LOCUS       NM_007231               4536 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 6 member 14 (SLC6A14), mRNA.
ACCESSION   NM_007231
VERSION     NM_007231.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4536)
  AUTHORS   Dang,C., Bian,Q., Wang,F., Wang,H. and Liang,Z.
  TITLE     Machine learning identifies SLC6A14 as a novel biomarker promoting
            the proliferation and metastasis of pancreatic cancer via
            Wnt/beta-catenin signaling
  JOURNAL   Sci Rep 14 (1), 2116 (2024)
   PUBMED   38267509
  REMARK    GeneRIF: Machine learning identifies SLC6A14 as a novel biomarker
            promoting the proliferation and metastasis of pancreatic cancer via
            Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4536)
  AUTHORS   Gu,Q., Xia,H., Song,Y.Q., Duan,J., Chen,Y., Zhang,Y., Chen,H.P. and
            Zhang,L.
  TITLE     SLC6A14 promotes ulcerative colitis progression by facilitating
            NLRP3 inflammasome-mediated pyroptosis
  JOURNAL   World J Gastroenterol 30 (3), 252-267 (2024)
   PUBMED   38314135
  REMARK    GeneRIF: SLC6A14 promotes ulcerative colitis progression by
            facilitating NLRP3 inflammasome-mediated pyroptosis.
REFERENCE   3  (bases 1 to 4536)
  AUTHORS   Chen,Y., Yan,W., Chen,Y., Zhu,J., Wang,J., Jin,H., Wu,H., Zhang,G.,
            Zhan,S., Xi,Q., Shi,T. and Chen,W.
  TITLE     SLC6A14 facilitates epithelial cell ferroptosis via the
            C/EBPbeta-PAK6 axis in ulcerative colitis
  JOURNAL   Cell Mol Life Sci 79 (11), 563 (2022)
   PUBMED   36272033
  REMARK    GeneRIF: SLC6A14 facilitates epithelial cell ferroptosis via the
            C/EBPbeta-PAK6 axis in ulcerative colitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4536)
  AUTHORS   Guo,Q., Xu,W., Li,X., Sun,J.L., Gu,X.C. and Jing,F.B.
  TITLE     SLC6A14 Depletion Contributes to Amino Acid Starvation to Suppress
            EMT-Induced Metastasis in Gastric Cancer by Perturbing the
            PI3K/AKT/mTORC1 Pathway
  JOURNAL   Biomed Res Int 2022, 7850658 (2022)
   PUBMED   35865664
  REMARK    GeneRIF: SLC6A14 Depletion Contributes to Amino Acid Starvation to
            Suppress EMT-Induced Metastasis in Gastric Cancer by Perturbing the
            PI3K/AKT/mTORC1 Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4536)
  AUTHORS   Wang,F., Panjwani,N., Wang,C., Sun,L. and Strug,L.J.
  TITLE     A flexible summary statistics-based colocalization method with
            application to the mucin cystic fibrosis lung disease modifier
            locus
  JOURNAL   Am J Hum Genet 109 (2), 253-269 (2022)
   PUBMED   35065708
  REMARK    GeneRIF: A flexible summary statistics-based colocalization method
            with application to the mucin cystic fibrosis lung disease modifier
            locus.
REFERENCE   6  (bases 1 to 4536)
  AUTHORS   Gupta,N., Miyauchi,S., Martindale,R.G., Herdman,A.V., Podolsky,R.,
            Miyake,K., Mager,S., Prasad,P.D., Ganapathy,M.E. and Ganapathy,V.
  TITLE     Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in
            colorectal cancer and metastasis in humans
  JOURNAL   Biochim Biophys Acta 1741 (1-2), 215-223 (2005)
   PUBMED   15905073
  REMARK    GeneRIF: The up-regulation of SLC6A14 may have a pathogenic role in
            colorectal neoplasms.
REFERENCE   7  (bases 1 to 4536)
  AUTHORS   Durand,E., Boutin,P., Meyre,D., Charles,M.A., Clement,K., Dina,C.
            and Froguel,P.
  TITLE     Polymorphisms in the amino acid transporter solute carrier family 6
            (neurotransmitter transporter) member 14 gene contribute to
            polygenic obesity in French Caucasians
  JOURNAL   Diabetes 53 (9), 2483-2486 (2004)
   PUBMED   15331564
  REMARK    GeneRIF: association of the SLC6A14 gene locus with obesity.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Diabetes. 2005 Feb;54(2):587]
REFERENCE   8  (bases 1 to 4536)
  AUTHORS   Suviolahti,E., Oksanen,L.J., Ohman,M., Cantor,R.M.,
            Ridderstrale,M., Tuomi,T., Kaprio,J., Rissanen,A., Mustajoki,P.,
            Jousilahti,P., Vartiainen,E., Silander,K., Kilpikari,R.,
            Salomaa,V., Groop,L., Kontula,K., Peltonen,L. and Pajukanta,P.
  TITLE     The SLC6A14 gene shows evidence of association with obesity
  JOURNAL   J Clin Invest 112 (11), 1762-1772 (2003)
   PUBMED   14660752
  REMARK    GeneRIF: SLC6A14 gene is an interesting novel candidate for obesity
            because it encodes an amino acid transporter, which potentially
            regulates tryptophan availability for serotonin synthesis and thus
            possibly affects appetite control.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4536)
  AUTHORS   Sloan,J.L., Grubb,B.R. and Mager,S.
  TITLE     Expression of the amino acid transporter ATB 0+ in lung: possible
            role in luminal protein removal
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 284 (1), L39-L49 (2003)
   PUBMED   12388375
REFERENCE   10 (bases 1 to 4536)
  AUTHORS   Sloan,J.L. and Mager,S.
  TITLE     Cloning and functional expression of a human Na(+) and
            Cl(-)-dependent neutral and cationic amino acid transporter B(0+)
  JOURNAL   J Biol Chem 274 (34), 23740-23745 (1999)
   PUBMED   10446133
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313390.1, BC093710.1,
            AF151978.1, DB207722.1, AC241580.2 and BU686768.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007231.4.
            
            Summary: This gene encodes a member of the solute carrier family 6.
            Members of this family are sodium and chloride dependent
            neurotransmitter transporters. The encoded protein transports both
            neutral and cationic amino acids. This protein may also function as
            a beta-alanine carrier. Mutations in this gene may be associated
            with X-linked obesity. A pseudogene of this gene is found on
            chromosome X.[provided by RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151978.1, AK313390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598581.3/ ENSP00000470801.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1622              AK313390.1         30-1651
            1623-2108           BC093710.1         1541-2026
            2109-2595           AF151978.1         2093-2579
            2596-2725           DB207722.1         364-493
            2726-2762           DB207722.1         495-531
            2763-4147           AC241580.2         94867-96251
            4148-4536           BU686768.1         17-405              c
FEATURES             Location/Qualifiers
     source          1..4536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..4536
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /note="solute carrier family 6 member 14"
                     /db_xref="GeneID:11254"
                     /db_xref="HGNC:HGNC:11047"
                     /db_xref="MIM:300444"
     exon            1..152
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2033
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /note="amino acid transporter B0+; solute carrier family 6
                     (neurotransmitter transporter), member 14; amino acid
                     transporter ATB0+; solute carrier family 6 (amino acid
                     transporter), member 14"
                     /codon_start=1
                     /product="sodium- and chloride-dependent neutral and basic
                     amino acid transporter B(0+)"
                     /protein_id="NP_009162.1"
                     /db_xref="CCDS:CCDS14570.1"
                     /db_xref="GeneID:11254"
                     /db_xref="HGNC:HGNC:11047"
                     /db_xref="MIM:300444"
                     /translation="MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSD
                     YLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASL
                     GPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWS
                     DKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYW
                     NKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVL
                     LILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALS
                     SYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAF
                     IAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPI
                     TLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIE
                     DTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALG
                     WCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDMVDP
                     KKEADHEIPTVSGSRKPE"
     exon            153..318
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            319..450
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            451..612
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            613..760
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            761..893
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1034
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1263
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1389
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1508
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1608
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1718
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1886
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..4536
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4516..4521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /note="hexamer: ATTAAA"
     polyA_site      4536
                     /gene="SLC6A14"
                     /gene_synonym="BMIQ11"
                     /note="major polyA site"
ORIGIN      
        1 ggctcactct ggcaggtagg aacaggggag agtgcacctg ctaccagtca agctcagcca
       61 gactgcaaga ggaggcgagg cggagccagc cgagggagtg aaccatggac aagttgaaat
      121 gcccgagttt cttcaagtgc agggagaagg agaaagtgtc ggcttcatca gagaatttcc
      181 atgttggtga aaatgatgag aatcaggacc gtggtaactg gtccaaaaaa tcggattatc
      241 ttctatctat gattggatac gcagtgggat taggaaatgt gtggagattt ccatatctga
      301 cctacagcaa tggtggaggc gccttcttga taccttatgc aattatgtta gcattggctg
      361 gtttaccttt gttctttctg gagtgttcac tgggacaatt tgctagctta ggtccagttt
      421 cagtttggag gattcttcca ttgtttcaag gtgtgggaat tacaatggtc ctgatctcca
      481 tttttgtgac aatctattac aatgtcataa ttgcctatag tctttactac atgtttgctt
      541 cttttcaaag tgaactacca tggaaaaatt gttcttcgtg gtcagataaa aactgtagca
      601 gatcaccaat agtaactcac tgtaatgtga gtacagtgaa taaaggaata caagagatca
      661 tccaaatgaa taaaagctgg gtagacatca acaattttac ctgcatcaac ggcagtgaaa
      721 tttatcagcc agggcagctt cccagtgaac aatattggaa taaagtggcg ctccaacggt
      781 caagtggaat gaatgagact ggagtaattg tttggtattt agcactttgt cttcttctgg
      841 cttggctcat agttggagca gcactattta aaggaatcaa atcgtctggc aaggtggtat
      901 attttacagc tcttttcccc tatgtggtcc tactcatcct gttagtacga ggtgcaactc
      961 tggagggtgc ttcaaaaggc atttcatact atattggagc ccagtcaaat tttacaaaac
     1021 ttaaggaagc tgaggtatgg aaagatgctg ccactcagat attttactcc ctttcagtgg
     1081 cttggggtgg cttagttgct ctatcatctt acaataagtt caaaaacaac tgcttctctg
     1141 atgccattgt ggtttgtttg acaaactgtc tcactagcgt gtttgctgga tttgctattt
     1201 tttctatatt gggacacatg gcccatatat ctggaaagga agtttctcaa gttgtaaaat
     1261 caggttttga tttggcattc attgcctatc cagaggctct agcccaactc ccaggtggtc
     1321 cattttggtc catattattt tttttcatgc ttttaacttt gggtctcgat tctcagtttg
     1381 cttcgattga aacgatcaca acaacaattc aagatttatt tcccaaagtg atgaagaaaa
     1441 tgagggttcc cataactttg ggctgctgct tggttttgtt tctccttggt ctcgtctgtg
     1501 tgactcaggc tggaatttac tgggttcatc tgattgacca cttctgtgct ggatggggca
     1561 ttttaattgc agctatactg gagctagttg gaatcatctg gatttatgga gggaacagat
     1621 tcattgagga tacagaaatg atgattggag caaagaggtg gatattctgg ctatggtgga
     1681 gagcttgctg gtttgtaatt acgcctatcc ttttgattgc aatatttatc tggtcattgg
     1741 tgcaatttca tagacctaat tatggcgcaa ttccataccc tgactgggga gttgctttag
     1801 gctggtgtat gattgttttc tgcattattt ggattccaat tatggctatc ataaaaataa
     1861 ttcaggctaa aggaaacatc tttcaacgcc ttataagttg ctgcagacca gcttctaact
     1921 ggggtccata cctggaacaa catcgtgggg aaagatataa agacatggta gatcctaaaa
     1981 aagaggctga ccatgaaata cctactgtta gtggcagcag aaaaccggaa tgagatctca
     2041 ttgaaaaaaa tatatgattg tataatgtga ttttttttag aataggggga accttattta
     2101 tttgtgtgtt aactgaatag gaaaatgtac atactatgtt catgatagtg tgattttttt
     2161 cacatttaag caggaatgca atataaaaat gtgaatctct taattctcag ccatgtgctt
     2221 attatatttc tttttagatt gtctatctgt ataacacaca cacacacacc taagagtctc
     2281 tatttcacaa ttatattttt gtaaatagta tatgcatttt taatacattg gaggctttat
     2341 tttgaactaa tttcttagag aatagttata ttttctatta cacaagttta aaaatattat
     2401 taacttgtat tttcttaata tacaatctat cttttccaca aatatgagtg ggaaataaat
     2461 cagcacattt gaaagaaagt gttaaaactg aaggcctcac ttaattagaa acgtgataaa
     2521 tatatggaca aatggactat acatactata agaggactgt agtttaatac tttttaccca
     2581 aatatgttta aaaacttcgt gcatttgtta cagctcatgt tttctatatg aacttagtca
     2641 ttaatgttct ttataaaaag tgaaataaga tggaaaaata aggatcctac agccagtaag
     2701 tgataaatct agaaaattga gttttgagta cctcttttcc catatacaat cttccttcct
     2761 taggtaattt ggaagaaaac tatgacccat ttaatttcta ttgtgtttca caaaattaag
     2821 tgttgttcat tatactctct gaaatatagg tttaatttca aatagaatat ggacttaaat
     2881 gttaatgaga aaatggcttt aatcaattct agcattttat tactgtaata cagggctgat
     2941 agagtgattt tgtcttatat gagtaagtta ctacttacag gtgataactt gcatactatt
     3001 ggaagataaa cttgtcaaac ttgtcaagaa tgagaaaagc caaattagaa aatcctatgt
     3061 cctagtttcc ttaccaagga taattaaata tatcactaag agctttatat attgattata
     3121 tattgttgac aactggttta agcatcatag cctatgatga taaacactgc ctatatatgt
     3181 aaatagcttt tcatcaattc ttaaatttct taacctaggc ttcagggagc atatgaaacc
     3241 aaaattatat ggaacatttt ctgtgtgtac atgtacatgc atttttctag ggagagagtc
     3301 cgtaggttta tcagaatatc aaggaaaact gtgacccaaa gaagtttaag aatcacatac
     3361 actgctgctg gctttttgtg cttggcaaat gagtgacaat agaagaaata atttttctta
     3421 cacattttaa aacgttttct cttccttgtg attgaagatg aaaggagtaa gaaattaagg
     3481 catttgttta atttatactg gtaacttatt taggggggag gggacatgaa ggtaggtaaa
     3541 taggtaggcc tctaattgaa ccacctctct aagttatgta cgtatatata agctgaaatt
     3601 gtgtttgaca ttctgagggt tttctttttc tttttccttt tttttttttt tggtgggggg
     3661 ctgggggtca gagtcttgtt ctgttgcccg ggctggagtg cagtggcatg atctcagctc
     3721 actgcaacct ctgccttctg gattcaagtg attctcctgc ctcagcctct tgagtagctg
     3781 ggactacagg tgcccgccac cacaccagct aatttttgta tttttagtag aggcgaagtt
     3841 tccccatgtt ggccaggctg gtcttgaact cccgacctca agtgatctgt ctacctcggc
     3901 ctcctaaagt gctgagatta caggtgtgag ccaccgtgcc cggcccattc taagggtttt
     3961 ctttgaagac aggtcaaatg ctgttagtaa gtttcaggag attgttaatt cctcagttat
     4021 accagatttt ataaaatatt tgagaataga tggctaacaa gaggttagaa atacttttcc
     4081 ttaattttaa tccacagtat gttacatgca ttctaccact acattttggt gctatttaag
     4141 gtgtgcaatt ttctataggt gacttttgca attcagggaa gatttgggca tattaaatga
     4201 aagaatatct aattggggga ggtgtgaagg gaaagaaatt cttttcaaaa gctgaccaca
     4261 aagagtagtt aaaagttttt gtcactatct tcacaagtgt gtaaagcaca gatttcaaca
     4321 gagtgcttgg catattgtag ggtgctcaat ggtggttttt attattatta ctcagattcc
     4381 acagtggcaa gaaacatcat tctacataat ggaaaacatt tacatcaaat cccacttact
     4441 ttaatgcgaa cttggagata atttatggta ttgtattgta aaccattaat gaaaactttt
     4501 tcacagttga gtgaaattaa aatcactata tctcaa
//
