LOCUS       NM_001199692            4934 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 4 member 2 (SLC4A2), transcript
            variant 2, mRNA.
ACCESSION   NM_001199692
VERSION     NM_001199692.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4934)
  AUTHORS   Michl,J., Monterisi,S., White,B., Blaszczak,W., Hulikova,A.,
            Abdullayeva,G., Bridges,E., Yin,Z., Bodmer,W.F. and Swietach,P.
  TITLE     Acid-adapted cancer cells alkalinize their cytoplasm by degrading
            the acid-loading membrane transporter anion exchanger 2, SLC4A2
  JOURNAL   Cell Rep 42 (6), 112601 (2023)
   PUBMED   37270778
  REMARK    GeneRIF: Acid-adapted cancer cells alkalinize their cytoplasm by
            degrading the acid-loading membrane transporter anion exchanger 2,
            SLC4A2.
REFERENCE   2  (bases 1 to 4934)
  AUTHORS   Xue,J.Y., Ikegawa,S. and Guo,L.
  TITLE     SLC4A2, another gene involved in acid-base balancing machinery of
            osteoclasts, causes osteopetrosis
  JOURNAL   Bone 167, 116603 (2023)
   PUBMED   36343920
  REMARK    GeneRIF: SLC4A2, another gene involved in acid-base balancing
            machinery of osteoclasts, causes osteopetrosis.
            Review article
REFERENCE   3  (bases 1 to 4934)
  AUTHORS   Xue,J.Y., Grigelioniene,G., Wang,Z., Nishimura,G., Iida,A.,
            Matsumoto,N., Tham,E., Miyake,N., Ikegawa,S. and Guo,L.
  TITLE     SLC4A2 Deficiency Causes a New Type of Osteopetrosis
  JOURNAL   J Bone Miner Res 37 (2), 226-235 (2022)
   PUBMED   34668226
REFERENCE   4  (bases 1 to 4934)
  AUTHORS   Calvete,O., Reyes,J., Valdes-Socin,H., Martin,P., Marazuela,M.,
            Barroso,A., Escalada,J., Castells,A., Torres-Ruiz,R.,
            Rodriguez-Perales,S., Curras-Freixes,M. and Benitez,J.
  TITLE     Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base
            Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel
            Mechanism for a Co-Occurring Polyautoimmune Scenario
  JOURNAL   Cells 10 (12), 3500 (2021)
   PUBMED   34944008
  REMARK    GeneRIF: Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base
            Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel
            Mechanism for a Co-Occurring Polyautoimmune Scenario.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4934)
  AUTHORS   Khosrowabadi,E., Rivinoja,A., Risteli,M., Tuomisto,A., Salo,T.,
            Makinen,M.J. and Kellokumpu,S.
  TITLE     SLC4A2 anion exchanger promotes tumour cell malignancy via
            enhancing net acid efflux across golgi membranes
  JOURNAL   Cell Mol Life Sci 78 (17-18), 6283-6304 (2021)
   PUBMED   34279699
  REMARK    GeneRIF: SLC4A2 anion exchanger promotes tumour cell malignancy via
            enhancing net acid efflux across golgi membranes.
REFERENCE   6  (bases 1 to 4934)
  AUTHORS   Rybicki,A.C., Musto,S. and Schwartz,R.S.
  TITLE     Identification of a band-3 binding site near the N-terminus of
            erythrocyte membrane protein 4.2
  JOURNAL   Biochem J 309 (Pt 2) (Pt 2), 677-681 (1995)
   PUBMED   7626035
REFERENCE   7  (bases 1 to 4934)
  AUTHORS   Gehrig,H., Muller,W. and Appelhans,H.
  TITLE     Complete nucleotide sequence of band 3 related anion transport
            protein AE2 from human kidney
  JOURNAL   Biochim Biophys Acta 1130 (3), 326-328 (1992)
   PUBMED   1562608
REFERENCE   8  (bases 1 to 4934)
  AUTHORS   Korsgren,C. and Cohen,C.M.
  TITLE     Associations of human erythrocyte band 4.2. Binding to ankyrin and
            to the cytoplasmic domain of band 3
  JOURNAL   J Biol Chem 263 (21), 10212-10218 (1988)
   PUBMED   2968981
REFERENCE   9  (bases 1 to 4934)
  AUTHORS   Palumbo,A.P., Isobe,M., Huebner,K., Shane,S., Rovera,G., Demuth,D.,
            Curtis,P.J., Ballantine,M., Croce,C.M. and Showe,L.C.
  TITLE     Chromosomal localization of a human band 3-like gene to region
            7q35----7q36
  JOURNAL   Am J Hum Genet 39 (3), 307-316 (1986)
   PUBMED   3020980
REFERENCE   10 (bases 1 to 4934)
  AUTHORS   Demuth,D.R., Showe,L.C., Ballantine,M., Palumbo,A., Fraser,P.J.,
            Cioe,L., Rovera,G. and Curtis,P.J.
  TITLE     Cloning and structural characterization of a human non-erythroid
            band 3-like protein
  JOURNAL   EMBO J 5 (6), 1205-1214 (1986)
   PUBMED   3015590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB065890.1, AB209158.1 and
            BM680391.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001199692.2.
            
            Summary: This gene encodes a member of the anion exchanger family
            of membrane transport proteins. The encoded protein regulates
            intracellular pH, biliary bicarbonate secretion, and chloride
            uptake. Reduced expression of this gene may be associated with
            primary biliary cirrhosis (PBC) in human patients, while
            differential expression of this gene may be associated with
            malignant hepatocellular carcinoma, colon and gastric cancers.
            [provided by RefSeq, Nov 2016].
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            and encodes the same isoform (1), as compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB065890.1         1-12
            13-4889             AB209158.1         1-4877
            4890-4934           BM680391.1         22-66               c
FEATURES             Location/Qualifiers
     source          1..4934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4934
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="solute carrier family 4 member 2"
                     /db_xref="GeneID:6522"
                     /db_xref="HGNC:HGNC:11028"
                     /db_xref="MIM:109280"
     exon            1..989
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1103
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             1053..4778
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="isoform 1 is encoded by transcript variant 2; anion
                     exchange protein 2; anion exchanger 2 type a; anion
                     exchanger 2 type b1; anion exchanger 2 type b2;
                     non-erythroid band 3-like protein; erythrocyte membrane
                     protein band 3-like 1; solute carrier family 4 (anion
                     exchanger), member 2"
                     /codon_start=1
                     /product="anion exchange protein 2 isoform 1"
                     /protein_id="NP_001186621.1"
                     /db_xref="CCDS:CCDS5917.1"
                     /db_xref="GeneID:6522"
                     /db_xref="HGNC:HGNC:11028"
                     /db_xref="MIM:109280"
                     /translation="MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGV
                     ERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGP
                     GRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDD
                     SADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGA
                     SGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSH
                     RFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDK
                     NQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQ
                     TLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSL
                     LGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLE
                     KIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSAN
                     MDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLR
                     SVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPF
                     GGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGV
                     SELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGF
                     WLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCS
                     ASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFI
                     AFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTA
                     PEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGS
                     GFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKE
                     QRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPP
                     KHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVL
                     TRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV"
     exon            1104..1269
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1511
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1630
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1875
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2018
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2199
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2335
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2501
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2616
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2801
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3027
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3243
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3392
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3587
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3842
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3932
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4099
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4353
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4523
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4697
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     exon            4698..4934
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4914..4919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="hexamer: AGTAAA"
     polyA_site      4934
                     /gene="SLC4A2"
                     /gene_synonym="AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9"
                     /note="major polyA site"
ORIGIN      
        1 cttttatgtg ctcccagccc tcttgaaaag ggccgctccg ggactacgcg ttccagaatg
       61 cagcggaaat gggggcggag cgctctcggt taggggtttg gggtttggcg gcctagatcc
      121 cgggcactgg cggcccagcg ctgacctggt tggtggcatt gtgttcccaa cggcctcttg
      181 acgacctcag cacgggtttc cacctctccc caagccacct agtgacccca gaattgactg
      241 gggaatgcct gtgagcgatg atgacctcac agggaacagc tgaccgcagg gctgggagaa
      301 cagctgtgcc ccttcgaggc tggattttag tggagggaca cacgccaaag accccctctc
      361 tgctgagccc cgtttgttgt ctcggagccc acccgactct agccgctgaa ctctgacatg
      421 ctgaggaaaa ctgggtggag ccctgggggt ccccctcaga ccccagtctc cggaacaggg
      481 cccactggag tcagccaggg tgtggcaggc aggttggtta accccctcca cagacaagac
      541 cacagaccga tgctcaactt gcagcagcct ctgcctcacc ccttaaagga gctgattata
      601 gattccctta cgctgcctct ctaattgtct catgattgca ttcttgaggg ctatggaccg
      661 agggaaaagg atcccaaaca gcactcctca gcaccggaac cagagttgct gctaaacacg
      721 tgttaattaa ctcgtttcta tctgaatgct tttgcataca caagggaaaa gaagcaaaaa
      781 gtgtattcct tatctggaag actttgtgat ttcgttgggc aaaaaagaac tacacacaaa
      841 ggtcttgaat gataagtgat ggctctgcct agggttcggt tcagtgtgga ggttccattc
      901 aagaggaagg aggccagcac agcgaatctc tgtccctctc tggaagtgga gagcctctaa
      961 caagttaccc tctcccagat cagctcaggg ttatgcctcc gcctcgttgc cctgaaagcc
     1021 gcagcgacag cgaaaagggc taagattcgg ccatgagcag cgcccctcgg cgccccgcca
     1081 agggcgcaga ttctttctgt acgccagagc cagagagctt gggccctggg acgcctgggt
     1141 tccccgagca ggaggaagac gaacttcacc gcaccctggg cgtggagcgg tttgaggaga
     1201 tcctacagga ggccgggtct cgtggagggg aggagccagg ccgcagctat ggggaggaag
     1261 actttgagta ccaccgccag tcctcccacc acatccatca cccactgtcc acccacctgc
     1321 ctccggatgc acgccgccgc aagacacccc agggcccagg acggaagcct cgaaggcgcc
     1381 cgggagcctc cccgactgga gaaaccccga ccattgagga gggggaggaa gatgaggatg
     1441 aggccagcga ggctgagggg gcccgggctc tcactcagcc gtcccctgtc tccacaccct
     1501 cctcggtgca gttctttctc caagaggatg acagtgctga ccggaaggca gagaggacca
     1561 gtccatcttc ccctgcacca ctgccccacc aggaggcgac tcctcgggcc tccaaagggg
     1621 cccaggctgg aacccaggtg gaggaggcgg aggcggaggc ggtggcggtg gccagtggca
     1681 ctgcaggggg tgacgacggg ggtgcctcgg ggcgccccct gcccaaagcc cagcctgggc
     1741 accgcagcta caaccttcag gagaggaggc gcatcgggag catgactggg gctgagcagg
     1801 cactgctgcc ccgggtcccc acggatgaga ttgaggccca gacgctggcc acggccgacc
     1861 tagacctcat gaagagtcac cggtttgagg acgttcctgg ggtgcggcgg cacttggtgc
     1921 ggaagaatgc caaaggttcc acacagagtg gccgagaagg gcgggagcct ggccccacac
     1981 ctcgggcccg accccgggcc ccccacaagc cccatgaggt gtttgtggag ctgaatgagt
     2041 tgctcctgga caaaaaccag gagccccagt ggcgggagac agctcgctgg atcaaatttg
     2101 aagaggacgt ggaggaggag actgagcgct gggggaagcc ccacgtggcc tccctctcct
     2161 tccgcagtct cctggagctc cgcaggaccc tggcccatgg ggctgtgctc ttggatctgg
     2221 accagcagac cctgcccgga gtggcccacc aggtggtgga gcagatggtc atctctgacc
     2281 agatcaaggc cgaggacagg gccaacgtgc tgcgggctct gctgttgaaa cacagccacc
     2341 caagtgatga gaaggacttc tccttccccc gcaacatctc agctggctcc ctgggctccc
     2401 tgctggggca tcaccatggt cagggggctg agagtgaccc ccacgtcacc gagcctctca
     2461 tgggaggtgt tcctgagacc cggctggagg tggagcgaga gcgtgagctg ccgcctccag
     2521 caccaccagc tggcatcacc cgctccaagt ccaagcacga gctgaaactg ctggagaaga
     2581 ttcctgagaa tgccgaggcc acggtggtcc ttgtgggctg cgtggagttc ctctcccgcc
     2641 ccaccatggc ctttgtgcgg ctccgggagg ctgtggagtt ggacgcagtg ttggaggtgc
     2701 cggtgcctgt gcgtttcctc ttcctgctgc tgggcccgag tagtgccaac atggactacc
     2761 acgagatcgg ccgctccatc tccaccctca tgtcagacaa gcaattccac gaggcagcct
     2821 acctggctga cgagcgggag gacctgctga cggccatcaa cgccttcctg gactgcagcg
     2881 tggtgctgcc gccttcagaa gtgcagggcg aggagctgct gcgctctgtg gcccacttcc
     2941 agcgccagat gctcaagaag cgagaggagc agggccggct gctacctaca ggggctgggc
     3001 tggagcccaa atctgcccaa gataaggcgc tcctgcagat ggtagaggcg gcaggggcag
     3061 ctgaagatga tccccttcgg cggacggggc ggccctttgg ggggctgatc cgagatgtgc
     3121 ggcgccgcta tccccactac ctgagtgact tccgagatgc acttgaccct cagtgcctgg
     3181 ccgcagtcat cttcatctac tttgccgccc tgtctcctgc catcaccttt ggggggctgc
     3241 tgggagagaa gacgcaggac ctgatagggg tgtcggagct gattatgtcc acagcgctcc
     3301 agggcgtggt cttctgcctg ctgggtgccc agcccctgtt ggtgatcggc ttctcagggc
     3361 ccctgctggt ctttgaggag gccttcttct cgttctgtag cagcaaccac ctggagtacc
     3421 tggtgggccg tgtgtggatc ggcttctggc tggtgttcct ggccctgctc atggtggccc
     3481 tggaggggag cttcctggtc cgcttcgtct cccgcttcac ccaggagatc ttcgccttct
     3541 tgatctcact catcttcatc tatgagacct tctacaagct ggtgaagatc ttccaggagc
     3601 accccctgca tggctgctca gcctccaaca gctcagaggt ggacggcggt gagaacatga
     3661 catgggccgg ggcaagaccc acgctggggc cgggcaacag gagcttggct gggcagtctg
     3721 ggcaggggaa gccccggggc cagcccaaca cggccctgct gtcgctggtg ctcatggccg
     3781 gcaccttctt catcgccttc ttcctgcgca aattcaagaa cagccggttc tttcctggcc
     3841 ggatccggcg ggtgattggg gactttgggg tgcccatcgc catcctcatc atggtgcttg
     3901 tggattacag tattgaggac acctataccc agaagctgag cgttcccagt ggattctcgg
     3961 tgactgcccc agaaaagagg ggctgggtca tcaaccccct gggagagaag agccccttcc
     4021 ctgtgtggat gatggttgcc agcctgctgc ccgccatcct ggtcttcatt ctcatcttca
     4081 tggagacaca gatcaccacg ctcatcatct ccaagaagga gcgcatgctg cagaagggct
     4141 ccggcttcca cctggacctg ctgctcatcg tggccatggg cggcatctgt gccctctttg
     4201 gcctgccctg gttggctgct gccactgtcc gctctgtcac tcacgccaac gcgctcactg
     4261 tcatgagcaa ggctgtggca cctggggaca agcccaagat tcaggaagtc aaggagcagc
     4321 gggtgacggg gctgctggtt gccctgcttg tgggcctctc catagttatc ggggatctgc
     4381 tccggcagat ccccctggcc gtgctctttg gaattttcct gtacatggga gtcacctccc
     4441 ttaacgggat ccagttctat gagcggctgc atctgctgct catgccgccc aaacaccacc
     4501 cagatgtcac ttacgtcaag aaggtccgga ccctccgtat gcacctgttc acggccctgc
     4561 agctgctctg cctggccctg ctctgggccg tcatgtccac agctgcctcc ctggccttcc
     4621 ccttcatcct catcctcaca gtgccgctcc gcatggtggt gctcacccgt atcttcaccg
     4681 accgagagat gaaatgtctg gatgctaacg aggcagagcc ggtgtttgat gagcgggagg
     4741 gtgtggacga gtacaatgag atgcccatgc ctgtgtagcc gccaccgagg gacagccgag
     4801 ggaccgatgg acgaggggac aggctggtgg gatggggttc cccctcccat gcccctccct
     4861 cctttttatt taagtgaata atttaaagtc ttctcctccc ccactgcccc tgcagtaaag
     4921 tgctttggcc ccca
//
