LOCUS       NM_003041               2267 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens solute carrier family 5 member 2 (SLC5A2), transcript
            variant 1, mRNA.
ACCESSION   NM_003041
VERSION     NM_003041.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Williams,T.L., Kuc,R.E., Paterson,A.L., Abraham,G.R.,
            Pullinger,A.L., Maguire,J.J., Sinha,S., Greasley,P.J., Ambery,P.
            and Davenport,A.P.
  TITLE     Co-localization of the sodium-glucose co-transporter-2 channel
            (SGLT-2) with endothelin ETA and ETB receptors in human cardiorenal
            tissue
  JOURNAL   Biosci Rep 44 (6) (2024)
   PUBMED   38747277
  REMARK    GeneRIF: Co-localization of the sodium-glucose co-transporter-2
            channel (SGLT-2) with endothelin ETA and ETB receptors in human
            cardiorenal tissue.
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Chen,B., Guo,J., Ye,H., Wang,X. and Feng,Y.
  TITLE     Role and molecular mechanisms of SGLT2 inhibitors in pathological
            cardiac remodeling (Review)
  JOURNAL   Mol Med Rep 29 (5) (2024)
   PUBMED   38488029
  REMARK    GeneRIF: Role and molecular mechanisms of SGLT2 inhibitors in
            pathological cardiac remodeling (Review).
            Review article
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Lin,L., Ning,K., Xiang,L., Peng,L. and Li,X.
  TITLE     SGLT2 inhibition and three urological cancers: Up-to-date results
  JOURNAL   Diabetes Metab Res Rev 40 (3), e3797 (2024)
   PUBMED   38523292
  REMARK    GeneRIF: SGLT2 inhibition and three urological cancers: Up-to-date
            results.
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Scisciola,L., Paolisso,P., Belmonte,M., Gallinoro,E., Delrue,L.,
            Taktaz,F., Fontanella,R.A., Degrieck,I., Pesapane,A., Casselman,F.,
            Puocci,A., Franzese,M., Van Praet,F., Torella,M., Marfella,R., De
            Feo,M., Bartunek,J., Paolisso,G., Barbato,E., Barbieri,M. and
            Vanderheyden,M.
  TITLE     Myocardial sodium-glucose cotransporter 2 expression and cardiac
            remodelling in patients with severe aortic stenosis: The BIO-AS
            study
  JOURNAL   Eur J Heart Fail 26 (2), 471-482 (2024)
   PUBMED   38247224
  REMARK    GeneRIF: Myocardial sodium-glucose cotransporter 2 expression and
            cardiac remodelling in patients with severe aortic stenosis: The
            BIO-AS study.
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Lee,J., Hong,S.W., Kim,M.J., Lim,Y.M., Moon,S.J., Kwon,H.,
            Park,S.E., Rhee,E.J. and Lee,W.Y.
  TITLE     Inhibition of Sodium-Glucose Cotransporter-2 during Serum
            Deprivation Increases Hepatic Gluconeogenesis via the AMPK/AKT/FOXO
            Signaling Pathway
  JOURNAL   Endocrinol Metab (Seoul) 39 (1), 98-108 (2024)
   PUBMED   38171209
  REMARK    GeneRIF: Inhibition of Sodium-Glucose Cotransporter-2 during Serum
            Deprivation Increases Hepatic Gluconeogenesis via the AMPK/AKT/FOXO
            Signaling Pathway.
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Santer,R., Kinner,M., Lassen,C.L., Schneppenheim,R., Eggert,P.,
            Bald,M., Brodehl,J., Daschner,M., Ehrich,J.H., Kemper,M., Li
            Volti,S., Neuhaus,T., Skovby,F., Swift,P.G., Schaub,J. and
            Klaerke,D.
  TITLE     Molecular analysis of the SGLT2 gene in patients with renal
            glucosuria
  JOURNAL   J Am Soc Nephrol 14 (11), 2873-2882 (2003)
   PUBMED   14569097
  REMARK    GeneRIF: SGLT2 plays an important role in renal tubular glucose
            reabsorption.
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   van den Heuvel,L.P., Assink,K., Willemsen,M. and Monnens,L.
  TITLE     Autosomal recessive renal glucosuria attributable to a mutation in
            the sodium glucose cotransporter (SGLT2)
  JOURNAL   Hum Genet 111 (6), 544-547 (2002)
   PUBMED   12436245
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Wright,E.M.
  TITLE     Renal Na(+)-glucose cotransporters
  JOURNAL   Am J Physiol Renal Physiol 280 (1), F10-F18 (2001)
   PUBMED   11133510
  REMARK    Review article
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   Wells,R.G., Mohandas,T.K. and Hediger,M.A.
  TITLE     Localization of the Na+/glucose cotransporter gene SGLT2 to human
            chromosome 16 close to the centromere
  JOURNAL   Genomics 17 (3), 787-789 (1993)
   PUBMED   8244402
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Wells,R.G., Pajor,A.M., Kanai,Y., Turk,E., Wright,E.M. and
            Hediger,M.A.
  TITLE     Cloning of a human kidney cDNA with similarity to the
            sodium-glucose cotransporter
  JOURNAL   Am J Physiol 263 (3 Pt 2), F459-F465 (1992)
   PUBMED   1415574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M95549.1 and AI222550.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003041.3.
            
            Summary: This gene encodes a member of the sodium glucose
            cotransporter family which are sodium-dependent glucose transport
            proteins. The encoded protein is the major cotransporter involved
            in glucose reabsorption in the kidney. Mutations in this gene are
            associated with renal glucosuria. Two transcript variants, one
            protein-coding and one not, have been found for this gene.
            [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) is the longer, protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M95549.1, DRR138523.217967.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330498.4/ ENSP00000327943.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2266              M95549.1           7-2272
            2267-2267           AI222550.1         8-8                 c
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2267
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /note="solute carrier family 5 member 2"
                     /db_xref="GeneID:6524"
                     /db_xref="HGNC:HGNC:11037"
                     /db_xref="MIM:182381"
     exon            1..140
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2033
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /note="low affinity sodium-glucose cotransporter;
                     Na(+)/glucose cotransporter 2; solute carrier family 5
                     (sodium/glucose transporter), member 2; solute carrier
                     family 5 (sodium/glucose cotransporter), member 2"
                     /codon_start=1
                     /product="sodium/glucose cotransporter 2"
                     /protein_id="NP_003032.1"
                     /db_xref="CCDS:CCDS10714.1"
                     /db_xref="GeneID:6524"
                     /db_xref="HGNC:HGNC:11037"
                     /db_xref="MIM:182381"
                     /translation="MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSM
                     CRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNA
                     LFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMF
                     SGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGY
                     AFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPW
                     PALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMI
                     SRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMS
                     SLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGG
                     QLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGS
                     GSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHS
                     KEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGS
                     PPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA"
     exon            141..212
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            213..317
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..482
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..588
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..669
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..899
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1035
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1143
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1294
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1463
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1679
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1806
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2267
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2245..2250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /note="hexamer: AATAAA"
     polyA_site      2267
                     /gene="SLC5A2"
                     /gene_synonym="SGLT2"
                     /note="major polyA site"
ORIGIN      
        1 agatcctggg gagaatggag gagcacacag aggcaggctc ggcaccagag atgggggccc
       61 agaaggccct gattgacaat cctgctgaca tcctagtcat tgctgcatat ttcctgctgg
      121 tcattggcgt tggcttgtgg tccatgtgca gaaccaacag aggcactgtg ggcggctact
      181 tcctggcagg acgcagcatg gtgtggtggc cggttggggc ctctctcttc gccagcaaca
      241 tcggcagtgg ccactttgtg ggcctggcag ggactggcgc tgcaagtggc ttggctgttg
      301 ctggattcga gtggaatgcg ctcttcgtgg tgctgctact gggctggctg tttgcacccg
      361 tgtacctgac agcgggggtc atcacgatgc cacagtacct gcgcaagcgc ttcggcggcc
      421 gccgcatccg cctctacctg tctgtgctct cccttttcct gtacatcttc accaagatct
      481 cagtggacat gttctccgga gctgtattca tccagcaggc tctgggctgg aacatctatg
      541 cctccgtcat cgcgcttctg ggcatcacca tgatttacac ggtgacagga gggctggccg
      601 cgctgatgta cacggacacg gtacagacct tcgtcattct ggggggcgcc tgcatcctca
      661 tgggttacgc cttccacgag gtgggcgggt attcgggtct cttcgacaaa tacctgggag
      721 cagcgacttc gctgacggtg tccgaggatc cagccgtggg aaacatctcc agcttctgct
      781 atcgaccccg gcccgactcc taccacctgc tccggcaccc cgtgaccggg gatctgccgt
      841 ggcccgcgct gctcctcgga ctcacaatcg tctcgggctg gtactggtgc agcgaccagg
      901 tcatcgtgca gcgctgcctg gccgggaaga gcctgaccca catcaaggcg ggctgcatcc
      961 tgtgtgggta cctgaagctg acgcccatgt ttctcatggt catgccaggc atgatcagcc
     1021 gcattctgta cccagacgag gtggcgtgcg tggtgcctga ggtgtgcagg cgcgtgtgcg
     1081 gcacggaggt gggctgctcc aacatcgcct acccgcggct cgtcgtgaag ctcatgccca
     1141 acggtctgcg cggactcatg ctggcggtca tgctggccgc gctcatgtcc tcgctggcct
     1201 ccatcttcaa cagcagcagc acgctcttca ccatggacat ctacacgcgc ctgcggccac
     1261 gcgccggcga ccgcgagctg ctgctggtgg gacggctctg ggtggtgttc atcgtggtag
     1321 tgtcggtggc ctggcttccc gtggtgcagg cggcacaggg cgggcagctc ttcgattaca
     1381 tccaggcagt ctctagctac ctggcaccgc ccgtgtccgc cgtcttcgtg ctggcgctct
     1441 tcgtgccgcg cgttaatgag cagggcgcct tctggggact catcgggggc ctgctgatgg
     1501 gcctggcacg cctgattccc gagttctcct tcggctcggg cagctgtgtg cagccctcgg
     1561 cgtgcccagc tttcctctgc ggcgtgcact acctctactt cgccattgtg ctgttcttct
     1621 gctctggcct cctcaccctc acggtctccc tgtgcaccgc gcccatcccc agaaagcacc
     1681 tccaccgcct ggtcttcagt ctccggcata gcaaggagga acgggaggac ctggatgctg
     1741 atgagcagca aggctcctca ctccctgtac agaatgggtg cccagagagt gccatggaga
     1801 tgaatgagcc ccaggccccg gcaccaagcc tcttccgcca gtgcctgctc tggttttgtg
     1861 gaatgagcag aggtggggtg ggcagtcctc cgccccttac ccaggaggag gcagcggcag
     1921 cagccaggcg gctggaggac atcagcgagg acccgagctg ggcccgtgtg gtcaacctca
     1981 atgccctgct catgatggca gtggccgtgt tcctctgggg cttctatgcc taagaccaac
     2041 tgcgttggac accataagcc acagcctcac aggaagtggg ggtgaggagc ctgcggtgct
     2101 ccccagaaaa ggggaagggg cagtggggtg agaaggtcct ggctcccctt ctcccggcct
     2161 tcctctgcct ggggcccact gcatctgatt ggcagtcact tcccatgagg gcctggccca
     2221 cccgctgcag ttgccctaag gaaaaataaa gctgcctttc ccctgtc
//
