LOCUS       NM_003983               6255 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 7 member 6 (SLC7A6), transcript
            variant 2, mRNA.
ACCESSION   NM_003983
VERSION     NM_003983.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6255)
  AUTHORS   Chen,X., Wang,Z., Zhao,X., Zhang,L., Zhou,L., Li,X., Ge,C.,
            Zhao,F., Chen,T., Xie,H., Cui,Y., Tian,H., Li,H., Yao,M. and Li,J.
  TITLE     STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation
            and invasion of hepatocellular carcinoma by targeting to mTORC1
  JOURNAL   Oncogene 41 (17), 2492-2504 (2022)
   PUBMED   35314791
  REMARK    GeneRIF: STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the
            proliferation and invasion of hepatocellular carcinoma by targeting
            to mTORC1.
REFERENCE   2  (bases 1 to 6255)
  AUTHORS   Rii,J., Sakamoto,S., Sugiura,M., Kanesaka,M., Fujimoto,A.,
            Yamada,Y., Maimaiti,M., Ando,K., Wakai,K., Xu,M., Imamura,Y.,
            Shindo,N., Hirota,T., Kaneda,A., Kanai,Y., Ikehara,Y., Anzai,N. and
            Ichikawa,T.
  TITLE     Functional analysis of LAT3 in prostate cancer: Its downstream
            target and relationship with androgen receptor
  JOURNAL   Cancer Sci 112 (9), 3871-3883 (2021)
   PUBMED   34050700
  REMARK    GeneRIF: Functional analysis of LAT3 in prostate cancer: Its
            downstream target and relationship with androgen receptor.
REFERENCE   3  (bases 1 to 6255)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6255)
  AUTHORS   Rotoli,B.M., Barilli,A., Visigalli,R., Ferrari,F. and Dall'Asta,V.
  TITLE     y+LAT1 and y+LAT2 contribution to arginine uptake in different
            human cell models: Implications in the pathophysiology of Lysinuric
            Protein Intolerance
  JOURNAL   J Cell Mol Med 24 (1), 921-929 (2020)
   PUBMED   31705628
  REMARK    GeneRIF: y+LAT1 and y+LAT2 contribution to arginine uptake in
            different human cell models: Implications in the pathophysiology of
            Lysinuric Protein Intolerance.
REFERENCE   5  (bases 1 to 6255)
  AUTHORS   Zhang,B.K., Moran,A.M., Bailey,C.G., Rasko,J.E.J., Holst,J. and
            Wang,Q.
  TITLE     EGF-activated PI3K/Akt signalling coordinates leucine uptake by
            regulating LAT3 expression in prostate cancer
  JOURNAL   Cell Commun Signal 17 (1), 83 (2019)
   PUBMED   31345230
  REMARK    GeneRIF: Growth factor-activated PI3K/Akt signalling pathway
            regulates leucine transport through LAT3 in prostate cancer cell
            lines
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6255)
  AUTHORS   Sperandeo,M.P., Paladino,S., Maiuri,L., Maroupulos,G.D.,
            Zurzolo,C., Taglialatela,M., Andria,G. and Sebastio,G.
  TITLE     A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity:
            implications for the molecular pathogenesis of lysinuric protein
            intolerance
  JOURNAL   Eur J Hum Genet 13 (5), 628-634 (2005)
   PUBMED   15756301
REFERENCE   7  (bases 1 to 6255)
  AUTHORS   Broer,A., Friedrich,B., Wagner,C.A., Fillon,S., Ganapathy,V.,
            Lang,F. and Broer,S.
  TITLE     Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2
            requires different domains
  JOURNAL   Biochem J 355 (Pt 3), 725-731 (2001)
   PUBMED   11311135
REFERENCE   8  (bases 1 to 6255)
  AUTHORS   Broer,A., Wagner,C.A., Lang,F. and Broer,S.
  TITLE     The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates
            arginine efflux in exchange with glutamine
  JOURNAL   Biochem J 349 Pt 3 (Pt 3), 787-795 (2000)
   PUBMED   10903140
REFERENCE   9  (bases 1 to 6255)
  AUTHORS   Pfeiffer,R., Rossier,G., Spindler,B., Meier,C., Kuhn,L. and
            Verrey,F.
  TITLE     Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and
            members of the glycoprotein-associated amino acid transporter
            family
  JOURNAL   EMBO J 18 (1), 49-57 (1999)
   PUBMED   9878049
REFERENCE   10 (bases 1 to 6255)
  AUTHORS   Torrents,D., Estevez,R., Pineda,M., Fernandez,E., Lloberas,J.,
            Shi,Y.B., Zorzano,A. and Palacin,M.
  TITLE     Identification and characterization of a membrane protein (y+L
            amino acid transporter-1) that associates with 4F2hc to encode the
            amino acid transport activity y+L. A candidate gene for lysinuric
            protein intolerance
  JOURNAL   J Biol Chem 273 (49), 32437-32445 (1998)
   PUBMED   9829974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB107640.1, BC028216.1, AC020978.10 and D87432.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003983.5.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749291.1, BC028216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219343.11/ ENSP00000219343.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DB107640.1         11-44
            35-3449             BC028216.1         1-3415
            3450-4493           AC020978.10        40999-42042         c
            4494-6255           D87432.1           4535-6296
FEATURES             Location/Qualifiers
     source          1..6255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..6255
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="solute carrier family 7 member 6"
                     /db_xref="GeneID:9057"
                     /db_xref="HGNC:HGNC:11064"
                     /db_xref="MIM:605641"
     exon            1..51
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            52..180
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            181..739
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1764
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 6; amino acid permease;
                     y+LAT2; y(+)L-type amino acid transporter 2; solute
                     carrier family 7 (amino acid transporter light chain, y+L
                     system), member 6"
                     /codon_start=1
                     /product="Y+L amino acid transporter 2"
                     /protein_id="NP_003974.3"
                     /db_xref="CCDS:CCDS32470.1"
                     /db_xref="GeneID:9057"
                     /db_xref="HGNC:HGNC:11064"
                     /db_xref="MIM:605641"
                     /translation="MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKE
                     ISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELG
                     TTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCD
                     PPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGH
                     SEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMP
                     IVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNA
                     SIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINY
                     FSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTIN
                     SLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEK
                     KDERKTD"
     exon            740..865
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1010
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1134
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1238
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1335
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1485
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1669
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..6255
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6235..6240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="hexamer: AATAAA"
     polyA_site      6255
                     /gene="SLC7A6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggcgg cggcgcgacc gagcatcctg gcggcgccgg gccactggga gagtttatgt
       61 ggccgaggca gacaagtgga attaggcctt gctgcagggg acttcatttc cttctcagta
      121 ctggacccat ttatgaggag gtggcttatg aaagtgtgat gttcgcgtat ttcttgacag
      181 gccacagcaa acacaggtgt gcaggaaccg tttgtcatgg aagccaggga gcctgggagg
      241 cccacaccca cctaccatct tgtccctaac accagccagt cccaggtgga agaagatgtc
      301 agctcgccac ctcaaaggtc ctccgaaact atgcagctga agaaggagat ctccctgctg
      361 aatggggtca gcctggtggt gggcaacatg atcggctcag ggatctttgt ctcacccaag
      421 ggtgtgctgg tacacactgc ctcctatggg atgtcactga ttgtgtgggc cattggtggg
      481 ctcttctctg ttgtgggtgc cctttgttat gcagagctgg ggaccaccat caccaagtcg
      541 ggagccagct acgcttatat tctagaggcc tttgggggct tcattgcctt catccgcctg
      601 tgggtctcac tgctagttgt tgagcccacc ggtcaggcca tcatcgccat cacctttgcc
      661 aactacatca tccagccgtc cttccccagc tgtgatcccc catacctggc ctgccgtctc
      721 ctggctgctg cttgcatatg tctgctgaca tttgtgaact gtgcctatgt caagtggggc
      781 acacgtgtgc aggacacgtt cacttacgcc aaggtcgtag cgctcattgc catcattgtc
      841 atgggccttg ttaaactgtg ccagggacac tctgagcact ttcaggacgc ctttgagggt
      901 tcctcctggg acatgggaaa cctctctctt gccctctact ctgccctctt ctcttactca
      961 ggttgggaca cccttaattt tgtaacagaa gaaatcaaaa acccagaaag aaatttgccc
     1021 ttggccattg ggatttctat gccaattgtg acgctcatct acatcctgac caatgtggcc
     1081 tattacacag tgctgaacat ttcagatgtc cttagcagtg atgctgtggc tgtgacattt
     1141 gctgaccaga cgtttggcat gttcagctgg accatcccca ttgctgttgc cctgtcctgc
     1201 tttgggggcc tcaatgcatc catctttgct tcatcaaggt tgttcttcgt gggctcccgg
     1261 gagggccacc taccggacct tctgtccatg atccacattg agcgttttac acctatccct
     1321 gctttactgt tcaattgcac catggcactc atctacctca tcgtggagga tgttttccag
     1381 cttatcaact acttcagctt cagctactgg ttcttcgtgg gcctgtctgt tgttggacag
     1441 ctctacctcc gctggaagga gcccaagcgg ccccggcctc tcaagctgag cgtgtttttc
     1501 cccatcgtgt tctgcatatg ctccgtgttt ctggtgatag tgcccctctt cactgacacc
     1561 attaattccc tcattggcat cgggattgcc ctttctggag tccctttcta cttcatgggt
     1621 gtttacctgc cagagtcccg gaggccattg tttattcgga atgtcctggc tgctatcacc
     1681 agaggcaccc agcagctttg cttttgtgtc ctgactgagc ttgatgtagc cgaagaaaaa
     1741 aaggatgaga ggaaaactga ctagaggtca gaggtggctt tctgaggcct ggaaggcagg
     1801 ccaaccagca aaatcctgat aacaagactc tgtgggccca actctcctga attaaaggag
     1861 ccttttgacc caatcatata gtggggctca gggccagtgc tcactcttat tggtaagcta
     1921 taggagactc aggatctggg ccaacctcaa ggtgggggct tcagagggtg gggggaagat
     1981 tggggaacgg ggggaatggt catttagttt tactcctgat aggtagatgc agctcttaca
     2041 gatatttact tggtaaagtg cagtggggaa gagggaatgc taggttgata gggctggtgg
     2101 cttctgaatt tggtatttga actaggagtc cctatagagg ggctgcttta tgggaagttt
     2161 ttctctgacc aggtacaaca cctgacttta aaggcctgaa atgctaccat ttcttcctct
     2221 ggctcaaaat tcttccctgg ggagagagtt atattccctt atttattgat atttagtcca
     2281 gaacaccagt tctaacgaag catgcgtgtc tcttcatcta caggatgcaa taggctgatt
     2341 gtatttaaaa atcaaagtac ccaaaactga gtccctttgg gctcagaaat gtctgtggta
     2401 ttgggtcaga ctctgaccac aggttttatg ctgtttagca caatttctat tgagtcttac
     2461 ctgcaacaat gaaccttaaa gattttttta ctcacgtacc tgttacactt tagcatacag
     2521 atagatcata gatcacgtta caagcacttg gctcaggtcc agcaaggaca gatgaacaaa
     2581 ttcctgagtc agaagtctgt taatattgct gttttgaagg acaatccttt attttacttg
     2641 agaccttaca tctttgttct agctgacagt aaatctctgg gtttctgtta cgaactctaa
     2701 gagggctgaa acttctgata ttcaggtgga tcacctgaat tctctcagct gtcaatggct
     2761 tggagaacat ctcatgggcc caagtcatca aataacctgt tcctctctgt aagggcagtg
     2821 tgagggactg ctgtgcagac ccaagcaatc ccaacctggt gctaggtcat ttcacttttc
     2881 tgaaaacctc acatcaggct gcatcctctt ctgtccctgg caccaggctt tgtttacact
     2941 tggagccacc ttggtgtggg tcaccgggac agtgtactcc tctcctgcca gcctcccctt
     3001 ccccgaggtg tggtggctgc agtctcagga agagcttggt acttgtgggg acttctgttt
     3061 tctccctgtg gagatcagtg aagactggga ggaaagctgc ttcaacctga gtccggctct
     3121 tcagcaggct gcacaagtgg aagcaactaa ttctggtgct caggctgggc tctccaccca
     3181 agttaggcct gctctggcct aatggatctt actgtatgag caggacggct gcattggatt
     3241 gtacaactgt tttgtgatgc ccccagacac tgtcatcctg ggccgagaag aacctgctag
     3301 cttgacatac cccatgggct tatccttagg ttttggaatt ggtcaacagt gaggcagtct
     3361 cccttcctga ccattcttct ccacccagtc acagataagg gaataacctt ggccatatat
     3421 ttgctcaata aagattgaag gaagcatggt catagttgcc ctgggttcag agcataatgc
     3481 atatgtgaag catggggtga cattcctact gtcatgggtt tgggatttgt aacggcaaat
     3541 tcctgcccga cgacagggtg tcttatgcaa aggctgactt gcctgaacgc taagaacatg
     3601 acttctgtct gagctaagct ggcacccatc ccagggctcc tctggagcta atcctttaag
     3661 caaaatgtgc ttgcctttta aagatccctg accccagctt tagctttctc caccagataa
     3721 ccagctaatc ccaggaattt gctgcccccc accagtggct tctagggaaa gcaaggacct
     3781 cacatgccag gtgccctagt acttgcttag tgagccatgt catcctcctt tcatttttgg
     3841 atggtgacag catttttccc ctctgtgctg gatacagact tctcccagga tcctctcttt
     3901 gggagcgaag ccagaggatc cctacagcac tcaagcttca tggtggaatt aatttctgcc
     3961 agctctttgt tgtctgtctc cttaaatcct tttcctggtg tgcttattat cccttttgca
     4021 gtgagtacag tttattaagt tgtcagccct ttaatattgg ggaaacttaa tgagtataaa
     4081 tagcagggag cacattgtaa cagcacagtg ttttgttttt ttcacccggt tgctgtatga
     4141 gaatggcttt caatcctttg tttctatgcc tacagacaga aagcaagatg tctaatatta
     4201 gacatacaag ttgctgcctg ttataacggt gaattatacc tttgtgcatg cctaggatgt
     4261 ttgttgtttt aattagctgc aatatatacg gcctgtgtac acagaattta atcacttcgg
     4321 caggttgaac aactccatgt agataagagc aagtgtaggc aaaggtttag aaaatggaca
     4381 taaagtcaaa gaatgatggc aggtaggatg aaggagagat acttaggaaa tcctaaaaga
     4441 ggcggcaaga aggtacctcc ctgtgtaact caccttcccc catgacagtg agtaagagac
     4501 actcacaggc tatgagggta cacccctagc tgaatgttct gtgttgtttc cttagacctg
     4561 tggtgtccgc tgcaacagct actagccacg tgtagctaat tacattaaaa tgaaataaaa
     4621 ttaaaagctc agtttctcag ttgcgctaat cacatttcaa gtgctcagca gccacccgtg
     4681 tctactacta cacagtgcag acacagaaca tatcatcact gcagatagtt ctactggaca
     4741 atgttacgct agaataaaca ccaaggcagt cagttaaggc agctatggtt tggaaaggca
     4801 tacggacaga gtctgcttag aagagataca agttgttaat aaaattgatc ctgttgatag
     4861 tagtttgttt ttgtggtggg tgctgtgaag agtaaacatt actcagtgga aagctaagtt
     4921 cagaaggtac tttgtttttc ctcccttgcc ttaagtcctt ggtatttata atcaatgctg
     4981 aaccttctat ttcactaccg ctccctgttt tagatattca gatttaaaag gttttcaaag
     5041 aattactttc ttccatgttc aaagctagat tttactaaac acatgtatca cattcatata
     5101 tattgtttct tggccccact gccaaaggaa gtcagtcagt aatttcacaa ccgttatcag
     5161 agtttggaag cagaaatagc tgttaactaa aatctcccac tgctcagact actttctgcc
     5221 ctaatggcca ttactatcca gtctgtattg ctacaaggga cccactggta ccccttttag
     5281 attctatcaa aaggaacagg gttttcctag aggcaggcag cctggtggta tggcacagca
     5341 gaagcttact gctaatgaaa tgggaacctc cccctccctt gtggtttcag cacagaacct
     5401 gaatgccagg aaaaattcct gggccaagaa gctaaagcta aagaaacctt ccttttttca
     5461 acgttttttt ttctttcaaa ctgtagggtc acttttgatt gaggcaaagg ggtcctactg
     5521 taagtggaaa agactcactc ccctaacata agttttcact gtggtgggat ggtgccgccc
     5581 gatatgcttg atatgctttt ccttccacat gttaagctag gaaacctaac aggatgtcag
     5641 cagggcagtt aactctggac tcagagccct caagggcatg tggcagaacc tcatggacat
     5701 cacaagacca tcagtctgaa tccaggtcgt gggggctgtc atagccgaac tccttctgca
     5761 catccagagg gtacttgctc cacatccgct gtctgctgct gcctctttcc tcctcactca
     5821 ggctgttgta gtcagcagag cctagaatga catcccggga gtggattcta aatgtgattt
     5881 tcctaggcta ctgcaggagc cccttctctt ctcagaaagg tctgtttttg ttcccgattg
     5941 taatgcaaaa tccttgctca ataaataaaa aagaatatag aattcttttt tttttaaaga
     6001 aggaatcact ttcctatcat ctaaaccaag ttccttcaca ctggagtatt ttgtcacttc
     6061 tcccctccgt ggagtatttt gtcacttctc ccctccgtat aggatttttt gttgttgtaa
     6121 gagttgtagt catattgtaa atatttttgt acctttctcc ttttaacgtg ttattgacaa
     6181 acctccccaa aagaatatgc aattgtttga ttcatttctc tgttatcaga caccaataaa
     6241 ttctttttgt tgggc
//
