LOCUS       NM_001370338            7615 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens solute carrier family 7 member 2 (SLC7A2), transcript
            variant 5, mRNA.
ACCESSION   NM_001370338 XM_005273610
VERSION     NM_001370338.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7615)
  AUTHORS   Gaudet,I.D., Xu,H., Gordon,E., Cannestro,G.A., Lu,M.L. and Wei,J.
  TITLE     Elevated SLC7A2 expression is associated with an abnormal
            neuroinflammatory response and nitrosative stress in Huntington's
            disease
  JOURNAL   J Neuroinflammation 21 (1), 59 (2024)
   PUBMED   38419038
  REMARK    GeneRIF: Elevated SLC7A2 expression is associated with an abnormal
            neuroinflammatory response and nitrosative stress in Huntington's
            disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7615)
  AUTHORS   Sun,Y., Li,Y., Jiang,C., Liu,C. and Song,Y.
  TITLE     SLC7A2-Mediated Lysine Catabolism Inhibits Immunosuppression in
            Triple Negative Breast Cancer
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (5), 31-43 (2024)
   PUBMED   38842202
  REMARK    GeneRIF: SLC7A2-Mediated Lysine Catabolism Inhibits
            Immunosuppression in Triple Negative Breast Cancer.
REFERENCE   3  (bases 1 to 7615)
  AUTHORS   Huang,T., Zhou,J., Wang,B., Wang,X., Xiao,W., Yang,M., Liu,Y.,
            Wang,Q., Xiang,Y. and Lan,X.
  TITLE     Integrated Amino Acids and Transcriptome Analysis Reveals Arginine
            Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation
  JOURNAL   Int J Mol Sci 25 (1), 95 (2023)
   PUBMED   38203268
  REMARK    GeneRIF: Integrated Amino Acids and Transcriptome Analysis Reveals
            Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic
            Differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7615)
  AUTHORS   Jiang,S., Zou,J., Dong,J., Shi,H., Chen,J., Li,Y., Duan,X. and
            Li,W.
  TITLE     Lower SLC7A2 expression is associated with enhanced multidrug
            resistance, less immune infiltrates and worse prognosis of NSCLC
  JOURNAL   Cell Commun Signal 21 (1), 9 (2023)
   PUBMED   36639771
  REMARK    GeneRIF: Lower SLC7A2 expression is associated with enhanced
            multidrug resistance, less immune infiltrates and worse prognosis
            of NSCLC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7615)
  AUTHORS   Xia,S., Wu,J., Zhou,W., Zhang,M., Zhao,K., Liu,J., Tian,D. and
            Liao,J.
  TITLE     SLC7A2 deficiency promotes hepatocellular carcinoma progression by
            enhancing recruitment of myeloid-derived suppressors cells
  JOURNAL   Cell Death Dis 12 (6), 570 (2021)
   PUBMED   34108444
  REMARK    GeneRIF: SLC7A2 deficiency promotes hepatocellular carcinoma
            progression by enhancing recruitment of myeloid-derived suppressors
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7615)
  AUTHORS   Hammermann,R., Brunn,G. and Racke,K.
  TITLE     Analysis of the genomic organization of the human cationic amino
            acid transporters CAT-1, CAT-2 and CAT-4
  JOURNAL   Amino Acids 21 (2), 211-219 (2001)
   PUBMED   11665818
  REMARK    GeneRIF: analysis of the genomic organization
REFERENCE   7  (bases 1 to 7615)
  AUTHORS   Suzuki,Y., Ishihara,D., Sasaki,M., Nakagawa,H., Hata,H.,
            Tsunoda,T., Watanabe,M., Komatsu,T., Ota,T., Isogai,T., Suyama,A.
            and Sugano,S.
  TITLE     Statistical analysis of the 5' untranslated region of human mRNA
            using 'Oligo-Capped' cDNA libraries
  JOURNAL   Genomics 64 (3), 286-297 (2000)
   PUBMED   10756096
REFERENCE   8  (bases 1 to 7615)
  AUTHORS   Closs,E.I., Graf,P., Habermeier,A., Cunningham,J.M. and
            Forstermann,U.
  TITLE     Human cationic amino acid transporters hCAT-1, hCAT-2A, and
            hCAT-2B: three related carriers with distinct transport properties
  JOURNAL   Biochemistry 36 (21), 6462-6468 (1997)
   PUBMED   9174363
REFERENCE   9  (bases 1 to 7615)
  AUTHORS   Hoshide,R., Ikeda,Y., Karashima,S., Matsuura,T., Komaki,S.,
            Kishino,T., Niikawa,N., Endo,F. and Matsuda,I.
  TITLE     Molecular cloning, tissue distribution, and chromosomal
            localization of human cationic amino acid transporter 2 (HCAT2)
  JOURNAL   Genomics 38 (2), 174-178 (1996)
   PUBMED   8954799
REFERENCE   10 (bases 1 to 7615)
  AUTHORS   Chinen,K., Isomura,M., Izawa,K., Fujiwara,Y., Ohata,H., Iwamasa,T.
            and Nakamura,Y.
  TITLE     Isolation of 45 exon-like fragments from 8p22-->p21.3, a region
            that is commonly deleted in hepatocellular, colorectal, and
            non-small cell lung carcinomas
  JOURNAL   Cytogenet Cell Genet 75 (2-3), 190-196 (1996)
   PUBMED   9040790
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP006248.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 7, 2019 this sequence version replaced XM_005273610.4.
            
            Summary: The protein encoded by this gene is a cationic amino acid
            transporter and a member of the APC (amino
            acid-polyamine-organocation) family of transporters. The encoded
            membrane protein is responsible for the cellular uptake of
            arginine, lysine and ornithine. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.141769.1,
                                           DRR138518.382821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000494857.6/ ENSP00000419140.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AP006248.1         63417-63566
            151-196             AP006248.1         68586-68631
            197-594             AP006248.1         109647-110044
            595-750             AP006248.1         110780-110935
            751-916             AP006248.1         115007-115172
            917-1050            AP006248.1         116630-116763
            1051-1273           AP006248.1         118093-118315
            1274-1413           AP006248.1         120889-121028
            1414-1516           AP006248.1         124624-124726
            1517-1722           AP006248.1         126657-126862
            1723-1889           AP006248.1         128273-128439
            1890-1998           AP006248.1         129932-130040
            1999-7615           AP006248.1         131279-136895
FEATURES             Location/Qualifiers
     source          1..7615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..7615
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /note="solute carrier family 7 member 2"
                     /db_xref="GeneID:6542"
                     /db_xref="HGNC:HGNC:11060"
                     /db_xref="MIM:601872"
     exon            1..150
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            151..196
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            197..594
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2195
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /note="isoform 2 is encoded by transcript variant 5; low
                     affinity cationic amino acid transporter 2; solute carrier
                     family 7 (cationic amino acid transporter, y+ system),
                     member 2"
                     /codon_start=1
                     /product="cationic amino acid transporter 2 isoform 2"
                     /protein_id="NP_001357267.1"
                     /db_xref="CCDS:CCDS34852.1"
                     /db_xref="GeneID:6542"
                     /db_xref="HGNC:HGNC:11060"
                     /db_xref="MIM:601872"
                     /translation="MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGV
                     GSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLY
                     TYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG
                     LAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANW
                     KISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIAT
                     TGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGW
                     GPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATL
                     SSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKD
                     GLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGL
                     SVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPA
                     FSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDN
                     VHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF"
     exon            595..750
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            751..916
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1050
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1273
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1413
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1516
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1722
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1889
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1998
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..7615
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7536..7541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /note="hexamer: AATAAA"
     polyA_site      7565
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /note="major polyA site"
     regulatory      7594..7599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
                     /note="hexamer: AATAAA"
     polyA_site      7615
                     /gene="SLC7A2"
                     /gene_synonym="ATRC2; CAT-2A; CAT-2B; CAT2; HCAT2;
                     SLC7A2A; SLC7A2B"
ORIGIN      
        1 ctccttctgc agcgcggccg gcgggcgctc ctcttcgcgg gaccagcgag gcggcggccg
       61 ctgctccagc gtcccccagc cgcgggcccc cgacgcgctg cagccggcag cccaccgccg
      121 ccttcttggc gcgaccccaa cccagcccca caggagactc tctgaagacc agcaggaaag
      181 cagtgagccc ttacaggtcg ccttcgtcag acgtcagaat gattccttgc agagccgcgc
      241 tgacctttgc ccgatgtctg atccggagaa aaatcgtgac cctggacagt ctagaagaca
      301 ccaaattatg ccgctgctta tccaccatgg acctcattgc cctgggcgtt ggaagcaccc
      361 ttggggccgg ggtttatgtc ctcgctgggg aggtggccaa ggcagactcg ggccccagca
      421 tcgtggtgtc cttcctcatt gctgccctgg cttcagtgat ggctggcctc tgctatgccg
      481 aatttggggc ccgtgttccc aagacggggt ctgcatattt gtacacctac gtgactgtcg
      541 gagagctgtg ggccttcatc actggctgga atctcatttt atcgtatgtg ataggtacat
      601 caagtgttgc aagagcctgg agtggcacct ttgatgaact tcttagcaaa cagattggtc
      661 agtttttgag gacatacttc agaatgaatt acactggtct tgcagaatat cccgattttt
      721 ttgctgtgtg ccttatatta cttctagcag gtcttttgtc ttttggagta aaagagtctg
      781 cttgggtgaa taaagtcttc acagctgtta atattctcgt ccttctgttt gtgatggttg
      841 ctgggtttgt gaaaggaaat gtggcaaact ggaagattag tgaagagttt ctcaaaaata
      901 tatcagcaag tgccagagag ccaccttctg aaaacggaac aagtatctat ggggctggtg
      961 gctttatgcc ttatggcttt acgggaacgt tggctggtgc tgcaacttgc ttttatgcct
     1021 ttgtgggatt tgactgcatt gcaacaactg gtgaagaagt tcggaatccc cagaaagcta
     1081 ttcccattgg aattgtgacg tctttgcttg tttgctttat ggcctatttt ggggtctctg
     1141 cagctttaac acttatgatg ccgtactacc tcctcgatga aaaaagcccc cttcctgtag
     1201 cgtttgaata tgtgggatgg ggtcctgcca aatatgtcgt cgcagctggt tctctctgcg
     1261 ccttgtcaac aagtcttctt ggatccattt tcccaatgcc tcgtgtaatc tatgctatgg
     1321 cggaggatgg gttgcttttc aaatgtctag ctcaaatcaa ttccaaaacg aagacaccaa
     1381 taattgctac tttatcatcg ggtgcagtgg cagctttgat ggcctttctg tttgacctga
     1441 aggcgcttgt ggacatgatg tccattggca cactcatggc ctactctctg gtggcagcct
     1501 gtgttctcat cctcaggtac cagcctggct tatcttacga ccagcccaaa tgttctcctg
     1561 agaaagatgg tctgggatcg tctcccaggg taacctcgaa gagtgagtcc caggtcacca
     1621 tgctgcagag acagggcttc agcatgcgga ccctcttctg cccctccctt ctgccaacac
     1681 agcagtcagc ttctctcgtg agctttctgg taggattcct agctttcctc gtgttgggcc
     1741 tgagtgtctt gaccacttac ggagttcatg ccatcaccag gctggaggcc tggagcctcg
     1801 ctctcctcgc gctgtttctt gttctcttcg ttgccatcgt tctcaccatc tggaggcagc
     1861 cccagaatca gcaaaaagta gccttcatgg ttccattctt accatttttg ccagcgttca
     1921 gcatcttggt gaacatttac ttgatggtcc agttaagtgc agacacttgg gtcagattca
     1981 gcatttggat ggcaattggc ttcctgattt acttttctta tggcattaga cacagcctgg
     2041 agggtcatct gagagatgaa aacaatgaag aagatgctta tccagacaac gttcatgcag
     2101 cagcagaaga aaaatctgcc attcaagcaa atgaccatca cccaagaaat ctcagttcac
     2161 ctttcatatt ccatgaaaag acaagtgaat tctaacactt gcaggagcag agctggtcat
     2221 cgtcttagca tacatatcct acactgagta aaccgtaacg ggatgtcatc agcatgctgg
     2281 gttgtcatgg gtttgctgca tacatagttc accctaattt atacttactc atctggacag
     2341 catctcctca gatggtgaat tatgtgcacg gggaaacctc ctgagtggaa gtttcattca
     2401 tcagtgatga atagccccca aacagtggga gtgtgtatgt atgtgtgtat gtatgtatct
     2461 atgtatatgc ttgggaacat gagtgttaca agttagctgg tgttttacta ttattgtgtt
     2521 acatttttcc agtgtcgtca ttaatcggtg gcatatactg cacatactga aatagaggga
     2581 aatcactgaa tgtaaagagg tttcatctat gccccctgca gttggggaaa tactagtagc
     2641 tttaccttgt ttgacttcat taatgtcagt ttaggggatg ccaaaaatgc agttactcat
     2701 catggtgtct gtcactggtt aggggtaaga tgaggggata aggaaagaga cttttcaata
     2761 agttgtgaat gccaacagtg ggtttaatgc aaattttttt tcctgtgagg tatgacagtt
     2821 tgctcaaact tcagccaaca ggggtgtctg cttctgctgc actacacagg ccaggagtgg
     2881 cattccatgc cactagttgg catccttttg aacttttgtc tcctttgcaa acagtggtcc
     2941 taaaatacga ggtcttcact tgctgtgaat gacgtatccc cagtcaggga cttaagagag
     3001 gcactgtgat atacttggga ccctttaaat taaaaagtga agatagtcac cagggccaga
     3061 aagctcatgg agtggccgta atgagaatat gtttgaagat caaagagtta gaccaatgct
     3121 tgaataagta gaccccaagc atccttttct aaaaagtgac ttaaaataag ccaacagact
     3181 ctcccagacc acacaactag tggaatgatt cctccttttt ccattactta cttaatcaca
     3241 gtttagtttt tttcttaacc tcgtcaggcc cagagttcac ttctttgttt ctctgtttct
     3301 tttgtcttgt cttagagatg agggggctac agcagcatca tgcaaagagg gaaagatgaa
     3361 gggatagaag aagagaaaat ccccctgttc tgataggaac ggcctgttcc attgttaaat
     3421 ggcaaatggc ccaatttaag ggctttggat ctaatttgcc tctgatgttt cctttggaaa
     3481 catttaggaa tatttttctc cccctacccc ataaattgtg tagcactttt tattccattt
     3541 gctttcaaat gactacacta agcctaataa tacaagctcc agtgttatac aataacccat
     3601 cagtgattgg ggaatcaaac attttggttt aaaaaacatg attatttaaa actggaaact
     3661 aaaaagaatc aaattgaatt aaagctatat aaacacagtt aacccttgta aatgagtaaa
     3721 caaattttta catgtaagat tctctaattg tcatatttta ctttttagga ttccctaata
     3781 gtggactgtt tatttgcagt gtatttgctt ctcatgaact atttctcgta caaatcatta
     3841 aatagttcat tggatgaggc tgggtgacat ttcccaggac agcatggtga acattaccag
     3901 gcatgctagc tggcccgtgt aatcccaaga caaggaaaac attcgttttc ctcatgggtc
     3961 ttccaagaaa tgagctattt tattgatgcc attaaaaagc aagttgcgat ggttttgtat
     4021 agccaggagt ttattgtgat taaacatcaa agaaacaggt agaaagcctg ggtttctggc
     4081 tgctagcgtt atagcatcca tgacacagaa ctcattacgg acattccaca acttccaggg
     4141 tgcacatggt aaaatctgaa gcccagaatt ttctctcaag ctgcgtggtt tactggagag
     4201 aaggagttgg ataagcacag gctcgggtat tttggtaggg actgtaggca tgctcataaa
     4261 tccttgctgt tgtcacagta cgctgaaaac ccgtttgatt ctatacccaa tcaagaatag
     4321 acccttcaca caggaaatgt gaacaattgt tatatatgaa cactcaaatc ttttactgta
     4381 acgaaaccaa gaaacttgtt tagaatgtga taggcagcta aaactgttat gcccactgtg
     4441 ctcaatttga agcagaattt agtgaaaaat tatttttcca cattgaaaca ctttgcagac
     4501 acaaatatct atgaaaagat gctttgtcag ccactgtgcc tttttttctg tgaagactca
     4561 acggatgtgt gtgtttgtat gtttgttaac agttacatat gtttgtatga gtgtatatat
     4621 atatctgtgt gtgtgtatct ctaacgtcag tgtataagta agttgggttt atggtgggct
     4681 ttgactatgt cattaggtgg gtacaaaacc caactgatgt ggagaaaaat tgatgtttga
     4741 tgttgataga tatgcttata cctaattttt agtttttaaa ctattttaaa atatactatg
     4801 attttatatg tatatttcct atagactctt taagacgtat ttataatgtt tctaatatga
     4861 aatcactaaa ctctagtaca ttatagcagg tgctttgtaa tctggaatgg agaagaggta
     4921 ggggcatttg gggattcctg tttacttgct gctgccacac cttttccgac tgatctgtcc
     4981 tggtaggtgt ttattagcaa aagtcagtat caccagctct ttggcacctt tctgtttctg
     5041 cttgtgaatt cataatgttt tcaactaaat tttttttttc tttctcagaa ttacctaaat
     5101 gttttgtaga gttttgacta gtaatcaatc aaaattatat aaagtcttct ccagtaatta
     5161 agaaatacat atgcaaattc ttttgtgatt gagtaaaagc agcttaaatt acttttcttt
     5221 tctacattaa gaaatatatt ctcaacattt tcagtgagaa tttcttgtaa tggcacctca
     5281 aattttatac tcttaaaaaa aaacaataat ttgtgaatta ccaccaaaag gcaatggcag
     5341 tcctacattt aagaatagag ctatgcaaac tctgttaaaa actatgagga aaacttatat
     5401 tagaactttt gatatatact aaaatactga ttatcttaat cacattttcc ccagagataa
     5461 acattgagag aacgaaagcc aaagtgtcat ttaagagaga tatatatgaa aaagtaacat
     5521 taatatatag aactttacca tcaccagccg tagttgatag aaaatattag tttcagaatt
     5581 accctccttt aaaaaataag agactatttg ttttctttta atttctatga ataaaagaaa
     5641 tttttaaaaa ctttaaaatt ttaaatatta gtcaaaatac tttttaagtc ctgagtgctt
     5701 acaggtagtt gttaaaaaaa ttttaaggcc aggcatggtg gctcgctcac acctataatc
     5761 ctaggatctt gggaggtcga ggcaagctga tcgcttgagc ccaggagttt aagaccggcc
     5821 tgagtagcat agcaagaccc tgtctctaca aaaaaaacaa aaattagctg ggcatggtgg
     5881 catgcacatg tagtcagagc tactgggggt gctgaggtgg gaggatcgct tgagcccagg
     5941 agagtgaggc tgcagtgagc tgagattacg ccactgcact ctagcctggg caacggtgag
     6001 accctgcctc aaaaaaaata aaaataaaaa taaaacactt taattagaat ctatttttac
     6061 ctattttcta aatttattta aatgcttagc aggaagcata aggaaaagcc atcggcctcc
     6121 aatacccatg atgacagagg gagcacttga gccttgcctt ccctcctctt aaatcagggt
     6181 gtgttccgag attacagaac atcacacctt ggcgtgatga aatcatgcca agattctgac
     6241 tctccctttc cggtgatact gctcatgatt tctcctaata cgcttcaagc aactgttacc
     6301 acaaaaaata cagtttccgc agggctttaa aggattgagt ttagcatgta tatcatgcgt
     6361 tattaaagtt cacgtgattc atgtgaaatt aactgtcctt tttgctagtg ccaaaacagt
     6421 gccttctctg cacactttac ttgtttataa agttctccca catgtcctta aatatcaagg
     6481 gggaaagtat ggatattcgc gtagcaataa tgccagcaaa ggtcattttc attttttagt
     6541 catatagata tgaaaataag ttcatataga tatgaaattg cttgacttta ttgttttggg
     6601 gagatttttt ttccttacat gattatatta aacactttaa aatagccttc cggtttctgg
     6661 attttgagaa gcctgatctg ttattgttgt ggttgttggt gtttgtaata ttcattattg
     6721 tttgtatata cacggtttag tcttactgat ttcaaatgca ttttgttatt gctcaaccca
     6781 actggtaaca ctgtttgctg ggagcattat acttaacttt gattcaccat ggttgatgcc
     6841 actgccatga tcgctgggtc ttaaagagct ttccctagcc actgacagcc ccgtggagat
     6901 cataatcagg gccccaggct ggttccagga tcaggcagcc tatagagtgt gagcatctat
     6961 gtgtagctac ccttgttggg tgggctctta gactgatggg gtaggatatg aagtgaaaga
     7021 cttcaaatgc aagtaaggta gtttgggctc cttaattcca aacatcccat gagtatatca
     7081 agatgaataa ggaccaaggg acctctgtga ctcatagaag ggctggctga atcctgaagt
     7141 agcatagtgg gacctggtct acaatttatg cacatgcact gacagccttg ctgtgccacg
     7201 tgtctcacca agacccagtt gggaaagagc gtcatattgc caacaggttg ggtttctctg
     7261 gcctacacct gattaatggg ccctttatct ttggtgtccc ctaggagtgt ccagttgttt
     7321 tattgctgta ttttgttatt gcagtactta ataaaaattg ttgatagggc ccaaaaccct
     7381 acagaaattc tatgtctgta aaaaccaaca aaggcattgg acttgtgtga atgtacaggg
     7441 tttttttagt agtaatttta aatttaaatg ttttaagtga tcatcagtgt tcctttttac
     7501 ttataaagtt ggattctttt ttagaatttg taataaataa aaactgctgc tttaccactg
     7561 taaaatatgc tttctgatgt ggtgtatttt taaaataaat tttaatatgt aataa
//
