LOCUS       NM_001045               6335 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens solute carrier family 6 member 4 (SLC6A4), mRNA.
ACCESSION   NM_001045
VERSION     NM_001045.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6335)
  AUTHORS   Koning,S.M., Kessler,C.L., Canli,T., Duman,E.A., Adam,E.K.,
            Zinbarg,R., Craske,M.G., Stephens,J.E. and Vrshek-Schallhorn,S.
  TITLE     Early-life adversity severity, timing, and context type are
            associated with SLC6A4 methylation in emerging adults: Results from
            a prospective cohort study
  JOURNAL   Psychoneuroendocrinology 170, 107181 (2024)
   PUBMED   39298801
  REMARK    GeneRIF: Early-life adversity severity, timing, and context type
            are associated with SLC6A4 methylation in emerging adults: Results
            from a prospective cohort study.
REFERENCE   2  (bases 1 to 6335)
  AUTHORS   Landoni,M., Di Tella,S., Ciuffo,G. and Ionio,C.
  TITLE     The Association between Post-Traumatic Stress Disorder, 5HTTLPR,
            and the Role of Ethnicity: A Meta-Analysis
  JOURNAL   Genes (Basel) 15 (10), 1270 (2024)
   PUBMED   39457394
  REMARK    GeneRIF: The Association between Post-Traumatic Stress Disorder,
            5HTTLPR, and the Role of Ethnicity: A Meta-Analysis.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6335)
  AUTHORS   Neukam,P.T., Muller,D.K., Deza-Lougovski,Y.I., Pooseh,S.,
            Witt,S.H., Rietschel,M. and Smolka,M.N.
  TITLE     Connection Failure: Differences in White Matter Microstructure Are
            Associated with 5-HTTLPR but Not with Risk Seeking for Losses
  JOURNAL   Int J Mol Sci 25 (12), 6666 (2024)
   PUBMED   38928372
  REMARK    GeneRIF: Connection Failure: Differences in White Matter
            Microstructure Are Associated with 5-HTTLPR but Not with Risk
            Seeking for Losses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6335)
  AUTHORS   Esmaeili,M., Nasr-Esfahani,M.H., Shoaraye Nejati,A.,
            Safaeinejad,Z., Atefi,A., L Megraw,T. and Ghaedi,K.
  TITLE     PPARgamma dependent PEX11beta counteracts the suppressive role of
            SIRT1 on neural differentiation of HESCs
  JOURNAL   PLoS One 19 (5), e0298274 (2024)
   PUBMED   38753762
  REMARK    GeneRIF: PPARgamma dependent PEX11beta counteracts the suppressive
            role of SIRT1 on neural differentiation of HESCs.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6335)
  AUTHORS   Gafarov,V.V., Gromova,E.A., Gubina,M.A., Gagulin,I.V.,
            Maksimov,V.N. and Gafarova,A.V.
  TITLE     [The association of polymorphisms of the serotonin transporter gene
            SLC6A4 with depression]
  JOURNAL   Zh Nevrol Psikhiatr Im S S Korsakova 124 (2), 135-139 (2024)
   PUBMED   38465822
  REMARK    GeneRIF: [The association of polymorphisms of the serotonin
            transporter gene SLC6A4 with depression].
REFERENCE   6  (bases 1 to 6335)
  AUTHORS   Gelernter,J., Pakstis,A.J. and Kidd,K.K.
  TITLE     Linkage mapping of serotonin transporter protein gene SLC6A4 on
            chromosome 17
  JOURNAL   Hum Genet 95 (6), 677-680 (1995)
   PUBMED   7789954
REFERENCE   7  (bases 1 to 6335)
  AUTHORS   Lesch,K.P., Balling,U., Gross,J., Strauss,K., Wolozin,B.L.,
            Murphy,D.L. and Riederer,P.
  TITLE     Organization of the human serotonin transporter gene
  JOURNAL   J Neural Transm Gen Sect 95 (2), 157-162 (1994)
   PUBMED   7865169
REFERENCE   8  (bases 1 to 6335)
  AUTHORS   Lesch,K.P., Wolozin,B.L., Murphy,D.L. and Reiderer,P.
  TITLE     Primary structure of the human platelet serotonin uptake site:
            identity with the brain serotonin transporter
  JOURNAL   J Neurochem 60 (6), 2319-2322 (1993)
   PUBMED   7684072
REFERENCE   9  (bases 1 to 6335)
  AUTHORS   Ramamoorthy,S., Bauman,A.L., Moore,K.R., Han,H., Yang-Feng,T.,
            Chang,A.S., Ganapathy,V. and Blakely,R.D.
  TITLE     Antidepressant- and cocaine-sensitive human serotonin transporter:
            molecular cloning, expression, and chromosomal localization
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2542-2546 (1993)
   PUBMED   7681602
REFERENCE   10 (bases 1 to 6335)
  AUTHORS   Epshtein,B.V., Nishchenko,V.F. and Timchenko,P.K.
  TITLE     [Hyperbaric oxygenation in the complex treatment of patients with
            diabetes mellitus]
  JOURNAL   Vrach Delo (1), 65-66 (1988)
   PUBMED   3363943
  REMARK    GeneRIF: [Hyperbaric oxygenation in the complex treatment of
            patients with diabetes mellitus].', trans 'Giperbaricheskaia
            oksigenatsiia v kompleknom lechenii bol'nykh sakharnym diabetom.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC345903.1, AC104984.14,
            AK313166.1, AY902473.1 and BE645279.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001045.5.
            
            Summary: This gene encodes an integral membrane protein that
            transports the neurotransmitter serotonin from synaptic spaces into
            presynaptic neurons. The encoded protein terminates the action of
            serotonin and recycles it in a sodium-dependent manner. This
            protein is a target of psychomotor stimulants, such as amphetamines
            and cocaine, and is a member of the sodium:neurotransmitter
            symporter family. A repeat length polymorphism in the promoter of
            this gene has been shown to affect the rate of serotonin uptake.
            There have been conflicting results in the literature about the
            possible effect, if any, that this polymorphism may play in
            behavior and depression. [provided by RefSeq, May 2019].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments. There is an
            upstream in-frame AUG at nt 451-453 with a weak Kozak signal. This
            was not annotated as the translation start because it has a weak
            Kozak signal, while the downstream AUG at nt 577-579 has a strong
            Kozak signal, and is not conserved in-frame in other vertebrates
            except chimp.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313166.1, AK308014.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000650711.1/
                                                ENSP00000498537.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                DC345903.1         272-356
            86-121              AC104984.14        40660-40695
            122-234             AK313166.1         122-234
            235-2339            AY902473.1         1-2105
            2340-5790           AC104984.14        65261-68711
            5791-6335           BE645279.1         10-554              c
FEATURES             Location/Qualifiers
     source          1..6335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..6335
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="solute carrier family 6 member 4"
                     /db_xref="GeneID:6532"
                     /db_xref="HGNC:HGNC:11050"
                     /db_xref="MIM:182138"
     exon            1..85
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..182
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..648
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..2198
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="5HT transporter; Na+/Cl- dependent serotonin
                     transporter; solute carrier family 6 (neurotransmitter
                     transporter, serotonin), member 4; serotonin transporter
                     1; 5-hydroxytryptamine (serotonin) transporter; solute
                     carrier family 6 (neurotransmitter transporter), member 4"
                     /codon_start=1
                     /product="sodium-dependent serotonin transporter"
                     /protein_id="NP_001036.1"
                     /db_xref="CCDS:CCDS11256.1"
                     /db_xref="GeneID:6532"
                     /db_xref="HGNC:HGNC:11050"
                     /db_xref="MIM:182138"
                     /translation="METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQIS
                     NGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNV
                     WRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKG
                     IGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNI
                     TWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKT
                     SGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIF
                     FSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNE
                     DVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAV
                     LDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIE
                     AVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLF
                     QYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGD
                     IRLNAV"
     exon            649..783
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1003
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1142
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1277
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1381
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1509
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1622
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1754
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1854
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1955
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2123
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..6335
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="hexamer: AATGAA"
     polyA_site      2766
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="major polyA site"
     regulatory      2870..2875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="hexamer: AACAAA"
     polyA_site      2889
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="major polyA site"
     regulatory      4466..4471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="hexamer: AATAGA"
     polyA_site      4488
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
     regulatory      6314..6319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
                     /note="hexamer: AATAAA"
     polyA_site      6335
                     /gene="SLC6A4"
                     /gene_synonym="5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1;
                     SERT; SERT1"
ORIGIN      
        1 acagccagcg ccgccgggtg cctcgagggc gcgaggccag cccgcctgcc cagcccggga
       61 ccagcctccc cgcgcagcct ggcaggtctc ctggaggcaa ggcgaccttg cttgccctct
      121 cttgcagaat aacaaggggc ttagccacag gagttgctgg caagtggaaa gaagaacaaa
      181 tgagtcaatc ccgacgtgtc aatcccgacg atagagagct cggaggtgat ccacaaatcc
      241 aagcacccag agatcaattg ggatccttgg cagatggaca tcagtgtcat ttactaacca
      301 gcaggatgga gacgacgccc ttgaattctc agaagcagct atcagcgtgt gaagatggag
      361 aagattgtca ggaaaacgga gttctacaga aggttgttcc caccccaggg gacaaagtgg
      421 agtccgggca aatatccaat gggtactcag cagttccaag tcctggtgcg ggagatgaca
      481 cacggcactc tatcccagcg accaccacca ccctagtggc tgagcttcat caaggggaac
      541 gggagacctg gggcaagaag gtggatttcc ttctctcagt gattggctat gctgtggacc
      601 tgggcaatgt ctggcgcttc ccctacatat gttaccagaa tggagggggg gcattcctcc
      661 tcccctacac catcatggcc atttttgggg gaatcccgct cttttacatg gagctcgcac
      721 tgggacagta ccaccgaaat ggatgcattt caatatggag gaaaatctgc ccgattttca
      781 aagggattgg ttatgccatc tgcatcattg ccttttacat tgcttcctac tacaacacca
      841 tcatggcctg ggcgctatac tacctcatct cctccttcac ggaccagctg ccctggacca
      901 gctgcaagaa ctcctggaac actggcaact gcaccaatta cttctccgag gacaacatca
      961 cctggaccct ccattccacg tcccctgctg aagaatttta cacgcgccac gtcctgcaga
     1021 tccaccggtc taaggggctc caggacctgg ggggcatcag ctggcagctg gccctctgca
     1081 tcatgctgat cttcactgtt atctacttca gcatctggaa aggcgtcaag acctctggca
     1141 aggtggtgtg ggtgacagcc accttccctt atatcatcct ttctgtcctg ctggtgaggg
     1201 gtgccaccct ccctggagcc tggaggggtg ttctcttcta cttgaaaccc aattggcaga
     1261 aactcctgga gacaggggtg tggatagatg cagccgctca gatcttcttc tctcttggtc
     1321 cgggctttgg ggtcctgctg gcttttgcta gctacaacaa gttcaacaac aactgctacc
     1381 aagatgccct ggtgaccagc gtggtgaact gcatgacgag cttcgtttcg ggatttgtca
     1441 tcttcacagt gctcggttac atggctgaga tgaggaatga agatgtgtct gaggtggcca
     1501 aagacgcagg tcccagcctc ctcttcatca cgtatgcaga agcgatagcc aacatgccag
     1561 cgtccacttt ctttgccatc atcttctttc tgatgttaat cacgctgggc ttggacagca
     1621 cgtttgcagg cttggagggg gtgatcacgg ctgtgctgga tgagttccca cacgtctggg
     1681 ccaagcgccg ggagcggttc gtgctcgccg tggtcatcac ctgcttcttt ggatccctgg
     1741 tcaccctgac ttttggaggg gcctacgtgg tgaagctgct ggaggagtat gccacggggc
     1801 ccgcagtgct cactgtcgcg ctgatcgaag cagtcgctgt gtcttggttc tatggcatca
     1861 ctcagttctg cagggacgtg aaggaaatgc tcggcttcag cccggggtgg ttctggagga
     1921 tctgctgggt ggccatcagc cctctgtttc tcctgttcat catttgcagt tttctgatga
     1981 gcccgccaca actacgactt ttccaatata attatcctta ctggagtatc atcttgggtt
     2041 actgcatagg aacctcatct ttcatttgca tccccacata tatagcttat cggttgatca
     2101 tcactccagg gacatttaaa gagcgtatta ttaaaagtat taccccagaa acaccaacag
     2161 aaattccttg tggggacatc cgcttgaatg ctgtgtaaca cactcaccga gaggaaaaag
     2221 gcttctccac aacctcctcc tccagttctg atgaggcacg cctgccttct cccctccaag
     2281 tgaatgagtt tccagctaag cctgatgatg gaagggcctt ctccacaggg acacagtctg
     2341 gtgcccagac tcaaggcctc cagccactta tttccatgga ttcccctgga catattccca
     2401 tggtagactg tgacacagct gagctggcct attttggacg tgtgaggatg tggatggagg
     2461 tgatgaaaac caccctatca tcagttagga ttaggtttag aatcaagtct gtgaaagtct
     2521 cctgtatcat ttcttggtat gatcattggt atctgatatc tgtttgcttc taaaggtttc
     2581 actgttcatg aatacgtaaa ctgcgtagga gagaacaggg atgctatctc gctagccata
     2641 tattttctga gtagcatata taattttatt gctggaatct actagaacct tctaatccat
     2701 gtgctgctgt ggcatcagga aaggaagatg taagaagcta aaatgaaaaa tagtgtgtcc
     2761 atgcaagctt gtgagtctgt gtatattgtt gtttcagtgt attcttatct ctagtccaat
     2821 attttgggcc cattacaaat atatgaattc cccaaatttt tcttacatta acaaattcta
     2881 ccaactcaat tgtgtatgga ggttattatt tgaagggtac aatcactaca acatgctctg
     2941 ccacccactc cttttccagt gacactactt gagccacaca ctttccttta caggccagcc
     3001 tctggcgttt gctgcacctc attgccacct tcctgtctct ctgtgctaaa cattcaggac
     3061 agtgttccac aggcagatct ggcctatttc attagtcacc atggcttggc tgtgaagtac
     3121 gttgaaggtg gatcttgtca catgcccctt cagtgttcac ctggccctct ggtttaagtt
     3181 ctgtctgcct tacgtgactg agtttgactg tccaggttgc tttgctcggt gaagagagga
     3241 gggtaaatcg gattctcgtt tagcactggg ttatacagat ctggcaccct aacctaaacc
     3301 aaggcatctt cactccaaga gcagttggag agtctgggtt agccttacgt ggacctcgcc
     3361 gctcgctggc ggtcacgatt gtgagccctc cagataattt ttaaggttga gtctaagtaa
     3421 ggctgcttgg gaaatggtca gctaagtaaa tcacctttca tttcacataa ggcccttaat
     3481 atagataagt aaatttggcc tttggtgtct cgtgactctc agaggcgtag gtagaggagc
     3541 aaattaatat ttgcagcatg ggaattcctt atcagaattt tgaggggaat aaatcctcat
     3601 cagagacaaa aggacttaat catctggcca cctatcactt cagttctctg tataaatgaa
     3661 atttaattct aacaacctta taaaaagaag gtccagacag cagaggaaac atcctgtcca
     3721 attctaggtt ttcctccctt ggcctccttt ccccagcatt gtctaccctg gcccacttcc
     3781 tgcattctcc ccatgccctg ctatttctga ttctttgctt ctcctagcga gatactttcc
     3841 ttatatgata gctgctgaga agtttcccag aactgctaga ggaaaagaag tggggaattt
     3901 aggaaatatc cctcactgac ctaactccat tatcttcact ctttccttct tcctgccacc
     3961 tcatgcccat tctctttact gtctagcatg ctgaaagaag gaagtgatct aaatgccagc
     4021 gtgttcagtg gtaaatatta gttggtgcaa aagaaaaacc atgattactt ttgcactaac
     4081 ctaatagctt tgcaaatttt aagaacttgc tttatgaaga tattcggata tggattctcc
     4141 ccaccccaca tacttagaca ttgttcaaat atactacttt taaaaaaaca ccttttcaaa
     4201 cagaattagc gttttgccaa gtctggtatt aatggaattg tacaggagct ttgaaagttt
     4261 tcaaacttta ttaaactaaa aaaaaaaaat cgaaaatctc tgtctgttcc gcatagtatg
     4321 catttatttg acccctattt atcaatacta tgatggggtt tttttttttt aaagaaaatt
     4381 taagagtagg taggtggatt ttaaaataat attttaaaga ccttttatat ctatatgtag
     4441 catttataga aaaataaaaa ctaaaaatag aattgaattg taacattatt taaggactga
     4501 agtttttttt cttgtatcag taagaaatac ccaagaggct gggtgcagtg actcacacct
     4561 gtaatcccag cactttggga ggctgcagtg ggaggatcac atgacatcag gagtttgaga
     4621 ccagcttggc caacatagtg aaacgccgtc tctattaaaa atacagaaaa ttagctgaat
     4681 gtggtggcag gcgcctataa ttcctgctac ttgggaggct gaggcaggag aattgcttga
     4741 acccaggagg cagaggttgc agtgagccaa acgttccact gcattccagc ctggatgaca
     4801 agagcgaaac tccgtctcaa aaaaaaaaaa aaaaattgtt atgcttagtt ccatggaaag
     4861 actattctga agctttaagt cttctttttc tattttccat agtattgccc cttccccact
     4921 tcattgctta actgtctcta aattttaatg ataataatat tttaaaggtc agataatgcc
     4981 attagaggca gagacaaacc tggggaccaa gctaatttct ctgttattga gagcgctaaa
     5041 gacaggtgaa ctggagtttt atttcctctg ctagagtgaa ataataccct ctccaccagg
     5101 cacaatggct cacacctgta attccagcac tttgggaggc caaggtgggc ggatcacttg
     5161 aggtcaggag ttcgagacca gcctggccaa catggtgaaa ccccatctct actaaaaata
     5221 caaaaattag ccagccatgg tggcatgctc ctgtaatccc agctacttgg gagactgagg
     5281 tgggataatc acttgaacct gggaggcgga ggttgcagtg agctgagatt gtgccactgc
     5341 actccagcct gggtgacaga gcaagactcc atctaaaaaa caaaaacaaa aacaaaaaaa
     5401 ccctctcaat tggtttaata ccacgataga aaagataaat attttaggat ggaatcttaa
     5461 atatgtctgt ccttttgttt catatagttg aaatcaattc agtattgttt ctacattagg
     5521 tgtttcaaaa acagtcacct ttgcaacaga agagctcttt tgttgaaaat gattcacaat
     5581 atatttcagt tggaatgtca ggtggtattt ctcttaccaa cacctcacag aatctatgcc
     5641 aagctgctct accaccaatg caagtatttt tttaaagcta ctaaaataaa ctttcttcac
     5701 cagccaactc taatttggag acagtgtgca ttggtgaagg acctcgtcag aataagtttg
     5761 aatgtctact gaactaagaa gaattttgtc gtttggggga gagaatagat ggcatcagtc
     5821 cttcaattct gtaactgaag actccaatta tagtagataa gaattgtgtc tagcaatttt
     5881 taaacactga cagtccaaac aaaaatattt ggtgaggaag gatgtcccat atttttgctt
     5941 aaatatcata aacaaatatg agcatttact aattttttaa atggcatttt gaaagattat
     6001 tcttatttac actctaaaat taaaggtgta ctttatctta agaaaatgat atattaaaaa
     6061 ttcatatttt aaaagataaa attggggaat ttacagttat tttgtgaatg gcctttaaac
     6121 tatgatttga tctatataca acttttcaga atacttttga ttgtgtgttg gacatatcta
     6181 aaattaattt tatctggcag aattaaacct aaatttattt gtataaaaga gtcccctttc
     6241 taaaattcat acagtgccct tgtattcatt tatgcagtgt ttataaatat ttcaagttag
     6301 attgtgagat attaataaat gatttatgct gtgaa
//
