LOCUS       NM_019849               1946 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens solute carrier family 7 member 10 (SLC7A10), mRNA.
ACCESSION   NM_019849 NM_017965
VERSION     NM_019849.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Drehmann,P., Milanos,S., Schaefer,N., Kasaragod,V.B., Herterich,S.,
            Holzbach-Eberle,U., Harvey,R.J. and Villmann,C.
  TITLE     Dual Role of Dysfunctional Asc-1 Transporter in Distinct Human
            Pathologies, Human Startle Disease, and Developmental Delay
  JOURNAL   eNeuro 10 (11) (2023)
   PUBMED   37903619
  REMARK    GeneRIF: Dual Role of Dysfunctional Asc-1 Transporter in Distinct
            Human Pathologies, Human Startle Disease, and Developmental Delay.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Jersin,R.A., Sri Priyanka Tallapragada,D., Skartveit,L.,
            Bjune,M.S., Muniandy,M., Lee-Odegard,S., Heinonen,S., Alvarez,M.,
            Birkeland,K.I., Andre Drevon,C., Pajukanta,P., McCann,A.,
            Pietilainen,K.H., Claussnitzer,M., Mellgren,G. and Dankel,S.N.
  TITLE     Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association
            With Insulin Resistance and Altered BCAA Metabolism
  JOURNAL   J Clin Endocrinol Metab 108 (9), 2217-2229 (2023)
   PUBMED   36916878
  REMARK    GeneRIF: Impaired Adipocyte SLC7A10 Promotes Lipid Storage in
            Association With Insulin Resistance and Altered BCAA Metabolism.
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Arianti,R., Vinnai,B.A., Toth,B.B., Shaw,A., Csosz,E., Vamos,A.,
            Gyory,F., Fischer-Posovszky,P., Wabitsch,M., Kristof,E. and
            Fesus,L.
  TITLE     ASC-1 transporter-dependent amino acid uptake is required for the
            efficient thermogenic response of human adipocytes to adrenergic
            stimulation
  JOURNAL   FEBS Lett 595 (16), 2085-2098 (2021)
   PUBMED   34197627
  REMARK    GeneRIF: ASC-1 transporter-dependent amino acid uptake is required
            for the efficient thermogenic response of human adipocytes to
            adrenergic stimulation.
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Jin,H. and Kim,H.J.
  TITLE     NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are
            Mediated by P2Y2R Activation in Breast Cancer Cells
  JOURNAL   Int J Mol Sci 21 (9), 3337 (2020)
   PUBMED   32397236
  REMARK    GeneRIF: NLRC4, ASC and Caspase-1 Are Inflammasome Components that
            Are Mediated by P2Y2R Activation in Breast Cancer Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Xu,D. and Hemler,M.E.
  TITLE     Metabolic activation-related CD147-CD98 complex
  JOURNAL   Mol Cell Proteomics 4 (8), 1061-1071 (2005)
   PUBMED   15901826
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Pineda,M., Font,M., Bassi,M.T., Manzoni,M., Borsani,G., Marigo,V.,
            Fernandez,E., Rio,R.M., Purroy,J., Zorzano,A., Nunes,V. and
            Palacin,M.
  TITLE     The amino acid transporter asc-1 is not involved in cystinuria
  JOURNAL   Kidney Int 66 (4), 1453-1464 (2004)
   PUBMED   15458438
  REMARK    GeneRIF: The lack of expression of asc-1 in the proximal tubule
            indicates that it plays no role in the bulk of renal reabsorption
            of amino acids
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Leclerc,D., Wu,Q., Ellis,J.R., Goodyer,P. and Rozen,R.
  TITLE     Is the SLC7A10 gene on chromosome 19 a candidate locus for
            cystinuria?
  JOURNAL   Mol Genet Metab 73 (4), 333-339 (2001)
   PUBMED   11509015
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Nakauchi,J., Matsuo,H., Kim,D.K., Goto,A., Chairoungdua,A.,
            Cha,S.H., Inatomi,J., Shiokawa,Y., Yamaguchi,K., Saito,I., Endou,H.
            and Kanai,Y.
  TITLE     Cloning and characterization of a human brain Na(+)-independent
            transporter for small neutral amino acids that transports D-serine
            with high affinity
  JOURNAL   Neurosci Lett 287 (3), 231-235 (2000)
   PUBMED   10863037
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Fukasawa,Y., Segawa,H., Kim,J.Y., Chairoungdua,A., Kim,D.K.,
            Matsuo,H., Cha,S.H., Endou,H. and Kanai,Y.
  TITLE     Identification and characterization of a Na(+)-independent neutral
            amino acid transporter that associates with the 4F2 heavy chain and
            exhibits substrate selectivity for small neutral D- and L-amino
            acids
  JOURNAL   J Biol Chem 275 (13), 9690-9698 (2000)
   PUBMED   10734121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022457.1 and AB037670.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019849.2.
            
            Summary: SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070),
            mediates high-affinity transport of D-serine and several other
            neutral amino acids (Nakauchi et al., 2000 [PubMed
            10863037]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022457.1, AB037670.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253188.8/ ENSP00000253188.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BC022457.1         1-48
            49-1851             AB037670.1         1-1803
            1852-1946           BC022457.1         1852-1946
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..1946
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /note="solute carrier family 7 member 10"
                     /db_xref="GeneID:56301"
                     /db_xref="HGNC:HGNC:11058"
                     /db_xref="MIM:607959"
     exon            1..298
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1719
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /note="solute carrier family 7, (neutral amino acid
                     transporter, y+ system) member 10; solute carrier family
                     7, (cationic amino acid transporter, y+ system) member 10;
                     solute carrier family 7 (neutral amino acid transporter
                     light chain, asc system), member 10"
                     /codon_start=1
                     /product="asc-type amino acid transporter 1"
                     /protein_id="NP_062823.1"
                     /db_xref="CCDS:CCDS12431.1"
                     /db_xref="GeneID:56301"
                     /db_xref="HGNC:HGNC:11058"
                     /db_xref="MIM:607959"
                     /translation="MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLS
                     ACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPK
                     SGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTA
                     SRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELR
                     PSNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLV
                     TFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYL
                     FTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVS
                     FINYLCYGVTILGLLLLRWRRPALHRPIKVNLLIPVAYLVFWAFLLVFSFISEPMVCG
                     VGVIIILTGVPIFFLGVFWRSKPKCVHRLTESMTHWGQELCFVVYPQDAPEEEENGPC
                     PPSLLPATDKPSKPQ"
     exon            299..503
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..655
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..781
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..935
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1059
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1163
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1260
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1410
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1588
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1946
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="SLC7A10"
                     /gene_synonym="asc-1; ASC1; HASC-1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgggc ccggagccag cgcatgcgcc cgcctgtggg cgctgtcccg gctgcgaggg
       61 ccgtgagctc acggaccgac ggaccgacgg gcggccggcc ggacagacgg ggcagcgcag
      121 ggagcgggga cgcggcggga cagcgacatg gccggccaca cgcagcagcc gagcgggcgc
      181 gggaacccca ggcctgcgcc ctcgccctcc ccagtcccag ggaccgtccc cggcgcctcg
      241 gagcgggtgg cgctcaagaa ggagatcggg ctgctgagcg cctgcaccat catcatcggg
      301 aacatcatcg gctcgggcat cttcatctcg cccaaggggg tcctggagca ctcaggctcc
      361 gtgggtctgg ccctgttcgt ctgggtcctg ggtgggggcg tgacggctct gggctccctc
      421 tgctatgcag agctgggagt cgccatcccc aagtctggcg gggactacgc ctacgtcaca
      481 gagatcttcg ggggcctggc tggctttctg ctgctctgga gcgccgtcct catcatgtac
      541 cccaccagcc ttgctgtcat ctccatgacc ttctccaact acgtgctgca gcccgtgttc
      601 cccaactgca tcccccccac cacagcctcc cgggtgctgt ccatggcctg cctgatgctc
      661 ctgacatggg tgaacagctc cagtgtgcgc tgggccacgc gcatccagga catgttcaca
      721 ggcgggaagc tgctggcctt gtccctcatc atcggcgtgg gccttctcca gatcttccaa
      781 ggacacttcg aggagctgag gcccagcaat gcctttgctt tctggatgac gccctccgtg
      841 ggacacctgg ccctggcctt cctccagggc tccttcgcct tcagtggctg gaacttcctc
      901 aactatgtca ccgaggagat ggttgacgcc cgaaagaacc tacctcgcgc catcttcatc
      961 tccatcccac tggtgacctt cgtgtacacg ttcaccaaca ttgcctactt cacggccatg
     1021 tccccccagg agctgctctc ctccaatgcg gtggctgtga ccttcgggga gaagctgctg
     1081 ggctactttt cttgggtcat gcctgtctcc gtggctctgt caaccttcgg agggatcaat
     1141 ggttacctgt tcacctactc caggctgtgc ttctctggag cccgcgaggg gcacctgccc
     1201 agcctgctgg ccatgatcca cgtcagacac tgcaccccca tccccgccct cctcgtctgt
     1261 tgcggggcca cagccgtcat catgctcgtg ggcgacacgt acacgctcat caactatgtg
     1321 tccttcatca actacctctg ctacggcgtc accatcctgg gcctgctgct gctgcgctgg
     1381 aggcggcctg cactccacag gcccatcaag gtgaaccttc tcatccccgt ggcgtacttg
     1441 gtcttctggg ccttcctgct ggtcttcagc ttcatctcag agcctatggt ctgtggggtc
     1501 ggcgtcatca tcatccttac gggggtgccc attttctttc tgggagtgtt ctggagaagc
     1561 aaaccaaagt gtgtgcacag actcacagag tccatgacac actggggcca ggagctgtgt
     1621 ttcgtggtct acccccagga cgcccccgaa gaggaggaga atggcccctg cccaccctcc
     1681 ctgctgcctg ccacagacaa gccctcgaag ccacaatgag atttttgtag agactgaagc
     1741 agttgtttct gtttacatgt tgtttattga ggaggtgttt tggcaaaaaa gttttgtttt
     1801 gtttttttct ggaaaaaaaa gaaaaaagat acgactctca gaagcctgtt taaggaagcc
     1861 ctaaaatgtg gactgggttt cctgtcttag cactgccctg ctagctcttc ctgaaaaggc
     1921 ctataaataa acagggctgg ctgttc
//
