LOCUS       NM_001172501            5933 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens solute carrier family 6 member 2 (SLC6A2), transcript
            variant 2, mRNA.
ACCESSION   NM_001172501
VERSION     NM_001172501.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5933)
  AUTHORS   Ji,W., Miao,A., Liang,K., Liu,J., Qi,Y., Zhou,Y., Duan,X., Sun,J.,
            Lai,L. and Wu,J.X.
  TITLE     Substrate binding and inhibition mechanism of norepinephrine
            transporter
  JOURNAL   Nature 633 (8029), 473-479 (2024)
   PUBMED   39143211
  REMARK    GeneRIF: Substrate binding and inhibition mechanism of
            norepinephrine transporter.
REFERENCE   2  (bases 1 to 5933)
  AUTHORS   Hu,T., Yu,Z., Zhao,J., Meng,Y., Salomon,K., Bai,Q., Wei,Y.,
            Zhang,J., Xu,S., Dai,Q., Yu,R., Yang,B., Loland,C.J. and Zhao,Y.
  TITLE     Transport and inhibition mechanisms of the human noradrenaline
            transporter
  JOURNAL   Nature 632 (8026), 930-937 (2024)
   PUBMED   39085602
  REMARK    GeneRIF: Transport and inhibition mechanisms of the human
            noradrenaline transporter.
REFERENCE   3  (bases 1 to 5933)
  AUTHORS   Tan,J., Xiao,Y., Kong,F., Zhang,X., Xu,H., Zhu,A., Liu,Y., Lei,J.,
            Tian,B., Yuan,Y. and Yan,C.
  TITLE     Molecular basis of human noradrenaline transporter reuptake and
            inhibition
  JOURNAL   Nature 632 (8026), 921-929 (2024)
   PUBMED   39048818
  REMARK    GeneRIF: Molecular basis of human noradrenaline transporter
            reuptake and inhibition.
REFERENCE   4  (bases 1 to 5933)
  AUTHORS   Zhang,H., Yin,Y.L., Dai,A., Zhang,T., Zhang,C., Wu,C., Hu,W.,
            He,X., Pan,B., Jin,S., Yuan,Q., Wang,M.W., Yang,D., Xu,H.E. and
            Jiang,Y.
  TITLE     Dimerization and antidepressant recognition at noradrenaline
            transporter
  JOURNAL   Nature 630 (8015), 247-254 (2024)
   PUBMED   38750358
  REMARK    GeneRIF: Dimerization and antidepressant recognition at
            noradrenaline transporter.
REFERENCE   5  (bases 1 to 5933)
  AUTHORS   Xia,Z., Cao,Z., Surento,W., Zhang,L., Qiu,L., Xu,Q., Zhang,L.,
            Li,L., Cao,Y., Luo,Y., Lu,G. and Qi,R.
  TITLE     Relationship between SLC6A2 gene polymorphisms and brain volume in
            Han Chinese adults who lost their sole child
  JOURNAL   BMC Psychiatry 24 (1), 11 (2024)
   PUBMED   38166870
  REMARK    GeneRIF: Relationship between SLC6A2 gene polymorphisms and brain
            volume in Han Chinese adults who lost their sole child.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5933)
  AUTHORS   Porzgen,P., Bonisch,H. and Bruss,M.
  TITLE     Molecular cloning and organization of the coding region of the
            human norepinephrine transporter gene
  JOURNAL   Biochem Biophys Res Commun 215 (3), 1145-1150 (1995)
   PUBMED   7488042
  REMARK    Erratum:[Biochem Biophys Res Commun. 1996 Oct 14;227(2):642-3. doi:
            10.1006/bbrc.1996.1559.. PMID: 8967904]
REFERENCE   7  (bases 1 to 5933)
  AUTHORS   Gu,H., Wall,S.C. and Rudnick,G.
  TITLE     Stable expression of biogenic amine transporters reveals
            differences in inhibitor sensitivity, kinetics, and ion dependence
  JOURNAL   J Biol Chem 269 (10), 7124-7130 (1994)
   PUBMED   8125921
REFERENCE   8  (bases 1 to 5933)
  AUTHORS   Gelernter,J., Kruger,S., Pakstis,A.J., Pacholczyk,T., Sparkes,R.S.,
            Kidd,K.K. and Amara,S.
  TITLE     Assignment of the norepinephrine transporter protein (NET1) locus
            to chromosome 16
  JOURNAL   Genomics 18 (3), 690-692 (1993)
   PUBMED   7905857
REFERENCE   9  (bases 1 to 5933)
  AUTHORS   Bruss,M., Kunz,J., Lingen,B. and Bonisch,H.
  TITLE     Chromosomal mapping of the human gene for the tricyclic
            antidepressant-sensitive noradrenaline transporter
  JOURNAL   Hum Genet 91 (3), 278-280 (1993)
   PUBMED   8478011
REFERENCE   10 (bases 1 to 5933)
  AUTHORS   Pacholczyk,T., Blakely,R.D. and Amara,S.G.
  TITLE     Expression cloning of a cocaine- and antidepressant-sensitive human
            noradrenaline transporter
  JOURNAL   Nature 350 (6316), 350-354 (1991)
   PUBMED   2008212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA853047.1, AK312793.1 and
            AC136621.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 29, 2020 this sequence version replaced NM_001172501.2.
            
            Summary: This gene encodes a member of the sodium:neurotransmitter
            symporter family. This member is a multi-pass membrane protein,
            which is responsible for reuptake of norepinephrine into
            presynaptic nerve terminals and is a regulator of norepinephrine
            homeostasis. Mutations in this gene cause orthostatic intolerance,
            a syndrome characterized by lightheadedness, fatigue, altered
            mentation and syncope. Alternatively spliced transcript variants
            encoding different isoforms have been identified in this
            gene.[provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) has an alternate 3' exon
            including the coding region, as compared to variant 1. The
            resulting isoform (2) is shorter and has a different C-terminus, as
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4368409.360450.1, AK312793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000568943.6/ ENSP00000457473.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               DA853047.1         359-506
            149-2087            AK312793.1         1-1939
            2088-5933           AC136621.2         114403-118248
FEATURES             Location/Qualifiers
     source          1..5933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..5933
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /note="solute carrier family 6 member 2"
                     /db_xref="GeneID:6530"
                     /db_xref="HGNC:HGNC:11048"
                     /db_xref="MIM:163970"
     exon            1..182
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            183..507
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..2087
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     norepinephrine transporter; neurotransmitter transporter;
                     sodium-dependent noradrenaline transporter; solute carrier
                     family 6 member 5; solute carrier family 6
                     (neurotransmitter transporter, noradrenalin), member 2;
                     solute carrier family 6 (neurotransmitter transporter),
                     member 2"
                     /codon_start=1
                     /product="sodium-dependent noradrenaline transporter
                     isoform 2"
                     /protein_id="NP_001165972.1"
                     /db_xref="CCDS:CCDS10754.1"
                     /db_xref="GeneID:6530"
                     /db_xref="HGNC:HGNC:11048"
                     /db_xref="MIM:163970"
                     /translation="MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQC
                     LLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFL
                     IIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSL
                     YYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGV
                     LHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFV
                     LLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNK
                     FDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYP
                     EAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVT
                     FSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQM
                     MGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSM
                     VLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI"
     exon            508..639
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            640..877
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1016
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1151
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1255
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1380
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1493
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1622
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1722
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1823
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1991
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2063
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..5933
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3500..3505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /note="major polyA site"
     regulatory      5786..5791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /note="hexamer: AATAAA"
     polyA_site      5807
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /note="major polyA site"
     regulatory      5911..5916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
                     /note="hexamer: AATAAT"
     polyA_site      5933
                     /gene="SLC6A2"
                     /gene_synonym="NAT1; NET; NET1; SLC6A5"
ORIGIN      
        1 acggccagaa ccagtcagcc cgcgccctgc cggccgcccc gcgcctccag ctcttccccg
       61 gccccgcccg aacgccacac ggcggagccc agccccagcc cgcgccctag agcctgccaa
      121 ggcgccgccg gtcgggggcc ggcagggcgc aaggcaccag ggatcccctc gccgccggac
      181 acagcctcgg cgtgccccca ggaccggtaa agttcctctc gccagccgca tccatgcttc
      241 tggcgcggat gaacccgcag gtgcagcccg agaacaacgg ggcggacacg ggtccagagc
      301 agccccttcg ggcgcgcaaa actgcggagc tgctggtggt gaaggagcgc aacggcgtcc
      361 agtgcctgct ggcgccccgc gacggcgacg cgcagccccg ggagacctgg ggcaagaaga
      421 tcgacttcct gctgtccgta gtcggcttcg cagtggacct ggccaacgtg tggcgcttcc
      481 cctacctctg ctacaagaac ggcggcggtg ccttcttgat cccgtacaca ctgttcctta
      541 tcatcgcggg gatgcccctg ttctacatgg agctggctct gggacagtac aaccgggagg
      601 gggctgccac cgtttggaaa atctgcccat tcttcaaagg cgttggctat gctgtcatcc
      661 tgatcgccct gtacgttggc ttctactaca acgtcatcat cgcctggtca ctctactacc
      721 tcttctcctc cttcaccctc aacctgccct ggaccgactg tggccacacc tggaacagcc
      781 ccaactgtac cgaccccaag ctcctcaatg gctccgtgct tggcaaccac accaagtact
      841 ccaagtacaa gttcacgccg gcagccgagt tttatgagcg tggtgtcctg caccttcacg
      901 agagcagcgg gattcatgac atcggcctgc cccagtggca gctcttgctc tgtctgatgg
      961 tcgtcgtcat cgtcttgtat tttagcctct ggaaaggggt gaagacatca ggaaaggtgg
     1021 tgtggatcac agccacgctg ccttacttcg tgctgttcgt gctcctggtc catggcgtca
     1081 cgctgcccgg agcctccaat ggcatcaatg cctacctgca catcgacttc taccgcttga
     1141 aagaggccac ggtatggatt gatgccgcaa ctcagatatt tttttccttg ggggctggat
     1201 ttggagtatt gattgcattt gccagttaca acaaatttga caacaactgt tacagggatg
     1261 ccctgctgac cagcagcatc aactgtatca ccagcttcgt ctctgggttc gccatcttct
     1321 ccatccttgg ttacatggcc catgaacaca aggtcaacat tgaggatgtg gccacagaag
     1381 gagctggcct agtgttcatc ctgtatccag aggccatttc taccctgtct ggatctacat
     1441 tctgggctgt tgtgtttttc gtcatgctcc tggcgctggg ccttgacagc tcaatgggag
     1501 gcatggaggc tgtcatcacg ggcctggcag atgacttcca ggtcctgaag cgacaccgga
     1561 aactcttcac atttggcgtc accttcagca ctttccttct cgccctgttc tgcataacca
     1621 agggtggaat ttacgtcttg accctcctgg acacctttgc tgcgggcacc tccatccttt
     1681 ttgctgtcct catggaagcc atcggagttt cctggtttta tggagtggac aggttcagca
     1741 acgacatcca gcagatgatg gggttcaggc cgggtctata ctggagactg tgctggaagt
     1801 tcgtcagtcc tgccttcctc ctgttcgtgg ttgtggtcag catcatcaac ttcaagccac
     1861 tcacctacga cgactacatc ttcccgccct gggccaactg ggtggggtgg ggcatcgccc
     1921 tgtcctccat ggtcctggtg cccatctacg tcatctataa gttcctcagc acgcagggct
     1981 ctctttggga gagactggcc tatggcatca cgccagagaa cgagcaccac ctggtggctc
     2041 agagggacat cagacagttc cagttgcaac actggctggc catctgagcc tgcctggagg
     2101 agaaggagga acccccatgc caatgtccag gtcacaggca tccgctgcgc tcccacctcg
     2161 gacaccatct tgggattcct cccctggaag ttgtcctttc tgatcctctc ttcttttccc
     2221 atttacaaat gatttcgtga ctgtagtttt tgttcacctt ctgtgcatct ggcctggggg
     2281 ctgttagctc agaggagagg agcaaacagg aaaatgactt ctgttctgtc cccgctgttt
     2341 tgggggaagt ctctcccact ttgggatcct gctgaagcta ggttcatgag gtcggaaatc
     2401 cccaccacat ttgcctagac tttgggcaca ggagttctta gtccaccaaa tcagagagag
     2461 gatgggcttt tgatcagata cccctcccaa aaaaaaaaaa aactaaaact aaagcaaaaa
     2521 tcaaacaaaa tctggctgag tttagtgggg tggttgggga aggtacatag accctcctct
     2581 tgcccaccct agacagccct ctcatgtctg aacctcagcc tgggagttag atttatttgt
     2641 ctctaaaatg aagtcagtgg atagatgctt tgagggattt tgagtagaaa cattcatagt
     2701 taattttcac tctggccaat ctgagtttga tgtgtgtgtt ctggaacatt cctccagctt
     2761 ttggtggtca gatggcccag agatatgggg gacaggagga agagggtaaa tgaaccacag
     2821 tgagcaggtt ctaggaggta cctgcatcag acaagctggt ggaggccacg tggcaagcca
     2881 catctactga ggcctcatgc tgctcttgct ctgtaagaca cggagcccag aaacccatct
     2941 gcacttcctg agacctgcct ggggaaacgg gggcagggac caagtgaggc ctcatgtgtg
     3001 tcttcaccgt gctgtcctca caaggccagg tgggtgccca aagggagcct gacaggctgt
     3061 tgtgttaatt tattgttctt gcacacctgc acagcctccc tctggggatc ccacctggag
     3121 tggaccaggg gtcttgagaa atggagagtt ggctgcaaaa actctcatgc actagatgtg
     3181 gcaccttgga gggcagggtg agacaagcag cccagaaata ctctctcaag tggaggggag
     3241 aattttgaga gtggatggaa cagtttggtg gtttcagaga atttctaggt ttctacttgg
     3301 atctacttct gatacaaact tgcacttggt gccctctggt ggtgtttagt tttagttccg
     3361 taagagaaat gattcctagt ttgctaaatt ggtggcatct ttgggagggg tttctgttta
     3421 tggttagagt ctcttacacc cttgttggag ggattcttat tctgactgtg ggagctcctg
     3481 ttgcgggatc ttgggaaaaa ataaagaagc cgctgcattc gcacgtcaag aaggtgcttt
     3541 gcctcaaatt ggggtgttgt tgagcctggt ggttcctgca tgaagaggat tatgagggga
     3601 ccagggtggg gcagggagat ggttttgtct cccagggtcc tgaggtttcc ttgctgggtc
     3661 ggggtcctca ggtcattcta tagataaaag agggaaaatc aggagacttt gaatctttct
     3721 gtataaaaag gtcagctgaa tgcctgagac agcccaggtg gcaggtgtct tggagccctg
     3781 tgaacagtga ggcttaagaa tggagaacaa tcaggtcggg gtctgggccc cattagtgac
     3841 tttatatcct cccataaaag gtaacttctt cctaggtgtt accatttttc ttttcgtttt
     3901 ttgtttttgt ttttgtttgt ttgtttgttt gtttgtaata aagcacttta atgcacatta
     3961 cctgccatct gcccagtgag gactgcaggg ctatagcttc tatctcccca tttcccaggt
     4021 gagagaacca aggcccagca ttttagtcac tcttgctcaa ggttttttag caactaacag
     4081 atcgagttgg gccttcaatt cacatccact gactctcagc ccagattatt ttgaatattc
     4141 cctgcacaat agggttcacc ccacccagga ctgtcatttt taaaaaactc attcaaaccg
     4201 caaaggaaaa tttcttagca aaagaacaat gtgttggagg atgggaaggg gcgagagaat
     4261 gccatttatt ttcctctagc tggtttccag agaggaaatt atttagctgc tctcttttga
     4321 tgaaaataat cactctttgg aatagttgga tgtgaaaagc tgagtctact tggttgaaat
     4381 gagagcaaac agtcagcaaa gccttttgca ttagagcagg gtcgtgcttc cgagagagcc
     4441 tgccatttcc tctttgccat ctgcatgtgg ccccttctgc ctccagacat ttgtcccggg
     4501 gtgaatcgga gatgtggtgc tagctgaacc aacaccaaac caacgcagtg gtgctgcctt
     4561 gcggcggaag ttggctcctg aatctgggat gggaacctgg ctccaagcct gggtcccctg
     4621 ggagggtggg ggtacccaga aagcccttgg aagttctcgg ggaggtgctt ggagatcatt
     4681 tgggtttacc tttccaccca catttaatgg agagagagta tgggctttat gttaagtcat
     4741 ctttgacttc ctttttgtag cttgttttta atagcagagg tcacccggga caagggtgct
     4801 gtgtactgta tatgacactt gacgcttttg atattttttc aggtttttaa agaattatta
     4861 tttttcatga aatgtaaaat atcagtttga gaacatcaca tttacgtcta ctcaatgtct
     4921 agttatttag cacccacctt ttagctttca ttctagatga aaacgagaca agggagaagg
     4981 agagctacca actcttgcca gatatcctgc tgaacagaaa tccctgaagc tgccttaatt
     5041 ctcaaaagga gttaccgctc agctgggagc cagttcctgc tatatgatct gttttctagc
     5101 ctcgctaatg tgagactgaa gcattcttac caaagaaatc atttcctagt aaagaagccc
     5161 attgaactca ctttatttgt ttatttcctt cgaaagccac cgaagagaga aaaacagaga
     5221 aggtgtgtag tgtggcggaa aaagcacagc atatagtttt acagacttgg gtctgcagct
     5281 gactagctgg gtggcctggg gatagtggct tcatcttttg gggcttcaag attctttgtc
     5341 tttaaaatca ggggttatat cagatcatca aagttcccat tccattaaag aaaaccctgc
     5401 atgtatccat aatgatgctc tcctgttaaa tttacaatga aggaaacaca tcacttaact
     5461 gtaagaattt cccaaaatga actgatgacc agtgatctct ctatcagaga aatgtcagat
     5521 ttctagcctc cagaactttg atttttctgg acattcaata gttcctcttt ctcagatatt
     5581 tttcaactga tgccagaaac acttggtatt tgtttttaat ccaacccttt tgttttgagg
     5641 ctttggaggg taacacattt tcataccctg tgagtcccag gatccacagc tctgctgtgg
     5701 tcttagaagc cactgaaaca ttggtgaatg tgaagtcact tttggggtgc ctgccctcat
     5761 ccctctgtct ctctgcttcc gtgtaaataa agactgtttc aattgtgtcc tctctgtgtc
     5821 atggactgtt ccaatgtcat gcagatttct gtgtctgata tggattttaa aagttgttct
     5881 ctttgtggaa tataagtgta cagaataata aataatgttt cctgggctgt gta
//
