LOCUS       NM_003040               4119 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens solute carrier family 4 member 2 (SLC4A2), transcript
            variant 1, mRNA.
ACCESSION   NM_003040
VERSION     NM_003040.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4119)
  AUTHORS   Michl,J., Monterisi,S., White,B., Blaszczak,W., Hulikova,A.,
            Abdullayeva,G., Bridges,E., Yin,Z., Bodmer,W.F. and Swietach,P.
  TITLE     Acid-adapted cancer cells alkalinize their cytoplasm by degrading
            the acid-loading membrane transporter anion exchanger 2, SLC4A2
  JOURNAL   Cell Rep 42 (6), 112601 (2023)
   PUBMED   37270778
  REMARK    GeneRIF: Acid-adapted cancer cells alkalinize their cytoplasm by
            degrading the acid-loading membrane transporter anion exchanger 2,
            SLC4A2.
REFERENCE   2  (bases 1 to 4119)
  AUTHORS   Xue,J.Y., Ikegawa,S. and Guo,L.
  TITLE     SLC4A2, another gene involved in acid-base balancing machinery of
            osteoclasts, causes osteopetrosis
  JOURNAL   Bone 167, 116603 (2023)
   PUBMED   36343920
  REMARK    GeneRIF: SLC4A2, another gene involved in acid-base balancing
            machinery of osteoclasts, causes osteopetrosis.
            Review article
REFERENCE   3  (bases 1 to 4119)
  AUTHORS   Xue,J.Y., Grigelioniene,G., Wang,Z., Nishimura,G., Iida,A.,
            Matsumoto,N., Tham,E., Miyake,N., Ikegawa,S. and Guo,L.
  TITLE     SLC4A2 Deficiency Causes a New Type of Osteopetrosis
  JOURNAL   J Bone Miner Res 37 (2), 226-235 (2022)
   PUBMED   34668226
REFERENCE   4  (bases 1 to 4119)
  AUTHORS   Calvete,O., Reyes,J., Valdes-Socin,H., Martin,P., Marazuela,M.,
            Barroso,A., Escalada,J., Castells,A., Torres-Ruiz,R.,
            Rodriguez-Perales,S., Curras-Freixes,M. and Benitez,J.
  TITLE     Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base
            Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel
            Mechanism for a Co-Occurring Polyautoimmune Scenario
  JOURNAL   Cells 10 (12), 3500 (2021)
   PUBMED   34944008
  REMARK    GeneRIF: Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base
            Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel
            Mechanism for a Co-Occurring Polyautoimmune Scenario.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4119)
  AUTHORS   Khosrowabadi,E., Rivinoja,A., Risteli,M., Tuomisto,A., Salo,T.,
            Makinen,M.J. and Kellokumpu,S.
  TITLE     SLC4A2 anion exchanger promotes tumour cell malignancy via
            enhancing net acid efflux across golgi membranes
  JOURNAL   Cell Mol Life Sci 78 (17-18), 6283-6304 (2021)
   PUBMED   34279699
  REMARK    GeneRIF: SLC4A2 anion exchanger promotes tumour cell malignancy via
            enhancing net acid efflux across golgi membranes.
REFERENCE   6  (bases 1 to 4119)
  AUTHORS   Rybicki,A.C., Musto,S. and Schwartz,R.S.
  TITLE     Identification of a band-3 binding site near the N-terminus of
            erythrocyte membrane protein 4.2
  JOURNAL   Biochem J 309 (Pt 2) (Pt 2), 677-681 (1995)
   PUBMED   7626035
REFERENCE   7  (bases 1 to 4119)
  AUTHORS   Gehrig,H., Muller,W. and Appelhans,H.
  TITLE     Complete nucleotide sequence of band 3 related anion transport
            protein AE2 from human kidney
  JOURNAL   Biochim Biophys Acta 1130 (3), 326-328 (1992)
   PUBMED   1562608
REFERENCE   8  (bases 1 to 4119)
  AUTHORS   Korsgren,C. and Cohen,C.M.
  TITLE     Associations of human erythrocyte band 4.2. Binding to ankyrin and
            to the cytoplasmic domain of band 3
  JOURNAL   J Biol Chem 263 (21), 10212-10218 (1988)
   PUBMED   2968981
REFERENCE   9  (bases 1 to 4119)
  AUTHORS   Palumbo,A.P., Isobe,M., Huebner,K., Shane,S., Rovera,G., Demuth,D.,
            Curtis,P.J., Ballantine,M., Croce,C.M. and Showe,L.C.
  TITLE     Chromosomal localization of a human band 3-like gene to region
            7q35----7q36
  JOURNAL   Am J Hum Genet 39 (3), 307-316 (1986)
   PUBMED   3020980
REFERENCE   10 (bases 1 to 4119)
  AUTHORS   Demuth,D.R., Showe,L.C., Ballantine,M., Palumbo,A., Fraser,P.J.,
            Cioe,L., Rovera,G. and Curtis,P.J.
  TITLE     Cloning and structural characterization of a human non-erythroid
            band 3-like protein
  JOURNAL   EMBO J 5 (6), 1205-1214 (1986)
   PUBMED   3015590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA103528.1, AK312699.1,
            AK295767.1 and BM680391.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003040.3.
            
            Summary: This gene encodes a member of the anion exchanger family
            of membrane transport proteins. The encoded protein regulates
            intracellular pH, biliary bicarbonate secretion, and chloride
            uptake. Reduced expression of this gene may be associated with
            primary biliary cirrhosis (PBC) in human patients, while
            differential expression of this gene may be associated with
            malignant hepatocellular carcinoma, colon and gastric cancers.
            [provided by RefSeq, Nov 2016].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62531.1, AK312699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413384.7/ ENSP00000405600.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA103528.1         20-21
            3-3963              AK312699.1         1-3961
            3964-4118           AK295767.1         3793-3947
            4119-4119           BM680391.1         22-22               c
FEATURES             Location/Qualifiers
     source          1..4119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4119
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="solute carrier family 4 member 2"
                     /db_xref="GeneID:6522"
                     /db_xref="HGNC:HGNC:11028"
                     /db_xref="MIM:109280"
     exon            1..174
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            175..288
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..3963
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="isoform 1 is encoded by transcript variant 1; anion
                     exchange protein 2; anion exchanger 2 type a; anion
                     exchanger 2 type b1; anion exchanger 2 type b2;
                     non-erythroid band 3-like protein; erythrocyte membrane
                     protein band 3-like 1; solute carrier family 4 (anion
                     exchanger), member 2"
                     /codon_start=1
                     /product="anion exchange protein 2 isoform 1"
                     /protein_id="NP_003031.3"
                     /db_xref="CCDS:CCDS5917.1"
                     /db_xref="GeneID:6522"
                     /db_xref="HGNC:HGNC:11028"
                     /db_xref="MIM:109280"
                     /translation="MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGV
                     ERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGP
                     GRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDD
                     SADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGA
                     SGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSH
                     RFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDK
                     NQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQ
                     TLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSL
                     LGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLE
                     KIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSAN
                     MDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLR
                     SVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPF
                     GGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGV
                     SELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGF
                     WLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS
                     ASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFI
                     AFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTA
                     PEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGS
                     GFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKE
                     QRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPP
                     KHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVL
                     TRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV"
     exon            289..454
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            455..696
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            697..815
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1060
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1203
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1384
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1520
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1686
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1801
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1986
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2212
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2428
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2577
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2772
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..3027
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3117
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3284
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3538
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3708
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3882
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4119
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4099..4104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="hexamer: AGTAAA"
     polyA_site      4119
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="major polyA site"
ORIGIN      
        1 gcacgcaggg ggctggcctg cccgcggcgc gggggaaagt tgagttggga gaagttggga
       61 gcggcggggg cgcgccccgg ggtgggcacg gggcagtcgt cgggagcgcg cgagtgcgcc
      121 ggaggacggg gagagacccc gagacccccg gggcacgaag tccagagcga gcgggttatg
      181 cctccgcctc gttgccctga aagccgcagc gacagcgaaa agggctaaga ttcggccatg
      241 agcagcgccc ctcggcgccc cgccaagggc gcagattctt tctgtacgcc agagccagag
      301 agcttgggcc ctgggacgcc tgggttcccc gagcaggagg aagacgaact tcaccgcacc
      361 ctgggcgtgg agcggtttga ggagatccta caggaggccg ggtctcgtgg aggggaggag
      421 ccaggccgca gctatgggga ggaagacttt gagtaccacc gccagtcctc ccaccacatc
      481 catcacccac tgtccaccca cctgcctccg gatgcacgcc gccgcaagac accccagggc
      541 ccaggacgga agcctcgaag gcgcccggga gcctccccga ctggagaaac cccgaccatt
      601 gaggaggggg aggaagatga ggatgaggcc agcgaggctg agggggcccg ggctctcact
      661 cagccgtccc ctgtctccac accctcctcg gtgcagttct ttctccaaga ggatgacagt
      721 gctgaccgga aggcagagag gaccagtcca tcttcccctg caccactgcc ccaccaggag
      781 gcgactcctc gggcctccaa aggggcccag gctggaaccc aggtggagga ggcggaggcg
      841 gaggcggtgg cggtggccag tggcactgca gggggtgacg acgggggtgc ctcggggcgc
      901 cccctgccca aagcccagcc tgggcaccgc agctacaacc ttcaggagag gaggcgcatc
      961 gggagcatga ctggggctga gcaggcactg ctgccccggg tccccacgga tgagattgag
     1021 gcccagacgc tggccacggc cgacctagac ctcatgaaga gtcaccggtt tgaggacgtt
     1081 cctggggtgc ggcggcactt ggtgcggaag aatgccaaag gttccacaca gagtggccga
     1141 gaagggcggg agcctggccc cacacctcgg gcccgacccc gggcccccca caagccccat
     1201 gaggtgtttg tggagctgaa tgagttgctc ctggacaaaa accaggagcc ccagtggcgg
     1261 gagacagctc gctggatcaa atttgaagag gacgtggagg aggagactga gcgctggggg
     1321 aagccccacg tggcctccct ctccttccgc agtctcctgg agctccgcag gaccctggcc
     1381 catggggctg tgctcttgga tctggaccag cagaccctgc ccggagtggc ccaccaggtg
     1441 gtggagcaga tggtcatctc tgaccagatc aaggccgagg acagggccaa cgtgctgcgg
     1501 gctctgctgt tgaaacacag ccacccaagt gatgagaagg acttctcctt cccccgcaac
     1561 atctcagctg gctccctggg ctccctgctg gggcatcacc atggtcaggg ggctgagagt
     1621 gacccccacg tcaccgagcc tctcatggga ggtgttcctg agacccggct ggaggtggag
     1681 cgagagcgtg agctgccgcc tccagcacca ccagctggca tcacccgctc caagtccaag
     1741 cacgagctga aactgctgga gaagattcct gagaatgccg aggccacggt ggtccttgtg
     1801 ggctgcgtgg agttcctctc ccgccccacc atggcctttg tgcggctccg ggaggctgtg
     1861 gagttggacg cagtgttgga ggtgccggtg cctgtgcgtt tcctcttcct gctgctgggc
     1921 ccgagtagtg ccaacatgga ctaccacgag atcggccgct ccatctccac cctcatgtca
     1981 gacaagcaat tccacgaggc agcctacctg gctgacgagc gggaggacct gctgacggcc
     2041 atcaacgcct tcctggactg cagcgtggtg ctgccgcctt cagaagtgca gggcgaggag
     2101 ctgctgcgct ctgtggccca cttccagcgc cagatgctca agaagcgaga ggagcagggc
     2161 cggctgctac ctacaggggc tgggctggag cccaaatctg cccaagataa ggcgctcctg
     2221 cagatggtag aggcggcagg ggcagctgaa gatgatcccc ttcggcggac ggggcggccc
     2281 tttggggggc tgatccgaga tgtgcggcgc cgctatcccc actacctgag tgacttccga
     2341 gatgcacttg accctcagtg cctggccgca gtcatcttca tctactttgc cgccctgtct
     2401 cctgccatca cctttggggg gctgctggga gagaagacgc aggacctgat aggggtgtcg
     2461 gagctgatta tgtccacagc gctccagggc gtggtcttct gcctgctggg tgcccagccc
     2521 ctgttggtga tcggcttctc agggcccctg ctggtctttg aggaggcctt cttctcgttc
     2581 tgtagcagca accacctgga gtacctggtg ggccgtgtgt ggatcggctt ctggctggtg
     2641 ttcctggccc tgctcatggt ggccctggag gggagcttcc tggtccgctt cgtctcccgc
     2701 ttcacccagg agatcttcgc cttcttgatc tcactcatct tcatctatga gaccttctac
     2761 aagctggtga agatcttcca ggagcacccc ctgcatggct gctcagcctc caacagctca
     2821 gaggtggacg gcggtgagaa catgacatgg gccggggcaa gacccacgct ggggccgggc
     2881 aacaggagct tggctgggca gtctgggcag gggaagcccc ggggccagcc caacacggcc
     2941 ctgctgtcgc tggtgctcat ggccggcacc ttcttcatcg ccttcttcct gcgcaaattc
     3001 aagaacagcc ggttctttcc tggccggatc cggcgggtga ttggggactt tggggtgccc
     3061 atcgccatcc tcatcatggt gcttgtggat tacagtattg aggacaccta tacccagaag
     3121 ctgagcgttc ccagtggatt ctcggtgact gccccagaaa agaggggctg ggtcatcaac
     3181 cccctgggag agaagagccc cttccctgtg tggatgatgg ttgccagcct gctgcccgcc
     3241 atcctggtct tcattctcat cttcatggag acacagatca ccacgctcat catctccaag
     3301 aaggagcgca tgctgcagaa gggctccggc ttccacctgg acctgctgct catcgtggcc
     3361 atgggcggca tctgtgccct ctttggcctg ccctggttgg ctgctgccac tgtccgctct
     3421 gtcactcacg ccaacgcgct cactgtcatg agcaaggctg tggcacctgg ggacaagccc
     3481 aagattcagg aagtcaagga gcagcgggtg acggggctgc tggttgccct gcttgtgggc
     3541 ctctccatag ttatcgggga tctgctccgg cagatccccc tggccgtgct ctttggaatt
     3601 ttcctgtaca tgggagtcac ctcccttaac gggatccagt tctatgagcg gctgcatctg
     3661 ctgctcatgc cgcccaaaca ccacccagat gtcacttacg tcaagaaggt ccggaccctc
     3721 cgtatgcacc tgttcacggc cctgcagctg ctctgcctgg ccctgctctg ggccgtcatg
     3781 tccacagctg cctccctggc cttccccttc atcctcatcc tcacagtgcc gctccgcatg
     3841 gtggtgctca cccgtatctt caccgaccga gagatgaaat gtctggatgc taacgaggca
     3901 gagccggtgt ttgatgagcg ggagggtgtg gacgagtaca atgagatgcc catgcctgtg
     3961 tagccgccac cgagggacag ccgagggacc gatggacgag gggacaggct ggtgggatgg
     4021 ggttccccct cccatgcccc tccctccttt ttatttaagt gaataattta aagtcttctc
     4081 ctcccccact gcccctgcag taaagtgctt tggccccca
//
