LOCUS       NM_025078               2544 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 66 member 2 (SLC66A2),
            transcript variant 1, mRNA.
ACCESSION   NM_025078
VERSION     NM_025078.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2544)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2544)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB475520.1, BC030140.2, AC114341.9 and AK026031.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025078.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030140.2, SRR1163655.316253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154125 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397778.7/ ENSP00000380880.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DB475520.1         1-36
            37-1023             BC030140.2         1-987
            1024-2480           AC114341.9         103392-104848       c
            2481-2544           AK026031.1         2059-2122
FEATURES             Location/Qualifiers
     source          1..2544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..2544
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /note="solute carrier family 66 member 2"
                     /db_xref="GeneID:80148"
                     /db_xref="HGNC:HGNC:26188"
     exon            1..73
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..375
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..988
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PQ-loop repeat-containing protein 1; PQ loop repeat
                     containing 1"
                     /codon_start=1
                     /product="solute carrier family 66 member 2 isoform 1"
                     /protein_id="NP_079354.2"
                     /db_xref="CCDS:CCDS12020.1"
                     /db_xref="GeneID:80148"
                     /db_xref="HGNC:HGNC:26188"
                     /translation="MEAEGLDWLLVPLHQLVSWGAAAAMVFGGVVPYVPQYRDIRRTQ
                     NADGFSTYVCLVLLVANILRILFWFGRRFESPLLWQSAIMILTMLLMLKLCTEVRVAN
                     ELNARRRSFTAADSKDEEVKVAPRRSFLDFDPHHFWQWSSFSDYVQCVLAFTGVAGYI
                     TYLSIDSALFVETLGFLAVLTEAMLGVPQLYRNHRHQSTEGMSIKMVLMWTSGDAFKT
                     AYFLLKGAPLQFSVCGLLQVLVDLAILGQAYAFARHPQKPAPHAVHPTGTKAL"
     exon            376..509
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..563
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..780
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..2544
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /note="hexamer: CATAAA"
     polyA_site      1261
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /note="hexamer: ATTAAA"
     polyA_site      2499
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
     regulatory      2522..2527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /note="hexamer: AATAAA"
     polyA_site      2544
                     /gene="SLC66A2"
                     /gene_synonym="PQLC1"
                     /note="major polyA site"
ORIGIN      
        1 ggactgacgc cgagacgcgc gcgggtcagc ggcgcgggga cgcggggcgc tgggcgcggg
       61 gctgggggcg caggccccga ggccgcagga gcgcgcggag cggcgatgag caggcggccg
      121 gtggcccgcg gggcgcggag cccgtgacag cctcggccag gcgggcgctg cgatggaggc
      181 cgagggcctg gactggctcc tggtgccact gcaccagctg gtgtcctggg gcgcggccgc
      241 ggccatggtc ttcggagggg tggtgcccta cgtcccgcag tatcgggaca ttcgcaggac
      301 gcagaacgcc gacggcttct ccacctacgt gtgcctggtg ctgctggtgg ccaacatttt
      361 gcggatactc ttctggtttg gaaggcgctt tgagtccccg ctgctgtggc agagcgccat
      421 catgatcctg accatgctgc tgatgctgaa gctgtgcacc gaggtccgtg tggccaacga
      481 gctcaacgcc aggcgccgct cctttacagc tgcagatagc aaggatgaag aagtcaaggt
      541 tgcccccagg cggtccttcc tggacttcga cccccaccac ttctggcagt ggagcagctt
      601 ctcggactac gtgcagtgcg tcctggcctt cacgggcgtg gcgggctaca tcacctacct
      661 gtccattgac tccgccctgt ttgtggagac cctgggcttc ctggctgtgc tgaccgaagc
      721 catgctgggt gtgccccagc tttaccgcaa ccaccgccac cagtccacgg agggcatgag
      781 catcaagatg gtgctcatgt ggaccagtgg tgacgccttc aagacggcct acttcctgct
      841 gaagggtgcc cctctgcagt tctccgtgtg cggcctgctg caggtgctgg tggacctggc
      901 catcctgggg caggcctacg ccttcgcccg ccacccccag aagccggcgc cccacgccgt
      961 gcaccccact ggcaccaagg ccctctgaca gtggggagga cgaggatgtg ggaccgccag
     1021 ccgcgggcac tggtgggccc tgacctcccc gcggggaggg tgggtgctgt ggcccctgca
     1081 ggtgtggcag agatggggca tgggcattgg ggtctccatc agcctctgtg gggtgtctca
     1141 gggtgggcag tgggggtggg gctgggacgc tgtttgtgct cagcggggac agccagggtt
     1201 gatctggccc cgagggtttt ggatgttttt aggatgacat aaaaagcaag tgttttcccc
     1261 atttcctctt atgaaacacc gtctgagccc aaggtacaca ttgggcggcc tgcaggaacc
     1321 tgctccaggt ggacacacgg gccagcagcc gcgaaccttg aagctggggt gaccgcagga
     1381 gaccctgtaa ggcctgtgag cggagccctc gaccccgtga caccctggcc agacaccctg
     1441 cttggactgg ggtggcctct gctacccagg ggtctggcac gggggagggc tggggctttc
     1501 tctgcctggt acacacggaa aggcggctgt gcggacgcag ggtcaccgtg ctccgggttt
     1561 tctgacagtc ggtgtttcct gggcctttgg agtggctgcg aggcctgaac gccttgtgga
     1621 tccgctgtgt ccagcccggc tgagcatcgc cagggctagc tcatgctgct cttgtcagcc
     1681 tctggttctc ctcgagtcct tggggacgtg gcagatgcca gcgaccatca gacaacgtgg
     1741 aggccctcat gggcaatggc tgagggggcc gggctgaggc tgtgcacatg cagtctgcac
     1801 gccactcttg ggctctgctg gcggagatcc ccttccttct gggtgcagac tgcacctccg
     1861 gatgcagttt tgatgtccat cttccaggag agacggtctc gggtccaggg agtggagggg
     1921 gctgcccctg ccgtgcaggt cctggccgat ggcgccttac cctgctgccc tgggcttttg
     1981 gcctgaagca aattcctgag tggggggtac tggggcctgc cgcatcctgt cctgtccact
     2041 gcccaccccc gtgtgctggc tccctcactt ctggctgcag tgggagccgc cagtctgacc
     2101 cttgtcaccg cacgctctgc ccccaccccg ttgcaagagg tcacaccatg tcagcagcct
     2161 tgcactgacc gcagccggcc cccaggcctc agagttctgg atgcttccgt gcggctccaa
     2221 caggcatcgt cttcccttcc gcaggtggag gggccgcttc ccgcaggcat ctgagctctg
     2281 tgccggggcc gtggccatgg gaagatgttc cacgctgcct cctcctcgag ttttcctcgg
     2341 aaacactctt gaatgtctga gtgagggtcc tgcttagctc tttggcctgt gagatgcttt
     2401 gaaaattttt atttttttaa gatgaagcaa gatgtctgta gcggtaattg cctcacatta
     2461 aactgtcgcc gactgcaggc gcagtgactg ctgaatgtac cctgtgtggc gacttggaat
     2521 caataaacca tttgtggatc ctga
//
