LOCUS       NM_138817               1867 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens solute carrier family 7 member 13 (SLC7A13), mRNA.
ACCESSION   NM_138817
VERSION     NM_138817.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Profilo,E., Pena-Altamira,L.E., Corricelli,M., Castegna,A.,
            Danese,A., Agrimi,G., Petralla,S., Giannuzzi,G., Porcelli,V.,
            Sbano,L., Viscomi,C., Massenzio,F., Palmieri,E.M., Giorgi,C.,
            Fiermonte,G., Virgili,M., Palmieri,L., Zeviani,M., Pinton,P.,
            Monti,B., Palmieri,F. and Lasorsa,F.M.
  TITLE     Down-regulation of the mitochondrial aspartate-glutamate carrier
            isoform 1 AGC1 inhibits proliferation and N-acetylaspartate
            synthesis in Neuro2A cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (6), 1422-1435 (2017)
   PUBMED   28235644
  REMARK    GeneRIF: data suggest that the cellular energetic deficit due to
            AGC1 impairment is associated with inappropriate aspartate levels
            to support neuronal proliferation when glutamine is not used as
            metabolic substrate
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Matsuo,H., Kanai,Y., Kim,J.Y., Chairoungdua,A., Kim,D.K.,
            Inatomi,J., Shigeta,Y., Ishimine,H., Chaekuntode,S., Tachampa,K.,
            Choi,H.W., Babu,E., Fukuda,J. and Endou,H.
  TITLE     Identification of a novel Na+-independent acidic amino acid
            transporter with structural similarity to the member of a
            heterodimeric amino acid transporter family associated with unknown
            heavy chains
  JOURNAL   J Biol Chem 277 (23), 21017-21026 (2002)
   PUBMED   11907033
REFERENCE   3  (bases 1 to 1867)
  AUTHORS   Blondeau,J.P.
  TITLE     Homologues of amino acid permeases: cloning and tissue expression
            of XAT1 and XAT2
  JOURNAL   Gene 286 (2), 241-248 (2002)
   PUBMED   11943479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084128.6, AK055815.1 and AJ417661.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138817.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055815.1, BC125165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297524.8/ ENSP00000297524.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC084128.6         100677-100682       c
            7-848               AK055815.1         1-842
            849-1517            AJ417661.1         748-1416
            1518-1867           AK055815.1         1512-1861
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..1867
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /note="solute carrier family 7 member 13"
                     /db_xref="GeneID:157724"
                     /db_xref="HGNC:HGNC:23092"
                     /db_xref="MIM:617256"
     exon            1..789
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1517
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /note="solute carrier family 7, (cationic amino acid
                     transporter, y+ system) member 13; amino acid transporter
                     XAT2; X-amino acid transporter 2; solute carrier family 7
                     (anionic amino acid transporter), member 13;
                     sodium-independent aspartate/glutamate transporter 1"
                     /codon_start=1
                     /product="solute carrier family 7 member 13"
                     /protein_id="NP_620172.2"
                     /db_xref="CCDS:CCDS34917.1"
                     /db_xref="GeneID:157724"
                     /db_xref="HGNC:HGNC:23092"
                     /db_xref="MIM:617256"
                     /translation="MDRGEKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCM
                     NVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYYFLKRYFGSTVAFLNLWTSLF
                     LGSGVVAGQALLLAEYSIQPFFPSCSVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQ
                     IASSVLKVSILSFISLTGVVFLIRGKKENVERFQNAFDAELPDISHLIQAIFQGYFAY
                     SGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVA
                     ITWADRAFPSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTLNSHS
                     SPFTAVLLLVTLGSLAIILTSLIDLINYIFFTGSLWSILLMIGILRRRYQEPNLSIPY
                     KVFLSFPLATIVIDVGLVVIPLVKSPNVHYVYVLLLVLSGLLFYIPLIHFKIRLAWFE
                     KMTCYLQLLFNICLPDVSEE"
     exon            790..921
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1283
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1867
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="SLC7A13"
                     /gene_synonym="AGT-1; AGT1; XAT2"
                     /note="major polyA site"
ORIGIN      
        1 agaattattt tatttcagga atccatcaac atcctttgca gctacatagg caggaaaatc
       61 tagaaattgt aatttatata gaattttaaa actcttcaat tacaatggat agaggggaga
      121 aaatacagct caagagagtg tttggatatt ggtggggcac aagttttttg cttattaata
      181 tcattggtgc aggaattttt gtgtccccca aaggtgtgtt ggcatactct tgcatgaacg
      241 tgggagtctc cctgtgcgtt tgggctggct gtgccatact ggccatgaca tcaactcttt
      301 gctctgcaga gataagtata agcttcccat gcagtggagc tcaatactat tttctcaaga
      361 gatactttgg ctccacggtt gcttttttga atctctggac atccttgttt ctggggtcag
      421 gggtagttgc tggccaagct ctgctccttg ctgagtacag catccagcct ttttttccca
      481 gctgctctgt cccaaagctg cctaagaaat gtctggcatt ggccatgttg tggattgtag
      541 gaattctgac ttctcgtggt gtgaaagaag tgacttggct tcagatagct agctcagtgc
      601 tgaaagtgtc catacttagc ttcatttccc taactggagt agtgttcctg ataagaggga
      661 aaaaggagaa tgtagaacga tttcagaatg cttttgatgc tgaacttcca gatatctctc
      721 accttataca agccatcttc caaggatatt ttgcatattc aggcggggca tgctttacac
      781 ttatagcagg ggagctgaag aagcccagaa caacaattcc caaatgcata tttactgcgt
      841 tacctctggt gactgtagtt tatttactgg ttaacatttc ctatctgact gttctgacac
      901 ccagggaaat tctctcttca gatgctgtag ctatcacatg ggctgatcga gcttttccct
      961 cattagcatg gattatgcct tttgctattt ctacctcatt atttagcaac cttctgattt
     1021 ctatatttaa atcatcgaga ccaatatatc ttgcaagcca agagggccag ctgcctttgc
     1081 tatttaatac acttaatagt cactcttctc catttacagc tgtgctacta cttgtcactt
     1141 tgggatccct tgcaattatc ttaacaagtc taattgattt gataaactat atttttttca
     1201 cgggttcatt atggtctata ttattaatga taggaatact aaggcggaga taccaggaac
     1261 ccaatctatc tataccttat aaggtgtttt tgtcatttcc attagcaaca atagtcatcg
     1321 acgtgggctt ggttgtgata ccattggtaa agtctccaaa tgtgcattat gtctacgtgc
     1381 ttctgttagt tctcagcgga ttactatttt acataccttt aatacatttt aaaataagat
     1441 tggcttggtt tgagaagatg acttgctatt tacaattact atttaatatt tgcctccctg
     1501 atgtgtctga ggaatagatg tcggaagtgc aaactcttaa aaaattggcc ttctaaaaaa
     1561 catatatcag attccaaatc aaggttaaac atatgataga acattcatgg tgaaattcct
     1621 atggtaaata tttttttctc aaatgaaata agtaatgtat acaaaagtgc ctaagacagt
     1681 acctggcttc agagtcacta agaaattgct aaaagctctg cttcgcatgg taaaaaactt
     1741 aagtcctggt ttgcgtagct tgatagagtg attatacaac ttccattctc tcactttttt
     1801 tttctgtatc ccaccccttt tctactgaat ttgtggggat cctataataa aagtgaatga
     1861 ctaaaaa
//
