaga aaatgaccct ggacaccttt ctctaactga ttagctctgg ctgatttgtc
    16981 ttaatgctaa accactgtgt aacagtacta aattatactt aatgacacag tctactgttt
    17041 tgaagagtgc tgtgtatgac tgactgagct aaaaggattg ctggctatga gtgagtttta
    17101 gttttagaat tcattttcaa agactcacaa ggctcaagaa gcttgaaaac cacagatgat
    17161 gtatacagta gctggagttc cctggaggct cctttctagg gtctctcatt tgaattggtg
    17221 cagaactgaa agcagagagt cagaaagtaa ctctgcttgt aaaaatggct taggaaaagg
    17281 aacttaagat tgtgggttat atgtgtgtat gtgtgcacac acatgtatgt ttcctgaatt
    17341 ctaacctgaa aatatcacat ttgtggatac ttaaaatact catatgcatt ttgatacaca
    17401 aaagcaattc aaagtatgta aaaggaggct ggaaatgtaa gcttaacagt gatattctgg
    17461 agaaaaatgt tgtaactgtc actccaggcc tcccttagga gaaaccaaac ttgtcagata
    17521 ttttggaatg gtagctcttt ttcaggaatt agaataactg aagtatgata ctgtgttccg
    17581 tgtgctttaa aatctgtgac cctcccctgt tgctggtcat agcttcagca tttgagtgtc
    17641 cattgtctgt cgctgaggac attttctcat cggctctttt ccccattgtc ccattcctct
    17701 cactcacacc tgattaccaa atagctctaa cgaaatcaca gtcactcctt cctgtgtttc
    17761 caccattgtg tacatcttca tttgcacacc ctatttttta atcaaagtta aagcctcacc
    17821 aacaaggtac ttagaacaat cacccacttc tggccacttc gtgacgggaa atacatcttt
    17881 gcaggggaag gagctggatc agactgacag ggtttcactc agactatttc aaacaatgag
    17941 gagccttgac ctcattccca acttttgccg tccatagtgg ttgatttctt gttttctctt
    18001 tctctctttt tttaacagaa actcttaagc tcaaggctaa attacagtgg ggacttgcct
    18061 ttgtctacag tccatggttt ctgtattggc tcaagccttg aaatcttgaa acaagcctaa
    18121 attaaaattt tctcttagct taagaaaaaa agttacatat tgtcaagacc cttatgtgtg
    18181 tggtccatta aaaaggtctt gatattagaa gataacagca aattgtttct tatcccacaa
    18241 cagctttgcc tttcagtgtc ctttgtggtg gttttcgtag gtcagtggta caattcaaca
    18301 ctcttccaat aagccataat aataattgtt ggcacaactg ttattacaac aggacttgcc
    18361 tgggttccat ctattaattt ttacagacag taggaagctc acaccgagga gacattggta
    18421 acttcctgga caagggcaaa gaaaggaact agcatattgt acatactgtg tacgtgcaca
    18481 gaacactggt ctgtgccttt ggagtgttct cagaggggca ggccagaagg gaggattcag
    18541 gtaggaaatg aatctaggac ttctcttgcc tttgatggtt actgatggca attgtgtttc
    18601 ccactgaata acttggtgga caattttgat agtaaactga actcataccg agcaagcaca
    18661 atagtcaatc cataaagaaa agggtggcat atcataatgc cagaaacctt gtctccctaa
    18721 gaggtgatca tgaatttcct atacagggca aaaaagggaa gaatagccta ttcatattct
    18781 gtattcacag tttgaaggac ccatcacaaa tgaccttcaa agactgacag ggggcaggta
    18841 gaagggaggc aaaaatgcag agaaaaagat gttaccttga aaaatgaagt aagaaatcct
    18901 aatattcccg tagttgatcc taaagtttgt tcccatgtct acggttattt ctaaataact
    18961 tcactacact ttgaaattcc ttagtggtgg tttatcagta atacttaact gaatttttcc
    19021 gtttctattc tttgctgcca atgaatgtaa tctccacgac ttgccgttcg agtgcacgca
    19081 cagacacaca cacataatgg tatatgcatc atatattact cattttgtgg gaaacacaat
    19141 gtattataat gaaaaagatt ccagcacatt ctttcagtgt gtttcagtga taaaattttg
    19201 tgggggaata gaggtataca tactctcttt gctgaccata ttgttgaaat tatgatctta
    19261 agcaacactg ttagaaatgc ttgcataaag tatcttctct agtattaatg agttgattca
    19321 ctctgaattg aaggttcaaa aaaatgcact aaacaaatat ttttatatct gtggtatttt
    19381 cctattaact actcttagtg aacacgtgac catatacctg atatcattaa aaaggaaaat
    19441 ggcctaaacg aaacgttaaa agtggaggta tttataaagt cttctgccaa agaccattgt
    19501 ttaatgatct gtaaaatgta gattatcttc ttttattatg aatgtgattg taagaaacac
    19561 cctaacattc tctaactttt gaaaatgaat attttgtatt tctaaggacc aaggaaaata
    19621 ttttttaagc caatgtagta cacagaagcc ttgtaaatga gaggtacaat gacttggatc
    19681 aactgcataa tgctagatta gaattccagc atttgatgat aaatttatca atctttccta
    19741 taattcttat actgcactaa attacatttt ggaaatttta gctaatcttt tcaaattaaa
    19801 ggcaccaaca ttaatgacag atcttctcta atatgaaaag catcaaaaca ttccctttca
    19861 agcactttga atggatgaaa attgccatat aattttccca cctacctaac cattccatgt
    19921 aagttaactg agcagtctaa caatgttgta cagaaggttg acagactatg tgcaccaaga
    19981 atatttaagt tgtgcagtta gcaagaacta gccatttcaa atatactcaa atgttttgta
    20041 aataaaaatt ttgactccta taattttgtt caaactgatg tcttttaaaa taattagatt
    20101 ttatttgaat tttaaaagta atctgttgta aattagatgt tactttgttg actctgtgat
    20161 tcaatgtaca ctcagccata ttcctgtggg gaaatatcaa tcttactgac tttcatggca
    20221 tgagccagag attcatagtt tcctttagga ctataagtat gaagacaaaa cacaccaaaa
    20281 taaaatgcta gtgaagaaat tagaaaccta ttgtataaaa tgtattttta aaatcttaag
    20341 atatatgtga tttacactgc ctgttaatct agtctctttg tgattaaaaa aaaacataat
    20401 atttgttaag actcagacac caaatatttg tgatgtttgt atagcaccat cgttatatgt
    20461 gatttcaaag ggtaagcatc tctgtcgtaa tcatgtaagc ccacagaaga ataaattcct
    20521 gaggttatgt acaaccaact ctcagaattc agacttcctg cagctgccat atcaccaata
    20581 aatgagaatt gtgaaaaaca atttttaaag aattgagttt atgatcactg tgcattttgt
    20641 taatgaatga tttcagagtt ttatttttac cagaaatgct ctcagccagt aaacacaact
    20701 gctgatttca accatactat catttcaatg gtttctatat tcttgatcta actaccaaaa
    20761 actggaagct tgttgcaagg tgtgtcctaa caaacataca ataaatgact cttcctgcat
    20821 gctgcctgag atatgttgta atttgaaatg tcttatcaaa aaattataca tgttataacc
    20881 caaagttgaa ctggcaatat ttttcatgtg taaaattgat ggtatgttaa tatcaaaagc
    20941 agaagcattg tttgtcatac atgtatgtta tatgtgatgt ttaatcgtgt taaactgtaa
    21001 tctgtgaagt tttcattgcc tgaactagtc aattctgtat aaatcattgt cttaattgtt
    21061 ttcctaatct taccatattt cctaacactg aaatataaat gtttgtcaat tagcca
//
