LOCUS       NM_018158               2541 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens solute carrier family 4 member 1 adaptor protein
            (SLC4A1AP), mRNA.
ACCESSION   NM_018158
VERSION     NM_018158.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Xu,Q., Deller,M.C., Nielsen,T.K., Grant,J.C., Lesley,S.A.,
            Elsliger,M.A., Deacon,A.M. and Wilson,I.A.
  TITLE     Structural insights into the recognition of phosphopeptide by the
            FHA domain of kanadaptin
  JOURNAL   PLoS One 9 (9), e107309 (2014)
   PUBMED   25197798
  REMARK    GeneRIF: Structural insights into the recognition of phosphopeptide
            by the FHA domain of kanadaptin
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Eriksson,N., Benton,G.M., Do,C.B., Kiefer,A.K., Mountain,J.L.,
            Hinds,D.A., Francke,U. and Tung,J.Y.
  TITLE     Genetic variants associated with breast size also influence breast
            cancer risk
  JOURNAL   BMC Med Genet 13, 53 (2012)
   PUBMED   22747683
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Logue,M.W., Schu,M., Vardarajan,B.N., Buros,J., Green,R.C.,
            Go,R.C., Griffith,P., Obisesan,T.O., Shatz,R., Borenstein,A.,
            Cupples,L.A., Lunetta,K.L., Fallin,M.D., Baldwin,C.T. and
            Farrer,L.A.
  CONSRTM   Multi-Institutional Research on Alzheimer Genetic Epidemiology
            (MIRAGE) Study Group
  TITLE     A comprehensive genetic association study of Alzheimer disease in
            African Americans
  JOURNAL   Arch Neurol 68 (12), 1569-1579 (2011)
   PUBMED   22159054
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Keskanokwong,T., Shandro,H.J., Johnson,D.E., Kittanakom,S.,
            Vilas,G.L., Thorner,P., Reithmeier,R.A., Akkarapatumwong,V.,
            Yenchitsomanus,P.T. and Casey,J.R.
  TITLE     Interaction of integrin-linked kinase with the kidney
            chloride/bicarbonate exchanger, kAE1
  JOURNAL   J Biol Chem 282 (32), 23205-23218 (2007)
   PUBMED   17553790
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Kittanakom,S., Keskanokwong,T., Akkarapatumwong,V.,
            Yenchitsomanus,P.T. and Reithmeier,R.A.
  TITLE     Human kanadaptin and kidney anion exchanger 1 (kAE1) do not
            interact in transfected HEK 293 cells
  JOURNAL   Mol Membr Biol 21 (6), 395-402 (2004)
   PUBMED   15764369
  REMARK    GeneRIF: human kanadaptin did not interact with kidney anion
            exchanger 1 (kAE1) and had no effect on trafficking of kAE1 to the
            plasma membrane
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Quilty,J.A., Li,J. and Reithmeier,R.A.
  TITLE     Impaired trafficking of distal renal tubular acidosis mutants of
            the human kidney anion exchanger kAE1
  JOURNAL   Am J Physiol Renal Physiol 282 (5), F810-F820 (2002)
   PUBMED   11934690
REFERENCE   7  (bases 1 to 2541)
  AUTHORS   Hubner,S., Jans,D.A., Xiao,C.Y., John,A.P. and Drenckhahn,D.
  TITLE     Signal- and importin-dependent nuclear targeting of the kidney
            anion exchanger 1-binding protein kanadaptin
  JOURNAL   Biochem J 361 (Pt 2), 287-296 (2002)
   PUBMED   11772400
REFERENCE   8  (bases 1 to 2541)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   9  (bases 1 to 2541)
  AUTHORS   Chen,J., Vijayakumar,S., Li,X. and Al-Awqati,Q.
  TITLE     Kanadaptin is a protein that interacts with the kidney but not the
            erythroid form of band 3
  JOURNAL   J Biol Chem 273 (2), 1038-1043 (1998)
   PUBMED   9422766
REFERENCE   10 (bases 1 to 2541)
  AUTHORS   Prashar,Y. and Weissman,S.M.
  TITLE     Analysis of differential gene expression by display of 3' end
            restriction fragments of cDNAs
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 659-663 (1996)
   PUBMED   8570611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074091.6.
            
            On Jul 1, 2021 this sequence version replaced NM_018158.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028435.1, AK001486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326019.11/ ENSP00000323837.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-689               AC074091.6         115656-116344       c
            690-885             AC074091.6         114938-115133       c
            886-1008            AC074091.6         112843-112965       c
            1009-1069           AC074091.6         111330-111390       c
            1070-1209           AC074091.6         110846-110985       c
            1210-1370           AC074091.6         104541-104701       c
            1371-1440           AC074091.6         102869-102938       c
            1441-1627           AC074091.6         102309-102495       c
            1628-1739           AC074091.6         97874-97985         c
            1740-1980           AC074091.6         94956-95196         c
            1981-2067           AC074091.6         92213-92299         c
            2068-2135           AC074091.6         91466-91533         c
            2136-2205           AC074091.6         86479-86548         c
            2206-2541           AC074091.6         85264-85599         c
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2541
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /note="solute carrier family 4 member 1 adaptor protein"
                     /db_xref="GeneID:22950"
                     /db_xref="HGNC:HGNC:13813"
                     /db_xref="MIM:602655"
     exon            1..689
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2255
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /note="kidney anion exchanger adaptor protein; solute
                     carrier family 4 (anion exchanger), member 1, adapter
                     protein; lung cancer oncogene 3; HLC-3; human lung cancer
                     oncogene 3 protein; kidney anion exchanger adapter
                     protein; solute carrier family 4 anion exchanger member 1
                     adapter protein; solute carrier family 4 (anion
                     exchanger), member 1, adaptor protein"
                     /codon_start=1
                     /product="kanadaptin"
                     /protein_id="NP_060628.3"
                     /db_xref="CCDS:CCDS33166.2"
                     /db_xref="GeneID:22950"
                     /db_xref="HGNC:HGNC:13813"
                     /db_xref="MIM:602655"
                     /translation="MADILSQSETLASQDLSGDFKKPALPVSPAARSKAPASSSSNPE
                     EVQKEGPTALQDSNSGEPDIPPPQPDCGDFRSLQEEQSRPPTAVSSPGGPARAPPYQE
                     PPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGRLSGCDVCLEHPSVSRYHAVLQ
                     HRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLF
                     ILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLGEDSDEEEEMDTSERKINAGSQ
                     DDEMGCTWGMGEDAVEDDAEENPIVLEFQQEREAFYIKDPKKALQGFFDREGEELEYE
                     FDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMIQCSLEACRILDTLGLLRQ
                     EAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLIEKKRLNRMKKAGKIDEKPETFESLVA
                     KLNDAERELSEISERLKASSQVLSESPSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTF
                     ELRKEQQRLKGLIKIVKPAEIPELKKTETQTTGAENKAKKLTLPLFGAMKGGSKFKLK
                     TGTVGKLPPKRPELPPTLMRMKDEPEVEEEEEEEEEEEKEKEEHEKKKLEDGSLSRPQ
                     PEIEPEAAVQEMRPPTDLTHFKETQTHENMSQLSEEEQNKDYQDCSKTTSLCAGPSAS
                     KNEYEKSRGELKKKKTPGPGKLPPTLSSKYPEDDPDYCVWVPPEGQSGDGRTHLNDKY
                     GY"
     exon            690..885
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1008
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1069
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1209
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1370
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1440
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1627
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1739
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1980
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2067
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2135
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2205
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2541
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2521..2526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /note="hexamer: ATTAAA"
     polyA_site      2541
                     /gene="SLC4A1AP"
                     /gene_synonym="HLC3"
                     /note="major polyA site"
ORIGIN      
        1 ggatttcgaa gttgcaccgg ttgaggatgg ctgacattct ctctcagtca gagaccctgg
       61 cgtcgcaaga cctcagtggg gacttcaaga agccagctct gccggtgtcc ccagcggcgc
      121 ggagtaaggc cccggccagc agttcttcaa accctgagga ggtacagaag gaagggccca
      181 ctgcgttgca ggactccaat tctggggagc ccgacatccc tcctcctcag ccggactgcg
      241 gtgattttag gagtctacag gaggagcagt cgcgcccccc gacagcggtt tcttcccctg
      301 gcggtccagc ccgggctccc ccctaccaag agcctccatg gggtggccct gccacagccc
      361 cctacagctt agagaccctg aagggcggca ctatccttgg cacccgtagc ttgaaaggga
      421 cgagttactg ccttttcggg aggctgtctg gctgcgacgt gtgcctggag cacccttcgg
      481 tgtctcggta ccacgcagtg ctgcagcaca gggcgtccgg ccctgacgga gaatgcgaca
      541 gcaacgggcc gggcttctac ctctacgatc tgggaagcac ccatggcact tttctcaaca
      601 aaactcgcat cccacctcgc acctactgtc gagtccacgt tgggcatgtt gttcgctttg
      661 gaggcagcac ccggctcttt atcctgcagg gaccagagga agaccgagag gcagaatccg
      721 agttaacagt aacacagttg aaggaattgc gcaagcagca gcaaatattg ttggagaaga
      781 agatgctagg agaagactca gatgaagaag aggaaatgga tacctctgaa aggaagataa
      841 atgctggtag ccaagatgat gagatgggtt gcacctgggg aatgggagaa gatgcagtag
      901 aggatgatgc tgaagagaac cctattgtct tagagtttca gcaggaaagg gaggcctttt
      961 atataaagga tcccaaaaag gctctccaag gcttttttga ccgagaagga gaagaattag
     1021 aatatgaatt tgatgaacag ggacatagca cttggctctg cagggtgaga ttacctgtgg
     1081 acgattcaac tggaaaacaa ctggtggctg aggccattca ctcaggaaag aaaaaagaag
     1141 caatgatcca gtgctcattg gaagcttgtc ggattcttga cactttggga ttgcttcggc
     1201 aggaagcagt atctcggaaa aggaaagcca agaactggga agatgaagac ttttatgata
     1261 gtgatgatga cacatttctt gataggactg gcctgattga gaagaagcgt ctgaacagaa
     1321 tgaagaaggc tggcaagatt gatgagaagc cagagacctt tgaatcattg gttgcaaaat
     1381 taaatgatgc tgaaagggaa ctttctgaaa tttctgagag attgaaagcc tcaagccaag
     1441 ttctatcaga gtctccatct caggattctt tagatgcgtt catgtcagaa atgaaatcag
     1501 gcagtacatt agatggtgtg tcccggaaga aacttcacct gagaactttt gaactgagga
     1561 aagaacaaca gagacttaaa gggttaataa aaattgtaaa gccagcagag attccagaac
     1621 taaaaaagac tgaaactcag actacaggtg cagaaaacaa agctaaaaag cttacattgc
     1681 ctctatttgg tgccatgaaa ggaggaagca aattcaaatt aaaaactgga acagtaggga
     1741 agttaccccc caagcgtcca gaactccctc caactctaat gagaatgaaa gatgagcctg
     1801 aagtagaaga ggaggaggaa gaggaagagg aagaagagaa agaaaaggag gagcatgaaa
     1861 agaaaaaact ggaggatgga agcctcagta ggccacagcc agagatagag ccagaagcag
     1921 cagtgcagga aatgaggcct cccacagatc tcacacattt taaagaaacc caaacccatg
     1981 aaaacatgtc tcaacttagc gaggaagaac agaataaaga ttatcaagac tgtagcaaaa
     2041 ccacttcatt gtgcgcagga ccctcagcat caaagaatga atatgagaaa agcagaggtg
     2101 aattgaagaa aaagaaaaca cctggtccag gcaaacttcc accaacactt tcttccaaat
     2161 atcctgaaga tgacccagac tactgtgtgt gggtcccacc tgaaggtcaa agtggagatg
     2221 gcagaaccca tcttaatgac aagtatggct attgattgct tcagaatccc aaaagaaaac
     2281 cttgtggacc atgtgacatg gaatatttgg gataatgtat caaattgaat ggccagagaa
     2341 gtttagatga ttatttgtaa gatctggtga ctggcttttc gttctgtgtt cttggcttcc
     2401 taaatttatc tgcccatatg attctcatgc atttgatatt tatgtttaaa agtgtttata
     2461 tatgtatgta aaaagggaac catatgtttt gagaatttgt aaagtgagag acatgatcct
     2521 attaaaataa gaaggcaaaa a
//
