LOCUS       NM_182767               4799 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 6 member 15 (SLC6A15),
            transcript variant 1, mRNA.
ACCESSION   NM_182767
VERSION     NM_182767.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4799)
  AUTHORS   Chen,Y., Li,H., Liang,W., Guo,Y., Peng,M., Ke,W., Xiao,H., Guan,H.
            and Li,Y.
  TITLE     SLC6A15 acts as a tumor suppressor to inhibit migration and
            invasion in human papillary thyroid cancer
  JOURNAL   J Cell Biochem 122 (8), 814-826 (2021)
   PUBMED   33690923
  REMARK    GeneRIF: SLC6A15 acts as a tumor suppressor to inhibit migration
            and invasion in human papillary thyroid cancer.
REFERENCE   2  (bases 1 to 4799)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4799)
  AUTHORS   Haydar,S., Grigorescu,F., Vintila,M., Cogne,Y., Lautier,C.,
            Tutuncu,Y., Brun,J.F., Robine,J.M., Pugeat,M., Normand,C.,
            Poucheret,P., Gheorghiu,M.L., Georgescu,C., Badiu,C., Baculescu,N.,
            Renard,E., Ylli,D., Badiou,S., Sutra,T., Cristol,J.P., Mercier,J.,
            Gomis,R., Macias,J.M., Litvinov,S., Khusnutdinova,E., Poiana,C.,
            Pasquali,R., Lauro,D., Sesti,G., Prudente,S., Trischitta,V.,
            Tsatsoulis,A., Abdelhak,S., Barakat,A., Zenati,A., Ylli,A.,
            Satman,I., Kanninen,T., Rinato,Y. and Missoni,S.
  TITLE     Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes
            indicates association with insulin resistance of metabolic syndrome
            and relationship with branched chain amino acid metabolism or
            regulation
  JOURNAL   PLoS One 14 (3), e0214122 (2019)
   PUBMED   30913280
  REMARK    GeneRIF: Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and
            PRKCA genes indicates association with insulin resistance of
            metabolic syndrome and relationship with branched chain amino acid
            metabolism or regulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4799)
  AUTHORS   Wang,L., Liu,Z., Cao,X., Li,J., Zhang,A., Sun,N., Yang,C. and
            Zhang,K.
  TITLE     A Combined Study of SLC6A15 Gene Polymorphism and the Resting-State
            Functional Magnetic Resonance Imaging in First-Episode Drug-Naive
            Major Depressive Disorder
  JOURNAL   Genet Test Mol Biomarkers 21 (9), 523-530 (2017)
   PUBMED   28915082
  REMARK    GeneRIF: We observed an association between the SLC6A15 rs1545843
            and resting-state brain function of the corpus callosum, cingulum
            and the frontal, parietal, and temporal lobes in MDD patients,
            which may be involved in the pathogenesis of Major Depressive
            Disorder. There was no interaction between rs1545843 genotypes and
            disease status.
REFERENCE   5  (bases 1 to 4799)
  AUTHORS   Zaia,K.A. and Reimer,R.J.
  TITLE     Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled
            Neutral Amino Acid Transport
  JOURNAL   J Biol Chem 284 (13), 8439-8448 (2009)
   PUBMED   19147495
  REMARK    GeneRIF: The substrate profile of the NTT4/XT1-dependent activity
            is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15),
            including a submillimolar apparent affinity for proline and leucine
            and a low millimolar apparent affinity for glutamine.
REFERENCE   6  (bases 1 to 4799)
  AUTHORS   Broer,S.
  TITLE     Amino acid transport across mammalian intestinal and renal
            epithelia
  JOURNAL   Physiol Rev 88 (1), 249-286 (2008)
   PUBMED   18195088
  REMARK    Review article
REFERENCE   7  (bases 1 to 4799)
  AUTHORS   Broer,A., Tietze,N., Kowalczuk,S., Chubb,S., Munzinger,M., Bak,L.K.
            and Broer,S.
  TITLE     The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral
            amino acid transporter (B0AT2)
  JOURNAL   Biochem J 393 (Pt 1), 421-430 (2006)
   PUBMED   16185194
REFERENCE   8  (bases 1 to 4799)
  AUTHORS   Takanaga,H., Mackenzie,B., Peng,J.B. and Hediger,M.A.
  TITLE     Characterization of a branched-chain amino-acid transporter SBAT1
            (SLC6A15) that is expressed in human brain
  JOURNAL   Biochem Biophys Res Commun 337 (3), 892-900 (2005)
   PUBMED   16226721
  REMARK    GeneRIF: SBAT1-mediated transport of BCAA, particularly leucine,
            may be an important source of amino nitrogen for neurotransmitter
            synthesis in glutamatergic and GABAergic neurons.
REFERENCE   9  (bases 1 to 4799)
  AUTHORS   Farmer,M.K., Robbins,M.J., Medhurst,A.D., Campbell,D.A.,
            Ellington,K., Duckworth,M., Brown,A.M., Middlemiss,D.N., Price,G.W.
            and Pangalos,M.N.
  TITLE     Cloning and characterization of human NTT5 and v7-3: two orphan
            transporters of the Na+/Cl- -dependent neurotransmitter transporter
            gene family
  JOURNAL   Genomics 70 (2), 241-252 (2000)
   PUBMED   11112352
REFERENCE   10 (bases 1 to 4799)
  AUTHORS   Masson,J., Sagne,C., Hamon,M. and El Mestikawy,S.
  TITLE     Neurotransmitter transporters in the central nervous system
  JOURNAL   Pharmacol Rev 51 (3), 439-464 (1999)
   PUBMED   10471414
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA247242.1, AF265577.1, AC018922.22 and AI368909.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182767.5.
            
            Summary: This gene encodes a member of the solute carrier family 6
            protein family which transports neutral amino acids. The encoded
            protein is thought to play a role in neuronal amino acid transport
            (PMID: 16185194) and may be associated with major depression (PMID:
            21521612). Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.81153.1,
                                           SRR1660803.227168.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266682.10/ ENSP00000266682.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               DA247242.1         29-493
            466-2658            AF265577.1         1-2193
            2659-4439           AC018922.22        112559-114339       c
            4440-4799           AI368909.1         13-372              c
FEATURES             Location/Qualifiers
     source          1..4799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..4799
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /note="solute carrier family 6 member 15"
                     /db_xref="GeneID:55117"
                     /db_xref="HGNC:HGNC:13621"
                     /db_xref="MIM:607971"
     exon            1..277
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            278..754
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..2658
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homolog of rat orphan transporter v7-3; solute carrier
                     family 6 (neurotransmitter transporter), member 15;
                     sodium/chloride dependent neurotransmitter transporter
                     Homo sapiens orphan neurotransmitter transporter NTT7;
                     orphan sodium- and chloride-dependent neurotransmitter
                     transporter NTT73; sodium-dependent neutral amino acid
                     transporter B(0)AT2; sodium-coupled branched-chain
                     amino-acid transporter 1; solute carrier family 6 (neutral
                     amino acid transporter), member 15"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT2 isoform 1"
                     /protein_id="NP_877499.1"
                     /db_xref="CCDS:CCDS9026.1"
                     /db_xref="GeneID:55117"
                     /db_xref="HGNC:HGNC:13621"
                     /db_xref="MIM:607971"
                     /translation="MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQ
                     EEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLP
                     YLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNV
                     IIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSI
                     SESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLN
                     GSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA
                     VLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHH
                     INLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAM
                     THFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCI
                     GLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPS
                     RYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVS
                     LVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIP
                     SEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADIMPDMPESDL"
     exon            755..912
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1039
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1221
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1332
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1574
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1767
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1960
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2120
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2283
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..4799
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /note="hexamer: AATAAA"
     polyA_site      3640
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /note="major polyA site"
     regulatory      4555..4560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /note="hexamer: AATAAA"
     polyA_site      4588
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
                     /note="hexamer: AATAAA"
     polyA_site      4799
                     /gene="SLC6A15"
                     /gene_synonym="hv7-3; NTT73; SBAT1; V7-3"
ORIGIN      
        1 atacgcatgt acacgcgcac ccgcacccgc gcgcctgtat cccgtgctgt ttccctggca
       61 gacacacagg cgctcacgag tctctccttg ccagcctgca gggcggcgac ccccaaaacc
      121 cagctccggg tcccaaccta ggcaagaagc tgcttctctg ccaacagctc ctcttcggcc
      181 tccgtcacag ccacctggac cctacccttt cgcgactgct gctgctgctg cccggacgtg
      241 gaagcagcaa gaggcgcttg gtcaagacac actgacggta cctacagaat actggacata
      301 cggattcaga atccataagg ctttatcacc ttgaatcaag gatttatttg atatcatcct
      361 cggtctttac ttcctatcaa gtaacattgt tttgaaaaat agagttaaca catttgccat
      421 aagggagttt tttttttttt ttttaaatac ttcgcatact ctccaatgcc caaaaatagc
      481 aaggtggtaa aaagagaatt agatgatgat gttactgagt ctgtcaaaga ccttctttcc
      541 aatgaagacg cagctgatga tgcttttaag acaagtgaac taattgttga tggccaggaa
      601 gagaaagata cagatgttga agaaggatct gaagtcgaag atgaaagacc agcttggaac
      661 agtaaactac aatacatcct ggcccaagtt ggattttctg taggtttagg aaatgtgtgg
      721 cgatttccat acctatgtca gaagaatggg ggcggtgcat atcttttacc atatttaata
      781 ctacttatgg taataggtat tccccttttt ttcttggaac tctctgtggg tcaaagaatt
      841 cggcgaggca gcattggtgt atggaattac ataagcccta aactgggcgg gattggattt
      901 gcaagttgtg tagtgtgcta ttttgtagct ctctactaca acgtcatcat tggctggagt
      961 ttgttttatt tttctcagtc ttttcagcaa cccctgcctt gggatcagtg tcctttggtg
     1021 aaaaatgctt cacacacttt tgtagaacca gaatgtgaac aaagttctgc caccacctat
     1081 tactggtaca gggaagcact gaatatttca agttccattt ctgaaagtgg gggcttaaac
     1141 tggaagatga ccatctgctt gttggctgcc tgggtcatgg tttgcttggc tatgatcaaa
     1201 ggcattcagt cttctggaaa aatcatatat tttagttctc tgtttccata tgtggtactt
     1261 atttgcttcc tcatcagagc attcctttta aatggttcaa ttgatggcat tcgccacatg
     1321 tttaccccta agcttgaaat aatgctggag cccaaggtct ggagagaagc tgctactcaa
     1381 gtgttctttg ccttaggtct gggatttggt ggtgtcattg ccttttcaag ctacaacaag
     1441 agagacaaca actgccactt tgatgctgtc ctggtgtcct tcatcaattt tttcacttct
     1501 gtcctggcaa cattggtggt gtttgcagtt ctgggcttca aagcaaatgt cataaatgag
     1561 aaatgcatta cacaaaattc agagacgatc atgaaatttt tgaaaatggg gaacattagt
     1621 caggatatta ttccccatca tatcaacctt tcaactgtta ctgcagaaga ttatcattta
     1681 gtttatgaca tcattcaaaa agtgaaagaa gaagagtttc ctgctcttca tctcaattcc
     1741 tgtaaaattg aagaagagct aaataaagct gttcagggga ccggcttagc ttttattgcc
     1801 tttacagaag cgatgacaca ttttcctgca tctcccttct ggtcagtgat gtttttcctc
     1861 atgctggtca atctaggcct tggcagtatg tttggaacca ttgaagggat tgtcacgcct
     1921 attgtggaca ctttcaaagt gaggaaagaa attcttactg ttatctgttg tcttctggca
     1981 ttttgtattg gcctgatatt tgtgcaacgc tctggaaatt actttgttac aatgtttgat
     2041 gattattctg ctacactgcc tctgctaatt gtagtcattt tggagaatat tgctgtatgc
     2101 tttgtttatg gcatagataa gtttatggaa gacctaaaag atatgctggg ctttgctccc
     2161 agcagatatt actactatat gtggaaatat atttctcctc taatgctatt atcattgcta
     2221 atagctagtg ttgtgaatat gggattaagt cctcctggct ataacgcatg gattgaagat
     2281 aaggcatctg aagaatttct gagctatcca acatggggac tggttgtttg tgtctctctg
     2341 gttgtctttg caatactccc agtccctgta gttttcattg ttcgtcgctt caaccttata
     2401 gatgatagtt ctggtaattt agcatctgtg acctataaga gaggaagggt cctgaaagag
     2461 cctgtgaact tagagggcga tgatacaagc ctcattcacg gaaaaatacc gagcgagatg
     2521 ccatctccaa attttggtaa aaatatttat cgaaaacaga gtggatcccc aactctggat
     2581 actgctccca atggacggta tggaataggg tacttgatgg cagatattat gccagatatg
     2641 ccagaatctg atttgtagct gggggaaaag tcagtgggtt ttatttggtt catttttacc
     2701 aatgaacatt ggccctagta ggagaagcat taggcttcac ttatcagagg gcaatctcag
     2761 gtgttccgtg gctgtgatct ttaatcctaa cagtatatgt cagttcaact tgagcattct
     2821 tttggattct ttggtttaca tttgtgcaga aaggattgca gacaaatctt aggagggctg
     2881 aggtacatgt ttgccaggat ttttttttaa gtacctttgg tgtattttca aatatttcta
     2941 tctcttaaaa aaatggtatt acctcagttt ctaataattt ctgggtttag tagtgttgac
     3001 aattaaaaat ggtatacatt aaaatttata agtttgcctt cagggtaact tccagtgtca
     3061 caatgagcag ttctgtaagt gggtgcctct cagcacattt ctatgaatat attatgtaga
     3121 taggctgtat tgattttggt agcattgaca ccttcttagg caattagttg aagaaaactg
     3181 caaaatattt tcttatgtaa tagctgtata gagcaatagc aatcaaagca tgagaaggca
     3241 ctaacgctgg gatgaaagat gagattcaga ggtgactgag aatcatgtga gtgatggctg
     3301 tatattttgt gtaaaatata tgtgtgaaaa tgaactaaga gtgagttact cagcactctc
     3361 aagaattatg cagattctgc atttttctta tgccgtgtgc ctaaaaacct acttgatatt
     3421 tattgtggtt tcaagattat tcatagtata tttatacaat atacttgcaa tgcatttaag
     3481 tacttaaagt actaatttga aaacttgaag caagatggca ttttaattaa tatatttctg
     3541 ttttgcttct gttttatgca aatataaatc atttttaagt gattgttaaa attgtaatgc
     3601 attacatttt aatctacaaa taaacaaagt ttaaaaatga tgtttgtttt tcacattgat
     3661 tttctttgta tcacctgaac tggattgtct ttcatttcag tcagcactta gacatttcat
     3721 aataactaaa catcacattc caagtgggat gaattacatt aattgaatag agttaccacc
     3781 gcttcagagt ctaaggaaaa atagagtatt atggttcaat ggtgttctta tgtagtctta
     3841 tgattcttga aaaagtactt acagcctccc aagaaaccat gtgtacaatt gactgcttgc
     3901 tgattcaata ttgtctgcaa agtataaaag actatgattt ttaaataaaa ctgttgtata
     3961 tatgaaattg gatagagcag aggaacctca ctgagtgtcc tctagttaaa aatctttcat
     4021 ttatcctacc accagatcag ttacattttt aaaacaatga tggatatagc agcaaaataa
     4081 gtgaggtaat acacatgcca tatcaattga tttatttcag ccagtattct cgctctgcta
     4141 tagatagatg ttaataaatg gtatcacagc atttaaagta ttaaatccac tggtgcataa
     4201 atttttagtc ttttaaaata tattcatgaa tattgtgttt gtatcccttt aaaatgttta
     4261 atattttata aataggcagt atatgcacat tatacaaaac taaaaaatta tgacaattca
     4321 gtgtgaagta agttctcatc caacatttct cctggccatc cattctccat ctttaaaggc
     4381 aatcaccatt gccagtttct tctgtatcct tctggaaata caatatatta cataaatgac
     4441 agcattctat attctctctt ctatatctta cctatttctg tgaataattt attttggaca
     4501 gcattttatg tatgaatatt cacaaatgtg cttccttatt tcagaggctg aactaataaa
     4561 aattttgttt atttttgtgt tgaggcaata tttttatatg gtaccctaat ctttaatact
     4621 taacctgcca gactttaacc gtaacacaat aatgtattgc caaatagcac cattcttctt
     4681 ctctcactct cttgccatgg gggctcttaa aaaaaaaagt atacatctaa ggtgtacaac
     4741 atgctgtttt gatgtatata aatatagtga aagcaaataa agtatatatc taaggtgta
//
