LOCUS       NM_145913               4009 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 5 member 8 (SLC5A8), mRNA.
ACCESSION   NM_145913
VERSION     NM_145913.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4009)
  AUTHORS   Vargas-Sierra,O., Hernandez-Juarez,J., Uc-Uc,P.Y., Herrera,L.A.,
            Dominguez-Gomez,G., Gariglio,P. and Diaz-Chavez,J.
  TITLE     Role of SLC5A8 as a Tumor Suppressor in Cervical Cancer
  JOURNAL   Front Biosci (Landmark Ed) 29 (1), 16 (2024)
   PUBMED   38287802
  REMARK    GeneRIF: Role of SLC5A8 as a Tumor Suppressor in Cervical Cancer.
REFERENCE   2  (bases 1 to 4009)
  AUTHORS   Yang,Y., Liao,C., Yang,Q., Li,Y., Tang,Y. and Xu,B.
  TITLE     Role of hypermethylated SLC5A8 in follicular thyroid cancer
            diagnosis and prognosis prediction
  JOURNAL   World J Surg Oncol 21 (1), 367 (2023)
   PUBMED   38007446
  REMARK    GeneRIF: Role of hypermethylated SLC5A8 in follicular thyroid
            cancer diagnosis and prognosis prediction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4009)
  AUTHORS   Kim,H.J., An,J. and Ha,E.M.
  TITLE     Lactobacillus plantarum-derived metabolites sensitize the
            tumor-suppressive effects of butyrate by regulating the functional
            expression of SMCT1 in 5-FU-resistant colorectal cancer cells
  JOURNAL   J Microbiol 60 (1), 100-117 (2022)
   PUBMED   34964946
  REMARK    GeneRIF: Lactobacillus plantarum-derived metabolites sensitize the
            tumor-suppressive effects of butyrate by regulating the functional
            expression of SMCT1 in 5-FU-resistant colorectal cancer cells.
REFERENCE   4  (bases 1 to 4009)
  AUTHORS   Han,L., Qu,Q., Aydin,D., Panova,O., Robertson,M.J., Xu,Y.,
            Dror,R.O., Skiniotis,G. and Feng,L.
  TITLE     Structure and mechanism of the SGLT family of glucose transporters
  JOURNAL   Nature 601 (7892), 274-279 (2022)
   PUBMED   34880492
  REMARK    GeneRIF: Structure and mechanism of the SGLT family of glucose
            transporters.
REFERENCE   5  (bases 1 to 4009)
  AUTHORS   Anbazhagan,A.N., Priyamvada,S., Kumar,A., Jayawardena,D.,
            Borthakur,A., Saksena,S., Gill,R.K., Alrefai,W.A. and Dudeja,P.K.
  TITLE     miR-29a, b, and c regulate SLC5A8 expression in intestinal
            epithelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 321 (2), G223-G231 (2021)
   PUBMED   34231393
  REMARK    GeneRIF: miR-29a, b, and c regulate SLC5A8 expression in intestinal
            epithelial cells.
REFERENCE   6  (bases 1 to 4009)
  AUTHORS   Gopal,E., Fei,Y.J., Sugawara,M., Miyauchi,S., Zhuang,L., Martin,P.,
            Smith,S.B., Prasad,P.D. and Ganapathy,V.
  TITLE     Expression of slc5a8 in kidney and its role in Na(+)-coupled
            transport of lactate
  JOURNAL   J Biol Chem 279 (43), 44522-44532 (2004)
   PUBMED   15322102
REFERENCE   7  (bases 1 to 4009)
  AUTHORS   Coady,M.J., Chang,M.H., Charron,F.M., Plata,C., Wallendorff,B.,
            Sah,J.F., Markowitz,S.D., Romero,M.F. and Lapointe,J.Y.
  TITLE     The human tumour suppressor gene SLC5A8 expresses a
            Na+-monocarboxylate cotransporter
  JOURNAL   J Physiol 557 (Pt 3), 719-731 (2004)
   PUBMED   15090606
REFERENCE   8  (bases 1 to 4009)
  AUTHORS   Miyauchi,S., Gopal,E., Fei,Y.J. and Ganapathy,V.
  TITLE     Functional identification of SLC5A8, a tumor suppressor
            down-regulated in colon cancer, as a Na(+)-coupled transporter for
            short-chain fatty acids
  JOURNAL   J Biol Chem 279 (14), 13293-13296 (2004)
   PUBMED   14966140
  REMARK    GeneRIF: functional identity of SLC5A8 as a Na(+)-coupled
            transporter for short-chain fatty acids.
REFERENCE   9  (bases 1 to 4009)
  AUTHORS   Lacroix,L., Pourcher,T., Magnon,C., Bellon,N., Talbot,M.,
            Intaraphairot,T., Caillou,B., Schlumberger,M. and Bidart,J.M.
  TITLE     Expression of the apical iodide transporter in human thyroid
            tissues: a comparison study with other iodide transporters
  JOURNAL   J Clin Endocrinol Metab 89 (3), 1423-1428 (2004)
   PUBMED   15001644
  REMARK    GeneRIF: In thyroid carcinomas, the mean and median hAIT mRNA
            levels were significantly decreased
REFERENCE   10 (bases 1 to 4009)
  AUTHORS   Li,H., Myeroff,L., Smiraglia,D., Romero,M.F., Pretlow,T.P.,
            Kasturi,L., Lutterbaugh,J., Rerko,R.M., Casey,G., Issa,J.P.,
            Willis,J., Willson,J.K., Plass,C. and Markowitz,S.D.
  TITLE     SLC5A8, a sodium transporter, is a tumor suppressor gene silenced
            by methylation in human colon aberrant crypt foci and cancers
  JOURNAL   Proc Natl Acad Sci U S A 100 (14), 8412-8417 (2003)
   PUBMED   12829793
  REMARK    GeneRIF: SLC5A8 exon 1 methylation is an early event, detectable in
            colon adenomas & microscopic aberrant crypt foci. SLC5A8 is a
            member of the family of sodium solute symporters, now added to the
            candidate colon cancer suppressor genes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB229173.1, BC110492.2 and AC079953.28.
            
            On May 17, 2019 this sequence version replaced NM_145913.4.
            
            Summary: SLC5A8 has been shown to transport iodide by a passive
            mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and
            monocarboxylates and short-chain fatty acids by a sodium-coupled
            mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8
            functions as a high-affinity sodium-coupled lactate transporter
            involved in reabsorption of lactate and maintenance of blood
            lactate levels (Thangaraju et al., 2006 [PubMed
            16873376]).[supplied by OMIM, Dec 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF536216.1, AY081220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536262.3/ ENSP00000445340.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               DB229173.1         37-401
            366-2051            BC110492.2         1-1686
            2052-2052           AC079953.28        100003-100003
            2053-2670           BC110492.2         1688-2305
            2671-4009           AC079953.28        101469-102807
FEATURES             Location/Qualifiers
     source          1..4009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1-q23.2"
     gene            1..4009
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /note="solute carrier family 5 member 8"
                     /db_xref="GeneID:160728"
                     /db_xref="HGNC:HGNC:19119"
                     /db_xref="MIM:608044"
     exon            1..741
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..2223
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /note="apical iodide transporter; sodium iodide-related
                     cotransporter; solute carrier family 5
                     (sodium/monocarboxylate cotransporter), member 8; solute
                     carrier family 5 (iodide transporter), member 8;
                     electrogenic sodium monocarboxylate cotransporter"
                     /codon_start=1
                     /product="sodium-coupled monocarboxylate transporter 1"
                     /protein_id="NP_666018.3"
                     /db_xref="CCDS:CCDS9080.1"
                     /db_xref="GeneID:160728"
                     /db_xref="HGNC:HGNC:19119"
                     /db_xref="MIM:608044"
                     /translation="MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKD
                     FLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEV
                     FLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGF
                     DLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTIL
                     NDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQA
                     KLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDY
                     PGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVY
                     GALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGF
                     AISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLMTTTEMPFTTSVFQIYNVQ
                     RTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFD
                     IFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL"
     exon            742..807
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..859
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..927
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1082
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1223
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1353
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1442
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1555
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1623
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1710
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1916
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2020
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2100
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..4009
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /note="hexamer: AATACA"
     polyA_site      2524
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
     regulatory      3265..3270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /note="hexamer: ATTAAA"
     polyA_site      3288
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /note="major polyA site"
     regulatory      3837..3842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
                     /note="hexamer: AATAAA"
     polyA_site      3856
                     /gene="SLC5A8"
                     /gene_synonym="AIT; SMCT; SMCT1"
ORIGIN      
        1 gaacaaaacc tgcccagagc gctccctgtg tagattcgct ggaagcagct ggaggctcca
       61 gttctcatct gctcaggtgt ccccggcgcc ttggcgaact cggccactcc agttcctcac
      121 gtggtgagca ctcagggcag cgggtcgatt ttccgaggtc ccatacctgg gtttgagggg
      181 cgcggctcgc agcggcgggt gcaggggcga ctgccagccc tcaccccgcc tcggggtgcg
      241 ttcggaggcc gacacctgga ggacgcctcc agtccccgcg ggacgccacg cctgcgcgcc
      301 agggatccgg gataagaagt gcgcgccggg ctccggctgc gcgccgcggg gccaccagtt
      361 tgcgcgcagg gctcaggcga ccgtgcggcc atggacacgc cacggggcat cggcaccttc
      421 gtggtgtggg actacgtggt gttcgcgggc atgctggtca tctcggccgc catcggcatc
      481 tactacgcct tcgctggggg cggccagcag acctccaagg acttcctgat gggcggccgc
      541 agaatgaccg cagtgcccgt ggcgctgtcc ctcaccgcta gcttcatgtc agccgtcact
      601 gtcctgggca ccccctccga ggtctaccgt tttggggcca tttttagcat ctttgccttc
      661 acctacttct ttgtggtggt catcagcgcg gaggtcttcc tcccggtgtt ctacaaactg
      721 ggaattacca gcacctacga gtatttagaa cttcgattta acaaatgtgt tcgtctctgt
      781 ggaacagtcc tcttcattgt tcaaacaatt ctgtatactg gaattgttat ttatgcccct
      841 gccctggctt tgaatcaagt cacaggattt gatctgtggg gcgcggtagt ggcaacgggg
      901 gtggtctgca cattctactg cacactgggt ggtcttaaag cagttatctg gacagatgtt
      961 tttcaagttg ggatcatggt ggctggattt gcatccgtga ttatacaggc tgtggtgatg
     1021 caaggtggaa tcagcactat tttaaatgat gcctatgatg gtggaagatt aaatttctgg
     1081 aattttaatc ctaacccttt gcaaagacac accttctgga caattattat aggagggacc
     1141 ttcacatgga ccagcatcta cggtgtcaac caatcccagg tgcagagata tatttcttgt
     1201 aaaagcagat tccaggcaaa actgtctctc tacatcaatc ttgtgggact ctgggcaatc
     1261 ctcacatgct cagtgttttg tgggctcgcc ctatattcca ggtaccatga ctgtgatcct
     1321 tggacagcca agaaagtgtc tgcaccagac cagctcatgc cttatttggt actggacatt
     1381 ctgcaagatt atccaggact tcctggactt tttgtggcct gtgcttacag tgggacatta
     1441 agcacagtgt cctccagtat taatgcctta gcagcagtaa ctgtggaaga tctaatcaaa
     1501 ccttacttca gatcgctctc agaaaggtct ctgtcttgga tttcccaagg aatgagtgtg
     1561 gtgtatggag ccctgtgtat tggaatggct gcgctggcgt cacttatggg agctttgttg
     1621 caggcagcac tcagcgtatt tggtatggtt ggtggaccac ttatgggcct gttcgctttg
     1681 ggcattttgg ttccctttgc caactcaatt ggagcacttg ttggtctgat ggctggattt
     1741 gccatttctc tatgggttgg aattggagct caaatatatc ctccacttcc tgagagaaca
     1801 ttgccattgc accttgatat ccaaggctgt aacagcacct acaatgagac aaatttgatg
     1861 acaaccacag aaatgccatt tactactagt gtttttcaaa tatacaatgt tcaaaggact
     1921 ccactgatgg ataactggta ttctttatca tatctgtact tcagcactgt tggaactttg
     1981 gtaacattat tagtggggat acttgtcagt ttatcaacag gaggaagaaa acagaactta
     2041 gaccccagat acatactaac caaagaggac tttttatcca attttgatat ttttaagaaa
     2101 aagaagcatg ttttgagcta taaatcacat ccagtggaag atggtggaac tgataatcct
     2161 gctttcaacc acattgaatt gaactcagat cagagtggca agagcaatgg gactcgtttg
     2221 tgaagctgct ctgatactag atatccttaa atgatgtttc aattttatat gttttctaag
     2281 ataattggat caggttttct ttgtgtgtgt gtgtgtgttg tatcatgagt gtttggggga
     2341 taagtttttg ttaaaacaaa gtctggacta tcttcattta ctacatcatt aattgatgtt
     2401 actctggagt ttagaattct ggcattgaca tttccctctc tttcctttat ttcgatgaag
     2461 ctataattgt gaaaattgta actacataga tgctgaaagg ctaatacaca catatgcaca
     2521 tgtatttgat tgtcaaaggt atattcttaa atttgggtat tattgaaaat attttccatg
     2581 ccttggtgct agcatataag tttggaagtt tgccaacatc acaattcatc ttgaaaagag
     2641 cttttttccc tcctaccaca tacaccattc ttagggagca atgaggtaac aggtctgtgt
     2701 tgtctagatc tttgcttttt atccccctat cagtccaggg catatactaa cctgcaaact
     2761 gattctgaat caggaaggtg gtaatcaata agtattctgg ctgggaaaga ccgtgggccc
     2821 aatgatcaaa gtcttcttgg tgctgttcat taattcttgt gccttttggc ttgttttcta
     2881 gagtttctgg gctttggctg ctgatactgc ctttcttaga ctgtaatttt tatctgcatg
     2941 cccagtttct gacctatcaa cttgggtttt attgtgcact ctaactgagc ttgtcttcat
     3001 aattttctgt ttattgccct gggcttggat atgtctcaag acactcatgt gaatcatgcc
     3061 accccaaatc ctggcttatc aagtcccaga ctataaatta tgaactccca ttagcttggt
     3121 actaacatat acttgatgta ggtatttatg gacttgatga tccaagaata ttatattctt
     3181 caaaatggtt aagctccatg gagttagatg actacactta atgctattaa gttgaacttt
     3241 tgaatgtcaa ctaatttgca atcaattaaa gatacatatg cctagaaatt ttgaaatttc
     3301 ggtatattta tccagttaaa gggctaaatt atataagcaa acactacttt ttttaaaacg
     3361 tctggactca aaaaatgctt tgttccatgt tttaaaattt ttaagtagca gtctcaaagt
     3421 tgcttagctg tttattttgc tatgttccta gctaagagtt tggttatagg agttcatcaa
     3481 taacttattt tttgtacagt tcccacatta gatactgttt aaaagttctt ttttaaactc
     3541 aatttttttt agaaacataa gagaaatatt tagatacata caaatgtttt tatgattaaa
     3601 taattttatg cttattttct gatacgtgtt atttaggtaa tcatgccctg tacatttaga
     3661 ggttgctaac tgacaatgtt aagaaattta aaaaaaaaaa aaagcctggg catgatggct
     3721 catgcttgta atctgaacat ttgggaggct gaggcaggaa gatcgcttga ggtccagagt
     3781 ttaagtccag cctggaaaca tagttagacc tcatctctac aaaaataaaa aataaaaata
     3841 aaaaaaactt agctaggcat gttgccacat acttgtagtc ccagttatta gggaagctga
     3901 ggtgggagga tagcttaagc ccaggatttc aaggctgcat tgagctatga ttacaccact
     3961 gcactccagc ctgggtaaca gagtgaaatc ttgtctctgg gaaaaaaaa
//
