LOCUS       NM_004211               6876 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens solute carrier family 6 member 5 (SLC6A5), transcript
            variant 1, mRNA.
ACCESSION   NM_004211
VERSION     NM_004211.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6876)
  AUTHORS   Wilson,K.A., Mostyn,S.N., Frangos,Z.J., Shimmon,S., Rawling,T.,
            Vandenberg,R.J. and O'Mara,M.L.
  TITLE     The allosteric inhibition of glycine transporter 2 by bioactive
            lipid analgesics is controlled by penetration into a deep lipid
            cavity
  JOURNAL   J Biol Chem 296, 100282 (2021)
   PUBMED   33450225
  REMARK    GeneRIF: The allosteric inhibition of glycine transporter 2 by
            bioactive lipid analgesics is controlled by penetration into a deep
            lipid cavity.
REFERENCE   2  (bases 1 to 6876)
  AUTHORS   Mostyn,S.N., Sarker,S., Muthuraman,P., Raja,A., Shimmon,S.,
            Rawling,T., Cioffi,C.L. and Vandenberg,R.J.
  TITLE     Photoswitchable ORG25543 Congener Enables Optical Control of
            Glycine Transporter 2
  JOURNAL   ACS Chem Neurosci 11 (9), 1250-1258 (2020)
   PUBMED   32191428
  REMARK    GeneRIF: Photoswitchable ORG25543 Congener Enables Optical Control
            of Glycine Transporter 2.
REFERENCE   3  (bases 1 to 6876)
  AUTHORS   Kitzenmaier,A., Schaefer,N., Kasaragod,V.B., Polster,T.,
            Hantschmann,R., Schindelin,H. and Villmann,C.
  TITLE     The P429L loss of function mutation of the human glycine
            transporter 2 associated with hyperekplexia
  JOURNAL   Eur J Neurosci 50 (12), 3906-3920 (2019)
   PUBMED   31370103
REFERENCE   4  (bases 1 to 6876)
  AUTHORS   Lopez-Corcuera,B., Arribas-Gonzalez,E. and Aragon,C.
  TITLE     Hyperekplexia-associated mutations in the neuronal glycine
            transporter 2
  JOURNAL   Neurochem Int 123, 95-100 (2019)
   PUBMED   29859229
  REMARK    GeneRIF: An overview of hyperekplexia-associated mutations in the
            neuronal glycine transporter 2 (GlyT2) with special focus on
            dominant mutations that effect the quaternary structure of GlyT2
            (review).
            Review article
REFERENCE   5  (bases 1 to 6876)
  AUTHORS   Arribas-Gonzalez,E., de Juan-Sanz,J., Aragon,C. and
            Lopez-Corcuera,B.
  TITLE     Molecular basis of the dominant negative effect of a glycine
            transporter 2 mutation associated with hyperekplexia
  JOURNAL   J Biol Chem 290 (4), 2150-2165 (2015)
   PUBMED   25480793
  REMARK    GeneRIF: analysis of the human SLC6A5 gene mutation associated with
            hyperekplexia
REFERENCE   6  (bases 1 to 6876)
  AUTHORS   Martinez-Maza,R., Poyatos,I., Lopez-Corcuera,B., N unez,E.,
            Gimenez,C., Zafra,F. and Aragon,C.
  TITLE     The role of N-glycosylation in transport to the plasma membrane and
            sorting of the neuronal glycine transporter GLYT2
  JOURNAL   J Biol Chem 276 (3), 2168-2173 (2001)
   PUBMED   11036075
REFERENCE   7  (bases 1 to 6876)
  AUTHORS   Evans,J., Herdon,H., Cairns,W., O'Brien,E., Chapman,C., Terrett,J.
            and Gloger,I.
  TITLE     Cloning, functional characterisation and population analysis of a
            variant form of the human glycine type 2 transporter
  JOURNAL   FEBS Lett 463 (3), 301-306 (1999)
   PUBMED   10606742
REFERENCE   8  (bases 1 to 6876)
  AUTHORS   Gallagher,M.J., Burgess,L.H. and Brunden,K.R.
  TITLE     Characterization of multiple forms of the human glycine transporter
            type-2
  JOURNAL   Brain Res Mol Brain Res 70 (1), 101-115 (1999)
   PUBMED   10381548
REFERENCE   9  (bases 1 to 6876)
  AUTHORS   Morrow,J.A., Collie,I.T., Dunbar,D.R., Walker,G.B., Shahid,M. and
            Hill,D.R.
  TITLE     Molecular cloning and functional expression of the human glycine
            transporter GlyT2 and chromosomal localisation of the gene in the
            human genome
  JOURNAL   FEBS Lett 439 (3), 334-340 (1998)
   PUBMED   9845349
REFERENCE   10 (bases 1 to 6876)
  AUTHORS   Balint,B. and Thomas,R.
  TITLE     Hereditary Hyperekplexia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301437
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090707.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2019 this sequence version replaced NM_004211.4.
            
            Summary: This gene encodes a sodium- and chloride-dependent glycine
            neurotransmitter transporter. This integral membrane glycoprotein
            is responsible for the clearance of extracellular glycine during
            glycine-mediated neurotransmission. This protein is found in
            glycinergic axons and maintains a high presynaptic pool of
            neurotransmitter at glycinergic synapses. Mutations in this gene
            cause hyperekplexia; a heterogenous neurological disorder
            characterized by exaggerated startle responses and neonatal apnea.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Jan 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096319.3, AF085412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2144835 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525748.6/ ENSP00000434364.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC090707.16        52996-53063
            69-605              AC090707.16        54517-55053
            606-744             AC090707.16        57674-57812
            745-876             AC090707.16        60395-60526
            877-1050            AC090707.16        60867-61040
            1051-1192           AC090707.16        68067-68208
            1193-1325           AC090707.16        71140-71272
            1326-1460           AC090707.16        80096-80230
            1461-1564           AC090707.16        81368-81471
            1565-1689           AC090707.16        84079-84203
            1690-1802           AC090707.16        89695-89807
            1803-1934           AC090707.16        90560-90691
            1935-2034           AC090707.16        91847-91946
            2035-2135           AC090707.16        100222-100322
            2136-2303           AC090707.16        105677-105844
            2304-6876           AC090707.16        108101-112673
FEATURES             Location/Qualifiers
     source          1..6876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..6876
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /note="solute carrier family 6 member 5"
                     /db_xref="GeneID:9152"
                     /db_xref="HGNC:HGNC:11051"
                     /db_xref="MIM:604159"
     exon            1..68
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2459
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium- and chloride-dependent glycine transporter 2;
                     solute carrier family 6 (neurotransmitter transporter,
                     glycine), member 5; norepinephrine transporter 1"
                     /codon_start=1
                     /product="sodium- and chloride-dependent glycine
                     transporter 2 isoform 1"
                     /protein_id="NP_004202.4"
                     /db_xref="CCDS:CCDS7854.1"
                     /db_xref="GeneID:9152"
                     /db_xref="HGNC:HGNC:11051"
                     /db_xref="MIM:604159"
                     /translation="MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAA
                     APPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQG
                     AQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVV
                     LATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFP
                     YLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAM
                     LIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIS
                     DHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEI
                     RWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGI
                     WYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCT
                     NSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAII
                     FFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQG
                     GIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWA
                     FVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLA
                     PGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC"
     exon            69..605
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..744
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..876
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1050
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1192
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1325
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1460
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1564
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1689
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1802
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1934
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2034
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2135
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2303
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..6876
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6851..6856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /note="hexamer: AATAAA"
     polyA_site      6876
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /note="major polyA site"
ORIGIN      
        1 caaacccagt cttgtcaata gcgggtttca ccctccacca gttcagtctg ttgcctgtgt
       61 cagacatgga ttgcagtgct cccaaggaaa tgaataaact gccagccaac agcccggagg
      121 cggcggcggc gcagggccac ccggatggcc catgcgctcc caggacgagc ccggagcagg
      181 agcttcccgc ggctgccgcc ccgccgccgc cacgtgtgcc caggtccgct tccaccggcg
      241 cccaaacttt ccagtcagcg gacgcgcgag cctgcgaggc tgagcggcca ggagtggggt
      301 cttgcaaact cagtagcccg cgggcgcagg cggcctctgc agctctgcgg gacttgagag
      361 aggcgcaagg cgcgcaggcc tcgccccctc ccgggagctc cgggcccggc aacgcgctgc
      421 actgtaagat cccttttctg cgaggcccgg agggggatgc gaacgtgagt gtgggcaagg
      481 gcaccctgga gcggaacaat acccctgttg tgggctgggt gaacatgagc cagagcaccg
      541 tggtgctggc cacggatgga atcacgtccg tgctcccggg cagcgtggcc accgttgcca
      601 cccaggagga cgagcaaggg gatgagaata aggcccgagg gaactggtcc agcaaactgg
      661 acttcatcct gtccatggtg gggtacgcag tggggctggg caatgtctgg aggtttccct
      721 acctggcctt ccagaacggg ggaggtgctt tcctcatccc ttacctgatg atgctggctc
      781 tggctggatt acccatcttc ttcttggagg tgtcgctggg ccagtttgcc agccagggac
      841 cagtgtctgt gtggaaggcc atcccagctc tacaaggctg tggcatcgcg atgctgatca
      901 tctctgtcct aatagccata tactacaatg tgattatttg ctatacactt ttctacctgt
      961 ttgcctcctt tgtgtctgta ctaccctggg gctcctgcaa caacccttgg aatacgccag
     1021 aatgcaaaga taaaaccaaa cttttattag attcctgtgt tatcagtgac catcccaaaa
     1081 tacagatcaa gaactcgact ttctgcatga ccgcttatcc caacgtgaca atggttaatt
     1141 tcaccagcca ggccaataag acatttgtca gtggaagtga agagtacttc aagtactttg
     1201 tgctgaagat ttctgcaggg attgaatatc ctggcgagat caggtggcca ctagctctct
     1261 gcctcttcct ggcttgggtc attgtgtatg catcattggc taaaggaatc aagacttcag
     1321 gaaaagtggt gtacttcacg gccacgttcc cgtatgtcgt actcgtgatc ctcctcatcc
     1381 gaggagtcac cctgcctgga gctggagctg ggatctggta cttcatcaca cccaagtggg
     1441 agaaactcac ggatgccacg gtgtggaaag atgctgccac tcagattttc ttctctttat
     1501 ctgctgcatg gggaggcctg atcactctct cttcttacaa caaattccac aacaactgct
     1561 acagggacac tctaattgtc acctgcacca acagtgccac aagcatcttt gccggcttcg
     1621 tcatcttctc cgttatcggc ttcatggcca atgaacgcaa agtcaacatt gagaatgtgg
     1681 cagaccaagg gccaggcatt gcatttgtgg tttacccgga agccttaacc aggctgcctc
     1741 tctctccgtt ctgggccatc atctttttcc tgatgctcct cactcttgga cttgacacta
     1801 tgtttgccac catcgagacc atagtgacct ccatctcaga cgagtttccc aagtacctac
     1861 gcacacacaa gccagtgttt actctgggct gctgcatttg tttcttcatc atgggttttc
     1921 caatgatcac tcagggtgga atttacatgt ttcagcttgt ggacacctat gctgcctcct
     1981 atgcccttgt catcattgcc atttttgagc tcgtggggat ctcttatgtg tatggcttgc
     2041 aaagattctg tgaagatata gagatgatga ttggattcca gcctaacatc ttctggaaag
     2101 tctgctgggc atttgtaacc ccaaccattt taacctttat cctttgcttc agcttttacc
     2161 agtgggagcc catgacctat ggctcttacc gctatcctaa ctggtccatg gtgctcggat
     2221 ggctaatgct cgcctgttcc gtcatctgga tcccaattat gtttgtgata aaaatgcatc
     2281 tggcccctgg aagatttatt gagaggctga agttggtgtg ctcgccacag ccggactggg
     2341 gcccattctt agctcaacac cgcggggagc gttacaagaa catgatcgac cccttgggaa
     2401 cctcttcctt gggactcaaa ctgccagtga aggatttgga actgggcact cagtgctagt
     2461 ccagtggtgt gggatggtcc agacttgatc ctgtttttcc tctctgcctc ctcctaatgt
     2521 tttccatagc tctcctccca tttttcttca tctttcttcc tacatcttgg ttcacatcca
     2581 cgcatgagag tgattatgta gaaaagtagg catagtgtcg catgctgcag taaagagcta
     2641 catagaccac ctgaagcgct gtttgcctgt gcccatggtg actgtttctg gtcaggttgg
     2701 tcccctgacc acacgtttta ccctgcagag gaggatcagt taggtgagca ctggtaggta
     2761 tgcgtggttt tgtcaataga gaggtatcca ctgtgtgatg gcatgggggg tgccagtaag
     2821 gcatgtatag agtggccgaa ttacaagact ttatttggac ttgaacagaa ctgagcaatg
     2881 tggtgatctt gttcagacac acaaagttca agacaggttt tttttttttt cagagagtta
     2941 gcagtggtca gaaaatgttt tggatgtaag acaagaccat tcaatttgga caccactgag
     3001 gtggttaagt ttatatttcc agtcaccact ggggatctgt ttccttcgtt tggatcagca
     3061 atctccagtt accactaact cagatgctac agtctacaca ttgtgacttt gattgaactg
     3121 tcagttttct tccctcaact gtcttttttt gttttaaata accacatttg tgagttcttt
     3181 tggtcatttc ctccacctct gcccaagaag ccatcatata agttgtgcct cattttgtac
     3241 gttcatagta gagctccatg ctcatttcta catgatattt agcaccatgg ttcaatgtca
     3301 cgatcctgtg tttcttctct aaatgtcttt ctataagctg tagacacctt gtcttttgac
     3361 ctctgggaaa acaagactta ccctggttct gtctatatat tatatatata ggacacatgc
     3421 tcttaaaaga cagataactt cttaattttt actctttttc attcacagta aatgccaact
     3481 gtggtcatag agaaatcaaa gaaatggaga gtttaataga aagcaaccac aatattcact
     3541 gcactggtag tacattttag gacatggtat ttatagaact ttctgataaa tacagcttag
     3601 gtaagtagcg agtgagccaa ttaagactat agcttttaag actacattta gccaattcaa
     3661 ttttaagagt tccctattca cagtactcat tttaacggca ctctaatgag agctgatcat
     3721 atgtctgcag aaattggcaa agtgtaaact ttattatctt cttgtatcct gaacatgcat
     3781 atatgaaatt tttaaaatgt gacatgtgtt catgtagtgt gtacttgtag tggtgttttc
     3841 tgtccttata aatatctttt gaattctgta gagatggtga gtttagtata gtgtagtctg
     3901 gggattttat tttcccttac agtaataata tctaaaccta aaattgtttc ctttagggga
     3961 gatcatttca atcattttct tcatttatct tcatagtaca gggtctcagg caaagttttt
     4021 cagttcaaat cttgtatatt gttgtgacat tttcatcctg tttaacagca atgaaaccca
     4081 acaacaggct ttaatgtaca ttttttttta aaagatttca tttgttaaaa aaagtctcaa
     4141 ctcattttac tgagctctcc cttttctagg gcaagtatca tcgccatttg ccaacatcaa
     4201 tatgaacttc cagtttttaa gagtagcttg tgaaaggttt tagaaaagga aacaaagatg
     4261 ggttttgaac tttagatttt catgtctttt gtctgcagtg tatatttgtt ctcccctctc
     4321 cttctcctcc tttcccccct tgtctcccaa agctcaaact tgcttgagtc tatcatagag
     4381 actaaacctt gagcttcccc taaacttagc tttaggaagc tgagctgtgg cctcacctgt
     4441 ctgccatgaa cacagatttc tctaagaaag ccatattgat gagaagcccc caattactgc
     4501 agcagacgtc gcacaatggt accaaaaatg agcctctcca gctgatacct ggtagagtga
     4561 gaggagccag gaggaataac ttaggcctgg aaattatctg caggctttgc aatttgaagg
     4621 ttgagaaaga gagcttaaat caattagcat tctctcatgg gactggtatg tttgtgtcag
     4681 gatgaatggt ttttggctct cctgttgcct cttggctaaa actctgattg agccaatggt
     4741 tgcagtctga tgctggacgc caacccaatt tctgctaatt attgcttttg tgattaaaag
     4801 aaggtggggg tggggggctc ccacagatgc tgccaggttt gttttgtaca aactgaaagt
     4861 taacttaatt gtgagaacgg agacctcatc actagctgca tgttttggat ttgggggcat
     4921 ttacatttgt gttaattatg atttgtccag gtaagatgca gtagctgctc cctgagcagc
     4981 tgtttccccc ccaccccact tcactataat ttccaagatt tatttccctt tgtttaaagg
     5041 gacacgctta ggtgaaaggt tccaaattta cctggaaatg gttaccttgt aaatttagct
     5101 tgtctaatgg attgtttcca tgatattaaa atgtacagtc aattggaaga aaaaaaatga
     5161 aaaaaataaa atgaataaca ttgttagaaa ctggcacctg aaaacttccc ttcaaagtgg
     5221 gggaaaaaac cgagtagctg aggaaagact ttcattggtt cactgtgtag aatggtggag
     5281 cattttccac ttgtgagatt atttcataac accaacaaat gccagaaact cattcagaaa
     5341 aaaagccata tgtgaaaaac agtaatcctg tcatatcctt agaggagaaa aaatgtatat
     5401 ttcttaacaa gtggtgttgt gacttcttat gcaaatgtct tgcatattag taacttttat
     5461 tatctttagg actgtgctta tcaggtacaa atgtgtctag ttctgtttta ttgtttcttt
     5521 ttcctttata tttatgtatt gcatgaggtc tgtggtcaat gcaaaatcat gatgacctca
     5581 atgtctttga aatttgcaat gtgtttttaa tatgtaagaa atgtaatcaa cttgtatttc
     5641 agtaagcagc actttaaaaa gagtttaaca tgatgacctt taaatggata ggacttgggt
     5701 tgtttttatg gtaatgttgc attggagttg agttttcctt taattaagtt cttgtttcct
     5761 catctatgtg tctctcagtg cttcctgtcc acctttgctc tcagcatggt ttcccatgcc
     5821 taaaagtaag attttctttt ctctttgttc ccttggctgt aggtcattgt cctcttccca
     5881 gaggctagca caataactgt tgctcaatgt aagatgagat ggcaagatca tactactgtt
     5941 gttgcacctg gatttgagtt gggacatgct tctttgaggc agatgattca agagaggacg
     6001 tgctgtgtgg caggtgtttt gcaggaccaa aaggccaagg ccaacagagg agcatttcct
     6061 tctctttcac actgggtatc aagcagaaaa cttccaggct gggagcaaag gtgtgggtga
     6121 ttctgccttg atactcattt ccccacaaag tggccctagg atttgtgaaa gtgaagcttc
     6181 ctatctttcc cagattttgc tttaattgcc cagaaaggcc aagtagtttt gaaatgtggt
     6241 ctttgctcag gtcacctctg agcagcctgc agccaaagag aaagtgtttt cagattaggt
     6301 attcatcacc tctgaaaagc aagcagtggt ttgacttgcc tgccacggat taaatacatc
     6361 ttcaggtaac catttgcctt acaggtgtat tttactgtta ggatgattct tagtaattga
     6421 ctaaaaactg ttttgtctct catttgtttg tggtttttgc actttattat ggacctgtaa
     6481 aggaataggt taattcttac attgtgtact tggctaatgt cctaaatgca ggcatctttt
     6541 gtgggtactg ttgcccatga ataaacatat gttccctaat caggtcctta tatttttcca
     6601 ttaactatac atgaagaaaa tatattatgt tacaaatgat gcatcatata tatatatata
     6661 tatatatata tatcttatag attacatatt atatactgca cattattcat ttaagaagtc
     6721 attcttgagg ccctacctca aattttctat ttatgtataa aaatgcaatt tattgtatta
     6781 tatatttgcc tattatgtac tgatataaat tagaatttac cctaataatg tatgagttca
     6841 caaaacccta aataaatgtc agtgtttaaa acatga
//
