LOCUS       NM_152672               1430 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens solute carrier family 51 member A (SLC51A), mRNA.
ACCESSION   NM_152672
VERSION     NM_152672.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1430)
  AUTHORS   Feofanova,E.V., Chen,H., Dai,Y., Jia,P., Grove,M.L., Morrison,A.C.,
            Qi,Q., Daviglus,M., Cai,J., North,K.E., Laurie,C.C., Kaplan,R.C.,
            Boerwinkle,E. and Yu,B.
  TITLE     A Genome-wide Association Study Discovers 46 Loci of the Human
            Metabolome in the Hispanic Community Health Study/Study of Latinos
  JOURNAL   Am J Hum Genet 107 (5), 849-863 (2020)
   PUBMED   33031748
  REMARK    GeneRIF: A Genome-wide Association Study Discovers 46 Loci of the
            Human Metabolome in the Hispanic Community Health Study/Study of
            Latinos.
REFERENCE   2  (bases 1 to 1430)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1430)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1430)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: SLC51A expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 1430)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 1430)
  AUTHORS   Landrier,J.F., Eloranta,J.J., Vavricka,S.R. and Kullak-Ublick,G.A.
  TITLE     The nuclear receptor for bile acids, FXR, transactivates human
            organic solute transporter-alpha and -beta genes
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 290 (3), G476-G485 (2006)
   PUBMED   16269519
  REMARK    GeneRIF: OSTalpha/OSTbeta expression is induced by bile acids
            through ligand-dependent transactivation of both OST genes by the
            nuclear bile acid receptor/farnesoid X receptor (FXR).
REFERENCE   7  (bases 1 to 1430)
  AUTHORS   Lee,H., Zhang,Y., Lee,F.Y., Nelson,S.F., Gonzalez,F.J. and
            Edwards,P.A.
  TITLE     FXR regulates organic solute transporters alpha and beta in the
            adrenal gland, kidney, and intestine
  JOURNAL   J Lipid Res 47 (1), 201-214 (2006)
   PUBMED   16251721
  REMARK    GeneRIF: overexpression of human OSTalpha and OSTbeta facilitated
            the uptake of conjugated chenodeoxycholate and the activation of
            FXR target genes
REFERENCE   8  (bases 1 to 1430)
  AUTHORS   Ballatori,N., Christian,W.V., Lee,J.Y., Dawson,P.A., Soroka,C.J.,
            Boyer,J.L., Madejczyk,M.S. and Li,N.
  TITLE     OSTalpha-OSTbeta: a major basolateral bile acid and steroid
            transporter in human intestinal, renal, and biliary epithelia
  JOURNAL   Hepatology 42 (6), 1270-1279 (2005)
   PUBMED   16317684
  REMARK    GeneRIF: the selective localization of OSTalpha and OSTbeta to the
            basolateral plasma membrane of epithelial cells responsible for
            bile acid and sterol reabsorption.
REFERENCE   9  (bases 1 to 1430)
  AUTHORS   Dawson,P.A., Hubbert,M., Haywood,J., Craddock,A.L., Zerangue,N.,
            Christian,W.V. and Ballatori,N.
  TITLE     The heteromeric organic solute transporter alpha-beta,
            Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
  JOURNAL   J Biol Chem 280 (8), 6960-6968 (2005)
   PUBMED   15563450
REFERENCE   10 (bases 1 to 1430)
  AUTHORS   Seward,D.J., Koh,A.S., Boyer,J.L. and Ballatori,N.
  TITLE     Functional complementation between a novel mammalian polygenic
            transport complex and an evolutionarily ancient organic solute
            transporter, OSTalpha-OSTbeta
  JOURNAL   J Biol Chem 278 (30), 27473-27482 (2003)
   PUBMED   12719432
  REMARK    GeneRIF: OSTalpha has roles in biological transport and is widely
            expressed in human tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069257.28.
            
            On Nov 22, 2018 this sequence version replaced NM_152672.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172837.1, AY194243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296327.10/ ENSP00000296327.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC069257.28        163182-163398       c
            218-312             AC069257.28        161996-162090       c
            313-467             AC069257.28        152813-152967       c
            468-541             AC069257.28        152195-152268       c
            542-700             AC069257.28        151659-151817       c
            701-812             AC069257.28        151012-151123       c
            813-959             AC069257.28        149871-150017       c
            960-1065            AC069257.28        147408-147513       c
            1066-1430           AC069257.28        146505-146869       c
FEATURES             Location/Qualifiers
     source          1..1430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1430
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /note="solute carrier family 51 member A"
                     /db_xref="GeneID:200931"
                     /db_xref="HGNC:HGNC:29955"
                     /db_xref="MIM:612084"
     exon            1..217
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1202
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /note="solute carrier family 51 alpha subunit; OST-alpha;
                     organic solute transporter alpha; organic solute
                     transporter, alpha subunit; solute carrier family 51
                     subunit alpha"
                     /codon_start=1
                     /product="organic solute transporter subunit alpha"
                     /protein_id="NP_689885.4"
                     /db_xref="CCDS:CCDS3314.1"
                     /db_xref="GeneID:200931"
                     /db_xref="HGNC:HGNC:29955"
                     /db_xref="MIM:612084"
                     /translation="MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLR
                     ALGPVELALTSILTLLALGSIAIFLEDAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLC
                     CFGLWIPRSLVLVEMTITSFYAVCFYLLMLVMVEGFGGKEAVLRTLRDTPMMVHTGPC
                     CCCCPCCPRLLLTRKKLQLLMLGPFQYAFLKITLTLVGLFLVPDGIYDPADISEGSTA
                     LWINTFLGVSTLLALWTLGIISRQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVL
                     ANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKDHKVGYETFSSPDL
                     DLNLKA"
     exon            218..312
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..467
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..541
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..700
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..812
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..959
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1065
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1430
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1407..1412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /note="hexamer: AACAAG"
     polyA_site      1430
                     /gene="SLC51A"
                     /gene_synonym="OSTA; OSTalpha; PFIC6; SLC51A1"
                     /note="major polyA site"
ORIGIN      
        1 gagatagaaa gttggcccgg gaagctcaag gagggagagc ggcagagggg aagactctgc
       61 aattctgctt gccccccacc ccggcccagg caagccaccc tgcccccggc ccccacctgc
      121 ccgccccgcc tgcccttcct caccccggtg cctgcgggat tgctggagag aacgcggcga
      181 tggagccggg caggacccag ataaagcttg accccaggta cacagcagat cttctggagg
      241 tgctgaagac caattacggc atcccctccg cctgcttctc tcagcctccc acagcagccc
      301 aactcctgag agccctgggc cctgtggaac ttgccctcac tagcatcctg accttgctgg
      361 cgctgggctc cattgccatc ttcctggagg atgccgtcta cctgtacaag aacacccttt
      421 gccccatcaa gaggcggact ctgctctgga agagctcggc acccacggtg gtgtctgtgc
      481 tgtgctgctt tggtctctgg atccctcgtt ccctggtgct ggtggaaatg accatcacct
      541 cgttttatgc cgtgtgcttt tacctgctga tgctggtcat ggtggaaggc tttgggggga
      601 aggaggcagt gctgaggacg ctgagggaca ccccgatgat ggtccacaca ggcccctgct
      661 gctgctgctg cccctgctgt ccacggctgc tgctcaccag gaagaagctt cagctgctga
      721 tgttgggccc tttccaatac gccttcttga agataacgct gaccctggtg ggcctgtttc
      781 tcgtccccga cggcatctat gacccagcag acatttctga ggggagcaca gctctatgga
      841 tcaacacttt ccttggcgtg tccacactgc tggctctctg gaccctgggc atcatttccc
      901 gtcaagccag gctacacctg ggtgagcaga acatgggagc caaatttgct ctgttccagg
      961 ttctcctcat cctgactgcc ctacagccct ccatcttctc agtcttggcc aacggtgggc
     1021 agattgcttg ttcgcctccc tattcctcta aaaccaggtc tcaagtgatg aattgccacc
     1081 tcctcatact ggagactttt ctaatgactg tgctgacacg aatgtactac cgaaggaaag
     1141 accacaaggt tgggtatgaa actttctctt ctccagacct ggacttgaac ctcaaagcct
     1201 aaggtggatg gcttggacaa tgaaaggatg ctgtactcat tagaatacaa gattccttta
     1261 ctgtccctca accttgacca aatgggaagc attccccctt gtcaacacaa gctggcagat
     1321 acatttgact ctacagatga aggtgaacaa tgttagaata aaattgcttt ggatcttgcc
     1381 tggaaggtgt tttaagtttt gtaataaaca agatgatgtc tgaaaatgtg
//
