LOCUS       NM_014227               2048 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 5 member 4 (SLC5A4), mRNA.
ACCESSION   NM_014227
VERSION     NM_014227.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2048)
  AUTHORS   Sotak,M., Casselbrant,A., Rath,E., Zietek,T., Stromstedt,M.,
            Adingupu,D.D., Karlsson,D., Fritsch Fredin,M., Ergang,P., Pacha,J.,
            Batorsky,A., Alpers,C.E., Borgeson,E., Hansen,P.B.L., Ericsson,A.,
            Bjornson Granqvist,A., Wallenius,V., Fandriks,L. and Unwin,R.J.
  TITLE     Intestinal sodium/glucose cotransporter 3 expression is epithelial
            and downregulated in obesity
  JOURNAL   Life Sci 267, 118974 (2021)
   PUBMED   33385407
  REMARK    GeneRIF: Intestinal sodium/glucose cotransporter 3 expression is
            epithelial and downregulated in obesity.
REFERENCE   2  (bases 1 to 2048)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2048)
  AUTHORS   Schafer,N., Friedrich,M., Jorgensen,M.E., Kollert,S., Koepsell,H.,
            Wischmeyer,E., Lesch,K.P., Geiger,D. and Doring,F.
  TITLE     Functional analysis of a triplet deletion in the gene encoding the
            sodium glucose transporter 3, a potential risk factor for ADHD
  JOURNAL   PLoS One 13 (10), e0205109 (2018)
   PUBMED   30286162
  REMARK    GeneRIF: Whole-exome sequencing (WES) of several extended pedigrees
            with high density of attention-deficit/hyperactivity disorder
            (ADHD) identified a triplet ATG deletion in SLC5A4 leading to a
            single amino acid loss (DeltaM500) in the hSGLT3 protein
            imperfectly co-segregating with the clinical phenotype of ADHD.
            [DeltaM500] in hSGLT3 inhibits membrane targeting and thus largely
            disrupts glucose-induced sodium conductance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2048)
  AUTHORS   Mithieux,G.
  TITLE     Metabolic effects of portal vein sensing
  JOURNAL   Diabetes Obes Metab 16 Suppl 1, 56-60 (2014)
   PUBMED   25200297
  REMARK    GeneRIF: Data suggest SGLT3 in neurons of portal vein wall plays
            role in sensing blood glucose level and in satiety response;
            dietary protein indirectly affects satiety response via
            up-regulation of intestinal gluconeogenesis and thus blood glucose.
            [REVIEW]
            Review article
REFERENCE   5  (bases 1 to 2048)
  AUTHORS   Kothinti,R.K., Blodgett,A.B., North,P.E., Roman,R.J. and
            Tabatabai,N.M.
  TITLE     A novel SGLT is expressed in the human kidney
  JOURNAL   Eur J Pharmacol 690 (1-3), 77-83 (2012)
   PUBMED   22766068
  REMARK    GeneRIF: the expression and functional role of SGLT3 in the human
            kidney
REFERENCE   6  (bases 1 to 2048)
  AUTHORS   Munafo,M.R., Clark,T.G., Roberts,K.H. and Johnstone,E.C.
  TITLE     Neuroticism mediates the association of the serotonin transporter
            gene with lifetime major depression
  JOURNAL   Neuropsychobiology 53 (1), 1-8 (2006)
   PUBMED   16319503
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2048)
  AUTHORS   Diez-Sampedro,A., Hirayama,B.A., Osswald,C., Gorboulev,V.,
            Baumgarten,K., Volk,C., Wright,E.M. and Koepsell,H.
  TITLE     A glucose sensor hiding in a family of transporters
  JOURNAL   Proc Natl Acad Sci U S A 100 (20), 11753-11758 (2003)
   PUBMED   13130073
  REMARK    GeneRIF: determination that SGLT3 is not a Na+/glucose
            cotransporter but instead a glucose sensor in the plasma membrane
            of cholinergic neurons, skeletal muscle, and other tissues
REFERENCE   8  (bases 1 to 2048)
  AUTHORS   Jung,H.
  TITLE     The sodium/substrate symporter family: structural and functional
            features
  JOURNAL   FEBS Lett 529 (1), 73-77 (2002)
   PUBMED   12354616
  REMARK    Review article
REFERENCE   9  (bases 1 to 2048)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 2048)
  AUTHORS   Veyhl,M., Wagner,K., Volk,C., Gorboulev,V., Baumgarten,K.,
            Weber,W.M., Schaper,M., Bertram,B., Wiessler,M. and Koepsell,H.
  TITLE     Transport of the new chemotherapeutic agent
            beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells
            is mediated by the Na+-D-glucose cotransporter SAAT1
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2914-2919 (1998)
   PUBMED   9501190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL008723.8 and AJ133127.1.
            
            On Jun 2, 2019 this sequence version replaced NM_014227.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ133127.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266086.6/ ENSP00000266086.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL008723.8         98188-98203         c
            17-806              AJ133127.1         15-804
            807-813             AL008723.8         77819-77825         c
            814-2036            AJ133127.1         812-2034
            2037-2048           AL008723.8         61320-61331         c
FEATURES             Location/Qualifiers
     source          1..2048
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2048
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /note="solute carrier family 5 member 4"
                     /db_xref="GeneID:6527"
                     /db_xref="HGNC:HGNC:11039"
                     /db_xref="MIM:618633"
     exon            1..153
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1998
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /note="solute carrier family 5 (neutral amino acid
                     transporters, system A), member 4; low affinity
                     sodium-glucose cotransporter; sodium transporter;
                     sodium/glucose cotransporter 3; solute carrier family 5
                     (glucose activated ion channel), member 4; solute carrier
                     family 5 (low affinity glucose cotransporter), member 4;
                     Na(+)/glucose cotransporter 3"
                     /codon_start=1
                     /product="probable glucose sensor protein SLC5A4"
                     /protein_id="NP_055042.1"
                     /db_xref="CCDS:CCDS13903.1"
                     /db_xref="GeneID:6527"
                     /db_xref="HGNC:HGNC:11039"
                     /db_xref="MIM:618633"
                     /translation="MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGL
                     WAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFE
                     WTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISA
                     DIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFIL
                     MGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPW
                     PGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMI
                     SRILYTDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMS
                     SLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNG
                     QLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGT
                     GSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNS
                     TEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALS
                     KKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA"
     exon            154..225
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            226..330
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            331..390
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..495
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..601
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            602..682
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..903
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1039
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1147
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1298
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1467
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1683
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1786
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2048
                     /gene="SLC5A4"
                     /gene_synonym="DJ90G24.4; SAAT1; SGLT3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagcactgc ctgcagccat ggccagtacg gttagcccca gcaccatagc tgagacccca
       61 gagccacctc cattgtctga ccacatccga aatgctgctg acatctcagt cattgtcatc
      121 tattttctgg tggtgatggc tgttgggctg tgggcgatgc tgaagaccaa ccgaggtact
      181 ataggaggct tcttcctcgc tggtcgtgat atggcctggt ggccgatggg cgcctctctc
      241 tttgccagta acatcggcag caaccactat gtggggctgg ctgggacagg agcagcttca
      301 ggagtcgcca ccgtaacatt tgaatggact tcctcagtaa tgttgctgat tcttgggtgg
      361 atctttgtcc ctatctacat caagtcgggg gtgatgacca tgccggaata tctcaagaag
      421 cggtttggtg gggagcgact ccaggtctac ctctccatcc tctccctctt catctgtgtg
      481 gttttgttaa tttctgcaga catatttgct ggagccatat tcatcaagct ggccttggga
      541 ttggaccttt acctggcaat cttcatcctc ttggctatga ctgctgttta caccaccact
      601 gggggcttgg cctcggtgat ttacacagac accctccaga ccatcatcat gctgattggc
      661 tcttttattc tcatggggtt tgcatttaac gaagttggag gttatgagag ctttaccgag
      721 aagtacgtga atgccacccc atccgtagtc gagggggaca acttgacaat cagtgccagt
      781 tgctacacac ctcgggcgga ctccttccac atcttccgag atgctgtgac tggggacatt
      841 ccatggccag gaattatatt tggaatgccc attacagctt tgtggtactg gtgcacaaat
      901 caggtcattg tgcagcgctg cctgtgtggc aaggacatgt ctcacgtgaa ggccgcttgc
      961 attatgtgtg cttacctgaa gctgctgccc atgttcctca tggtgatgcc ggggatgatc
     1021 agccgcatcc tgtacacaga tatggtagca tgtgtggtac cttctgaatg cgtgaaacac
     1081 tgtggcgttg atgttggctg caccaactac gcatacccca cgatggtgct ggaactgatg
     1141 ccccaaggac tgcgaggcct gatgctttcg gtcatgctgg cctctctcat gagctccctg
     1201 acctccatct tcaacagcgc cagcaccctc ttcaccattg acctctacac caagatgcgg
     1261 aagcaagcgt cggagaaaga gctcctgata gctggacgga tatttgttct tctattaact
     1321 gttgtgagca ttgtgtgggt cccactggta caagtttctc aaaatggaca actaatccat
     1381 tacacagaat caatttctag ctaccttggg cctccaattg cagctgtctt tgtgcttgcc
     1441 atcttctgta aaagagtcaa tgaacaggga gcattctggg gtctaatggt tggacttgca
     1501 atgggcctca ttcgtatgat aacagagttt gcttatggaa cagggagttg cttggctccc
     1561 agtaactgtc ccaagattat ctgtggagtg cactatctgt acttttccat cgttctcttt
     1621 tttgggtcca tgctggtcac cctgggaatt tccctcttaa caaaacccat tcctgatgta
     1681 catctgtacc gcctgtgctg ggttcttcgg aacagtacag aggagcgaat cgatatagat
     1741 gcagaagaga aaagtcagga agaaacagat gatggtgttg aagaagatta tcctgagaaa
     1801 tcacgtggat gcctcaagaa agcttatgac ttgttctgcg gtttgcagaa gggacccaag
     1861 ctaaccaagg aggaggagga agccttgagc aagaagctca cagacacgtc tgagaggccc
     1921 tcgtggagga caatagtgaa catcaacgcc atcctcctcc tggctgtggt ggtctttatt
     1981 cacggctact atgcctgaac tctatctgag ccattagaat aatgaataat tcttaataat
     2041 gaaccaaa
//
