LOCUS       NM_003045               7343 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens solute carrier family 7 member 1 (SLC7A1), mRNA.
ACCESSION   NM_003045
VERSION     NM_003045.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7343)
  AUTHORS   Gai,X., Liu,Y., Lan,X., Chen,L., Yuan,T., Xu,J., Li,Y., Zheng,Y.,
            Yan,Y., Yang,L., Fu,Y., Tang,S., Cao,S., Dai,X., Zhu,H., Geng,M.,
            Ding,J., Pu,C. and Huang,M.
  TITLE     Oncogenic KRAS Induces Arginine Auxotrophy and Confers a
            Therapeutic Vulnerability to SLC7A1 Inhibition in Non-Small Cell
            Lung Cancer
  JOURNAL   Cancer Res 84 (12), 1963-1977 (2024)
   PUBMED   38502865
  REMARK    GeneRIF: Oncogenic KRAS Induces Arginine Auxotrophy and Confers a
            Therapeutic Vulnerability to SLC7A1 Inhibition in Non-Small Cell
            Lung Cancer.
REFERENCE   2  (bases 1 to 7343)
  AUTHORS   Kurtyka,M., Wessely,F., Bau,S., Ifie,E., He,L., de Wit,N.M.,
            Pedersen,A.B.V., Keller,M., Webber,C., de Vries,H.E., Ansorge,O.,
            Betsholtz,C., De Bock,M., Chaves,C., Brodin,B., Nielsen,M.S.,
            Neuhaus,W., Bell,R.D., Letoha,T., Meyer,A.H., Leparc,G., Lenter,M.,
            Lesuisse,D., Cader,Z.M., Buckley,S.T., Loryan,I. and Pietrzik,C.U.
  TITLE     The solute carrier SLC7A1 may act as a protein transporter at the
            blood-brain barrier
  JOURNAL   Eur J Cell Biol 103 (2), 151406 (2024)
   PUBMED   38547677
  REMARK    GeneRIF: The solute carrier SLC7A1 may act as a protein transporter
            at the blood-brain barrier.
REFERENCE   3  (bases 1 to 7343)
  AUTHORS   You,S., Han,X., Xu,Y., Sui,L., Song,K. and Yao,Q.
  TITLE     High expression of SLC7A1 in high-grade serous ovarian cancer
            promotes tumor progression and is involved in MAPK/ERK pathway and
            EMT
  JOURNAL   Cancer Med 13 (10), e7217 (2024)
   PUBMED   38752472
  REMARK    GeneRIF: High expression of SLC7A1 in high-grade serous ovarian
            cancer promotes tumor progression and is involved in MAPK/ERK
            pathway and EMT.
REFERENCE   4  (bases 1 to 7343)
  AUTHORS   Contreras-Duarte,S., Cantin,C., Farias,M. and Leiva,A.
  TITLE     High total cholesterol and triglycerides levels increase arginases
            metabolism, impairing nitric oxide signaling and worsening
            fetoplacental endothelial dysfunction in gestational diabetes
            mellitus pregnancies
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (12), 166216 (2021)
   PUBMED   34314821
  REMARK    GeneRIF: High total cholesterol and triglycerides levels increase
            arginases metabolism, impairing nitric oxide signaling and
            worsening fetoplacental endothelial dysfunction in gestational
            diabetes mellitus pregnancies.
REFERENCE   5  (bases 1 to 7343)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7343)
  AUTHORS   Vekony,N., Wolf,S., Boissel,J.P., Gnauert,K. and Closs,E.I.
  TITLE     Human cationic amino acid transporter hCAT-3 is preferentially
            expressed in peripheral tissues
  JOURNAL   Biochemistry 40 (41), 12387-12394 (2001)
   PUBMED   11591158
REFERENCE   7  (bases 1 to 7343)
  AUTHORS   Kamath,S.G., Furesz,T.C., Way,B.A. and Smith,C.H.
  TITLE     Identification of three cationic amino acid transporters in
            placental trophoblast: cloning, expression, and characterization of
            hCAT-1
  JOURNAL   J Membr Biol 171 (1), 55-62 (1999)
   PUBMED   10485994
REFERENCE   8  (bases 1 to 7343)
  AUTHORS   Closs,E.I., Graf,P., Habermeier,A., Cunningham,J.M. and
            Forstermann,U.
  TITLE     Human cationic amino acid transporters hCAT-1, hCAT-2A, and
            hCAT-2B: three related carriers with distinct transport properties
  JOURNAL   Biochemistry 36 (21), 6462-6468 (1997)
   PUBMED   9174363
REFERENCE   9  (bases 1 to 7343)
  AUTHORS   Albritton,L.M., Bowcock,A.M., Eddy,R.L., Morton,C.C., Tseng,L.,
            Farrer,L.A., Cavalli-Sforza,L.L., Shows,T.B. and Cunningham,J.M.
  TITLE     The human cationic amino acid transporter (ATRC1): physical and
            genetic mapping to 13q12-q14
  JOURNAL   Genomics 12 (3), 430-434 (1992)
   PUBMED   1348489
REFERENCE   10 (bases 1 to 7343)
  AUTHORS   Yoshimoto,T., Yoshimoto,E. and Meruelo,D.
  TITLE     Molecular cloning and characterization of a novel human gene
            homologous to the murine ecotropic retroviral receptor
  JOURNAL   Virology 185 (1), 10-17 (1991)
   PUBMED   1718082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596114.10.
            
            On Nov 24, 2018 this sequence version replaced NM_003045.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB105377.1, SRR14038191.1238336.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380752.10/ ENSP00000370128.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AL596114.10        165026-165298       c
            274-373             AL596114.10        123371-123470       c
            374-757             AL596114.10        105429-105812       c
            758-916             AL596114.10        102434-102592       c
            917-1091            AL596114.10        100148-100322       c
            1092-1213           AL596114.10        93742-93863         c
            1214-1436           AL596114.10        92876-93098         c
            1437-1576           AL596114.10        91927-92066         c
            1577-1679           AL596114.10        89057-89159         c
            1680-1897           AL596114.10        87183-87400         c
            1898-2064           AL596114.10        86754-86920         c
            2065-2173           AL596114.10        85748-85856         c
            2174-7343           AL596114.10        79024-84193         c
FEATURES             Location/Qualifiers
     source          1..7343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..7343
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /note="solute carrier family 7 member 1"
                     /db_xref="GeneID:6541"
                     /db_xref="HGNC:HGNC:11057"
                     /db_xref="MIM:104615"
     exon            1..273
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            274..373
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            374..757
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2277
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /note="ecotropic retroviral receptor; amino acid
                     transporter, cationic 1; CAT1; ecotropic retrovirus
                     receptor homolog; system Y+ basic amino acid transporter;
                     ecotropic retroviral leukemia receptor homolog; solute
                     carrier family 7 (cationic amino acid transporter, y+
                     system), member 1"
                     /codon_start=1
                     /product="high affinity cationic amino acid transporter 1"
                     /protein_id="NP_003036.1"
                     /db_xref="CCDS:CCDS9333.1"
                     /db_xref="GeneID:6541"
                     /db_xref="HGNC:HGNC:11057"
                     /db_xref="MIM:104615"
                     /translation="MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGS
                     TLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSY
                     VTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVL
                     AENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQ
                     LTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTG
                     EEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEG
                     AKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLAS
                     GAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDEL
                     DPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAVLII
                     TFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVL
                     PILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQARTPDGN
                     LDQCK"
     exon            758..916
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1091
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1213
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1436
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1576
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1679
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1897
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2064
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2173
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..7343
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7324..7329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /note="hexamer: AATAAA"
     polyA_site      7343
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /note="major polyA site"
ORIGIN      
        1 gcactgctga tgaaacctgg cgccggaacc cgccagccct cggcgcccat tcagtccgcg
       61 caggcaggtg tgagcagcgg gtcaactacc tggcaggcgc gcacgcggcc gcgggctccc
      121 gctaaccgca gcctccactc ctctccccgc gcgccgcgcc cccgccccgc cccgccccgc
      181 ccggtctcgc cggccgagcg tccgttggtc cttgagcgcg tccgacagtc tgtctgttcg
      241 cgatcctgcc ggagccccgc cgccgccggc ttggattctg aaaccttcct tgtatccctc
      301 ctgagacatc tttgctgcaa gatcgaggct gtcctctggt gagaaggtgg tgaggcttcc
      361 cgtcatattc cagctctgaa cagcaacatg gggtgcaaag tcctgctcaa cattgggcag
      421 cagatgctgc ggcggaaggt ggtggactgt agccgggagg agacgcggct gtctcgctgc
      481 ctgaacactt ttgatctggt ggccctcggg gtgggcagca cactgggtgc tggtgtctac
      541 gtcctggctg gagctgtggc ccgtgagaat gcaggccctg ccattgtcat ctccttcctg
      601 atcgctgcgc tggcctcagt gctggctggc ctgtgctatg gcgagtttgg tgctcgggtc
      661 cccaagacgg gctcagctta cctctacagc tatgtcaccg ttggagagct ctgggccttc
      721 atcaccggct ggaacttaat cctctcctac atcatcggta cttcaagcgt agcgagggcc
      781 tggagcgcca ccttcgacga gctgataggc agacccatcg gggagttctc acggacacac
      841 atgactctga acgcccccgg cgtgctggct gaaaaccccg acatattcgc agtgatcata
      901 attctcatct tgacaggact tttaactctt ggtgtgaaag agtcggccat ggtcaacaaa
      961 atattcactt gtattaacgt cctggtcctg ggcttcataa tggtgtcagg atttgtgaaa
     1021 ggatcggtta aaaactggca gctcacggag gaggattttg ggaacacatc aggccgtctc
     1081 tgtttgaaca atgacacaaa agaagggaag cccggtgttg gtggattcat gcccttcggg
     1141 ttctctggtg tcctgtcggg ggcagcgact tgcttctatg ccttcgtggg ctttgactgc
     1201 atcgccacca caggtgaaga ggtgaagaac ccacagaagg ccatccccgt ggggatcgtg
     1261 gcgtccctct tgatctgctt catcgcctac tttggggtgt cggctgccct cacgctcatg
     1321 atgccctact tctgcctgga caataacagc cccctgcccg acgcctttaa gcacgtgggc
     1381 tgggaaggtg ccaagtacgc agtggccgtg ggctccctct gcgctctttc cgccagtctt
     1441 ctaggttcca tgtttcccat gcctcgggtt atctatgcca tggctgagga tggactgcta
     1501 tttaaattct tagccaacgt caatgatagg accaaaacac caataatcgc cacattagcc
     1561 tcgggtgccg ttgctgctgt gatggccttc ctctttgacc tgaaggactt ggtggacctc
     1621 atgtccattg gcactctcct ggcttactcg ttggtggctg cctgtgtgtt ggtcttacgg
     1681 taccagccag agcagcctaa cctggtatac cagatggcca gtacttccga cgagttagat
     1741 ccagcagacc aaaatgaatt ggcaagcacc aatgattccc agctgggctt tttaccagag
     1801 gcagagatgt tctctttgaa aaccatactc tcacccaaaa acatggagcc ttccaaaatc
     1861 tctgggctaa ttgtgaacat ttcaaccagc ctcatagctg ttctcatcat caccttctgc
     1921 attgtgaccg tgcttggaag ggaggctctc accaaagggg cgctgtgggc agtctttctg
     1981 ctcgcagggt ctgccctcct ctgtgccgtg gtcacgggcg tcatctggag gcagcccgag
     2041 agcaagacca agctctcatt taaggttccc ttcctgccag tgctccccat cctgagcatc
     2101 ttcgtgaacg tctatctcat gatgcagctg gaccagggca cctgggtccg gtttgctgtg
     2161 tggatgctga taggcttcat catctacttt ggctatggcc tgtggcacag cgaggaggcg
     2221 tccctggatg ccgaccaagc aaggactcct gacggcaact tggaccagtg caagtgacgc
     2281 acagccccgc cccccggagg tggcagcagc cccgagggac gcccccagag gaccgggagg
     2341 caccccaccc tccccaccag tgcaacagaa accacctgcg tccacaccct cactgcagcc
     2401 aaaggtgcaa ttacttgacc tgcagcccca gcccaccctc ggctctgcag ccggttctcc
     2461 gggccctggt cacctccaga cagctgcctg gccggggcca ctaggctgcg gctggccact
     2521 gtgtctcctc acttctctga acaaagcagt tcctccccta ccagctcagc cccgagctgc
     2581 cgcagcctca ggcagaacgg aggtcacctt ctctccttat cttgggaacc aggccttcct
     2641 cccggggact gttctgggat tgaaattgtg catactccaa actttcgcag ccatcttccc
     2701 gctcagcccc agacacccag caatcaagcc agatgagtac cacaaaacag tgtgtcccca
     2761 gcagctcccc accccagagc caaatgacag tagtgcactt aaaaaggaaa atcaggcctg
     2821 ttgtccttct ccggttgcat tcagatgggt cattagggcc ggaccctgcc tgccccttgg
     2881 cttctcaggg ctttgctctg acaccatgac agctgcccgg ggctgagggc agctggctcc
     2941 actcaaatga ggaagaaggg atcactccca ttagggcctg ctttgcttat gcatgtgtgt
     3001 gcacatgcat gtaaaccagg gaccttcagc tcacggcctc caggcctggg ccagttcttg
     3061 ctgctcctgc cgtctccccc gactggctgt gtcctgagta actggaacat gagacagtat
     3121 ctgcaggact ggccccatgg tggccgagtc agaagtctgt ttcctgtgag tcgccaccgt
     3181 tcactcagtc ttgccctccc atgctttgga gccagtctgg tggctcctgt aaggttctca
     3241 aggctggtgg cagctcagtc tggggtcagg acatgtcggg gtcatgcgtt tctggccctg
     3301 acataagctg tctggcctct ctgtgacatg atgaaattga aatcaatcca cagtccatga
     3361 aattgtgaca ctccaccaga ttaagttagg gcataacatt aacttggaaa tggccatgtc
     3421 atcacccctg cggctgtcct atagctgaga tgcgtgggtc gcaggggagg tgatttctag
     3481 gcatattgct gtcccttttg tgtatctgtc atccggatgc ttcggacccc acgcctctgc
     3541 aagtgggaga gacccgagca tcctccccac ccccatagct ccagtgcacg ccacccccgt
     3601 cttgcctggg tcggggcctg cggccagcac catttcacac acactccttg tagatgggag
     3661 ccagaggaaa cctgaacgtg ggtggagcgt tccactgagt ctacttcagg agacagaagg
     3721 cccatgctga tgggggagga ggagggatgt gggcattttg gacaccaggg gaaatggaaa
     3781 tgctgctttc aaaacttagt ttcctttcca tttcttccta gtctggcctt tgacacaaat
     3841 ctggtagaaa gaagcctgat aaattgaggg cacttgtacc ctccctgtgc ccccagaagg
     3901 ttcttggaga gaagtgcaag aatttgtgaa cacggcggtg gagggcgggt ggatggccat
     3961 gggctgagcc tccgtatcag gcctgctcac cttgctggga gctttattct gatctcattt
     4021 tgaatgttcc agagggagca tcataagagc ccagagctcc gatttccaaa gagtgatatt
     4081 gacatttatg gagattggtg ttgtaacata ttttgataaa tactaactta ttttgttggg
     4141 gttttggttg tctcttgtct taggacctgg tagttatttg cttgattttt ttttccgtta
     4201 ttttctacat aggcaaagag aattcgaggg atagacagtc tccaagaaaa gtgaagtggt
     4261 gggagagaat tgcttttttc ttttttttct tttctctagt ttttctttct ggctgagatt
     4321 tccgtgcaag acagcaccca atagactatt tagagttgac atttgacatt ttaatgggcg
     4381 ccatggctca ttttgtagat tgagaaggtg cgtctcccct gctccaagtc tcatcatgac
     4441 agcgtgctga cagctgggag tctgtggcct tcctcacgca gaggccttaa agctggacac
     4501 agaagcacgc ctaggctggg cagggatggg acccatgccc cctccttaga ggacgggctt
     4561 cctggttagg aaaggacacg tgggggtgcc ttgcataata gttcactggt caccgtgctt
     4621 ttatgagtag tgtttttgtg cacttgccag gggttttctc tctgtgtgag aggggagtga
     4681 tttaagcaat ggtgtctgga gtaagcctta caattttaat agactttttc ttatcatatc
     4741 cctcatttct ttccctgaaa taaaaataca cacaagcaaa aaaaaaatga tagtttcaca
     4801 tctcttagtt cccttgccca aacaagaata ttcttagttc cactggccag gattttccta
     4861 catagtcaga acttacacat tactagaggc acacccacca aggagtattg tgtctacttt
     4921 tatctgtgca ccagccacaa atacccacat tggaaagacc catttgtgat gggtaaacat
     4981 cccttcctgt ctcccacaac ccctgtgact gccctgcatg tgttcatgac ctccgaaggc
     5041 ccaaattcat gaagcagcaa acccagcaga tctccacccc cctgcctcag gacctctgct
     5101 gaagaggggg atgaagtggg tctccaggga ggcagtgggg gccttgttgg cagctggctc
     5161 gggagccggc ttacaggagg gcagctctgc agttgggagg ggcaccgtcc ggaggagacc
     5221 aggcctctac acacccccca ctctacttat catccctgct cacacaccct tgtccaaggc
     5281 tttatgcatc ggatttattt ttccaaatca agaggacagt gatagatgca ttttccccag
     5341 gctgtctcag aaaggtcgct aaatgtatac tgttgtcaga attgctgaga tctcccccca
     5401 cttttggttt ttgcagcagt aaaaactctt tccactgtga cttattttct ctctcaggca
     5461 gccagccacc tggtcccttg tgctgactct agcacagtgg ccaggatcca atacgagtcc
     5521 aggggtgacc gcaggatggt gggggcagcg ggcttctcca cctaccccag ccaccaaggc
     5581 cctgacgcac tgcctcctgc accttcagca catccctgtg cacagctgga agggtgcatg
     5641 gcccgctcac ctttgttcag atgggtggaa acgctgatga taccagctcc tccctgccgt
     5701 gcccctgcca cggagcaggc attgtgaact ggctggtgtt tgcagtccca cgtggcatgg
     5761 cctccagccc aacccacagt ggagactgga gacagggcaa tgagtctggt ggggggcacg
     5821 tggacatgcc ccataggggc cccacccaga cttaacaggc aaggtcctgg gcattgcgcg
     5881 acgcaggact caatgctaaa gcaagcctgc ctggctctgt gccagggccc ctcttctgat
     5941 tcacacatcc catttttaca cagacccttc cttcttaata aaggctgaca gttctgttgg
     6001 cagccaagaa cccacaccat gaagacaggg agtgaggggc ctttgtgccc aactccagca
     6061 cagctgcgtt ctggggtgtg tgagaggcat gttcgtgtct gtgcgctggt ggtctcgtga
     6121 gacagttccg aggacgggga aattgcaggg tggtgggggc gtgaggctta tatgtggaac
     6181 tgatgcagag ttcgcctgca gacggatctg gatatacact atgtataatt gttacgtgta
     6241 atttaaaata tatctgtttg ccatcgtcat gagaagatta tatgtaaggc tctgaaggga
     6301 gagggagatg tacattctgc caggctcctg gggaccttat ccgagtcatg aaattgatta
     6361 ctgttgatcc agtggtgcaa gaagctacac tccatgtgtc atcacgctta tgactcctaa
     6421 tgtattttta aggcaaaaaa tgtcagccga ctccatcttc acccctcgat tcctcgagtc
     6481 cagcctttct gtgccagtgc ttcactgagc cacaacgctc tcgccatcgg gacccggctg
     6541 ggcctggagt ctcggggcac agttgccatg gagccctcct gggtcattct acaaatgtgc
     6601 tgagtgccag ctgaaaaccc cacaggagat ggagtacctt ggccaagctt aaagagaaga
     6661 ttttctcagg gtatttatta gtgtgtccag cagggtcagg aagcaggatg gaaagatgca
     6721 ctcagactgt taatttatta acaaggcaaa tgattttgtg tttcttgatg acagactatt
     6781 aagtttggga cttattttcc catttgagaa gttataatat atatttaaga tgataagttt
     6841 cctgcttaag ttgtgccttt cagcttcaat gagtttaagg agcactaagg gtaatgatac
     6901 caatgagggt tggtttatta tcaaacctga atagctgtgg tttctccagt aaatattttc
     6961 ttctactgaa catggagcca ttattaagag ttgtgtgttt tttattatgt acatttgtat
     7021 atttttttgc ttgtttgatg ttctattttt ctaatagttt tcttttagtt tcttaaagtt
     7081 gtgatactag atttagattc tgatgctaac tgcaaatcag gttggtctct gctgggtctc
     7141 tcctgctttt attttacttt aaggacaagt gtagttgtcg tccaccacct ttcaaaaaat
     7201 gtgaaactgc cctgcctccc ctttttgctg acaacactgt gtacattgac cacttcctac
     7261 catactttat gttgtaaaat caaactcttt tgtggtacat tatctcatgc ttctgcaaat
     7321 tcgaataaat tctatggctt cca
//
