LOCUS       NM_152391               1717 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens solute carrier family 66 member 3 (SLC66A3),
            transcript variant 1, mRNA.
ACCESSION   NM_152391
VERSION     NM_152391.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1717)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001091.2 and BQ574369.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152391.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027625.1, AK001091.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295083.8/ ENSP00000295083.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-928               AK001091.2         12-939
            929-1191            AK001091.2         943-1205
            1192-1267           BQ574369.1         468-543             c
            1268-1601           AK001091.2         1282-1615
            1602-1717           AK001091.2         1617-1732
FEATURES             Location/Qualifiers
     source          1..1717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..1717
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /note="solute carrier family 66 member 3"
                     /db_xref="GeneID:130814"
                     /db_xref="HGNC:HGNC:28503"
     exon            1..223
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..689
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; PQ-loop repeat-containing protein 3; PQ loop
                     repeat containing 3"
                     /codon_start=1
                     /product="solute carrier family 66 member 3 isoform a
                     precursor"
                     /protein_id="NP_689604.1"
                     /db_xref="CCDS:CCDS1679.1"
                     /db_xref="GeneID:130814"
                     /db_xref="HGNC:HGNC:28503"
                     /translation="MEAALLGLCNWSTLGVCAALKLPQISAVLAARSARGLSLPSLLL
                     ELAGFLVFLRYQCYYGYPPLTYLEYPILIAQDVILLLCIFHFNGNVKQATPYIAVLVS
                     SWFILALQKWIIDLAMNLCTFISAASKFAQLQCLWKTRDSGTVSALTWSLSSYTCATR
                     IITTLMTTNDFTILLRFVIMLALNIWVTVTVLRYRKTAIKAE"
     exon            224..306
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            307..376
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            377..434
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            435..555
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            556..597
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1717
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /note="hexamer: AATAAA"
     polyA_site      1717
                     /gene="SLC66A3"
                     /gene_synonym="C2orf22; PQLC3"
                     /note="major polyA site"
ORIGIN      
        1 aggcttcggc agagctgcgc cgccgaggct gagcggtccc ttctcgctgc ggccgcccag
       61 gtgcccgcgc ccgtggcgct atggaggcgg cgctgctggg gctgtgtaac tggagcacgc
      121 tgggcgtgtg cgccgcgctg aagctgccgc agatctccgc tgtgctagcg gcgcgcagcg
      181 cgcggggcct cagccttccg agtttacttc tggagctggc aggattcctg gtgtttctgc
      241 ggtaccagtg ttactatggg tatccgccgc tgacctacct ggagtacccc atcctcatcg
      301 cgcaagatgt catcctcctg ctctgtatct ttcattttaa cgggaacgtg aagcaggcca
      361 ctccttacat cgctgtattg gtgtcttctt ggttcatcct tgccctgcag aagtggatca
      421 tagacctggc catgaatcta tgtactttca tcagcgcggc cagtaagttt gcacagctcc
      481 agtgtctgtg gaagacgaga gactcaggaa ctgtgagtgc gctgacttgg agcctctctt
      541 cctatacctg tgcaacaaga ataatcacaa ccttaatgac caccaatgat tttacaattc
      601 ttctacgttt tgtgatcatg ctggctttaa atatatgggt aacagtgaca gtacttcgct
      661 accggaagac cgctataaag gctgaatgat ggatacatta ttccttcaca cagtggattt
      721 tgagtaactg aaccaaagga aaaagaagct ctttgctaaa ttaaggtctt ttataaattt
      781 agtaaatcag tttataatct ttaaagccaa aggttttttt agacttgaaa gaaagagcca
      841 cttaaattct tgtttaaaaa taccaatttg cctcctcctt cctcacttcg ttaggttatg
      901 gtagtgctca gacatctgca gtgttgaggc cagtcactgt tggaagtcat ccaagaagcc
      961 cattttgagg ccattttgag ccttactctt aagttctcta tgaagaacta cattgatttg
     1021 ttggctttca gaatctttta ggaaataaat cctctccagg acaaaaatga acatgaatgg
     1081 agtggcattt tgttccaagt cagaggtggg cacctataat aaatgactag ggttcacttt
     1141 ctgggactga tgtttaattg taacacagat acaacagggt ggccttgttg tgtataatac
     1201 ggtattatac ccgcatgtgc tctagcaagg ataccaaggc aagcatacat gtagctggct
     1261 tgagtttgta ccaaaacagt ccttcaactt tgcactgtgc cttaagtaat tactaacaaa
     1321 aggtactagg attagctgca atctctactt tcgatgagga aatcccagta agctttctga
     1381 ttcaagtaca atgctgccat tttttaaagg gccacaacta tagaattacc actgttggaa
     1441 tttggtacaa aatatgtttt gtctattgaa aacatacacg gtaaatggtg ttgttaggta
     1501 ggttctgtcc agttcttagg gacttttttc acattatagc atttttaccc taaacatgat
     1561 gttgagatta ttatatactg tattttcttc taaattaacc ctaatgttta aaaactcact
     1621 ttcccccttt aattgaaggc attgttttgt tagatgcagt aatgatgttt accagagatt
     1681 attgtttcct atgcaaaata aattttcata ttttgaa
//
