LOCUS       NP_001308032            1259 aa            linear   PRI 23-APR-2024
DEFINITION  sodium bicarbonate cotransporter 3 isoform d [Homo sapiens].
ACCESSION   NP_001308032 XP_011532557
VERSION     NP_001308032.1
DBSOURCE    REFSEQ: accession NM_001321103.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1259)
  AUTHORS   Axelsen,T.V., Olesen,C., Khan,D., Mohammadi,A., Bouzinova,E.V.,
            Nielsen,C.J.F., Mele,M., Hauerslev,K.R., Pedersen,H.L., Balling,E.,
            Vahl,P., Tramm,T., Christiansen,P.M. and Boedtkjer,E.
  TITLE     Antibodies toward Na+,HCO3--cotransporter NBCn1/SLC4A7 block net
            acid extrusion and cause pH-dependent growth inhibition and
            apoptosis in breast cancer
  JOURNAL   Br J Cancer 130 (7), 1206-1220 (2024)
   PUBMED   38310186
  REMARK    GeneRIF: Antibodies toward Na[+],HCO3[-]-cotransporter NBCn1/SLC4A7
            block net acid extrusion and cause pH-dependent growth inhibition
            and apoptosis in breast cancer.
REFERENCE   2  (residues 1 to 1259)
  AUTHORS   Severin,M., Pedersen,E.L., Borre,M.T., Axholm,I.,
            Christiansen,F.B., Ponniah,M., Czaplinska,D., Larsen,T., Pardo,L.A.
            and Pedersen,S.F.
  TITLE     Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the
            plasma membrane, centrosomes, spindle and primary cilia
  JOURNAL   J Cell Sci 136 (7) (2023)
   PUBMED   37039101
  REMARK    GeneRIF: Dynamic localization of the Na+-HCO3- co-transporter NBCn1
            to the plasma membrane, centrosomes, spindle and primary cilia.
REFERENCE   3  (residues 1 to 1259)
  AUTHORS   Zhou,Y., Ma,X. and Sun,J.
  TITLE     Update on the relationship between the SLC4A7 variant rs4973768 and
            breast cancer risk: a systematic review and meta-analysis
  JOURNAL   J Int Med Res 51 (4), 3000605231166517 (2023)
   PUBMED   37128157
  REMARK    GeneRIF: Update on the relationship between the SLC4A7 variant
            rs4973768 and breast cancer risk: a systematic review and
            meta-analysis.
REFERENCE   4  (residues 1 to 1259)
  AUTHORS   Ali,E.S., Liponska,A., O'Hara,B.P., Amici,D.R., Torno,M.D., Gao,P.,
            Asara,J.M., Yap,M.F., Mendillo,M.L. and Ben-Sahra,I.
  TITLE     The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de
            novo nucleotide synthesis
  JOURNAL   Mol Cell 82 (17), 3284-3298 (2022)
   PUBMED   35772404
  REMARK    GeneRIF: The mTORC1-SLC4A7 axis stimulates bicarbonate import to
            enhance de novo nucleotide synthesis.
REFERENCE   5  (residues 1 to 1259)
  AUTHORS   Pushkin,A., Abuladze,N., Newman,D., Muronets,V., Sassani,P.,
            Tatishchev,S. and Kurtz,I.
  TITLE     The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ
            motifs involved in their interaction
  JOURNAL   Am J Physiol Cell Physiol 284 (3), C667-C673 (2003)
   PUBMED   12444018
REFERENCE   6  (residues 1 to 1259)
  AUTHORS   Park,M., Ko,S.B., Choi,J.Y., Muallem,G., Thomas,P.J., Pushkin,A.,
            Lee,M.S., Kim,J.Y., Lee,M.G., Muallem,S. and Kurtz,I.
  TITLE     The cystic fibrosis transmembrane conductance regulator interacts
            with and regulates the activity of the HCO3- salvage transporter
            human Na+-HCO3- cotransport isoform 3
  JOURNAL   J Biol Chem 277 (52), 50503-50509 (2002)
   PUBMED   12403779
  REMARK    GeneRIF: The cystic fibrosis transmembrane conductance regulator
            interacts with and regulates the activity of the bicarbonate
            salvage trransporter isoform 3
REFERENCE   7  (residues 1 to 1259)
  AUTHORS   Pushkin,A., Yip,K.P., Clark,I., Abuladze,N., Kwon,T.H.,
            Tsuruoka,S., Schwartz,G.J., Nielsen,S. and Kurtz,I.
  TITLE     NBC3 expression in rabbit collecting duct: colocalization with
            vacuolar H+-ATPase
  JOURNAL   Am J Physiol 277 (6), F974-F981 (1999)
   PUBMED   10600945
REFERENCE   8  (residues 1 to 1259)
  AUTHORS   Pushkin,A., Abuladze,N., Lee,I., Newman,D., Hwang,J. and Kurtz,I.
  TITLE     Cloning, tissue distribution, genomic organization, and functional
            characterization of NBC3, a new member of the sodium bicarbonate
            cotransporter family
  JOURNAL   J Biol Chem 274 (23), 16569-16575 (1999)
   PUBMED   10347222
REFERENCE   9  (residues 1 to 1259)
  AUTHORS   Pushkin,A., Abuladze,N., Lee,I., Newman,D., Hwang,J. and Kurtz,I.
  TITLE     Mapping of the human NBC3 (SLC4A7) gene to chromosome 3p22
  JOURNAL   Genomics 57 (2), 321-322 (1999)
   PUBMED   10198178
REFERENCE   10 (residues 1 to 1259)
  AUTHORS   Ishibashi,K., Sasaki,S. and Marumo,F.
  TITLE     Molecular cloning of a new sodium bicarbonate cotransporter cDNA
            from human retina
  JOURNAL   Biochem Biophys Res Commun 246 (2), 535-538 (1998)
   PUBMED   9610397
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK309734.1, EU934248.1,
            EU934249.1, FJ178574.1, EU499349.1, AK310865.1, AF053755.1,
            AF047033.1, AL389947.1 and AA569234.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 18, 2016 this sequence version replaced XP_011532557.1.
            
            Summary: This locus encodes a sodium bicarbonate cotransporter. The
            encoded transmembrane protein appears to transport sodium and
            bicarbonate ions in a 1:1 ratio, and is thus considered an
            electroneutral cotransporter. The encoded protein likely plays a
            critical role in regulation of intracellular pH involved in visual
            and auditory sensory transmission. Alternatively spliced transcript
            variants encoding distinct isoforms have been described. [provided
            by RefSeq, Apr 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU934248.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454389.6/ ENSP00000390394.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.1"
     Protein         1..1259
                     /product="sodium bicarbonate cotransporter 3 isoform d"
                     /note="sodium bicarbonate cotransporter 2; sodium
                     bicarbonate cotransporter 3; electroneutral Na/HCO(3)
                     cotransporter; bicarbonate transporter; sodium bicarbonate
                     cotransporter 2b; solute carrier family 4, sodium
                     bicarbonate cotransporter, member 7"
                     /calculated_mol_wt=140636
     Region          122..1144
                     /region_name="Band_3_cyto"
                     /note="Band 3 cytoplasmic domain; cl26877"
                     /db_xref="CDD:452680"
     CDS             1..1259
                     /gene="SLC4A7"
                     /gene_synonym="NBC2; NBC3; NBCN1; SBC2; SLC4A6"
                     /coded_by="NM_001321103.2:259..4038"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS82747.1"
                     /db_xref="GeneID:9497"
                     /db_xref="HGNC:HGNC:11033"
                     /db_xref="MIM:603353"
ORIGIN      
        1 meadgageqm rplltrvtsr gpdeeavvdl gktsstvntk fekeeleshr avyigvhvpf
       61 skesrrrhrh rghkhhhrrr kdkesdkedg respsydtps qrvqfilgte dddeehiphd
      121 lftemdelcy rdgeeyewke tarwlkfeed vedggdrwsk pyvatlslhs lfelrsciln
      181 gtvmldmras tldeiadmvl dnmiasgqld esirenvrea llkrhhhqne krftsriplv
      241 rsfadigkkh sdphllerng eglsasrhsl rtglsasnls lrgesplsll lghllpssra
      301 gtpagsrctt pvptpqnspp sspsisrlts rssqesqrqa pellvspasd diptvvihpp
      361 eedleaalkg eeqkneenvd ltpgilaspq sapgnldnsk sgeikgngsg gsrenstvdf
      421 skvdmnfmrk iptgaeasnv lvgevdfler piiafvrlap avlltgltev pvptrflfll
      481 lgpagkapqy heigrsiatl mtdeifhdva ykakdrndll sgidefldqv tvlppgewdp
      541 sirieppksv psqekrkipv fhngstptlg etpkeaahha gpelqrtgrl fgglildikr
      601 kapfflsdfk dalslqclas ilflycacms pvitfggllg eategrisai eslfgasltg
      661 iayslfagqp ltilgstgpv lvfekilykf crdyqlsyls lrtsiglwts flcivlvatd
      721 asslvcyitr fteeafaali ciifiyeale klfdlgetya fnmhnnldkl tsyscvctep
      781 pnpsnetlaq wkkdnitahn iswrnltvse ckklrgvflg sacghhgpyi pdvlfwcvil
      841 ffttfflssf lkqfktkryf ptkvrstisd favfltivim vtidylvgvp spklhvpekf
      901 epthpergwi isplgdnpww tlliaaipal lctilifmdq qitaviinrk ehklkkgagy
      961 hldllmvgvm lgvcsvmglp wfvaatvlsi shvnslkves ecsapgeqpk flgireqrvt
     1021 glmifilmgl svfmtsvlkf ipmpvlygvf lymgvsslkg iqlfdriklf gmpakhqpdl
     1081 iylryvplwk vhiftviqlt clvllwvikv saaavvfpmm vlalvfvrkl mdlcftkrel
     1141 swlddlmpes kkkkeddkkk kekeeaerml qddddtvhlp feggsllqip vkalkysvdp
     1201 sivnisdema ktaqwkalsm ntenakvtrs nmspdkpvsv kisfedeprk kyvdaetsl
//
