LOCUS       NM_014037               2904 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens solute carrier family 6 member 16 (SLC6A16), mRNA.
ACCESSION   NM_014037
VERSION     NM_014037.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Farmer,M.K., Robbins,M.J., Medhurst,A.D., Campbell,D.A.,
            Ellington,K., Duckworth,M., Brown,A.M., Middlemiss,D.N., Price,G.W.
            and Pangalos,M.N.
  TITLE     Cloning and characterization of human NTT5 and v7-3: two orphan
            transporters of the Na+/Cl- -dependent neurotransmitter transporter
            gene family
  JOURNAL   Genomics 70 (2), 241-252 (2000)
   PUBMED   11112352
REFERENCE   2  (bases 1 to 2904)
  AUTHORS   Masson,J., Sagne,C., Hamon,M. and El Mestikawy,S.
  TITLE     Neurotransmitter transporters in the central nervous system
  JOURNAL   Pharmacol Rev 51 (3), 439-464 (1999)
   PUBMED   10471414
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG772801.1, AL136856.1 and AW451672.1.
            
            On May 17, 2019 this sequence version replaced NM_014037.2.
            
            Summary: SLC6A16 shows structural characteristics of an Na(+)- and
            Cl(-)-dependent neurotransmitter transporter, including 12
            transmembrane (TM) domains, intracellular N and C termini, and
            large extracellular loops containing multiple N-glycosylation
            sites.[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            CDS exon combination :: AF151977.1, AL136856.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335875.9/ ENSP00000338627.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               BG772801.1         34-195
            163-2894            AL136856.1         1-2732
            2895-2904           AW451672.1         16-25               c
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2904
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /note="solute carrier family 6 member 16"
                     /db_xref="GeneID:28968"
                     /db_xref="HGNC:HGNC:13622"
                     /db_xref="MIM:607972"
     exon            1..144
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            145..623
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2419
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 16; CTC-301O7.4"
                     /codon_start=1
                     /product="orphan sodium- and chloride-dependent
                     neurotransmitter transporter NTT5"
                     /protein_id="NP_054756.2"
                     /db_xref="CCDS:CCDS42590.1"
                     /db_xref="GeneID:28968"
                     /db_xref="HGNC:HGNC:13622"
                     /db_xref="MIM:607972"
                     /translation="MKTEAQPSTSLLANTSWTGTVISDSVPGSQTWEDKGSLTRSATS
                     WTSEAQVSAARVAEAQARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLA
                     RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLE
                     MAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFP
                     VPWEKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCW
                     CLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVY
                     NMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFN
                     FCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLP
                     QHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAM
                     GLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLS
                     DYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLI
                     IFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCR
                     IHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEILQVDETKYPSTCNVTS"
     exon            624..781
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            782..908
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1084
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1195
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1437
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1624
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1826
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1986
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2149
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2904
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2752..2757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /note="hexamer: AATAAA"
     polyA_site      2777
                     /gene="SLC6A16"
                     /gene_synonym="NT5; NTT5"
                     /note="major polyA site"
ORIGIN      
        1 agatcgaggg gtgtcgccca aaccgatctg tcgacgcctg aaggggcctg aggagattgc
       61 taggcttctc agctggggct tcttcaccct catttttgtc cgactggctg gactgaagaa
      121 cctggcagaa gccttggggc tagggtctcc tcaggaagat gaaccctccc ttgcagaagc
      181 gggagctgcc ccagagagtc tgtgtgagat gaagacagag gcccagcctt cgacatcctt
      241 gctggcaaac acctcatgga ctggcacagt gatttctgac agtgtcccag gaagtcaaac
      301 gtgggaagac aagggttcat tgacccggtc tgcaacatct tggacctcag aggcccaagt
      361 ttcagcagcc cgggttgcag aggctcaggc caggaccagt cagcccaagc aaatttctgt
      421 attggaggcg ttaactgcct cagccctgaa ccagaaaccc acgcatgaga aggtgcagat
      481 gacagagaag aaagagagtg aggtcctcct tgcccgtccg ttctggtcca gcaaaactga
      541 gtatattctg gctcaggtgg gcttctctat gaagccatct tgtctctggc gctttgccta
      601 cctgtggctt aacagtggag gctgcagttt cgctgccatc tacatcttca tgctgttcct
      661 ggtcggggtt cctcttctct tcctggagat ggcagctggt cagagcatgc gtcagggtgg
      721 catgggtgta tggaagatca ttgccccctg gattggtggt gtggggtatt ctagcttcat
      781 ggtgtgcttc atcctcggcc tgtacttcaa tgtggtcaat tcctggatca tcttctacat
      841 gagccagtcc ttccagtttc ccgttccatg ggagaaatgt cccttaacga tgaactctag
      901 tggctttgat cctgaatgtg aacggacaac accctccata tacttctggt accagcaggc
      961 cttgaaggcc tcagacagaa tcgaggatgg cgggtcacca gtctacagtc tggtcctgcc
     1021 cttctttctt tgctggtgtc ttgttggtgc tttcatgatc aatgggctca agtccactgg
     1081 gaaggtaatc tatgtcttgg tactgctccc ctgtttcatc attgtcggtt tcttcatccg
     1141 gactctactc ctggaagggg caaaatttgg ccttcaacag ttggtggttg ccaagatatc
     1201 ggatgtgtac aatatgagtg tgtggtctct agcagggggt caagttttgt ctaacacagg
     1261 cataggcctt ggctccgttg cctccttagc ctcctacatg ccccagtcca acaactgtct
     1321 cagtgatgcc tttctcgtgt ctgtgataaa cctgctcact ttgttggttt tcacatcttt
     1381 caacttctgt gtcctgggct tctgggcgac agtcatcaca catcgctgct gtgagaggaa
     1441 tgctgaaata cttttaaagc tgataaacct agggaaactg cctcctgatg ccaagccccc
     1501 tgtcaacctg ctttacaacc caacctccat ctacaatgcc tggctcagtg gccttcccca
     1561 gcacatcaaa agcatggttc tccgcgaggt gactgagtgc aacatagaga ctcagtttct
     1621 taaggctagc gagggcccaa agtttgcatt cctgtccttt gttgaagcca tgtccttcct
     1681 tcctccgtct gtcttctggt cttttatctt cttcctgatg ttgctggcca tggggctgag
     1741 cagcgcaata gggattatgc agggcatcat tactccactc caggacacct tctctttctt
     1801 caggaaacat acaaagctgc tcatagtggg agtctttttg ctcatgttcg tgtgcggcct
     1861 cttcttcact cgaccttcag gcagctactt catcagactg ctgagtgact actggatagt
     1921 cttccccatc atcgtcgttg tcgtatttga aaccatggct gtatcctggg cctatggggc
     1981 caggaggttc cttgcagacc tgacgatcct gttgggccac cccatctctc ccatctttgg
     2041 ttggctgtgg ccccatctgt gtccagttgt gctgctaatc atctttgtga ccatgatggt
     2101 tcatctttgt atgaagccga tcacctacat gtcctgggac tcaagcacct caaaagaggt
     2161 gcttcgacca tacccaccgt gggcactgct cttgatgatc accctttttg ccattgtcat
     2221 cctccccatc cctgcatact ttgtatactg ccgcatacat aggattccct tcaggcccaa
     2281 gagcggagac gggcctatga cagcctccac atccctaccc ctaagtcacc agctaacacc
     2341 cagtaaagag gttcaaaagg aagaaattct acaagttgat gaaacaaagt acccatcaac
     2401 ttgtaatgtg acttcctaac ttcattaatt tggcttcaca taacatatcc cttagaacag
     2461 atccaataga caactcttaa tatcagcttg caactgttga tctccctgga tccagaacca
     2521 cttttatttc caagaggagg ggcattcttt gggggtgttc atggggcctg gacttgcaat
     2581 cccttcctgg gtcccatctt acctggtgac caccatcatt gttttcccca tcctcttcct
     2641 caacacacat acatgcacaa cacatataca atactagtga tgtctaccag tcctgctact
     2701 tctggggtgc ctgtctcctg gaatggagct ggaggagcaa tgctgttggt gaataaatca
     2761 gtctactgga actccaagga ctggatgtaa gcagatcttt ttttcctata gatgtctcag
     2821 atgttcagtt ttcctgtcac aaggcttcca gtctgtatta gttcattttc acactgctaa
     2881 taaagacata cctgaaactg ggaa
//
