LOCUS       NM_006933              11566 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 5 member 3 (SLC5A3), mRNA.
ACCESSION   NM_006933
VERSION     NM_006933.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11566)
  AUTHORS   Li,L., Shen,F.R., Cheng,Q., Sun,J., Li,H., Sun,H.T., Cai,X.,
            Chen,M., Yang,B., Wang,L. and Xu,L.
  TITLE     SLC5A3 is important for cervical cancer cell growth
  JOURNAL   Int J Biol Sci 19 (9), 2787-2802 (2023)
   PUBMED   37324953
  REMARK    GeneRIF: SLC5A3 is important for cervical cancer cell growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11566)
  AUTHORS   Cui,Z., Mu,C., Wu,Z., Pan,S., Cheng,Z., Zhang,Z.Q., Zhao,J. and
            Xu,C.
  TITLE     The sodium/myo-inositol co-transporter SLC5A3 promotes non-small
            cell lung cancer cell growth
  JOURNAL   Cell Death Dis 13 (6), 569 (2022)
   PUBMED   35760803
  REMARK    GeneRIF: The sodium/myo-inositol co-transporter SLC5A3 promotes
            non-small cell lung cancer cell growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11566)
  AUTHORS   De Paepe,B., Merckx,C., Jarosova,J., Cannizzaro,M. and De
            Bleecker,J.L.
  TITLE     Myo-Inositol Transporter SLC5A3 Associates with Degenerative
            Changes and Inflammation in Sporadic Inclusion Body Myositis
  JOURNAL   Biomolecules 10 (4), 521 (2020)
   PUBMED   32235474
  REMARK    GeneRIF: Myo-Inositol Transporter SLC5A3 Associates with
            Degenerative Changes and Inflammation in Sporadic Inclusion Body
            Myositis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11566)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   5  (bases 1 to 11566)
  AUTHORS   Manville,R.W., Neverisky,D.L. and Abbott,G.W.
  TITLE     SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical
            Interaction with the Pore
  JOURNAL   Biophys J 113 (3), 613-626 (2017)
   PUBMED   28793216
  REMARK    GeneRIF: SMIT1 Modifies KCNQ Channel Function and Pharmacology by
            Physical Interaction with the Pore
REFERENCE   6  (bases 1 to 11566)
  AUTHORS   Porcellati,F., Hlaing,T., Togawa,M., Stevens,M.J., Larkin,D.D.,
            Hosaka,Y., Glover,T.W., Henry,D.N., Greene,D.A. and Killen,P.D.
  TITLE     Human Na(+)-myo-inositol cotransporter gene: alternate splicing
            generates diverse transcripts
  JOURNAL   Am J Physiol 274 (5), C1215-C1225 (1998)
   PUBMED   9612208
REFERENCE   7  (bases 1 to 11566)
  AUTHORS   Mallee,J.J., Atta,M.G., Lorica,V., Rim,J.S., Kwon,H.M.,
            Lucente,A.D., Wang,Y. and Berry,G.T.
  TITLE     The structural organization of the human Na+/myo-inositol
            cotransporter (SLC5A3) gene and characterization of the promoter
  JOURNAL   Genomics 46 (3), 459-465 (1997)
   PUBMED   9441750
REFERENCE   8  (bases 1 to 11566)
  AUTHORS   Berry,G.T., Mallee,J.J., Blouin,J.L. and Antonarakis,S.E.
  TITLE     The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3'
            sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 77-78 (1996)
   PUBMED   8646889
REFERENCE   9  (bases 1 to 11566)
  AUTHORS   Berry,G.T., Mallee,J.J., Kwon,H.M., Rim,J.S., Mulla,W.R., Muenke,M.
            and Spinner,N.B.
  TITLE     The human osmoregulatory Na+/myo-inositol cotransporter gene
            (SLC5A3): molecular cloning and localization to chromosome 21
  JOURNAL   Genomics 25 (2), 507-513 (1995)
   PUBMED   7789985
REFERENCE   10 (bases 1 to 11566)
  AUTHORS   Kwon,H.M., Yamauchi,A., Uchida,S., Preston,A.S., Garcia-Perez,A.,
            Burg,M.B. and Handler,J.S.
  TITLE     Cloning of the cDNa for a Na+/myo-inositol cotransporter, a
            hypertonicity stress protein
  JOURNAL   J Biol Chem 267 (9), 6297-6301 (1992)
   PUBMED   1372904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000467.1, KF457230.1, KF457228.1, KF457229.1 and AP000315.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006933.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA570729.1, SRR1660807.242830.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381151.5/ ENSP00000370543.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AP000467.1         22488-22655
            169-517             AP000467.1         43772-44120
            518-786             KF457230.1         1-269               c
            787-2009            AP000467.1         44390-45612
            2010-2393           KF457228.1         1-384               c
            2394-2918           AP000467.1         45997-46521
            2919-3182           KF457229.1         1-264               c
            3183-3599           AP000467.1         46786-47202
            3600-11566          AP000315.1         1-7967
FEATURES             Location/Qualifiers
     source          1..11566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..11566
                     /gene="SLC5A3"
                     /gene_synonym="BCW2; SMIT; SMIT1; SMIT2"
                     /note="solute carrier family 5 member 3"
                     /db_xref="GeneID:6526"
                     /db_xref="HGNC:HGNC:11038"
                     /db_xref="MIM:600444"
     exon            1..168
                     /gene="SLC5A3"
                     /gene_synonym="BCW2; SMIT; SMIT1; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            169..11566
                     /gene="SLC5A3"
                     /gene_synonym="BCW2; SMIT; SMIT1; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..2661
                     /gene="SLC5A3"
                     /gene_synonym="BCW2; SMIT; SMIT1; SMIT2"
                     /note="sodium/myo-inositol cotransporter 1; solute carrier
                     family 5 (inositol transporters), member 3;
                     Na(+)/myo-inositol cotransporter; sodium/myo-inositol
                     transporter 1; solute carrier family 5
                     (sodium/myo-inositol cotransporter), member 3"
                     /codon_start=1
                     /product="sodium/myo-inositol cotransporter"
                     /protein_id="NP_008864.4"
                     /db_xref="CCDS:CCDS33549.1"
                     /db_xref="GeneID:6526"
                     /db_xref="HGNC:HGNC:11038"
                     /db_xref="MIM:600444"
                     /translation="MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGR
                     SMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYI
                     RSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYV
                     SVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYM
                     LASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYW
                     CADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPE
                     HCMLVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTL
                     DVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTP
                     PVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFAYRAPECDQPDNRPGFIKD
                     IHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSPKEEPYK
                     MQEKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEA
                     ETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEA
                     VCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL"
     regulatory      11549..11554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A3"
                     /gene_synonym="BCW2; SMIT; SMIT1; SMIT2"
                     /note="hexamer: AATAAA"
     polyA_site      11566
                     /gene="SLC5A3"
                     /gene_synonym="BCW2; SMIT; SMIT1; SMIT2"
                     /note="major polyA site"
ORIGIN      
        1 gctttcgccg cctgggagcc gtccggcgca gcagtttcta ggtccccact gtccccgccg
       61 tcccgcccct tcgcgtcccg ggaaccggct ggcttccgag ccgcactcgc cgatcctcca
      121 ggcatgcccc gctacgagct ggctttaatc ctgaaagcca tgcagcgggg ttggtacagt
      181 aggcttcact agacttagct gcaactcaga atttctcctc cagcacctga gtaaatgctg
      241 atggtcttgt ggagagtgga ttaagagtac gagctaagtt ctcaatccca attaagaagc
      301 ggaaaattta aactgtcttc ttcaaagttt atcacaacca ccaccatcaa gacagcaaac
      361 caaaggacaa agactttgac cctgctgtgt tgctctgtgt agtccagttc acgtatggtt
      421 tacagacttg gctggggtta ctaaaaataa ataaaaagtt ggacacttct gtcattggag
      481 cgctattatt cacaagttac cagaatgaga gctgtactgg acacagcaga cattgccata
      541 gtggccctgt attttatcct ggtcatgtgc attggttttt ttgccatgtg gaaatctaat
      601 agaagcaccg tgagtggata cttcctggcg gggcgctcta tgacctgggt agcaattggt
      661 gcctctctgt ttgtgagcaa tattgggagt gagcacttca ttgggctggc aggatctgga
      721 gctgcaagtg gatttgcagt gggcgcatgg gaattcaatg ccttactgct tttacaactt
      781 ctgggatggg ttttcatccc aatttacatc cggtcagggg tatataccat gcctgaatac
      841 ttgtccaagc gatttggtgg ccataggatt caggtctatt ttgcagcctt gtctctgatt
      901 ctctatattt tcaccaagct ctcggtggat ctgtattcgg gtgccctttt tatccaggag
      961 tctttgggtt ggaatcttta tgtgtctgtc atcctgctca ttggcatgac tgctttgctg
     1021 actgtcaccg gaggccttgt tgcagtgatc tacacagaca ctctgcaggc tctgctcatg
     1081 atcattgggg cacttacact tatgattatt agcataatgg agattggcgg gtttgaggaa
     1141 gttaagagaa ggtacatgtt ggcctcaccc gatgtcactt ccatcttatt gacatacaac
     1201 ctttccaaca caaattcttg taatgtctcc cctaagaaag aagccctgaa aatgctgcgg
     1261 aatccaacag atgaagatgt tccttggcct ggattcattc ttgggcagac cccagcttca
     1321 gtatggtact ggtgtgctga ccaagtcatc gtgcagaggg tccttgcagc caaaaacatt
     1381 gctcatgcca aaggctctac tcttatggct ggcttcttaa agctcctgcc aatgtttatc
     1441 atagttgtcc caggaatgat ttccaggata ctgtttactg atgatatagc ttgcatcaac
     1501 ccagagcact gcatgctggt gtgtggaagc agagctggtt gctccaatat tgcttaccca
     1561 cgcctggtga tgaagctggt tcctgtgggc cttcggggtt taatgatggc agtgatgatt
     1621 gcagctctga tgagtgactt agactctatc tttaacagtg ccagtaccat attcaccctc
     1681 gatgtgtaca aacttatccg caagagcgca agctcccggg agttaatgat tgtggggagg
     1741 atatttgtgg catttatggt ggtgatcagc atagcatggg tgccaatcat cgtggagatg
     1801 caaggaggcc agatgtacct ttacattcag gaggtagcag attacctgac acccccagtg
     1861 gcagccttgt tcctgctggc aattttctgg aagcgctgca atgaacaagg ggctttctat
     1921 ggtggaatgg ctggctttgt tcttggagca gtccgtttga tactggcctt tgcctaccgt
     1981 gccccagaat gtgaccaacc tgataatagg ccgggcttca tcaaagacat ccattatatg
     2041 tatgtggcca caggattgtt ttgggtcacg ggactcatta ctgtaattgt gagccttctc
     2101 acaccacctc ccacaaagga acagattcga accaccacct tttggtctaa gaagaacctg
     2161 gtggtgaagg agaactgctc cccaaaagag gaaccataca aaatgcaaga aaagagcatt
     2221 ctgagatgca gtgagaataa tgagaccatc aaccacatca ttcccaacgg gaaatctgaa
     2281 gacagcatta agggccttca gcctgaagat gttaatctgt tggtaacctg cagagaggag
     2341 ggcaacccag tggcatcctt aggtcattca gaggcagaaa caccagttga cgcttactcc
     2401 aatgggcaag cagctctcat gggtgagaaa gagagaaaga aagaaacgga tgatggaggt
     2461 cggtactgga agttcataga ctggttttgt ggctttaaaa gtaagagcct cagcaagagg
     2521 agtctcagag acctgatgga agaggaggct gtttgtttac agatgctaga agagactcgg
     2581 caagttaaag taatactaaa tattggactt tttgctgtgt gttcacttgg aattttcatg
     2641 tttgtttatt tctccttatg aacttaagga tatggtgaga cactaactta agacaatact
     2701 gactggtctt tggggaaaaa agttatgtaa ctgtgcatct ctcaggcatt gtttacgctg
     2761 taggttttag ccaaatttta cttagcagaa aatcatctaa ttacaagact ttattttccc
     2821 agagatggat taaagtaaat cttcaactta agtgaagcca aacctaacag actgaattgt
     2881 gcaaatgtgg ttttaaattt tgcataccaa agtaagaaga gaccaattat tctcacagag
     2941 cacttagagc agaatatatg ttaagttacc atgaattaag gtatactgtc tgcactgcca
     3001 agtcttggca gaccttaccc tgaagtagaa gatttgctca tttctaaatt tttttttctg
     3061 tctctgtaat ccctcctacc attaagaaaa acttatttct tagacattgt acaatcagtt
     3121 atgtactgaa aatcgaatgt gcttgtgtga tacttgtttc aggacaagtt catttgccag
     3181 gttcattttg ttagcatgag cctacggatt ctgatttccc aaagaaagaa tgttttcctg
     3241 taggtatttt tgtaccacca gtatatggaa tgttagggaa aaactttgtt ccagttcctt
     3301 tttttttttc tttctacttt caagtttaag tgaaccatac tgaaatgacc aacaagtctg
     3361 cctgtaaagt tacatgtcat gattgtgttg ttaaatgatt atgggggaga aaatgaagta
     3421 aatgttgctg atgatcccca tatttattga tcatattaag gttgtttata tagtttggaa
     3481 atgaccagcc ccctaagcag tgtttgatta acttatgcta atcagatgat tactcatata
     3541 ttctgctaat tttctagctt tattcttgtt atttggaaaa attattagcc aaatgccttc
     3601 ctaggtggat ccagttggaa gatatgtcca gaaacctgaa gaaaaattga cgctgccttt
     3661 gtgtgctgga ttgctctact tgattagatc atgatatatc aaggttgaat ttttagaggg
     3721 aaaatttaat tctgatatct tattgcatcc ttgataagtt tttccctgat tttttttttc
     3781 ctcaaaagac tttccatctg tacacagcct ctacattttt gttgtagtga cttagagcat
     3841 aaggatgttt cagtgcaaac tggccgtcgg taacagaaaa ctcagtgcat actttgctgt
     3901 tgttaggttg tcaatatagt ctttctgtag gatggatagc atgtttgaga ggtgccaaac
     3961 aagaactttt ggggttagta gtgtgtcttg tggagggtat tacaggactg tgtaattata
     4021 ggactctaac ttgacatggc ttggcaccca cttgcagcta gtgggtacag ggtacaaaag
     4081 atgttagaga aaagctctac agattacgta cttctgtgtc ttcgtatgct caacactgtc
     4141 ctttgtcctc catgaaagat gaaggaagca aattatgtat gtactttctt tgaccttctt
     4201 taatctctga tactttttag attgcatgat tttactaggc ttgtatttag ggaaattact
     4261 ttcataaata cttttgtaga ttttgaatca aaactcagtc tttttaattt ttttgtagtc
     4321 tataaactag tttcattatg atggacttga ttagtccaaa gttaatttta gaaattgtca
     4381 ggtagcatag tgtcttccca tgatcaggag gctttctgaa ggactgagtc tgtaaatgaa
     4441 aaaataattt atgtatgaat agcatgtatt tctgaagagc ttagagtgcc ttgtagaatt
     4501 tttttctcaa ttttattctt gaggtttata atttgggggc caaatagata gagctcatca
     4561 ttttcttgtt tggaagttga ggctgcgaca tgtccaaggt tatgaagtct cttttgggaa
     4621 gaacagaaac caggtctcca aatctggact catggtttgt tcagatgtgt ctggacaaat
     4681 ggttgtcaat gttttgtcct gttttttcaa aggaactgtt cttcctttgg gacaaccttt
     4741 tggtgtttgg gaaagtaata agatcttgga tttttcaaat taacattaag ttgtaagaac
     4801 taaaattttc tttgaaccac attactgtgt aattcactga taattgacat attggctggg
     4861 cagcctatct cttccatatc cagcgtaaat gaataggagg tgtttgtgat tttttttttc
     4921 tccctttatt taacattgag tcctagtagt ttggagaatt agggtccctc taccttcttt
     4981 ctgctcttgt cttagtaaga tacataaggt acatcatctt gtgtctgtgt gtatatagca
     5041 gtaggtcaag tttagagtac taaagtctgt aaataaggaa tgactattag catattcatt
     5101 agaattgttt attcttgcca gtataaacat cattttattt agactaaagt ccctgaagct
     5161 tgtctttctt attgcttccc agtaatagat aatgtgctcg agtaagtttg tgaattgctg
     5221 attgcaactt aattcaggga ccagtcttca atctatattt cattagaatg attgttcctg
     5281 gaatgatcat acatggactg tcttaagcta gcaaaatgtt catactttac actgactaaa
     5341 tgggtcctaa atgatgacat tggtctttag acattaacat gtgtatattt ttatattagc
     5401 tcaagctaag gttcagaatt gaagcttgat attgactaga atagctaaaa gtcaaaatga
     5461 ggtgaggaca ctggtcttgg aaggtagaga aaaataaatg tcttaccagg tgttaatggt
     5521 atccccagtt cttagacttt tgtcttctca ggcaattttc atctcaagat ctgatgagaa
     5581 gggcatatta cattggtatg caggatgatt attgcatatt ttgtgggacc tctaatttcc
     5641 ctggtcatct ttcagaatat tctgttctgc cacccccaga gagtaaacac ttgagccgat
     5701 ttcttcttcc ccagctattc tttcctgggg gtaattatgc tttgtcttta gattagagaa
     5761 gcatcaagca atagcaatgg tgctgtgtcc ttcggcctaa attcaataga tctcatctcc
     5821 tagggcttcc ttttcacttg gctcaaagga tccattgtat tttggcacaa agagcctggc
     5881 cagggtcatg tagccatagc tcttagggat gatacctcaa gaaattagct gggacccatc
     5941 actctgtgaa acttcacatt ttaagaactg agttgagggg gttgttatgc acttctgtaa
     6001 cttgaggcta agcaaggggt taactcttgt gagagccaat agagtgtgtc tgtattcgca
     6061 gtccatggct cattttcttt atagtaggca tatggatctt cccctctgac tttgaatatc
     6121 atttggtgtg gcctgtgggt tattttcatt ctttaccacc aaataaagcg gcttattagc
     6181 tactcagtta cttgctactc aaaggttagg tcttccctgt tcctgcttgg cagtgttaaa
     6241 gcttacaggg ttaacttatg atgattctcc tggctcattt tcatcagagg catgatgact
     6301 ggaaagggat cacatgggtc gttggtggtg acacctcact gtttcctagg tttggataga
     6361 gagatgtata caagaccttt cctgttaaat tacgtgacta cagagacttg ccaggacaaa
     6421 attttcctaa gaaatcagaa aaatgattaa gtgagataag tacctgggtg acacagatat
     6481 tagcccgttg gtaaaagaca acaaatatta gcttaaaatc tgcatatgta gaatcatttt
     6541 cattagattt agagcttgaa gcaccttggc tctcagctac tttaaactcc tccccatata
     6601 aatcagggca ccaataaata agtttcagct ttttaaaccc tggtttgatg ttaagcatta
     6661 taaagtacga agtttgttac cacagtagag ataatttagt agaaaaatgc tttgaggctt
     6721 cagtatttgt aagattttgc attagccaga tgctaggttg ttgaaggcat ttcagtgttg
     6781 ataatagcct gagcagactt ctttacaaat gggatctgtt tctatatgtg tatatgccca
     6841 cttaccattc agagagactg gtctttctct ttgtcttcct tcacattgct gtgtcagttc
     6901 tacacctagt cttttcagca cttagcaaat tcaaattttg atttttttgt cagcttagtt
     6961 cactttaagg catattggca tggtgtgtga aagtgatgtt ttgccccagt attgaggact
     7021 tttagatcca aataatgact cattaaatat aattatgttt taagtatact gaatttctgt
     7081 tagcttaaaa tgttaattct caggaatgat tttctcacac tttgtgttgg ctaataataa
     7141 aagcactgtt ttattctcaa aactcctttt tcaaaaatta gggagagagc agtagtgatc
     7201 atttatgtga gcccctttga aatgatggtg tcagagtgca gagaaacaat ggagttttga
     7261 tgccaaaaag gtttttttgc agtaaaagta aaaatttgga attagttggc atatagagga
     7321 acccttttgt actggaacgt atgaggctgg attgtgaaaa ggtaatcttt cgattgctag
     7381 acttggttaa cttagggctg caaatctttt tcttctgtca aggtcactta atatggaatg
     7441 tttttgtcag actgtccttt gttggaatac tttagctgtt cagctacttt gactcctagg
     7501 agagaattta gttaaggttc aaagtaatta actggctttg ccagtggtga gtcccacacc
     7561 attattcact tagtagtcat ataaatgttt ttatttaaac ttctctctct tcaatgctga
     7621 gaataaggct ttaaattact gattcacctt taaaggaatg ttgtgagaat tgatgtaatt
     7681 tctgtttctg tttccatcta aacttcttta taaaaagagg gattagtttt tttgttttgg
     7741 ggtaagcacc taatttatcc agtaaccaac aaccctaacc attggcatat atagtctttc
     7801 actcagaaat aaacaaaaac tgtttggtat atctgtatca ttgctaatct tgtgcacttt
     7861 actttttggg cagtaccata catagtctga ggctattgac ttaaaccaat aactgtactt
     7921 tatgtaatga ctcttaaatt tggttacctg ggttcacagc ttgcttgaag agaaaggatg
     7981 ctagaataaa gtaagcagct gaagagcgag caaatcaaga caaaacacag tggtctcaga
     8041 tttttcgtag tgtgggaaca gtggttttgc tctataccac tgaaaagcac tataacataa
     8101 ttgttgtcca tgatactgaa gcttttcccc tcacttctag gttgtttaca ttcagagctc
     8161 tatcaataag aggaatacat attacagtga attcgacaac cgcacaagtt ggcagtaggt
     8221 atccccaacc taatttatct tggtaaattc accctgtttc ctagtgctgc tggataaaag
     8281 agtgtttact ttttattgct cttagacaga gtagtctaga taagttttca atttatcaac
     8341 atagcctaga cttctgtaag tggaatgttc attagtaact catctttttg ttgttataat
     8401 tggaaacaga aacgaggctt attgctattg cagaaatccc aaactggcaa aggccagtat
     8461 atatggtatt ccataatata accagctttt gaaatttatg tgtttggatt agtgccttct
     8521 ggttaccagt attgactctg ctagtttgca cctttccgtt cttaacagaa aatttgtatt
     8581 tgttattcct cttaaatttt gtcgtaacta gtgaaggaag taaaaaaaaa aaaaaaacat
     8641 gcattacatt gacatacttt atgtgcagcc tttatttagg ttcagtgaaa ccaggtagtt
     8701 ctgtatttgt gttgtagcct aaatgttgtt tcttttatat ccattaaaaa cttaaagtta
     8761 cttatgttct gtgatcttaa ttttgttgtg tttccattgt aggttgatag gtatatcgag
     8821 aacaggtacg tgacaacagt ttatattcca tgatagaaag ctaaagtcca tagaaagcac
     8881 aaaatcgtgt tcacacatta gtgtacccac acatagaaag cacaagacta atagtattct
     8941 ctgtatccca caagtgccag tcataaaggc caccaggtat ttgtctcaga gttgctatga
     9001 gcactacagt attgataagc ccaagacaat gcggtatcta aactggtcct aatggtaagg
     9061 gacccaaagg aataatctca ataagtttgt accacattga tggagggaga gaatataaat
     9121 gtcaagaatg ccaaaattat atttgggggt tactagctaa aatggggttt gagggctttt
     9181 tactgcaact tgaaactgga gaaataggga cagatgtcta ggtttttggt gggtggaaca
     9241 ggtgacatat ttctgtttta agctgtagtg tgattggggt tttttgtaaa aaatcttaaa
     9301 tcttttagga aatattacct cttaacagtg cccccccaaa catgcagaaa gtcatacttt
     9361 aacagggcaa atactacttg tctttgattt tttttgtgta cgtttgtatg tgagagatga
     9421 agttaccttt atttttttcc tatacttgac tgtgcttcat tttaataaag gataatttga
     9481 tctgagtgtt ctgagcatca gactaattct gaagcatatt tgctagagga gctactttgc
     9541 ttttcacaat ggggtggaga ggattctttc acttgtccca ttaaccctct tctagtctag
     9601 atgagatgaa atctgttaat gtgtgtgtag aagaaaacgt atgttcttct actcagcatt
     9661 gcccttttcc acctcctcac ttcacctccg agtagcttgt ttatcaagaa tgaatgaatg
     9721 tctttgtctt aaattttgcc catgtgttaa aagatgtaat tctcagaatg ggagagaaat
     9781 gactaccttt gttcctactc ttttatataa ttatcctttt agggaaagac ttggtcaact
     9841 ctaatatatc tagaaggaag actatatctg gtgtagacta atatgagatg ttttagaaga
     9901 gttaacctga acactttgag ggagagatta ttcttgccag caaaaagcta gccaggaatg
     9961 agcctaccac attatttgag aatatcaaac ctcaggcctg gggggatgag gggaagaaga
    10021 ttaccagaag tgcaggaaag agaagtttga ggaacaccct tggcttagca acatgtgata
    10081 atgcaaagct gttataacct gttaatccta cgtactatgt gttctgtacc tttacatgtt
    10141 tttaaattta agatagtttg taagaactgt acaaaaaaat gcttctggag atttctttgg
    10201 cagaaatgcc tttcatctat aatttcatgg agaactgctt taattagcct aggtgaaaag
    10261 tagtcctagc agtgtaaata tgtataatta gagttttcta atttcactgt gagatctcta
    10321 acttttgagt ggcaaacaga tcaagtcttt tgctcataga cttttctgtg gggttattaa
    10381 aatgcaaaag ctttattttt tttaataatg ccatactcca ttagtgtcag atgatggtat
    10441 ggaatttgtt cccttgcttt cccccactgt tactgcttca gtttatagat tgccagcaga
    10501 gttcagaaat agagcaggga tttacccgtt ctttgcttgg acatcccatt ttcttttgtc
    10561 cagacccatg ttggcaatca tgtatgaact gtgttatact tctcagtgct ttcttttttc
    10621 tttttgataa gatggatatc aaaaatagtt gctgtgcaaa agttagtagt cttcttcaag
    10681 aagaaaacca attctttttc taataatatc ctgtgaaatt gcttcattca ttcatttatt
    10741 tttaagccaa atgtcagcag agtgctgctg cttttatcta gtaattttga tatgtaagta
    10801 ttaatgcatt tttaaaagat gtctacattg aaacatgttc ttcccagtgt cctgcttatg
    10861 atgctttgtt cagatttttt gtaagagacc agttagtaca ctgggggtgt atattgtgta
    10921 catgtgtcat tttagttagg cattgtaggc caaatgtgat tataaatgaa gttgatgaac
    10981 attaattttg ttattagtga gttttttgaa ttgtaaatgg atttccagtt taccttctgt
    11041 tgtctacagc ttttttaatt ttaaggtttg actaattgta tccatctcat tgtacagtgt
    11101 tttagttgca agcagaaagt agaatttggt ataaagcagg ttatttctat attgaaagga
    11161 gtacagttga aattgtagat ttaagattgt taaaatcatg acaattctaa cttgtctatt
    11221 ctaacctatt gtgtacaatc tgatttttta aaattgtaaa catgtatgat cttggtttca
    11281 tgtgtttttg aaagtgttat tgtttaaaaa atgaaaaaag catatctgct aaagagctgt
    11341 cagttttcat tactgactct gtaaaataca ctgttctttg tgtactgtgt gttattttgc
    11401 cagctgctgc attagccttc aaaagtattt ggaaacttaa gatgaactac atttcttgca
    11461 aagtacattc ctttctgtgg tattttgtcc tgtaactgaa gtatagtaat tattttatgg
    11521 aaatgttagc aattctgtac caactttgaa taaaatgaaa aattta
//
