LOCUS       NM_005070               4151 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens solute carrier family 4 member 3 (SLC4A3), transcript
            variant 1, mRNA.
ACCESSION   NM_005070
VERSION     NM_005070.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Jian,L., Zhang,Q., Yao,D., Wang,Q., Chen,M., Xia,Y., Li,S.,
            Shen,Y., Cao,M., Qin,A., Li,L. and Cao,Y.
  TITLE     The structural insight into the functional modulation of human
            anion exchanger 3
  JOURNAL   Nat Commun 15 (1), 6134 (2024)
   PUBMED   39033175
  REMARK    GeneRIF: The structural insight into the functional modulation of
            human anion exchanger 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Christiansen,M.K., Kjaer-Sorensen,K., Clavsen,N.C., Dittmann,S.,
            Jensen,M.F., Guldbrandsen,H.O., Pedersen,L.N., Sorensen,R.H.,
            Lildballe,D.L., Muller,K., Muller,P., Vogel,K., Rudic,B.,
            Borggrefe,M., Oxvig,C., Aalkjaer,C., Schulze-Bahr,E., Matchkov,V.,
            Bundgaard,H. and Jensen,H.K.
  TITLE     Genetic analysis identifies the SLC4A3 anion exchanger as a major
            gene for short QT syndrome
  JOURNAL   Heart Rhythm 20 (8), 1136-1143 (2023)
   PUBMED   36806574
  REMARK    GeneRIF: Genetic analysis identifies the SLC4A3 anion exchanger as
            a major gene for short QT syndrome.
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Thorsen,K., Dam,V.S., Kjaer-Sorensen,K., Pedersen,L.N.,
            Skeberdis,V.A., Jurevicius,J., Treinys,R., Petersen,I.M.B.S.,
            Nielsen,M.S., Oxvig,C., Morth,J.P., Matchkov,V.V., Aalkjaer,C.,
            Bundgaard,H. and Jensen,H.K.
  TITLE     Loss-of-activity-mutation in the cardiac chloride-bicarbonate
            exchanger AE3 causes short QT syndrome
  JOURNAL   Nat Commun 8 (1), 1696 (2017)
   PUBMED   29167417
  REMARK    GeneRIF: Identify a missense mutation in the anion exchanger
            (AE3)-encoding SLC4A3 gene in two unrelated families with short QT
            syndrome. The mutation causes reduced surface expression of AE3 and
            reduced membrane bicarbonate transport.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Dudeja,P.K., Hafez,N., Tyagi,S., Gailey,C.A., Toofanfard,M.,
            Alrefai,W.A., Nazir,T.M., Ramaswamy,K. and Al-Bazzaz,F.J.
  TITLE     Expression of the Na+/H+ and Cl-/HCO-3 exchanger isoforms in
            proximal and distal human airways
  JOURNAL   Am J Physiol 276 (6), L971-L978 (1999)
   PUBMED   10362722
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Yannoukakos,D., Stuart-Tilley,A., Fernandez,H.A., Fey,P., Duyk,G.
            and Alper,S.L.
  TITLE     Molecular cloning, expression, and chromosomal localization of two
            isoforms of the AE3 anion exchanger from human heart
  JOURNAL   Circ Res 75 (4), 603-614 (1994)
   PUBMED   7923606
REFERENCE   8  (bases 1 to 4151)
  AUTHORS   Su,Y.R., Klanke,C.A., Houseal,T.W., Linn,S.C., Burk,S.E.,
            Varvil,T.S., Otterud,B.E., Shull,G.E., Leppert,M.F. and Menon,A.G.
  TITLE     Molecular cloning and physical and genetic mapping of the human
            anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36
  JOURNAL   Genomics 22 (3), 605-609 (1994)
   PUBMED   8001971
REFERENCE   9  (bases 1 to 4151)
  AUTHORS   Morgans,C.W. and Kopito,R.R.
  TITLE     Association of the brain anion exchanger, AE3, with the repeat
            domain of ankyrin
  JOURNAL   J Cell Sci 105 (Pt 4), 1137-1142 (1993)
   PUBMED   8227202
REFERENCE   10 (bases 1 to 4151)
  AUTHORS   Kopito,R.R., Lee,B.S., Simmons,D.M., Lindsey,A.E., Morgans,C.W. and
            Schneider,K.
  TITLE     Regulation of intracellular pH by a neuronal homolog of the
            erythrocyte anion exchanger
  JOURNAL   Cell 59 (5), 927-937 (1989)
   PUBMED   2686841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009955.4 and KF459589.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005070.3.
            
            Summary: The protein encoded by this gene is a plasma membrane
            anion exchange protein. The encoded protein has been found in
            brain, heart, kidney, small intestine, and lung. [provided by
            RefSeq, May 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289974.1, BC146656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358055.8/ ENSP00000350756.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC009955.4         98519-98634
            117-260             AC009955.4         98789-98932
            261-426             AC009955.4         99294-99459
            427-704             AC009955.4         100033-100310
            705-820             AC009955.4         100469-100584
            821-1020            AC009955.4         101042-101241
            1021-1169           AC009955.4         102857-103005
            1170-1350           AC009955.4         103151-103331
            1351-1486           AC009955.4         103763-103898
            1487-1670           AC009955.4         104163-104346
            1671-1770           AC009955.4         104769-104868
            1771-1955           AC009955.4         105309-105493
            1956-2181           AC009955.4         106160-106385
            2182-2339           KF459589.1         110-267
            2340-2400           AC009955.4         106720-106780
            2401-2549           AC009955.4         107191-107339
            2550-2744           AC009955.4         107569-107763
            2745-2975           AC009955.4         108470-108700
            2976-3065           AC009955.4         109053-109142
            3066-3232           AC009955.4         109592-109758
            3233-3486           AC009955.4         110371-110624
            3487-3656           AC009955.4         111319-111488
            3657-3830           AC009955.4         111678-111851
            3831-4151           AC009955.4         112540-112860
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..4151
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /note="solute carrier family 4 member 3"
                     /db_xref="GeneID:6508"
                     /db_xref="HGNC:HGNC:11029"
                     /db_xref="MIM:106195"
     exon            1..116
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            117..260
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..3908
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /note="isoform 1 is encoded by transcript variant 1; Anion
                     exchanger 3, neuronal; anion exchange protein 3; neuronal
                     band 3-like protein; cardiac/brain band 3-like protein;
                     solute carrier family 4 (anion exchanger), member 3"
                     /codon_start=1
                     /product="anion exchange protein 3 isoform 1"
                     /protein_id="NP_005061.3"
                     /db_xref="CCDS:CCDS2445.1"
                     /db_xref="GeneID:6508"
                     /db_xref="HGNC:HGNC:11029"
                     /db_xref="MIM:106195"
                     /translation="MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAV
                     SRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTS
                     ARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVEPPHSGT
                     PQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGE
                     KSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLED
                     NPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQ
                     EPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTL
                     PGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVL
                     GNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEK
                     IPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTST
                     DYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRS
                     VAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVF
                     GGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGV
                     SELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGL
                     WLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFY
                     PPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFR
                     NSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFI
                     PPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLL
                     IGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLI
                     ASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPY
                     VTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRE
                     LQALDSEDAEPNFDEDGQDEYNELHMPV"
     exon            261..426
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            427..704
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            705..820
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1020
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1169
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1350
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1486
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1670
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1770
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1955
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2181
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2400
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2549
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2744
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2975
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3065
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3232
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3486
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3656
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3830
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..4151
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4126..4131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /note="hexamer: ATTATA"
     polyA_site      4151
                     /gene="SLC4A3"
                     /gene_synonym="AE3; CAE3/BAE3; SLC2C; SQT7"
                     /note="major polyA site"
ORIGIN      
        1 agcccggctc tgcgctgcga gaggccggac ggcagtcgcg gctgcgctcg ggagagagcg
       61 cgggggacat ggggcgcggc ggcccgcctg ggcctcgcag gctccggagc cccgagggct
      121 ccccgctagg ccccctcagt ggcccctcct tctcacctgg gtctcgggtc ccctagtgag
      181 cgagagcgtc cccagccgcc tacctggcca tggccaacgg agtgatcccg ccgcccgggg
      241 gcgcctcccc cctaccccag gtccgggtgc ccttggagga gccccctcta agtccagacg
      301 tggaggagga ggacgatgac ttgggcaaga ccttggctgt gagcaggttt ggggacctca
      361 tcagcaagcc cccggcctgg gaccccgaga agcccagccg cagctacagc gagcgggact
      421 ttgagtttca ccggcacaca tcccaccaca cccaccaccc gctctcagcg cgcctgcctc
      481 caccccacaa gctgcggcgg ctgcccccca cctctgcccg gcacaccagg agaaagagga
      541 agaaggagaa aacctctgct cctccctccg aggggacccc tcccatccag gaggaggggg
      601 gagctggagt ggatgaggaa gaggaggaag aggaggaaga ggaaggagaa tctgaggcag
      661 aacctgtgga gcccccccac tcagggaccc cacagaaggc aaagttctcc attggaagtg
      721 acgaggatga cagtccaggc ctccctggga gggctgctgt caccaagccc ctgccctcgg
      781 tgggcccaca cactgacaag agcccccagc actccagcag ctcccccagc ccccgggccc
      841 gggcctcccg actcgctggg gagaaaagcc ggccctggag cccatcggcc agttatgacc
      901 tgcgggagcg actgtgccca ggcagtgccc tgggcaaccc aggtggtcca gagcagcagg
      961 tgcccacaga tgaggcggag gcccagatgc tgggttctgc agacctggac gacatgaaga
     1021 gtcaccgact ggaggacaac cctggtgtgc ggcgacactt agtgaaaaag ccctcccgga
     1081 cgcagggcgg gaggggcagt cccagcggcc tggcccccat ccttcgcagg aagaagaaga
     1141 agaaaaagct ggaccggagg cctcatgagg tgttcgtgga gctgaacgag ctgatgctgg
     1201 accgcagcca ggagccccac tggcgggaga cggcccgctg gatcaagttt gaggaggacg
     1261 tggaggagga gacggagcgc tgggggaagc cccatgttgc ctcgctctcc ttccgtagcc
     1321 ttctggagct caggaggacc atcgcccatg gagctgccct cctggacctg gagcaaacca
     1381 ccctgccagg cattgcacac ctcgtggtgg agaccatgat tgtgtctgac cagatccggc
     1441 cggaggacag ggccagcgtc ctacgtaccc tgctactgaa gcacagccat cccaacgatg
     1501 acaaggacag tggcttcttt ccccgaaacc catcgagctc cagcatgaac tcggttctgg
     1561 ggaatcatca cccaactccc agccatggcc ctgatggggc ggtgcctacc atggctgatg
     1621 acctggggga gccagcccca ctctggccac atgaccctga cgccaaggag aagcccctcc
     1681 acatgcctgg gggagatggt caccggggga aaagcctgaa gctgctggag aagatccctg
     1741 aagatgctga ggccacggtt gtgcttgtgg gttgtgtgcc tttcttggag cagcctgcag
     1801 cagccttcgt gcgtctgaat gaggctgtac tcctggagtc tgtgcttgag gtccctgtcc
     1861 cggtccgctt cctcttcgtg atgctggggc ccagccacac cagcactgac tatcacgagc
     1921 ttgggcgctc cattgccacc cttatgtctg acaagctgtt tcatgaggct gcctaccagg
     1981 cagatgaccg gcaagacctc ctaagtgcca tcagcgagtt cctggatggc agcattgtga
     2041 tccccccgtc cgaggtggag ggccgtgacc tgctgcgctc cgtggctgct ttccagcgag
     2101 agctgcttag gaagcggcga gagcgtgaac agaccaaagt cgagatgacc acacggggtg
     2161 gctacacggc ccctgggaaa gaactgtctt tggagttggg gggctctgag gcaacccctg
     2221 aagatgaccc cttgctgcgg acgggctcgg tatttggggg gcttgtgcgg gatgtgaggc
     2281 gccggtaccc gcactacccc agtgacctgc gagatgcgct gcactcccag tgtgtggccg
     2341 ctgtgctctt catctacttc gcagccctca gccctgccat caccttcggg gggctgctgg
     2401 gagagaagac cgaggggctg atgggcgtgt ccgagctgat cgtgtccacc gctgtgctcg
     2461 gcgtcctctt ctctctgctg ggagctcagc cgctgcttgt ggttggcttc tctgggccgc
     2521 tgcttgtgtt tgaggaagcc ttcttcaagt tctgccgagc ccaggacctg gagtacctca
     2581 ctggccgggt gtgggttggt ctctggctgg tggtcttcgt ccttgccctg gtggccgccg
     2641 aaggcagctt cctggtccgc tacatctcgc ctttcaccca ggagatcttt gcctttctca
     2701 tctcactcat tttcatctac gagaccttct acaagctcta caaggtgttc acagagcacc
     2761 cactgctgcc gttctacccc cctgaggggg ccctggaggg gtccctggat gctggtctgg
     2821 agccaaatgg cagtgccctg ccccccaccg agggcccccc cagcccgagg aaccagccca
     2881 atacggcact gctctcactc atcctcatgc tcgggacctt cttcatagcc ttcttcctgc
     2941 gcaagttcag gaacagccgc ttcctggggg gcaaggctcg tcgcatcatc ggggactttg
     3001 gcatccccat ctccatcctg gtgatggtcc tggtggatta ctccatcaca gacacctaca
     3061 cgcagaagct gacagtgcct acagggctct cagtgacctc tcccgataag cgctcgtggt
     3121 tcatcccacc cctgggcagt gcccgtcctt tcccgccgtg gatgatggtg gcagccgctg
     3181 ttcccgccct cctcgtcctc atcctgatct tcatggagac acagatcacg gcgcttatcg
     3241 tcagccagaa ggcgcggagg ctgctcaagg gctccggttt ccacctggac ctgctcctca
     3301 ttggctccct gggggggctc tgtgggctgt ttgggttgcc ctggctcacg gctgccacgg
     3361 tccgctccgt cacccatgtc aatgcgttga cagtgatgcg tactgccatc gcgcctggtg
     3421 acaagcccca gatccaggag gtgcgggagc agcgggtcac tggtgtgctc atcgccagcc
     3481 tcgtgggcct gtccatcgtc atgggggctg tgctgcgtcg gatcccattg gctgtgctct
     3541 ttgggatctt cctgtacatg ggggtcacgt ccctgtctgg tatccagctg tcccagcgtt
     3601 tgttgctcat cctcatgccg gcaaaacacc atcctgagca gccctatgtg accaaggtga
     3661 agacgtggcg gatgcatctg ttcacctgca tccagctggg ctgcatcgca ctgctctggg
     3721 tggtcaagtc cacggcggcc tcactcgcct ttcccttcct gctgctgctc acggtgcctc
     3781 tgaggcattg ccttctgccc cggctcttcc aggacaggga gctgcaggcg ctggactcgg
     3841 aagatgctga accaaacttc gatgaggatg gccaggatga gtacaatgag ctgcacatgc
     3901 cagtgtgacc cttgaagaca gtgcccctca gagaccccaa gaccttaggg attgacacct
     3961 gggcctcagg cagagcccag ccctgggctg gggggctcct caggacccag agatgtgcct
     4021 ggaaccactc ctgatgccat ggctagagtg gcccccctga cttctgcccg gggtgttgac
     4081 ctcgcctcac ctttcacaga ccagaccggc acaggctttg agctcattat aaccacactc
     4141 cttgtctcgt g
//
