LOCUS       NM_001011547            3162 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 5 member 9 (SLC5A9), transcript
            variant 2, mRNA.
ACCESSION   NM_001011547 XM_117174
VERSION     NM_001011547.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3162)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 3162)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 3162)
  AUTHORS   Tazawa,S., Yamato,T., Fujikura,H., Hiratochi,M., Itoh,F., Tomae,M.,
            Takemura,Y., Maruyama,H., Sugiyama,T., Wakamatsu,A., Isogai,T. and
            Isaji,M.
  TITLE     SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an
            essential transporter for mannose, 1,5-anhydro-D-glucitol, and
            fructose
  JOURNAL   Life Sci 76 (9), 1039-1050 (2005)
   PUBMED   15607332
  REMARK    GeneRIF: SGLT4 would have unique physiological functions (i.e.,
            absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition
            to Glc).
            Erratum:[Life Sci. 2010 Oct 9;87(15-16):514]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104857.1, AL109659.20 and AI767388.1.
            
            On Jun 3, 2019 this sequence version replaced NM_001011547.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the mid coding region, compared to variant 1, resulting in
            an isoform (2) that is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131200.1, BC104863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438567.7/ ENSP00000401730.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-827               BC104857.1         32-858
            828-828             AL109659.20        51399-51399         c
            829-2118            BC104857.1         860-2149
            2119-3064           AL109659.20        34920-35865         c
            3065-3162           AI767388.1         26-123              c
FEATURES             Location/Qualifiers
     source          1..3162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..3162
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /note="solute carrier family 5 member 9"
                     /db_xref="GeneID:200010"
                     /db_xref="HGNC:HGNC:22146"
                     /db_xref="MIM:620216"
     exon            1..183
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2067
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sodium/glucose cotransporter 4; hSGLT4; Na(+)/glucose
                     cotransporter 4; solute carrier family 5 (sodium/glucose
                     cotransporter), member 9; solute carrier family 5
                     (sodium/sugar cotransporter), member 9"
                     /codon_start=1
                     /product="sodium/glucose cotransporter 4 isoform 2"
                     /protein_id="NP_001011547.2"
                     /db_xref="CCDS:CCDS30709.2"
                     /db_xref="GeneID:200010"
                     /db_xref="HGNC:HGNC:22146"
                     /db_xref="MIM:620216"
                     /translation="MSKELAAMGPGASGDGVRTETAPHIALDSRVGLHAYDISVVVIY
                     FVFVIAVGIWSSIRASRGTIGGYFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAA
                     GGLAVGGFEWNATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLI
                     LYIFTKISTDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTV
                     IMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRDPVSG
                     DIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVM
                     PGMISRALFPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMA
                     ALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQS
                     SNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEF
                     SYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWW
                     TRNCPLSELEKEAHESTPEISERPAGECPAGGGAAENSSLGQEQPEAPSRSWGKLLWS
                     WFCGLSGTPEQALSPAEKAALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA"
     exon            184..255
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            256..360
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            361..525
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            526..631
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..712
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            713..918
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1054
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1162
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1313
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1482
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1698
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1858
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..3162
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3142..3147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /note="hexamer: AATAAA"
     polyA_site      3162
                     /gene="SLC5A9"
                     /gene_synonym="SGLT4"
                     /note="major polyA site"
ORIGIN      
        1 gctgttgacc aacactaaca gatgagcaag gagctggcag caatggggcc tggagcttca
       61 ggggacgggg tcaggactga gacagctcca cacatagcac tggactccag agttggtctg
      121 cacgcctacg acatcagcgt ggtggtcatc tactttgtct tcgtcattgc tgtggggatc
      181 tggtcgtcca tccgtgcaag tcgagggacc attggcggct atttcctggc cgggaggtcc
      241 atgagctggt ggccaattgg agcatctctg atgtccagca atgtgggcag tggcttgttc
      301 atcggcctgg ctgggacagg ggctgccgga ggccttgccg taggtggctt cgagtggaac
      361 gcaacctggc tgctcctggc ccttggctgg gtcttcgtcc ctgtgtacat cgcagcaggt
      421 gtggtcacaa tgccgcagta tctgaagaag cgatttgggg gccagaggat ccaggtgtac
      481 atgtctgtcc tgtctctcat cctctacatc ttcaccaaga tctcgactga catcttctct
      541 ggagccctct tcatccagat ggcattgggc tggaacctgt acctctccac agggatcctg
      601 ctggtggtga ctgccgtcta caccattgca ggtggcctca tggccgtgat ctacacagat
      661 gctctgcaga cggtgatcat ggtaggggga gccctggtcc tcatgtttct gggctttcag
      721 gacgtgggct ggtacccagg cctggagcag cggtacaggc aggccatccc taatgtcaca
      781 gtccccaaca ccacctgtca cctcccacgg cccgatgctt tccacattct tcgggaccct
      841 gtgagcgggg acatcccttg gccaggtctc attttcgggc tcacagtgct ggccacctgg
      901 tgttggtgca cagaccaggt cattgtgcag cggtctctct cggccaagag tctgtctcat
      961 gccaagggag gctccgtgct ggggggctac ctgaagatcc tccccatgtt cttcatcgtc
     1021 atgcctggca tgatcagccg ggccctgttc ccagacgagg tgggctgcgt ggaccctgat
     1081 gtctgccaaa gaatctgtgg ggcccgagtg ggatgttcca acattgccta ccctaagttg
     1141 gtcatggccc tcatgcctgt tggtctgcgg gggctgatga ttgccgtgat catggccgct
     1201 ctcatgagct cactcacctc catcttcaac agcagcagca ccctgttcac cattgatgtg
     1261 tggcagcgct tccgcaggaa gtcaacagag caggagctga tggtggtggg cagagtgttt
     1321 gtggtgttcc tggttgtcat cagcatcctc tggatcccca tcatccaaag ctccaacagt
     1381 gggcagctct tcgactacat ccaggctgtc accagttacc tggccccacc catcaccgct
     1441 ctcttcctgc tggccatctt ctgcaagagg gtcacagagc ccggagcttt ctggggcctc
     1501 gtgtttggcc tgggagtggg gcttctgcgt atgatcctgg agttctcata cccagcgcca
     1561 gcctgtgggg aggtggaccg gaggccagca gtgctgaagg acttccacta cctgtacttt
     1621 gcaatcctcc tctgcgggct cactgccatc gtcattgtca ttgtcagcct ctgtacaact
     1681 cccatccctg aggaacagct cacacgcctc acatggtgga ctcggaactg ccccctctct
     1741 gagctggaga aggaggccca cgagagcaca ccggagatat ccgagaggcc agccggggag
     1801 tgccctgcag gaggtggagc ggcagagaac tcgagcctgg gccaggagca gcctgaagcc
     1861 ccaagcaggt cctggggaaa gttgctctgg agctggttct gtgggctctc tggaacaccg
     1921 gagcaggccc tgagcccagc agagaaggct gcgctagaac agaagctgac aagcattgag
     1981 gaggagccac tctggagaca tgtctgcaac atcaatgctg tccttttgct ggccatcaac
     2041 atcttcctct ggggctattt tgcgtgattc cacagacctg gcttcagtgt agacagatta
     2101 aacaaagccc aagcctgtca gccacagaaa caggctctcc tcttactttg ctgtctaaac
     2161 tggagatcac agaagtcaag actgcaagct cccctgaaga gaatccaact caacctgcac
     2221 acttgacaag tggagaaaca gaagcccaga gagagcactg ggtttgttca ggaccaccca
     2281 gaaggtgtca cacggggttt ccccactctt tctgatatat tgccttacag acctacctca
     2341 aacacactgt ttccaccctc ttcttgaatg tattcagtag cctttactga atgtgtgtct
     2401 tgagagtaga aaaatggagg atacaagaaa aggagcagga agaaatttgc aaaaatccaa
     2461 gagcaccttt gctccccctt atcctccttc ctcttcccct ttctagttcc cctacctctc
     2521 tatctttcta ttctcaccaa taatctcttt gttgcatgaa tttacccagg agagtcctat
     2581 atttccattg gtggctccac agtggtggct gtcagacccg aaggggtggg gagccaaggg
     2641 tggactttaa gcatggtgac agatggtatt ttgggcagaa agctcttaga caatggacta
     2701 tccaaagcac tatttaaatt ctgcctcttc ctactctcta acccaaatat gcacaaactc
     2761 tctatggcct tgagaagcag ttggagagac atgacttgtt aaaacctcaa ggaatcaaga
     2821 catgttactc tgtatttaag ggtaagcccc acagcgggca gcacaaacag cctgggagcc
     2881 actgtgcctg tgcttctctg tccttctccc tttgcttgcc atgaatccgc ataccttgga
     2941 atacactgtg accccagtta agtgtccctt cgccaggaag ctgccgcaac gtccagacct
     3001 gggtcaagtt cccactcctg ctcccatagc cttgacctgc ttctgtcaca gcactgatca
     3061 cactgagatg gaagactcca gggggcaagg accaagggcc atatcccaag tgactttgta
     3121 cccagaaaat aacagctgtt caataaatgt gtattgagtt aa
//
