LOCUS       NM_001042450            3966 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens solute carrier family 5 member 10 (SLC5A10),
            transcript variant 2, mRNA.
ACCESSION   NM_001042450 XM_001132895
VERSION     NM_001042450.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3966)
  AUTHORS   Diederich,J., Mounkoro,P., Tirado,H.A., Chevalier,N., Van
            Schaftingen,E. and Veiga-da-Cunha,M.
  TITLE     SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major
            player in two rare forms of neutropenia
  JOURNAL   Cell Mol Life Sci 80 (9), 259 (2023)
   PUBMED   37594549
  REMARK    GeneRIF: SGLT5 is the renal transporter for 1,5-anhydroglucitol, a
            major player in two rare forms of neutropenia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3966)
  AUTHORS   Loomis,S.J., Kottgen,A., Li,M., Tin,A., Coresh,J., Boerwinkle,E.,
            Gibbs,R., Muzny,D., Pankow,J., Selvin,E. and Duggal,P.
  TITLE     Rare variants in SLC5A10 are associated with serum
            1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in
            Communities (ARIC) Study
  JOURNAL   Sci Rep 9 (1), 5941 (2019)
   PUBMED   30976018
  REMARK    GeneRIF: Rare variants in SLC5A10 are associated with serum
            1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in
            Communities (ARIC) Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3966)
  AUTHORS   Hong,M.J., Yoo,S.S., Choi,J.E., Kang,H.G., Do,S.K., Lee,J.H.,
            Lee,W.K., Lee,J., Lee,S.Y., Cha,S.I., Kim,C.H., Lee,E.B., Cho,S.,
            Jheon,S. and Park,J.Y.
  TITLE     Functional intronic variant of SLC5A10 affects DRG2 expression and
            survival outcomes of early-stage non-small-cell lung cancer
  JOURNAL   Cancer Sci 109 (12), 3902-3909 (2018)
   PUBMED   30281872
  REMARK    GeneRIF: Results show that rs2257609 C>T is located in the intron
            region of SLC5A10 and is significantly associated with worse
            overall and disease-free survival of non-small-cell lung cancer
            (NSCLC) patients. The rs2257609 C>T variant does not affect the
            expression of SLC5A10 mRNA, but alters the mRNA expression and
            promoter activity of DRG2.
REFERENCE   4  (bases 1 to 3966)
  AUTHORS   Ghezzi,C., Gorraitz,E., Hirayama,B.A., Loo,D.D., Grempler,R.,
            Mayoux,E. and Wright,E.M.
  TITLE     Fingerprints of hSGLT5 sugar and cation selectivity
  JOURNAL   Am J Physiol Cell Physiol 306 (9), C864-C870 (2014)
   PUBMED   24573086
  REMARK    GeneRIF: hSGLT5 is a sodium/mannose transporter that is blocked by
            phlorizin. Li(+) and H(+) ions were also able to drive mannose
            transport, and transport was electrogenic.
REFERENCE   5  (bases 1 to 3966)
  AUTHORS   Fukuzawa,T., Fukazawa,M., Ueda,O., Shimada,H., Kito,A.,
            Kakefuda,M., Kawase,Y., Wada,N.A., Goto,C., Fukushima,N.,
            Jishage,K., Honda,K., King,G.L. and Kawabe,Y.
  TITLE     SGLT5 reabsorbs fructose in the kidney but its deficiency
            paradoxically exacerbates hepatic steatosis induced by fructose
  JOURNAL   PLoS One 8 (2), e56681 (2013)
   PUBMED   23451068
REFERENCE   6  (bases 1 to 3966)
  AUTHORS   Grempler,R., Augustin,R., Froehner,S., Hildebrandt,T., Simon,E.,
            Mark,M. and Eickelmann,P.
  TITLE     Functional characterisation of human SGLT-5 as a novel
            kidney-specific sodium-dependent sugar transporter
  JOURNAL   FEBS Lett 586 (3), 248-253 (2012)
   PUBMED   22212718
  REMARK    GeneRIF: SGLT-5 as a kidney mannose transporter
REFERENCE   7  (bases 1 to 3966)
  AUTHORS   Chen,J., Williams,S., Ho,S., Loraine,H., Hagan,D., Whaley,J.M. and
            Feder,J.N.
  TITLE     Quantitative PCR tissue expression profiling of the human SGLT2
            gene and related family members
  JOURNAL   Diabetes Ther 1 (2), 57-92 (2010)
   PUBMED   22127746
REFERENCE   8  (bases 1 to 3966)
  AUTHORS   Lynn,K.S., Li,L.L., Lin,Y.J., Wang,C.H., Sheng,S.H., Lin,J.H.,
            Liao,W., Hsu,W.L. and Pan,W.H.
  TITLE     A neural network model for constructing endophenotypes of common
            complex diseases: an application to male young-onset hypertension
            microarray data
  JOURNAL   Bioinformatics 25 (8), 981-988 (2009)
   PUBMED   19237446
REFERENCE   9  (bases 1 to 3966)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 3966)
  AUTHORS   Wright,E.M. and Turk,E.
  TITLE     The sodium/glucose cotransport family SLC5
  JOURNAL   Pflugers Arch 447 (5), 510-518 (2004)
   PUBMED   12748858
  REMARK    Review article
            Erratum:[Pflugers Arch. 2004 Feb;447(5):813-5]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP332461.1, DR003789.1,
            BC034380.1, AA745934.1 and AC003957.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001042450.3.
            
            Summary: This gene is a member of the sodium/glucose transporter
            family. Members of this family are sodium-dependent transporters
            and can be divided into two subfamilies based on sequence homology,
            one that co-transports sugars and the second that transports
            molecules such as ascorbate, choline, iodide, lipoate,
            monocaroboxylates, and pantothenate. The protein encoded by this
            gene has the highest affinity for mannose and has been reported to
            be most highly expressed in the kidney. This protein may function
            as a kidney-specific, sodium-dependent mannose and fructose
            co-transporter. Alternative splicing results in multiple transcript
            variants that encode different protein isoforms. [provided by
            RefSeq, Jul 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395645.4/ ENSP00000379007.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BP332461.1         1-7
            8-55                DR003789.1         8-55
            56-2086             BC034380.1         1-2031
            2087-2092           AA745934.1         5-10                c
            2093-3966           AC003957.1         10873-12746         c
FEATURES             Location/Qualifiers
     source          1..3966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..3966
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /note="solute carrier family 5 member 10"
                     /db_xref="GeneID:125206"
                     /db_xref="HGNC:HGNC:23155"
                     /db_xref="MIM:618636"
     exon            1..152
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1832
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sodium/glucose cotransporter 5; Na(+)/glucose
                     cotransporter 5; solute carrier family 5 (sodium/sugar
                     cotransporter), member 10; solute carrier family 5
                     (sodium/glucose cotransporter), member 10; sodium/mannose
                     cotransporter SLC5A10"
                     /codon_start=1
                     /product="sodium/mannose cotransporter SLC5A10 isoform 2"
                     /protein_id="NP_001035915.1"
                     /db_xref="CCDS:CCDS42275.1"
                     /db_xref="GeneID:125206"
                     /db_xref="HGNC:HGNC:23155"
                     /db_xref="MIM:618636"
                     /translation="MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASR
                     NTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLL
                     ALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALF
                     VHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQI
                     GGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATW
                     YWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVV
                     PSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLF
                     TMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSL
                     APPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVL
                     GSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQT
                     PQKHAFWARVCGFNAILLMCVNIFFYAYFA"
     exon            153..224
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            225..329
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            330..389
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            390..494
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            495..600
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            601..681
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            682..887
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1023
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1131
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1282
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1451
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1667
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1725
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..3966
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2086
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /note="major polyA site"
     regulatory      3944..3949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
                     /note="hexamer: TATAAA"
     polyA_site      3966
                     /gene="SLC5A10"
                     /gene_synonym="SGLT-5; SGLT5"
ORIGIN      
        1 agtccctcgg gctcatacct agtgcctgcg gcaggacagc catggccgcc aactccacca
       61 gcgacctcca cactcccggg acgcagctga gcgtggctga catcatcgtc atcactgtgt
      121 attttgctct gaatgtggcc gtgggcatat ggtcctcttg tcgggccagt aggaacacgg
      181 tgaatggcta cttcctggca ggccgggaca tgacgtggtg gccgattgga gcctccctct
      241 tcgccagcag cgagggctct ggcctcttca ttggactggc gggctcaggc gcggcaggag
      301 gtctggccgt ggcaggcttc gagtggaatg ccacgtacgt gctgctggca ctggcatggg
      361 tgttcgtgcc catctacatc tcctcagaga tcgtcacctt acctgagtac attcagaagc
      421 gctacggggg ccagcggatc cgcatgtacc tgtctgtcct gtccctgcta ctgtctgtct
      481 tcaccaagat atcgctggac ctgtacgcgg gggctctgtt tgtgcacatc tgcctgggct
      541 ggaacttcta cctctccacc atcctcacgc tcggcatcac agccctgtac accatcgcag
      601 ggggcctggc tgctgtaatc tacacggacg ccctgcagac gctcatcatg gtggtggggg
      661 ctgtcatcct gacaatcaaa gcttttgacc agatcggtgg ttacgggcag ctggaggcag
      721 cctacgccca ggccattccc tccaggacca ttgccaacac cacctgccac ctgccacgta
      781 cagacgccat gcacatgttt cgagaccccc acacagggga cctgccgtgg accgggatga
      841 cctttggcct gaccatcatg gccacctggt actggtgcac cgaccaggtc atcgtgcagc
      901 gatcactgtc agcccgggac ctgaaccatg ccaaggcggg ctccatcctg gccagctacc
      961 tcaagatgct ccccatgggc ctgatcatca tgccgggcat gatcagccgc gcattgttcc
     1021 cagatgatgt gggctgcgtg gtgccgtccg agtgcctgcg ggcctgcggg gccgaggtcg
     1081 gctgctccaa catcgcctac cccaagctgg tcatggaact gatgcccatc ggtctgcggg
     1141 ggctgatgat cgcagtgatg ctggcggcgc tcatgtcgtc gctgacctcc atcttcaaca
     1201 gcagcagcac cctcttcact atggacatct ggaggcggct gcgtccccgc tccggcgagc
     1261 gggagctcct gctggtggga cggctggtca tagtggcact catcggcgtg agtgtggcct
     1321 ggatccccgt cctgcaggac tccaacagcg ggcaactctt catctacatg cagtcagtga
     1381 ccagctccct ggccccacca gtgactgcag tctttgtcct gggcgtcttc tggcgacgtg
     1441 ccaacgagca gggggccttc tggggcctga tagcagggct ggtggtgggg gccacgaggc
     1501 tggtcctgga attcctgaac ccagccccac cgtgcggaga gccagacacg cggccagccg
     1561 tcctggggag catccactac ctgcacttcg ctgtcgccct ctttgcactc agtggtgctg
     1621 ttgtggtggc tggaagcctg ctgaccccac ccccacagag tgtccagatt gagaacctta
     1681 cctggtggac cctggctcag gatgtgccct tgggaactaa agcaggtgat ggccaaacac
     1741 cccagaaaca cgccttctgg gcccgtgtct gtggcttcaa tgccatcctc ctcatgtgtg
     1801 tcaacatatt cttttatgcc tacttcgcct gacactgcca tcctggacag aaaggcagga
     1861 gctctgagtc ctcaggtcca cccatttccc tcatggggat cccgaggccc caagaggggc
     1921 agattcccct cacagctgca cagcagctcg gtgcccaaga actggccaag ccagcaaagc
     1981 gggagccctg aaaaattagg ggggaaatgg gagaaaataa tgtgacattt caaaaacagc
     2041 accaaagcag tcagcattgg aaggaaaatt agatttctga cggacatcct gatgttggtt
     2101 ttactgtttt cgttttgaat acacaggctg ggtcaggagc agtgagattt gccagcactc
     2161 agggttctaa gggtcttggg ccagctctgg atggaggaag agccccacat gcccagagca
     2221 aggcccccca ttaagggact gcagccacct ccaagggctc ctccctccac ccaccggctc
     2281 ccaaatgcca gagggagcct cttcgccctc cctccctgcc caccatccct caaccatcag
     2341 cctggcgttc aaagcctttc caagtcccac ctcacttttc cctctcccaa aggtgcccag
     2401 gctctgggca ggccctgctc atatccctga tcatggcaca ttctctggag gaccctcctg
     2461 ttctcgggta ggggccgtgc cccacctagg tagccgtccc atgtgggatc ctgtaggatc
     2521 tctaaaacct agctctggcc ccaactttct gtctgccctg gaggtttctc agcctcctga
     2581 gagctctgct gggccccggt ctgggcagaa cctgggccta aacaaacaag agccagggca
     2641 gccagggtct ctgcgtggct gggcccaggg cttgccctca gagctcacct gtccaacaga
     2701 agaggagtgt gcctccacct tccctactgc ccgccccttt ttcagggtct tagggcctct
     2761 agccctgtgg tggggtgctg ggtgccccag gtggagctga agtcatgggg ctgttgagga
     2821 gttggtgtcc acctggagtc tgtccagtga gtttaggtca acaggtgtgc agtctgtcct
     2881 tcgaggctga gccacctccc aacagcctga acaactccag gggccttttg agggaggggc
     2941 aggcaggccc agtgggtggt cagcccaagg tgaacccacc caccatggcc agggttcctt
     3001 aggttgagcc tccagtgggt gaaacctggg agtcctcaac cttcctggca gatggggcca
     3061 ttgacaagag gaggtgggcg gggcctccac agactccgcc ctgtggtgtc acacagctgg
     3121 cagccaatgg aaagcaacca gccaggaagc cccggagcta cccttgctgg gtacccttgc
     3181 tgggggacct gggccatccc agtttgtgca gagcggccgg aggcagttag gagcccacgt
     3241 tcagtccaag gccgtccact gagccccgtg tgactctgac agagctgggg gtgtccatgt
     3301 cctctctgga cctcagttcc tgtaaaaagg cccgttggcc agatcggccg ccgggctgct
     3361 cacaggtgca cgggctgcac gtaactccgt gggaagaagc caacgcgccc gcaggaccgg
     3421 ccccgccacc agtgggggtc tgggcgctcc aggacctcaa tgatgtcgcc acggcggaag
     3481 ctgagctgcg aggggtcctg ggctgagaag tcaaactggg cctgggcaaa gcaggcccca
     3541 ggtgactgca agaagaggag gtggttagta gggtgccttc agaagccctg caacccaccc
     3601 tccctcagag gcacccaaga gaagtgattt gccacaggtg aggaggggtc tcgggcagca
     3661 ccggagttga actttaagtc cagatcaatg gtagtgccac cactgggcct cctgctgccc
     3721 acacccctgc ctgtctgctg tgcagatgct gcatctacat agaacacggc tttcccagcc
     3781 gcccagctgg gacaataggg ctggtgggtc aggggacctg agtcctggtc cttagggtgg
     3841 gattttggtt aggtccctgc ttctcttggg atcttattta cccgactctg cagcagccat
     3901 ggtagctttt gactccaggc cacaaagcca tgagaatggg ccttataaac tgtaaagtga
     3961 cgtgca
//
