LOCUS       NM_001099646            2099 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 47 member 2 (SLC47A2),
            transcript variant 2, mRNA.
ACCESSION   NM_001099646
VERSION     NM_001099646.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Favela-Mendoza,A.F., Fricke-Galindo,I., Cuevas-Sanchez,W.F.,
            Aguilar-Velazquez,J.A., Martinez-Cortes,G. and Rangel-Villalobos,H.
  TITLE     Population diversity of three variants of the SLC47A2 gene (MATE2-K
            transporter) in Mexican Mestizos and Native Americans
  JOURNAL   Mol Biol Rep 48 (9), 6343-6348 (2021)
   PUBMED   34383246
  REMARK    GeneRIF: Population diversity of three variants of the SLC47A2 gene
            (MATE2-K transporter) in Mexican Mestizos and Native Americans.
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Kantauskaite,M., Hucke,A., Reike,M., Ahmed Eltayeb,S., Xiao,C.,
            Barz,V. and Ciarimboli,G.
  TITLE     Rapid Regulation of Human Multidrug and Extrusion Transporters
            hMATE1 and hMATE2K
  JOURNAL   Int J Mol Sci 21 (14), 5157 (2020)
   PUBMED   32708212
  REMARK    GeneRIF: Rapid Regulation of Human Multidrug and Extrusion
            Transporters hMATE1 and hMATE2K.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Gao,Z., Chen,M., Tian,X., Chen,L., Chen,L., Zheng,X., Wang,H.,
            Chen,J., Zhao,A., Yao,Q., Zhu,Q., Jin,S., Hu,H., Zeng,S. and Yu,L.
  TITLE     A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2
            by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal
            cell carcinoma
  JOURNAL   RNA Biol 16 (7), 940-949 (2019)
   PUBMED   30951404
  REMARK    GeneRIF: the SLC47A2 locus highly expresses SANT1, which can remove
            the regulatory SFPQ/E2F1/HDAC1 suppressor complex from the promoter
            region.
REFERENCE   4  (bases 1 to 2099)
  AUTHORS   Raj,G.M., Mathaiyan,J., Wyawahare,M. and Priyadarshini,R.
  TITLE     Lack of effect of the SLC47A1 and SLC47A2 gene polymorphisms on the
            glycemic response to metformin in type 2 diabetes mellitus patients
  JOURNAL   Drug Metab Pers Ther 33 (4), 175-185 (2018)
   PUBMED   30433870
  REMARK    GeneRIF: The studied SLC47A1 and SLC47A2 SNPs had no influence on
            the dose requirement or adverse effects of metformin.
REFERENCE   5  (bases 1 to 2099)
  AUTHORS   Fukuda,Y., Kaishima,M., Ohnishi,T., Tohyama,K., Chisaki,I.,
            Nakayama,Y., Ogasawara-Shimizu,M. and Kawamata,Y.
  TITLE     Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway
            activation
  JOURNAL   Biochem Biophys Res Commun 484 (2), 358-364 (2017)
   PUBMED   28131833
  REMARK    GeneRIF: Network and cell biological analysis additionally showed
            that expression of MATE2-K is regulated by Nrf2 signaling
REFERENCE   6  (bases 1 to 2099)
  AUTHORS   Kajiwara,M., Terada,T., Ogasawara,K., Iwano,J., Katsura,T.,
            Fukatsu,A., Doi,T. and Inui,K.
  TITLE     Identification of multidrug and toxin extrusion (MATE1 and MATE2-K)
            variants with complete loss of transport activity
  JOURNAL   J Hum Genet 54 (1), 40-46 (2009)
   PUBMED   19158817
  REMARK    GeneRIF: These findings suggested that the loss of transport
            activities of the MATE1 G64D and MATE2-K G211V variants were due to
            the alteration of protein expression in cell surface membranes.
REFERENCE   7  (bases 1 to 2099)
  AUTHORS   Tanihara,Y., Masuda,S., Sato,T., Katsura,T., Ogawa,O. and Inui,K.
  TITLE     Substrate specificity of MATE1 and MATE2-K, human multidrug and
            toxin extrusions/H(+)-organic cation antiporters
  JOURNAL   Biochem Pharmacol 74 (2), 359-371 (2007)
   PUBMED   17509534
  REMARK    GeneRIF: hMATE1 and hMATE2-K function together as a detoxication
            system, by mediating the tubular secretion of intracellular ionic
            compounds across the brush-border membranes of the kidney.
REFERENCE   8  (bases 1 to 2099)
  AUTHORS   Omote,H., Hiasa,M., Matsumoto,T., Otsuka,M. and Moriyama,Y.
  TITLE     The MATE proteins as fundamental transporters of metabolic and
            xenobiotic organic cations
  JOURNAL   Trends Pharmacol Sci 27 (11), 587-593 (2006)
   PUBMED   16996621
REFERENCE   9  (bases 1 to 2099)
  AUTHORS   Masuda,S., Terada,T., Yonezawa,A., Tanihara,Y., Kishimoto,K.,
            Katsura,T., Ogawa,O. and Inui,K.
  TITLE     Identification and functional characterization of a new human
            kidney-specific H+/organic cation antiporter, kidney-specific
            multidrug and toxin extrusion 2
  JOURNAL   J Am Soc Nephrol 17 (8), 2127-2135 (2006)
   PUBMED   16807400
REFERENCE   10 (bases 1 to 2099)
  AUTHORS   Otsuka,M., Matsumoto,T., Morimoto,R., Arioka,S., Omote,H. and
            Moriyama,Y.
  TITLE     A human transporter protein that mediates the final excretion step
            for toxic organic cations
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 17923-17928 (2005)
   PUBMED   16330770
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005722.1 and AB250364.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 8, 2020 this sequence version replaced NM_001099646.2.
            
            Summary: This gene encodes a protein belonging to a family of
            transporters involved in excretion of toxic electrolytes, both
            endogenous and exogenous, through urine and bile. This transporter
            family shares homology with the bacterial MATE (multidrug and toxin
            extrusion) protein family responsible for drug resistance. This
            gene is one of two members of the MATE transporter family located
            near each other on chromosome 17. Alternatively spliced transcript
            variants encoding different isoforms have been identified for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2, also known as MATE2-K),
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB250364.1, SRR11853566.11162.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433844.4/ ENSP00000391848.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC005722.1         118546-118556
            12-1895             AB250364.1         1-1884
            1896-2099           AC005722.1         156610-156813
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..2099
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /note="solute carrier family 47 member 2"
                     /db_xref="GeneID:146802"
                     /db_xref="HGNC:HGNC:26439"
                     /db_xref="MIM:609833"
     exon            1..152
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1730
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /note="isoform 2 is encoded by transcript variant 2;
                     multidrug and toxin extrusion protein 2; kidney-specific
                     H(+)/organic cation antiporter; solute carrier family 47
                     (multidrug and toxin extrusion), member 2"
                     /codon_start=1
                     /product="multidrug and toxin extrusion protein 2 isoform
                     2"
                     /protein_id="NP_001093116.1"
                     /db_xref="CCDS:CCDS92273.1"
                     /db_xref="GeneID:146802"
                     /db_xref="HGNC:HGNC:26439"
                     /db_xref="MIM:609833"
                     /translation="MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLF
                     QVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGS
                     PNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPG
                     LPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANII
                     SQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIG
                     SFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVS
                     GVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYG
                     GVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFV
                     AYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITLTTYS
                     RSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH
                     "
     exon            153..254
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            255..323
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            324..472
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            473..515
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            516..560
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            561..658
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            659..756
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            757..870
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            871..938
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1047
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1123
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1193
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1326
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1421
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1509
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2099
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /note="hexamer: ATTAAA"
     polyA_site      2099
                     /gene="SLC47A2"
                     /gene_synonym="MATE2; MATE2-B; MATE2-K; MATE2K"
                     /note="major polyA site"
ORIGIN      
        1 gtgcagggta gccagtgccc cggccaggaa tggacagcct ccaggacaca gtggccctgg
       61 accatggggg ctgctgccct gccctcagca ggctggttcc cagaggcttt gggactgaga
      121 tgtggactct ctttgccctt tctggacccc tgttcctgtt ccaggtgctg acttttatga
      181 tctacatcgt gagcactgtg ttctgcgggc acctgggcaa ggtggagctg gcatcggtga
      241 ccctcgcggt ggcctttgtc aatgtctgcg gagtttctgt aggagttggt ttgtcttcgg
      301 catgtgacac cttgatgtct cagagcttcg gcagccccaa caagaagcac gtgggcgtga
      361 tcctgcagcg gggcgcgctg gtcctgctcc tctgctgcct cccttgctgg gcgctcttcc
      421 tcaacaccca gcacatcctg ctgctcttcc ggcaggaccc ggacgtgtcc aggttgaccc
      481 aggactatgt aatgattttc attccaggac ttccggtgat ttttctttac aatctgctgg
      541 caaaatattt gcaaaatcag aagatcacct ggccccaagt cctcagtggt gtggtgggca
      601 actgtgtcaa cggtgtggcc aactatgccc tggtttctgt gctgaacctg ggggtcaggg
      661 gctccgccta tgccaacatc atctcccagt ttgcacagac cgtcttcctc cttctctaca
      721 ttgtgctgaa gaagctgcac ctggagacgt gggcaggttg gtccagccag tgcctgcagg
      781 actggggccc cttcttctcc ctggctgtcc ccagcatgct catgatctgt gttgagtggt
      841 gggcctatga gatcgggagc ttcctcatgg ggctgctcag tgtggtggat ctctctgccc
      901 aggctgtcat ctacgaggtg gccactgtga cctacatgat tcccttgggg ctcagcatcg
      961 gggtctgtgt ccgagtgggg atggctctgg gggctgcgga tactgtgcag gccaagcgct
     1021 cggccgtctc gggcgtgctc agcatagttg gcatttccct ggtcctgggc accctgataa
     1081 gcatcctgaa aaatcagctg gggcatattt ttaccaatga tgaagatgtc attgccctgg
     1141 tgagccaggt cttgccggtt tatagtgtct ttcacgtgtt tgaggccatc tgttgtgtct
     1201 atggcggagt tctgagagga actgggaagc aggcctttgg tgccgctgtg aatgccatca
     1261 catattacat catcggccta ccactgggca tccttctgac ctttgtggtc agaatgagaa
     1321 tcatgggcct ctggctgggc atgctggcct gtgtcttcct ggcaactgct gcctttgttg
     1381 cttatactgc ccggctggac tggaagcttg ctgcagagga ggctaagaaa cattcaggcc
     1441 ggcagcagca gcagagagca gagagcactg caaccagacc tgggcctgag aaagcagtcc
     1501 tatcttcagt ggctacaggc agttcccctg gcattacctt gacaacgtat tcaaggtctg
     1561 agtgccacgt ggacttcttc aggactccag aggaggccca cgccctttca gctcctacca
     1621 gcagactatc agtgaaacag ctggtcatcc gccgtggggc tgctctgggg gcggcgtcag
     1681 ccacactgat ggtggggctc acggtcagga tcctagccac caggcactag caaagaagct
     1741 tggaaataga aagccaggag tggctgtccc cagtatgcaa acacaccacg gtctgccctg
     1801 caaaaacacc aatggggtct agtgcaggtg gacactttga accactcctc aaaaaaagaa
     1861 ctttggctga ttccttgtgg tgacactcag aggggtctga acagacttga caattctgtt
     1921 ctggtcaagc tggagttttc ttctgtgact tggactgctc tacagaagac atcagccaac
     1981 tgcacgagtc agagtccagg gattgtcact attattaata atgtaaatgg cttcaaatgg
     2041 gacactgcag ataaaatcac aaaaaccact gttatattaa agattacaca tttcctggg
//
