LOCUS       NM_031467               3283 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 4 member 9 (SLC4A9), transcript
            variant 2, mRNA.
ACCESSION   NM_031467
VERSION     NM_031467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3283)
  AUTHORS   Pena-Munzenmayer,G., George,A.T., Shull,G.E., Melvin,J.E. and
            Catalan,M.A.
  TITLE     Ae4 (Slc4a9) is an electroneutral monovalent cation-dependent
            Cl-/HCO3- exchanger
  JOURNAL   J Gen Physiol 147 (5), 423-436 (2016)
   PUBMED   27114614
REFERENCE   2  (bases 1 to 3283)
  AUTHORS   Parker,M.D., Ourmozdi,E.P. and Tanner,M.J.
  TITLE     Human BTR1, a new bicarbonate transporter superfamily member and
            human AE4 from kidney
  JOURNAL   Biochem Biophys Res Commun 282 (5), 1103-1109 (2001)
   PUBMED   11302728
REFERENCE   3  (bases 1 to 3283)
  AUTHORS   Lipovich,L., Lynch,E.D., Lee,M.K. and King,M.C.
  TITLE     A novel sodium bicarbonate cotransporter-like gene in an ancient
            duplicated region: SLC4A9 at 5q31
  JOURNAL   Genome Biol 2 (4), RESEARCH0011 (2001)
   PUBMED   11305939
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008438.6, AF332961.1,
            AB032762.1 and CB046220.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031467.2.
            
            Summary: The protein encoded by this gene is a membrane protein
            involved in anion exchange. Expression of this gene is mostly
            limited to the kidney. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, May 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) lacks an alternate internal segment compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000506757.7/ ENSP00000424424.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC008438.6         18593-18600
            9-49                AF332961.1         1-41
            50-3152             AB032762.1         1-3103
            3153-3279           CB046220.1         27-153              c
            3280-3283           AC008438.6         33537-33540
FEATURES             Location/Qualifiers
     source          1..3283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3283
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /note="solute carrier family 4 member 9"
                     /db_xref="GeneID:83697"
                     /db_xref="HGNC:HGNC:11035"
                     /db_xref="MIM:610207"
     exon            1..273
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2923
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /note="isoform 2 is encoded by transcript variant 2; anion
                     exchange protein 4; anion exchanger 4; sodium bicarbonate
                     cotransporter 5; solute carrier family 4, sodium
                     bicarbonate cotransporter, member 9"
                     /codon_start=1
                     /product="anion exchange protein 4 isoform 2"
                     /protein_id="NP_113655.2"
                     /db_xref="CCDS:CCDS47278.1"
                     /db_xref="GeneID:83697"
                     /db_xref="HGNC:HGNC:11035"
                     /db_xref="MIM:610207"
                     /translation="MEMKLPGQEGFEASSAPRNIPSGELDSNPDPGTGPSPDGPSDTE
                     SKELGVPKDPLLFIQLNELLGWPQALEWRETGRWVLFEEKLEVAAGRWSAPHVPTLAL
                     PSLQKLRSLLAEGLVLLDCPAQSLLELVEQVTRVESLSPELRGQLQALLLQRPQHYNQ
                     TTGTRPCWGSTHPRKASDNEEAPLREQCQNPLRQKLPPGAEAGTVLAGELGFLAQPLG
                     AFVRLRNPVVLGSLTEVSLPSRFFCLLLGPCMLGKGYHEMGRAAAVLLSDPQFQWSVR
                     RASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPSQHKRLPSQQREIRGPAV
                     PRLTSAEDRHRHGPHAHSPELQRTGRLFGGLIQDVRRKVPWYPSDFLDALHLQCFSAV
                     LYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGP
                     VLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVLVRYFTRFTEEGFC
                     ALISLIFIYDAVGKMLNLTHTYPIQKPGSSAYGCLCQYPGPGGNESQWIRTRPKDRDD
                     IVSMDLGLINASLLPPPECTRQGGHPRGPGCHTVPDIAFFSLLLFLTSFFFAMALKCV
                     KTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFLGLATPKLMVPREFKPTLPGRGWLVS
                     PFGANPWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKGAGFHLDLFCVAVL
                     MLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGERPNFLGIREQRLTGLVVFILT
                     GASIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFTNRVKLLLMPAKHQPDLLLLRHV
                     PLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLMLLGLVGVRKALERVFSPQELLWLD
                     ELMPEEERSIPEKGLEPEHSFSGSDSEDSELMYQPKAPEINISVN"
     exon            274..434
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            435..548
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            549..604
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            605..762
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            763..850
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1005
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1122
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1297
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1431
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1694
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1753
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1942
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2056
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2218
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2397
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2470
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2539
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2713
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2869
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2968
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3283
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /note="hexamer: ATTAAA"
     polyA_site      3152
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /note="major polyA site"
     regulatory      3261..3266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /note="hexamer: AATAAA"
     polyA_site      3283
                     /gene="SLC4A9"
                     /gene_synonym="AE4"
                     /note="major polyA site"
ORIGIN      
        1 agaacctagg actgtactgg ttctgagatt ctgtgcaagc ctcatggaaa tgaagctgcc
       61 aggccaggaa gggtttgaag cctccagtgc tcctagaaat attccttcag gggagctgga
      121 cagcaaccct gaccctggca ccggccccag ccctgatggc ccctcagaca cagagagcaa
      181 ggaactggga gtacccaaag accctctgct cttcattcag ctgaatgagc tgctgggctg
      241 gccccaggcg ctggagtgga gagagacagg caggtgggta ctgtttgagg agaagttgga
      301 ggtggctgca ggccggtgga gtgcccccca cgtgcccacc ctggcactgc ccagcctcca
      361 gaagctccgc agcctgctgg ccgagggcct tgtactgctg gactgcccag ctcagagcct
      421 cctggagctc gtggagcagg tgaccagggt ggagtcgctg agcccagagc tgagagggca
      481 gttgcaggcc ttgctgctgc agagacccca gcattacaac cagaccacag gcaccaggcc
      541 ctgctggggc tctactcatc caagaaaggc ttctgacaat gaggaagccc ccctgaggga
      601 acagtgtcag aaccccctga gacagaagct acctccagga gctgaggcag ggactgtgct
      661 ggcaggggag ctgggcttcc tggcacagcc actgggagcc tttgttcgac tgcggaaccc
      721 tgtggtactg gggtccctta ctgaggtgtc cctcccaagc aggtttttct gccttctcct
      781 gggcccctgt atgctgggaa agggctacca tgagatggga cgggcagcag ctgtcctcct
      841 cagtgacccg caattccagt ggtcagttcg tcgggccagc aaccttcatg accttctggc
      901 agccctggat gcattcctag aggaggtgac agtgcttccc ccaggtcggt gggacccaac
      961 agcccggatt cccccgccca aatgtctgcc atctcagcac aaaaggcttc cctcgcaaca
     1021 gcgggagatc agaggtcccg ccgtcccgcg cctgacctcg gctgaggaca ggcaccgcca
     1081 tgggccacac gcacacagcc cggagttgca gcggaccggc aggctgtttg ggggccttat
     1141 ccaggacgtg cgcaggaagg tcccgtggta ccccagcgat ttcttggacg ccctgcatct
     1201 ccagtgcttc tcggccgtac tctacattta cctggccact gtcactaatg ccatcacttt
     1261 tgggggtctg ctgggagatg ccactgatgg tgcccaggga gtgctggaaa gtttcctggg
     1321 cacagcagtg gctggagctg ccttctgcct gatggcaggc cagcccctca ccattctgag
     1381 cagcacgggg ccagtgctgg tctttgagcg cctgctcttc tctttcagca gagattacag
     1441 cctggactac ctgcccttcc gcctatgggt gggcatctgg gtggctacct tttgcctggt
     1501 gctggtggcc acagaggcca gtgtgctggt gcgctacttc acccgcttca ctgaggaagg
     1561 tttctgtgcc ctcatcagcc tcatcttcat ctacgatgct gtgggcaaaa tgctgaactt
     1621 gacccatacc tatcctatcc agaagcctgg gtcctctgcc tacgggtgcc tctgccaata
     1681 cccaggccca ggaggaaatg agtctcaatg gataaggaca aggccaaaag acagagacga
     1741 cattgtaagc atggacttag gcctgatcaa tgcatccttg ctgccgccac ctgagtgcac
     1801 ccggcaggga ggccaccctc gtggccctgg ctgtcataca gtcccagaca ttgccttctt
     1861 ctcccttctc ctcttcctta cttctttctt ctttgctatg gccctcaagt gtgtaaagac
     1921 cagccgcttc ttcccctctg tggtgcgcaa agggctcagc gacttctcct cagtcctggc
     1981 catcctgctc ggctgtggcc ttgatgcttt cctgggccta gccacaccaa agctcatggt
     2041 acccagagag ttcaagccca cactccctgg gcgtggctgg ctggtgtcac cttttggagc
     2101 caacccctgg tggtggagtg tggcagctgc cctgcctgcc ctgctgctgt ctatcctcat
     2161 cttcatggac caacagatca cagcagtcat cctcaaccgc atggaataca gactgcagaa
     2221 gggagctggc ttccacctgg acctcttctg tgtggctgtg ctgatgctac tcacatcagc
     2281 gcttggactg ccttggtatg tctcagccac tgtcatctcc ctggctcaca tggacagtct
     2341 tcggagagag agcagagcct gtgcccccgg ggagcgcccc aacttcctgg gtatcaggga
     2401 acagaggctg acaggcctgg tggtgttcat ccttacagga gcctccatct tcctggcacc
     2461 tgtgctcaag ttcattccaa tgcctgtgct ctatggcatc ttcctgtata tgggggtggc
     2521 agcgctcagc agcattcagt tcactaatag ggtgaagctg ttgttgatgc cagcaaaaca
     2581 ccagccagac ctgctactct tgcggcatgt gcctctgacc agggtccacc tcttcacagc
     2641 catccagctt gcctgtctgg ggctgctttg gataatcaag tctacccctg cagccatcat
     2701 cttccccctc atgttgctgg gccttgtggg ggtccgaaag gccctggaga gggtcttctc
     2761 accacaggaa ctcctctggc tggatgagct gatgccagag gaggagagaa gcatccctga
     2821 gaaggggctg gagccagaac actcattcag tggaagtgac agtgaagatt cagagctgat
     2881 gtatcagcca aaggctccag aaatcaacat ttctgtgaat tagctggagt aggagtctgg
     2941 gagtggagac cccaggaaac agcatgagat gctcagtcgg cttggggaag gactgaaggg
     3001 cagctgccaa gacctcagtt acctcctgac ctgagggtgg agagtggcag gaagcaagca
     3061 tgtttgctgt gcacttagga aaggctggtg agccagaggg actgatcagg ccccattcac
     3121 tctctactca ttaaaaggtc ctgagccacg aagcgcttcc cattttgaac tttctgtcct
     3181 cacagattct gtttgacaga atctaagggc catcagggaa ctcttttcat cttgcaaaga
     3241 gaaaaagcca gtctttccag aataaatatt catctgtttg aaa
//
