LOCUS       NM_003486               4556 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens solute carrier family 7 member 5 (SLC7A5), mRNA.
ACCESSION   NM_003486 NM_015923
VERSION     NM_003486.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4556)
  AUTHORS   Yanagida,S., Yuki,R., Saito,Y. and Nakayama,Y.
  TITLE     LAT1 supports mitotic progression through Golgi unlinking in an
            amino acid transport activity-independent manner
  JOURNAL   J Biol Chem 300 (10), 107761 (2024)
   PUBMED   39270820
  REMARK    GeneRIF: LAT1 supports mitotic progression through Golgi unlinking
            in an amino acid transport activity-independent manner.
REFERENCE   2  (bases 1 to 4556)
  AUTHORS   Yang,B., Wang,Z., Niu,K., Li,T., Tong,T., Li,S., Su,L., Wang,Y.,
            Shen,C., Jin,X., Song,J. and Lu,X.
  TITLE     TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated
            amino acid transport and mTORC1 activation in fibroblasts
  JOURNAL   Cell Commun Signal 22 (1), 444 (2024)
   PUBMED   39304904
  REMARK    GeneRIF: TRIM35 triggers cardiac remodeling by regulating
            SLC7A5-mediated amino acid transport and mTORC1 activation in
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4556)
  AUTHORS   Ohgaki,R., Hirase,Y., Xu,M., Okanishi,H. and Kanai,Y.
  TITLE     LAT1 expression in colorectal cancer cells is unresponsive to
            HIF-1/2alpha accumulation under experimental hypoxia
  JOURNAL   Sci Rep 14 (1), 19635 (2024)
   PUBMED   39179631
  REMARK    GeneRIF: LAT1 expression in colorectal cancer cells is unresponsive
            to HIF-1/2alpha accumulation under experimental hypoxia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4556)
  AUTHORS   Chen,Z., Cai,H., Ye,W., Wu,J., Liu,J., Xie,Y., Feng,S., Jin,Y.,
            Lv,Y., Ye,H., Cai,C. and Cai,G.
  TITLE     TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in
            head and neck squamous cell carcinoma
  JOURNAL   Front Immunol 15, 1445472 (2024)
   PUBMED   39234254
  REMARK    GeneRIF: TP63 transcriptionally regulates SLC7A5 to suppress
            ferroptosis in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4556)
  AUTHORS   Hou,W., Chen,J. and Wang,Y.
  TITLE     MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in
            NSCLC Cells by Upregulating SLC7A5 Expression
  JOURNAL   Clin Respir J 18 (7), e13799 (2024)
   PUBMED   38987867
  REMARK    GeneRIF: MRPL35 Induces Proliferation, Invasion, and Glutamine
            Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression.
REFERENCE   6  (bases 1 to 4556)
  AUTHORS   Pfeiffer,R., Rossier,G., Spindler,B., Meier,C., Kuhn,L. and
            Verrey,F.
  TITLE     Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and
            members of the glycoprotein-associated amino acid transporter
            family
  JOURNAL   EMBO J 18 (1), 49-57 (1999)
   PUBMED   9878049
REFERENCE   7  (bases 1 to 4556)
  AUTHORS   Torrents,D., Estevez,R., Pineda,M., Fernandez,E., Lloberas,J.,
            Shi,Y.B., Zorzano,A. and Palacin,M.
  TITLE     Identification and characterization of a membrane protein (y+L
            amino acid transporter-1) that associates with 4F2hc to encode the
            amino acid transport activity y+L. A candidate gene for lysinuric
            protein intolerance
  JOURNAL   J Biol Chem 273 (49), 32437-32445 (1998)
   PUBMED   9829974
REFERENCE   8  (bases 1 to 4556)
  AUTHORS   Mastroberardino,L., Spindler,B., Pfeiffer,R., Skelly,P.J.,
            Loffing,J., Shoemaker,C.B. and Verrey,F.
  TITLE     Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a
            permease family
  JOURNAL   Nature 395 (6699), 288-291 (1998)
   PUBMED   9751058
REFERENCE   9  (bases 1 to 4556)
  AUTHORS   Maglott,D.R., Durkin,A.S., Lane,S.A., Callen,D.F., Feldblyum,T.V.
            and Nierman,W.C.
  TITLE     The gene for membrane protein E16 (D16S469E) maps to human
            chromosome 16q24.3 and is expressed in human brain, thymus, and
            retina
  JOURNAL   Genomics 23 (1), 303-304 (1994)
   PUBMED   7829099
REFERENCE   10 (bases 1 to 4556)
  AUTHORS   Gaugitsch,H.W., Prieschl,E.E., Kalthoff,F., Huber,N.E. and
            Baumruker,T.
  TITLE     A novel transiently expressed, integral membrane protein linked to
            cell activation. Molecular cloning via the rapid degradation signal
            AUUUA
  JOURNAL   J Biol Chem 267 (16), 11267-11273 (1992)
   PUBMED   1597461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126696.1 and AF104032.1.
            
            On Nov 25, 2018 this sequence version replaced NM_003486.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF104032.1, BC042600.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261622.5/ ENSP00000261622.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC126696.1         104304-104322       c
            20-2046             AF104032.1         1-2027
            2047-3163           AC126696.1         66231-67347         c
            3164-4556           AF104032.1         3148-4540
FEATURES             Location/Qualifiers
     source          1..4556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..4556
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /note="solute carrier family 7 member 5"
                     /db_xref="GeneID:8140"
                     /db_xref="HGNC:HGNC:11063"
                     /db_xref="MIM:600182"
     exon            1..623
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1609
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 5; 4F2 light chain; CD98
                     light chain; L-type amino acid transporter 1; integral
                     membrane protein E16; sodium-independent neutral amino
                     acid transporter LAT1; solute carrier family 7 (amino acid
                     transporter light chain, L system), member 5"
                     /codon_start=1
                     /product="large neutral amino acids transporter small
                     subunit 1"
                     /protein_id="NP_003477.4"
                     /db_xref="CCDS:CCDS10964.1"
                     /db_xref="GeneID:8140"
                     /db_xref="HGNC:HGNC:11063"
                     /db_xref="MIM:600182"
                     /translation="MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGV
                     TLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALC
                     YAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPL
                     FPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQ
                     IGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPL
                     AIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLS
                     CFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKD
                     IFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVS
                     FWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET"
     exon            624..749
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            750..855
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            856..900
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1024
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1128
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1225
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1375
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1553
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..4556
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4536..4541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /note="hexamer: AAGAAA"
     polyA_site      4556
                     /gene="SLC7A5"
                     /gene_synonym="4F2LC; CD98; D16S469E; E16; LAT1; MPE16"
                     /note="major polyA site"
ORIGIN      
        1 acgcagctgc gggcggcggg cggcgcgcac actgctcgct gggccgcggc tcccgggtgt
       61 cccaggcccg gccggtgcgc agagcatggc gggtgcgggc ccgaagcggc gcgcgctagc
      121 ggcgccggcg gccgaggaga aggaagaggc gcgggagaag atgctggccg ccaagagcgc
      181 ggacggctcg gcgccggcag gcgagggcga gggcgtgacc ctgcagcgga acatcacgct
      241 gctcaacggc gtggccatca tcgtggggac cattatcggc tcgggcatct tcgtgacgcc
      301 cacgggcgtg ctcaaggagg caggctcgcc ggggctggcg ctggtggtgt gggccgcgtg
      361 cggcgtcttc tccatcgtgg gcgcgctctg ctacgcggag ctcggcacca ccatctccaa
      421 atcgggcggc gactacgcct acatgctgga ggtctacggc tcgctgcccg ccttcctcaa
      481 gctctggatc gagctgctca tcatccggcc ttcatcgcag tacatcgtgg ccctggtctt
      541 cgccacctac ctgctcaagc cgctcttccc cacctgcccg gtgcccgagg aggcagccaa
      601 gctcgtggcc tgcctctgcg tgctgctgct cacggccgtg aactgctaca gcgtgaaggc
      661 cgccacccgg gtccaggatg cctttgccgc cgccaagctc ctggccctgg ccctgatcat
      721 cctgctgggc ttcgtccaga tcgggaaggg tgatgtgtcc aatctagatc ccaacttctc
      781 atttgaaggc accaaactgg atgtggggaa cattgtgctg gcattataca gcggcctctt
      841 tgcctatgga ggatggaatt acttgaattt cgtcacagag gaaatgatca acccctacag
      901 aaacctgccc ctggccatca tcatctccct gcccatcgtg acgctggtgt acgtgctgac
      961 caacctggcc tacttcacca ccctgtccac cgagcagatg ctgtcgtccg aggccgtggc
     1021 cgtggacttc gggaactatc acctgggcgt catgtcctgg atcatccccg tcttcgtggg
     1081 cctgtcctgc ttcggctccg tcaatgggtc cctgttcaca tcctccaggc tcttcttcgt
     1141 ggggtcccgg gaaggccacc tgccctccat cctctccatg atccacccac agctcctcac
     1201 ccccgtgccg tccctcgtgt tcacgtgtgt gatgacgctg ctctacgcct tctccaagga
     1261 catcttctcc gtcatcaact tcttcagctt cttcaactgg ctctgcgtgg ccctggccat
     1321 catcggcatg atctggctgc gccacagaaa gcctgagctt gagcggccca tcaaggtgaa
     1381 cctggccctg cctgtgttct tcatcctggc ctgcctcttc ctgatcgccg tctccttctg
     1441 gaagacaccc gtggagtgtg gcatcggctt caccatcatc ctcagcgggc tgcccgtcta
     1501 cttcttcggg gtctggtgga aaaacaagcc caagtggctc ctccagggca tcttctccac
     1561 gaccgtcctg tgtcagaagc tcatgcaggt ggtcccccag gagacatagc caggaggccg
     1621 agtggctgcc ggaggagcat gcgcagaggc cagttaaagt agatcacctc ctcgaaccca
     1681 ctccggttcc ccgcaaccca cagctcagct gcccatccca gtccctcgcc gtccctccca
     1741 ggtcgggcag tggaggctgc tgtgaaaact ctggtacgaa tctcatccct caactgaggg
     1801 ccagggaccc aggtgtgcct gtgctcctgc ccaggagcag cttttggtct ccttgggccc
     1861 tttttccctt ccctcctttg tttacttata tatatatttt ttttaaactt aaattttggg
     1921 tcaacttgac accactaaga tgatttttta aggagctggg ggaaggcagg agccttcctt
     1981 tctcctgccc caagggccca gaccctgggc aaacagagct actgagactt ggaacctcat
     2041 tgctaccaca gacttgcact gaagccggac agctgcccag acacatgggc ttgtgacatt
     2101 cgtgaaaacc aaccctgtgg gcttatgtct ctgccttagg gtttgcagag tggaaactca
     2161 gccgtagggt ggcactggga gggggtgggg gatctgggca aggtgggtga ttcctcccag
     2221 gaggtgcttg aggccccgat ggactcctga ccataatcct agccccgaga caccatcctg
     2281 agccagggaa cagccccagg gttggggggt gccggcatct cccctagctc accaggcctg
     2341 gcctctgggc agtgtggcct cttggctatt tctgtgtcca gttttggagg ctgagttctg
     2401 gttcatgcag acaaagccct gtccttcagt cttctagaaa cagagacaag aaaggcagac
     2461 acaccgcggc caggcaccca tgtgggcgcc caccctgggc tccacacagc agtgtcccct
     2521 gccccagagg tcgcagctac cctcagcctc caatgcattg gcctctgtac cgcccggcag
     2581 ccccttctgg ccggtgctgg gttcccactc ccggcctagg cacctccccg ctctccctgt
     2641 cacgctcatg tcctgtcctg gtcctgatgc ccgttgtcta ggagacagag ccaagcactg
     2701 ctcacgtctc tgccgcctgc gtttggaggc ccctgggctc tcacccagtc cccacccgcc
     2761 tgcagagagg gaactagggc accccttgtt tctgttgttc ccgtgaattt ttttcgctat
     2821 gggaggcagc cgaggcctgg ccaatgcggc ccactttcct gagctgtcgc tgcctccatg
     2881 gcagcagcca gggaccccca gaacaagaag accccgcagg atccctcctg agctcggggg
     2941 gctctgcctt ctcaggcccc gggcttccct tctccccagc cagaggtgga gccaagtggt
     3001 ccagcgtcac tccagtgctc agctgtggct ggaggagctg gcctgtggca cagccctgag
     3061 tgtcccaagc cgggagccaa cgaagccgga cacggcttca ctgaccagcg gctgctcaag
     3121 ccgcaagctc tcagcaagtg cccagtggag cctgccgccc ccgcctgggc accgggaccc
     3181 cctcaccatc cagtgggccc ggagaaacct gatgaacagt ttggggactc aggaccagat
     3241 gtccgtctct cttgcttgag gaatgaagac ctttattcac ccctgccccg ttgcttcccg
     3301 ctgcacatgg acagacttca cagcgtctgc tcataggacc tgcatccttc ctggggacga
     3361 attccactcg tccaagggac agcccacggt ctggaggccg aggaccacca gcaggcaggt
     3421 ggactgactg tgttgggcaa gacctcttcc ctctgggcct gttctcttgg ctgcaaataa
     3481 ggacagcagc tggtgcccca cctgcctggt gcattgctgt gtgaatccag gaggcagtgg
     3541 acatcgtagg cagccacggc cccgggtcca ggagaagtgc tccctggagg cacgcaccac
     3601 tgcttcccac tggggccggc ggggcccacg cacgacgtca gcctcttacc ttcccgcctc
     3661 ggctaggggt cctcgggatg ccgttctgtt ccaacctcct gctctgggac gtggacatgc
     3721 ctcaaggata cagggagccg gcggcctctc gacggcacgc acttgcctgt tggctgctgc
     3781 ggctgtgggc gagcatgggg gctgccagcg tctgttgtgg aaagtagctg ctagtgaaat
     3841 ggctggggcc gctggggtcc gtcttcacac tgcgcaggtc tcttctgggc gtctgagctg
     3901 gggtgggagc tcctccgcag aaggttggtg gggggtccag tctgtgatcc ttggtgctgt
     3961 gtgccccact ccagcctggg gaccccactt cagaaggtag gggccgtgtc ccgcggtgct
     4021 gactgaggcc tgcttccccc tccccctcct gctgtgctgg aattccacag ggaccagggc
     4081 caccgcaggg gactgtctca gaagacttga tttttccgtc cctttttctc cacactccac
     4141 tgacaaacgt ccccagcggt ttccacttgt gggcttcagg tgttttcaag cacaacccac
     4201 cacaacaagc aagtgcattt tcagtcgttg tgcttttttg ttttgtgcta acgtcttact
     4261 aatttaaaga tgctgtcggc accatgttta tttatttcca gtggtcatgc tcagccttgc
     4321 tgctctgcgt ggcgcaggtg ccatgcctgc tccctgtctg tgtcccagcc acgcagggcc
     4381 atccactgtg acgtcggccg accaggctgg acaccctctg ccgagtaatg acgtgtgtgg
     4441 ctgggacctt ctttattctg tgttaatggc taacctgtta cactgggctg ggttgggtag
     4501 ggtgttctgg cttttttgtg gggtttttat ttttaaagaa acactcaatc atccta
//
