LOCUS       NM_000343               4832 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens solute carrier family 5 member 1 (SLC5A1), transcript
            variant 1, mRNA.
ACCESSION   NM_000343
VERSION     NM_000343.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4832)
  AUTHORS   Hosnut,F.O., Janecke,A.R., Sahin,G., Vogel,G.F., Lafci,N.G.,
            Bichler,P., Muller,T., Huber,L.A., Valovka,T. and Aksu,A.U.
  TITLE     SLC5A1 Variants in Turkish Patients with Congenital
            Glucose-Galactose Malabsorption
  JOURNAL   Genes (Basel) 14 (7), 1359 (2023)
   PUBMED   37510265
  REMARK    GeneRIF: SLC5A1 Variants in Turkish Patients with Congenital
            Glucose-Galactose Malabsorption.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4832)
  AUTHORS   Fiorentino,T.V., De Vito,F., Suraci,E., Marasco,R., Hribal,M.L.,
            Luzza,F. and Sesti,G.
  TITLE     Obesity and overweight are linked to increased sodium-glucose
            cotransporter 1 and glucose transporter 5 levels in duodenum
  JOURNAL   Obesity (Silver Spring) 31 (3), 724-731 (2023)
   PUBMED   36746764
  REMARK    GeneRIF: Obesity and overweight are linked to increased
            sodium-glucose cotransporter 1 and glucose transporter 5 levels in
            duodenum.
REFERENCE   3  (bases 1 to 4832)
  AUTHORS   Chen,H., Zhang,X., Liao,N., Ji,Y., Mi,L., Gan,Y., Su,Y. and Wen,F.
  TITLE     Decreased expression of Glucagon-like peptide-1 receptor and
            Sodium-glucose co-transporter 2 in patients with proliferative
            diabetic retinopathy
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020252 (2022)
   PUBMED   36465606
  REMARK    GeneRIF: Decreased expression of Glucagon-like peptide-1 receptor
            and Sodium-glucose co-transporter 2 in patients with proliferative
            diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4832)
  AUTHORS   Chen,S., Wu,Y., Wang,S., Wu,J., Wu,X. and Zheng,Z.
  TITLE     A risk model of gene signatures for predicting platinum response
            and survival in ovarian cancer
  JOURNAL   J Ovarian Res 15 (1), 39 (2022)
   PUBMED   35361267
  REMARK    GeneRIF: A risk model of gene signatures for predicting platinum
            response and survival in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4832)
  AUTHORS   Kamitori,K., Shirota,M. and Fujiwara,Y.
  TITLE     Structural Basis of the Selective Sugar Transport in Sodium-Glucose
            Cotransporters
  JOURNAL   J Mol Biol 434 (5), 167464 (2022)
   PUBMED   35077764
REFERENCE   6  (bases 1 to 4832)
  AUTHORS   Delezay,O., Baghdiguian,S. and Fantini,J.
  TITLE     The development of Na(+)-dependent glucose transport during
            differentiation of an intestinal epithelial cell clone is regulated
            by protein kinase C
  JOURNAL   J Biol Chem 270 (21), 12536-12541 (1995)
   PUBMED   7759499
REFERENCE   7  (bases 1 to 4832)
  AUTHORS   Wright,E.M., Loo,D.D., Panayotova-Heiermann,M., Lostao,M.P.,
            Hirayama,B.H., Mackenzie,B., Boorer,K. and Zampighi,G.
  TITLE     'Active' sugar transport in eukaryotes
  JOURNAL   J Exp Biol 196, 197-212 (1994)
   PUBMED   7823022
  REMARK    Review article
REFERENCE   8  (bases 1 to 4832)
  AUTHORS   Turk,E., Martin,M.G. and Wright,E.M.
  TITLE     Structure of the human Na+/glucose cotransporter gene SGLT1
  JOURNAL   J Biol Chem 269 (21), 15204-15209 (1994)
   PUBMED   8195156
REFERENCE   9  (bases 1 to 4832)
  AUTHORS   Turk,E., Zabel,B., Mundlos,S., Dyer,J. and Wright,E.M.
  TITLE     Glucose/galactose malabsorption caused by a defect in the
            Na+/glucose cotransporter
  JOURNAL   Nature 350 (6316), 354-356 (1991)
   PUBMED   2008213
REFERENCE   10 (bases 1 to 4832)
  AUTHORS   Hediger,M.A., Turk,E. and Wright,E.M.
  TITLE     Homology of the human intestinal Na+/glucose and Escherichia coli
            Na+/proline cotransporters
  JOURNAL   Proc Natl Acad Sci U S A 86 (15), 5748-5752 (1989)
   PUBMED   2490366
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ656053.2, AK312948.1 and
            Z83839.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000343.3.
            
            Summary: This gene encodes a member of the sodium-dependent glucose
            transporter (SGLT) family. The encoded integral membrane protein is
            the primary mediator of dietary glucose and galactose uptake from
            the intestinal lumen. Mutations in this gene have been associated
            with glucose-galactose malabsorption. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M24847.1, CR456579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266088.9/ ENSP00000266088.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               DQ656053.2         230-457
            229-2016            AK312948.1         362-2149
            2017-4832           Z83839.1           781-3596
FEATURES             Location/Qualifiers
     source          1..4832
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..4832
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="solute carrier family 5 member 1"
                     /db_xref="GeneID:6523"
                     /db_xref="HGNC:HGNC:11036"
                     /db_xref="MIM:182380"
     exon            1..156
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2016
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Na+/glucose cotransporter 1; high affinity sodium-glucose
                     cotransporter; solute carrier family 5 (sodium/glucose
                     cotransporter), member 1"
                     /codon_start=1
                     /product="sodium/glucose cotransporter 1 isoform 1"
                     /protein_id="NP_000334.1"
                     /db_xref="CCDS:CCDS13902.1"
                     /db_xref="GeneID:6523"
                     /db_xref="HGNC:HGNC:11036"
                     /db_xref="MIM:182380"
                     /translation="MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGL
                     WAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFE
                     WNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISA
                     DIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLIL
                     TGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPW
                     PGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMI
                     SRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMS
                     SLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSG
                     QLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGT
                     GSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNS
                     KEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEE
                     EKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA"
     exon            157..228
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..333
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..393
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..498
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..604
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..685
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..906
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1042
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1150
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1301
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1470
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1686
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1792
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..4832
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2147..2152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="hexamer: ATTATA"
     polyA_site      2169
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="major polyA site"
     regulatory      2442..2447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="hexamer: AAGAAA"
     polyA_site      2462
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="major polyA site"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="hexamer: AATAAA"
     polyA_site      2814
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
     regulatory      4280..4285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="hexamer: AATAAA"
     polyA_site      4305
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
     regulatory      4754..4759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
                     /note="hexamer: TATAAA"
     polyA_site      4775
                     /gene="SLC5A1"
                     /gene_synonym="D22S675; NAGT; SGLT-1; SGLT1"
ORIGIN      
        1 gaaggacgca acgctgccac catggacagt agcacctgga gccccaagac caccgcggtc
       61 acccggcctg ttgagaccca cgagctcatt cgcaatgcag ccgatatctc catcatcgtt
      121 atctacttcg tggtagtgat ggccgtcgga ctgtgggcta tgttttccac caatcgtggg
      181 actgttggag gcttcttcct ggcaggccga agtatggtgt ggtggccgat tggagcctcc
      241 ctctttgcta gtaacattgg aagtggccac tttgtggggc tggccgggac tggggcagct
      301 tcaggcatcg ccattggagg ctttgaatgg aatgccctgg ttttggtggt tgtgctgggc
      361 tggctgtttg tccccatcta tattaaggct ggggtggtga caatgccaga gtacctgagg
      421 aagcggtttg gaggccagcg gatccaggtc tacctttccc ttctgtccct gctgctctac
      481 attttcacca agatctcggc agacatcttc tcgggggcca tattcatcaa tctggcctta
      541 ggcctgaatc tgtatttagc catctttctc ttattggcaa tcactgccct ttacacaatt
      601 acagggggcc tggcggcggt gatttacacg gacaccttgc agacggtgat catgctggtg
      661 gggtctttaa tcctgactgg gtttgctttt cacgaagtgg gaggctatga cgccttcatg
      721 gaaaagtaca tgaaagccat tccaaccata gtgtctgatg gcaacaccac ctttcaggaa
      781 aaatgctaca ctccaagggc cgactccttc cacatcttcc gagatcccct cacgggagac
      841 ctcccatggc ctgggttcat ctttgggatg tccatcctta ccttgtggta ctggtgcaca
      901 gatcaggtca ttgtgcagcg ctgcctctca gccaagaata tgtctcacgt gaagggtggc
      961 tgcatcctgt gtgggtatct aaagctgatg cccatgttca tcatggtgat gccaggaatg
     1021 atcagccgca ttctgtacac agaaaaaatt gcctgtgtcg tcccttcaga atgtgagaaa
     1081 tattgcggta ccaaggttgg ctgtaccaac atcgcctatc caaccttagt ggtggagctc
     1141 atgcccaatg gactgcgagg cctgatgcta tcagtcatgc tggcctccct catgagctcc
     1201 ctgacctcca tcttcaacag cgccagcacc ctcttcacca tggacatcta cgccaaggtc
     1261 cgcaagagag catctgagaa agagctcatg attgccggaa ggttgtttat cctggtgctg
     1321 attggcatca gcatcgcctg ggtgcccatt gtgcagtcag cacaaagtgg gcaactcttc
     1381 gattacatcc agtccatcac cagttacttg ggaccaccca ttgcggctgt cttcctgctt
     1441 gctattttct ggaagagagt caatgagcca ggagcctttt ggggactgat cctaggactt
     1501 ctgattggga tttcacgtat gattactgag tttgcttatg gaaccgggag ctgcatggag
     1561 cccagcaact gtcccacgat tatctgtggg gtgcactact tgtactttgc cattatcctc
     1621 ttcgccattt ctttcatcac catcgtggtc atctccctcc tcaccaaacc cattccggat
     1681 gtgcatctct accgtctgtg ttggagcctg cgcaacagca aagaggagcg tattgacctg
     1741 gatgcggaag aggagaacat ccaagaaggc cctaaggaga ccattgaaat agaaacacaa
     1801 gttcctgaga agaaaaaagg aatcttcagg agagcctatg acctattttg tgggctagag
     1861 cagcacggtg cacccaagat gactgaggaa gaggagaaag ccatgaagat gaagatgacg
     1921 gacacctctg agaagccttt gtggaggaca gtgttgaacg tcaatggcat catcctggtg
     1981 accgtggctg tcttttgcca tgcatatttt gcctgagtcc taccttttgc tgtagattta
     2041 ccatggctgg actcttactc accttccttt agtctcgtcc tgtggtgttg aagggaaatc
     2101 agccagttgt aaattttgcc caggtggata aatgtgtaca tgtgtaatta taggctagct
     2161 ggaagaaaac cattagtttg ctgttaattt atgcatttga agccagtgtg atacagccat
     2221 ctgtacctac tggagctgca gaagggaagt ccactcagtc acatccagaa aaaggcagac
     2281 taagaatcag aagccatgtg attgatgtct gacgtgagtc tgtctcaggt agattccggg
     2341 tgtcagtgtg gtttataatc cttgaatatt gttttagaaa ctttggtctc cctggttcct
     2401 gccacttttc ctgtccgtcc tcctccccat ttttttttta aaagaaagct gttttcccct
     2461 catcatatcc ctcttgagtt ttgcctggac tttccctctc aagtgtgtca atcaggtaaa
     2521 ctgaggaatg catggaagct gaggatggag cttgatgggc tccctgtcct gggtgtttgc
     2581 tctctgaagt ggaggcctga ggaaggtagt acttccacaa aagggaggga cccgggcccc
     2641 agcctcaagc tagtggggga ggcagatagc ctgaatccag gggattttct gggcttctta
     2701 aaatgtccat tgtgagttcc ccgtgtttgg gattccactc attttggcat tcacagtgcc
     2761 tggaatgtct tagattttca gcaatgcgtg ttgaataaat gaatgacata ggcatttatt
     2821 tttaaatctt tgcttgcttt ttacatgagc ctggccctta gttaaccttt tcttgtggct
     2881 acacaaagta tgctcactgg ttactaatga cttgggatgc atttgtcaaa ctgattatat
     2941 tagttttcta gggatgccat aacaaagtag cacagaccag atggctcaag cagcagacat
     3001 ttattttctc acagttctag aggctagaag ttggaggcca agatgtcagc agggttggtt
     3061 tcttctgagg cctctctcct tggttgcaga tggtcatatc tcactctgtc ttccgtggcc
     3121 ttccttttgt ctgtgtccta aatctactct tctgataagg acatcagtca tattggaata
     3181 ggacccaccc taatgtcttc attttaatca cctctttaaa gcccctacct ccaaatacag
     3241 tcacactgtg agaaactgag ggttaggaag tcagcaagtg agtcttgaag agatactaaa
     3301 caaacccaca acacagataa agtatgcatt ttggagattt ccaagccaga gtctcccgtg
     3361 aaaaaggtaa acggaagcag ttattgtgca gcaaaaggaa aaagaattac aaactgaacg
     3421 tatgtaggtg aggcaaggca gggtagggca gggcctttgg gtaggctgat cagagggttt
     3481 ttcaacaata aatcaatggg aatgcatttg ttgctcccag gaccctggca ccttgactct
     3541 ggtactatag catgtcagca aatacaagca aagcccaaca ctctgatttg catttatgcc
     3601 aatctaaact atccggtgtt tagtttgatt ttttgagtgc aggttcattc aaggaccagg
     3661 ttcccttgtg ctcagggtga agtagaacca gaaaacatcg ttatccattc ccagaagttt
     3721 tggaagagcc ttggtagaaa agcagaagct gctttgaccg tgaaaatatt tgactcctat
     3781 cagtttttgg tcaggagaag atatccacct agaccaacct gaggagaagg ctcagagtac
     3841 agatataccc cgagcaacgt gatcaatgtc cttgaacctt catttttcat ctgaaaacag
     3901 agacataaat gcctggctca cagatttaaa tgttatacat tgacagcatt tatcagtata
     3961 acatttattt aaataagtag gtgctcaata ggtgttggtc ttctaacttg tctacatccc
     4021 atccccattc cagggtcttc agaattgaag gagagatgtt gtatcactgt tagaaggctg
     4081 ctttgggaca ttctgcagca gggaggaggg actgtcaacc cctacaccat gaccaccaag
     4141 ttcctcacct tggctgagtc cctaaaactc tctgaacctc aggttcctcc aagcataatg
     4201 cagacttcac agagctgttg taaagattag gtgaggtcaa ttgatactgc ttaaaaggcc
     4261 cggtccgtag aaaatgccca ataaacatta ctgctttccc cctcacccta ctgcctgaaa
     4321 aaatattaca cctgtgagac tgactttgag aaccagtgtg ggtggggagt tgtgcatata
     4381 aactatttaa tgagtaccaa acacaaaagt caagcttgta aaatatcagg ccttgcccca
     4441 gaaagacaaa taccacatga tctcactgat atgtagaatc ttaaaaagtc aaactcagaa
     4501 gcagagagta gaatgatggt tatcaagggc tgggggaggg agggactggg gagatgttgg
     4561 tcaaatgata caaaggttta gttaggtgga ataagttcag aaaatcaatt gtacaatgta
     4621 tcaattatag ttaatagcaa tataacatat acttgaaaat tgctgagagt agtgtgagtg
     4681 ttctaccaca aaaaaatatg tgcagtaata gatgttaatt accttaattt agtcatttca
     4741 caatatgtac atatataaaa atatgttgta tgccatgagt atatataatt attatttgtg
     4801 aatttaaaaa ataaaaataa tttccaaaaa aa
//
