LOCUS       NM_032219               1833 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens solute carrier family 49 member 3 (SLC49A3),
            transcript variant 2, mRNA.
ACCESSION   NM_032219 XM_937455
VERSION     NM_032219.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   Khan,A.A. and Quigley,J.G.
  TITLE     Heme and FLVCR-related transporter families SLC48 and SLC49
  JOURNAL   Mol Aspects Med 34 (2-3), 669-682 (2013)
   PUBMED   23506900
  REMARK    Review article
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030246.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032219.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030246.1, AK292010.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322224.9/ ENSP00000320234.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1833              BC030246.1         34-1866
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1833
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /note="solute carrier family 49 member 3"
                     /db_xref="GeneID:84179"
                     /db_xref="HGNC:HGNC:26177"
                     /db_xref="MIM:620318"
     exon            1..159
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1704
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /note="isoform 2 is encoded by transcript variant 2; major
                     facilitator superfamily domain-containing protein 7; MYL5;
                     myosin light polypeptide 5 regulatory protein; solute
                     carrier family 49 member A3; major facilitator superfamily
                     domain containing 7"
                     /codon_start=1
                     /product="solute carrier family 49 member A3 isoform 2"
                     /protein_id="NP_115595.2"
                     /db_xref="CCDS:CCDS3338.1"
                     /db_xref="GeneID:84179"
                     /db_xref="HGNC:HGNC:26177"
                     /db_xref="MIM:620318"
                     /translation="MAGPTEAETGLAEPRALCAQRGHRTYARRWVFLLAISLLNCSNA
                     TLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILG
                     AWLNFAGSVLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQR
                     ATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYTIPAGVVCLLSTICLWESV
                     PPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILCAS
                     GHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQ
                     LQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIM
                     LAMTALTVRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSCILAVFFHTPYRRLQA
                     ESGEPPSTRNAVGGADSGPGVDRGGAGRAGVLGPSTATPECTARGASLEDPRGPGSPH
                     PACHRATPRAQGPAATDAPSRPGRLAGRVQASRFIDPAGSHSSFSSPWVIT"
     exon            160..318
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            319..532
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            533..609
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            610..747
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            748..864
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1017
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1175
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1285
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1833
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /note="hexamer: ATTACA"
     polyA_site      1833
                     /gene="SLC49A3"
                     /gene_synonym="LP2561; MFSD7"
                     /note="major polyA site"
ORIGIN      
        1 ggagacccgt ggaggccgcc gacgatggcg gggccgacgg aggccgagac ggggttggcc
       61 gagccccggg ccctgtgcgc gcagcggggc caccgcacct acgcgcgccg ctgggtgttc
      121 ctgctcgcga tcagcctgct caactgctcc aacgccacgc tgtggctcag ctttgcacct
      181 gtggctgacg tcattgctga ggacttggtc ctgtccatgg agcagatcaa ctggctgtca
      241 ctggtctacc tcgtggtatc caccccattt ggcgtggcgg ccatctggat cctggactcc
      301 gtcgggctcc gtgcggcgac catcctgggt gcgtggctga actttgccgg gagtgtgcta
      361 cgcatggtgc cctgcatggt tgttgggacc caaaacccat ttgccttcct catgggtggc
      421 cagagcctct gtgcccttgc ccagagcctg gtcatcttct ctccagccaa gctggctgcc
      481 ttgtggttcc cagagcacca gcgagccacg gccaacatgc tcgccaccat gtcgaaccct
      541 ctgggcgtcc ttgtggccaa tgtgctgtcc cctgtgctgg tcaagaaggg tgaggacatt
      601 ccgttaatgc tcggtgtcta taccatccct gctggcgtcg tctgcctgct gtccaccatc
      661 tgcctgtggg agagtgtgcc ccccaccccg ccctctgccg gggctgccag ctccacctca
      721 gagaagttcc tggatgggct caagctgctc atgtggaaca aggcctatgt catcctggct
      781 gtgtgcttgg ggggaatgat cgggatctct gccagcttct cagccctcct ggagcagatc
      841 ctctgtgcaa gcggccactc cagtgggttt tccggcctct gtggcgctct cttcatcacg
      901 tttgggatcc tgggggcact ggctctcggc ccctatgtgg accggaccaa gcacttcact
      961 gaggccacca agattggcct gtgcctgttc tctctggcct gcgtgccctt tgccctggtg
     1021 tcccagctgc agggacagac ccttgccctg gctgccacct gctcgctgct cgggctgttt
     1081 ggcttctcgg tgggccccgt ggccatggag ttggcggtcg agtgttcctt ccccgtgggg
     1141 gagggggctg ccacaggcat gatctttgtg ctggggcagg ccgagggaat actcatcatg
     1201 ctggcaatga cggcactgac tgtgcgacgc tcggagccgt ccttgtccac ctgccagcag
     1261 ggggaggatc cacttgactg gacagtgtct ctgctgctga tggccggcct gtgcaccttc
     1321 ttcagctgca tcctggcggt cttcttccac accccatacc ggcgcctgca ggccgagtct
     1381 ggggagcccc cctccacccg taacgccgtg ggcggcgcag actcagggcc gggtgtggac
     1441 cgagggggag caggaagggc tggggtcctg gggcccagca cggcgactcc ggagtgcacg
     1501 gcgagggggg cctcgctaga ggaccccaga gggcccggga gcccccaccc agcctgccac
     1561 cgagcgactc cccgtgcgca aggcccagca gccaccgacg cgccctcccg ccccggcaga
     1621 ctcgcaggca gggtccaagc gtccaggttt attgacccgg ctgggtctca ctcctccttc
     1681 tcctccccgt gggtgatcac gtagctgagc gccttgtagt ccaggttgcc cgccacatcg
     1741 atggaggcga actggaacat ctggtccacc tgcgggcggg ggcgaaaggg ctccttgcgg
     1801 gctccgggag cgaattacaa gcgcgcacct gca
//
