LOCUS       NM_178859                924 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SLC51 subunit beta (SLC51B), mRNA.
ACCESSION   NM_178859
VERSION     NM_178859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Chan,J.W., Neo,C.W.Y., Ghosh,S., Choi,H., Lim,S.C., Tai,E.S. and
            Teo,A.K.K.
  TITLE     HNF1A binds and regulates the expression of SLC51B to facilitate
            the uptake of estrone sulfate in human renal proximal tubule
            epithelial cells
  JOURNAL   Cell Death Dis 14 (5), 302 (2023)
   PUBMED   37137894
  REMARK    GeneRIF: HNF1A binds and regulates the expression of SLC51B to
            facilitate the uptake of estrone sulfate in human renal proximal
            tubule epithelial cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 924)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 924)
  AUTHORS   Zhou,Y., Ye,C., Lou,Y., Liu,J., Ye,S., Chen,L., Lei,J., Guo,S.,
            Zeng,S. and Yu,L.
  TITLE     Epigenetic Mechanisms Underlying Organic Solute Transporter beta
            Repression in Colorectal Cancer
  JOURNAL   Mol Pharmacol 97 (4), 259-266 (2020)
   PUBMED   32005758
  REMARK    GeneRIF: Study found lower organic solute transporter beta
            (OSTbeta) expression in colon cancer tissues compared with adjacent
            normal tissues and revealed the epigenetic mechanisms of it and
            proved that p300 controls OSTbeta expression through modulating
            H3K27Ac state at OSTbeta promoter region and hence causes low
            expression of OSTbeta in colorectal cancer.
REFERENCE   4  (bases 1 to 924)
  AUTHORS   Xu,S., Soroka,C.J., Sun,A.Q., Backos,D.S., Mennone,A., Suchy,F.J.
            and Boyer,J.L.
  TITLE     A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute
            Transporter Beta Is Essential for Protein Association and Membrane
            Localization
  JOURNAL   PLoS One 11 (6), e0158269 (2016)
   PUBMED   27351185
  REMARK    GeneRIF: Dileucine motif in the extracellular N-terminal region is
            essential for OSTB plasma membrane targeting.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 924)
  AUTHORS   Schaffner,C.A., Mwinyi,J., Gai,Z., Thasler,W.E., Eloranta,J.J. and
            Kullak-Ublick,G.A.
  TITLE     The organic solute transporters alpha and beta are induced by
            hypoxia in human hepatocytes
  JOURNAL   Liver Int 35 (4), 1152-1161 (2015)
   PUBMED   24703425
  REMARK    GeneRIF: Hepatic OSTalpha-OSTbeta expression is induced by hypoxia.
REFERENCE   6  (bases 1 to 924)
  AUTHORS   Landrier,J.F., Eloranta,J.J., Vavricka,S.R. and Kullak-Ublick,G.A.
  TITLE     The nuclear receptor for bile acids, FXR, transactivates human
            organic solute transporter-alpha and -beta genes
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 290 (3), G476-G485 (2006)
   PUBMED   16269519
  REMARK    GeneRIF: OSTalpha/OSTbeta expression is induced by bile acids
            through ligand-dependent transactivation of both OST genes by the
            nuclear bile acid receptor/farnesoid X receptor (FXR).
REFERENCE   7  (bases 1 to 924)
  AUTHORS   Lee,H., Zhang,Y., Lee,F.Y., Nelson,S.F., Gonzalez,F.J. and
            Edwards,P.A.
  TITLE     FXR regulates organic solute transporters alpha and beta in the
            adrenal gland, kidney, and intestine
  JOURNAL   J Lipid Res 47 (1), 201-214 (2006)
   PUBMED   16251721
  REMARK    GeneRIF: overexpression of human OSTalpha and OSTbeta facilitated
            the uptake of conjugated chenodeoxycholate and the activation of
            FXR target genes
REFERENCE   8  (bases 1 to 924)
  AUTHORS   Ballatori,N., Christian,W.V., Lee,J.Y., Dawson,P.A., Soroka,C.J.,
            Boyer,J.L., Madejczyk,M.S. and Li,N.
  TITLE     OSTalpha-OSTbeta: a major basolateral bile acid and steroid
            transporter in human intestinal, renal, and biliary epithelia
  JOURNAL   Hepatology 42 (6), 1270-1279 (2005)
   PUBMED   16317684
  REMARK    GeneRIF: the selective localization of OSTalpha and OSTbeta to the
            basolateral plasma membrane of epithelial cells responsible for
            bile acid and sterol reabsorption.
REFERENCE   9  (bases 1 to 924)
  AUTHORS   Dawson,P.A., Hubbert,M., Haywood,J., Craddock,A.L., Zerangue,N.,
            Christian,W.V. and Ballatori,N.
  TITLE     The heteromeric organic solute transporter alpha-beta,
            Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
  JOURNAL   J Biol Chem 280 (8), 6960-6968 (2005)
   PUBMED   15563450
REFERENCE   10 (bases 1 to 924)
  AUTHORS   Seward,D.J., Koh,A.S., Boyer,J.L. and Ballatori,N.
  TITLE     Functional complementation between a novel mammalian polygenic
            transport complex and an evolutionarily ancient organic solute
            transporter, OSTalpha-OSTbeta
  JOURNAL   J Biol Chem 278 (30), 27473-27482 (2003)
   PUBMED   12719432
  REMARK    GeneRIF: OSTbeta has roles in biological transport and is widely
            expressed in human tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI793107.1, AK129601.1 and AC013553.14.
            
            On Nov 23, 2018 this sequence version replaced NM_178859.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129601.1, ERR279837.11029.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334287.3/ ENSP00000335292.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AI793107.1         18-97
            81-814              AK129601.1         1-734
            815-815             AC013553.14        62423-62423
            816-923             AK129601.1         736-843
            924-924             AC013553.14        62532-62532
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..924
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /note="SLC51 subunit beta"
                     /db_xref="GeneID:123264"
                     /db_xref="HGNC:HGNC:29956"
                     /db_xref="MIM:612085"
     exon            1..196
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            197..401
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..691
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /note="OST-beta; organic solute transporter beta subunit;
                     solute carrier family 51 beta subunit; solute carrier
                     family 51 subunit beta; SLC51A1 binding protein"
                     /codon_start=1
                     /product="organic solute transporter subunit beta"
                     /protein_id="NP_849190.2"
                     /db_xref="CCDS:CCDS10199.1"
                     /db_xref="GeneID:123264"
                     /db_xref="HGNC:HGNC:29956"
                     /db_xref="MIM:612085"
                     /translation="MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALA
                     AVVVIISMVLLGRSIQASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPN
                     LAQVELELKERDVLSVFLPDVPETES"
     exon            402..492
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /inference="alignment:Splign:2.1.0"
     exon            493..924
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /note="hexamer: ATTAAA"
     regulatory      888..893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /note="hexamer: ATTAAA"
     polyA_site      894
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /note="major polyA site"
     polyA_site      924
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /note="major polyA site"
ORIGIN      
        1 gccagagcta ccagatgggt ccagctgccg caggctctcc aggcactgtc ccctaagtga
       61 cagctgttac tgcctgggag agctcaagtg caaagactat cctgttctcc cataaagagg
      121 aggaaaagga agatacagaa atcggtgctg ctcccaacag cagatcaagg cagtcgtcag
      181 gaactcagga tccggggggt cttcacggct tctctgccca ggggccagaa ccgaggaggc
      241 caggagggct gctggggcta aggggtctaa ggacctcgtt gcacacgcta ccaggagcag
      301 gggcatggag cacagtgagg gggctcccgg agacccagcc ggtactgtgg taccccagga
      361 gctgctggaa gagatgcttt ggttttttcg tgtggaagat gcatctccct ggaatcattc
      421 catccttgcc ctggcagctg tggtggtcat tataagcatg gtcctcctgg gaagaagcat
      481 ccaggcaagc agaaaagaaa agatgcagcc accagaaaaa gaaactccag aagtcctgca
      541 tttggatgag gccaaggatc acaacagcct aaacaaccta agagaaactt tgctctcaga
      601 aaagccaaac ttggcccagg tggaacttga gttaaaagag agagatgtgc tgtcagtttt
      661 ccttccggat gtaccagaaa ctgagagcta gtgagggttc agagaagccc catcctaagc
      721 cagacacatg atgtgggctc agctcagtgg cctgaaacct ctcaggtttt agagtctctc
      781 ccaagaagcc gcttttttct ttttctttct ttcttttttt ttttcttagc agatacaatg
      841 aatgaactgc aagcaaacta aaattctgtt attaaaaaaa atcttttatt aaaatgctcc
      901 tggaagggag caggtggtat tgca
//
