LOCUS       NM_018242               3280 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 47 member 1 (SLC47A1), mRNA.
ACCESSION   NM_018242
VERSION     NM_018242.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3280)
  AUTHORS   Semnani,A., Kazerouni,F., Kalbasi,S., Shahrokhi,S.Z. and
            Rahimipour,A.
  TITLE     The association study between changes in HbA1C with rs2250486 and
            rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian
            patients with type 2 diabetes mellitus: 6 months follow-up study
  JOURNAL   Endocrinol Diabetes Metab 6 (3), e410 (2023)
   PUBMED   36786075
  REMARK    GeneRIF: The association study between changes in HbA1C with
            rs2250486 and rs67238751 genetic variants for SLC47A1 in newly
            diagnosed Iranian patients with type 2 diabetes mellitus: 6 months
            follow-up study.
REFERENCE   2  (bases 1 to 3280)
  AUTHORS   Lin,Z., Liu,J., Long,F., Kang,R., Kroemer,G., Tang,D. and Yang,M.
  TITLE     The lipid flippase SLC47A1 blocks metabolic vulnerability to
            ferroptosis
  JOURNAL   Nat Commun 13 (1), 7965 (2022)
   PUBMED   36575162
  REMARK    GeneRIF: The lipid flippase SLC47A1 blocks metabolic vulnerability
            to ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3280)
  AUTHORS   Zhang,X. and Wright,S.H.
  TITLE     Transport Turnover Rates for Human OCT2 and MATE1 Expressed in
            Chinese Hamster Ovary Cells
  JOURNAL   Int J Mol Sci 23 (3), 1472 (2022)
   PUBMED   35163393
  REMARK    GeneRIF: Transport Turnover Rates for Human OCT2 and MATE1
            Expressed in Chinese Hamster Ovary Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3280)
  AUTHORS   Kantauskaite,M., Hucke,A., Reike,M., Ahmed Eltayeb,S., Xiao,C.,
            Barz,V. and Ciarimboli,G.
  TITLE     Rapid Regulation of Human Multidrug and Extrusion Transporters
            hMATE1 and hMATE2K
  JOURNAL   Int J Mol Sci 21 (14), 5157 (2020)
   PUBMED   32708212
  REMARK    GeneRIF: Rapid Regulation of Human Multidrug and Extrusion
            Transporters hMATE1 and hMATE2K.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3280)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3280)
  AUTHORS   Tsuda,M., Terada,T., Asaka,J., Ueba,M., Katsura,T. and Inui,K.
  TITLE     Oppositely directed H+ gradient functions as a driving force of rat
            H+/organic cation antiporter MATE1
  JOURNAL   Am J Physiol Renal Physiol 292 (2), F593-F598 (2007)
   PUBMED   17047166
  REMARK    GeneRIF: an oppositely directed H(+) gradient serves as a driving
            force of tetraethylammonium transport via rMATE1
REFERENCE   7  (bases 1 to 3280)
  AUTHORS   Omote,H., Hiasa,M., Matsumoto,T., Otsuka,M. and Moriyama,Y.
  TITLE     The MATE proteins as fundamental transporters of metabolic and
            xenobiotic organic cations
  JOURNAL   Trends Pharmacol Sci 27 (11), 587-593 (2006)
   PUBMED   16996621
REFERENCE   8  (bases 1 to 3280)
  AUTHORS   Ohta,K.Y., Inoue,K., Hayashi,Y. and Yuasa,H.
  TITLE     Molecular identification and functional characterization of rat
            multidrug and toxin extrusion type transporter 1 as an organic
            cation/H+ antiporter in the kidney
  JOURNAL   Drug Metab Dispos 34 (11), 1868-1874 (2006)
   PUBMED   16928787
REFERENCE   9  (bases 1 to 3280)
  AUTHORS   Otsuka,M., Matsumoto,T., Morimoto,R., Arioka,S., Omote,H. and
            Moriyama,Y.
  TITLE     A human transporter protein that mediates the final excretion step
            for toxic organic cations
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 17923-17928 (2005)
   PUBMED   16330770
  REMARK    GeneRIF: MATE1 appears to be the long searched for polyspecific
            organic cation exporter that directly transports toxic organic
            cations into urine and bile.
REFERENCE   10 (bases 1 to 3280)
  AUTHORS   Bi,W., Yan,J., Stankiewicz,P., Park,S.S., Walz,K., Boerkoel,C.F.,
            Potocki,L., Shaffer,L.G., Devriendt,K., Nowaczyk,M.J., Inoue,K. and
            Lupski,J.R.
  TITLE     Genes in a refined Smith-Magenis syndrome critical deletion
            interval on chromosome 17p11.2 and the syntenic region of the mouse
  JOURNAL   Genome Res 12 (5), 713-728 (2002)
   PUBMED   11997338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025627.13.
            
            On Nov 25, 2018 this sequence version replaced NM_018242.2.
            
            Summary: This gene is located within the Smith-Magenis syndrome
            region on chromosome 17. It encodes a protein of unknown function.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001709.1, SRR1803616.165350.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270570.8/ ENSP00000270570.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC025627.13        63023-63243
            222-323             AC025627.13        71562-71663
            324-392             AC025627.13        75604-75672
            393-541             AC025627.13        77154-77302
            542-584             AC025627.13        78804-78846
            585-629             AC025627.13        80593-80637
            630-727             AC025627.13        84381-84478
            728-825             AC025627.13        84762-84859
            826-939             AC025627.13        84965-85078
            940-1007            AC025627.13        85164-85231
            1008-1116           AC025627.13        89357-89465
            1117-1192           AC025627.13        89587-89662
            1193-1262           AC025627.13        95959-96028
            1263-1395           AC025627.13        96265-96397
            1396-1490           AC025627.13        100647-100741
            1491-1572           AC025627.13        101949-102030
            1573-3280           AC025627.13        106496-108203
FEATURES             Location/Qualifiers
     source          1..3280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..3280
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /note="solute carrier family 47 member 1"
                     /db_xref="GeneID:55244"
                     /db_xref="HGNC:HGNC:25588"
                     /db_xref="MIM:609832"
     exon            1..221
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1799
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /note="multidrug and toxin extrusion 1; MATE-1; hMATE-1;
                     solute carrier family 47 (multidrug and toxin extrusion),
                     member 1"
                     /codon_start=1
                     /product="multidrug and toxin extrusion protein 1"
                     /protein_id="NP_060712.2"
                     /db_xref="CCDS:CCDS11209.1"
                     /db_xref="GeneID:55244"
                     /db_xref="HGNC:HGNC:25588"
                     /db_xref="MIM:609832"
                     /translation="MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGP
                     AFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQ
                     TYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTI
                     FIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSAL
                     ANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWA
                     YEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARK
                     SSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALA
                     CTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQA
                     VCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTND
                     VGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFY
                     VRIQ"
     exon            222..323
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..392
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..541
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..584
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..629
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..727
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..825
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..939
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1007
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1116
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1192
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1262
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1395
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1490
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1572
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..3280
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3131..3136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /note="hexamer: AATAAA"
     polyA_site      3152
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /note="major polyA site"
     regulatory      3261..3266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
                     /note="hexamer: AATAAA"
     polyA_site      3280
                     /gene="SLC47A1"
                     /gene_synonym="MATE1"
ORIGIN      
        1 actgccggcc tgcgcggtac tcactgccgg cctccgcggt acccactgcc ggcctccgcg
       61 ctacccggcc gcagcgcgcg agtcacatgg aagctcctga ggagcccgcg ccagtgcgcg
      121 gaggcccgga ggccaccctt gaggtccgtg ggtcgcgctg cttgcggctg tccgccttcc
      181 gagaagagct gcgggcgctc ttggtcctgg ctggccccgc gttcttggtt cagctgatgg
      241 tgttcctgat cagcttcata agctccgtgt tctgtggcca cctgggcaag ctggagctgg
      301 atgcagtcac gctggcaatc gcggttatca atgtcactgg tgtctcagtg ggattcggct
      361 tatcttctgc ctgtgacacc ctcatctccc agacgtacgg gagccagaac ctgaagcacg
      421 tgggcgtgat cctgcagcgg agtgcgctcg tcctgctcct ctgctgcttc ccctgctggg
      481 cgctctttct caacacccag cacatcctgc tgctcttcag gcaggaccca gatgtgtcca
      541 ggcttaccca gacctatgtc acgatcttca ttccagctct tcctgcaacc tttctttata
      601 tgttacaagt taaatatttg ctcaaccagg gaattgtact gccccagatc gtaactggag
      661 ttgcagccaa ccttgtcaat gccctcgcca actatctgtt tctccatcaa ctgcatcttg
      721 gggtgatagg ctctgcactg gcaaacttga tttcccagta caccctggct ctactcctct
      781 ttctctacat cctcgggaaa aaactgcatc aagctacatg gggaggctgg tccctcgagt
      841 gcctgcagga ctgggcctcc ttcctccgcc tggccatccc cagcatgctc atgctgtgca
      901 tggagtggtg ggcctatgag gtcgggagct tcctcagtgg catcctcggc atggtggagc
      961 tgggcgctca gtccatcgtg tatgaactgg ccatcattgt gtacatggtc cctgcaggct
     1021 tcagtgtggc tgccagtgtc cgggtaggaa acgctctggg tgctggagac atggagcagg
     1081 cacggaagtc ctctaccgtt tccctgctga ttacagtgct ctttgctgta gccttcagtg
     1141 tcctgctgtt aagctgtaag gatcacgtgg ggtacatttt tactaccgac cgagacatca
     1201 ttaatctggt ggctcaggtg gttccaattt atgctgtttc ccacctcttt gaagctcttg
     1261 cttgcacgag tggtggtgtt ctgaggggga gtggaaatca gaaggttgga gccattgtga
     1321 ataccattgg gtactatgtg gttggcctcc ccatcgggat cgcgctgatg tttgcaacca
     1381 cacttggagt gatgggtctg tggtcaggga tcatcatctg tacagtcttt caagctgtgt
     1441 gttttctagg ctttattatt cagctaaatt ggaaaaaagc ctgtcagcag gctcaggtac
     1501 acgccaattt gaaagtaaac aacgtgcctc ggagtgggaa ttctgctctc cctcaggatc
     1561 cgcttcaccc agggtgccct gaaaaccttg aaggaatttt aacgaacgat gttggaaaga
     1621 caggcgagcc tcagtcagat cagcagatgc gccaagaaga acctttgccg gaacatccac
     1681 aggacggcgc taaattgtcc aggaaacagc tggtgctgcg gcgagggctt ctgctcctgg
     1741 gggtcttctt aatcttgctg gtggggattt tagtgagatt ctatgtcaga attcagtgac
     1801 gtggtaggaa agaaagtcag gtcaagtgat gcttttgagc ttacacacaa ttcacaggcc
     1861 caccagtgac aatttactgt gagttaatgt cattcaggtg tgcccatgga ttttgagggc
     1921 tggaaatgca aagacacatt tttctataaa aagaaaaagc aactaaggtt aaaagctata
     1981 ttgtggccca agacactgtc tgaaagatga catgagtagt aattcaccac tatctgaacc
     2041 aagcaaggat caatgtgctg actgcattgg ccaatggctt tgatacttct gctatttttt
     2101 tagacacaaa cccataaact aactgcttaa gaattcatac tgcttgaatt atgtaaaata
     2161 tattttacag tatatctttc cttgggcctt agattactat tcactgggca aatggtattt
     2221 gtttttgttt taattttttt tttaatagac ggaagtcttg ctctgtcatg caggctggag
     2281 tgcggtggtg cgatcatagc tcactgcagc ctcgaactct tgggcttcaa gcaatcctcc
     2341 tgtgtcagcc accagagtag ctgagactac aggggtatgc caccatgccc agctggcatt
     2401 tgttaatctt catttgaggt ctagatctag gcactgtgga cactgaaaaa cagttgggaa
     2461 atctttcgag ctgtggaaat ccaaacaaag actgataatt cctggtaggg gtgtgtgcgt
     2521 gacgtactgc agcctcaacc tcctgggctc aagtgatcct cccacctcag cctcctgagt
     2581 agctgagacc acaggcgtgt gccaccacgc ctagctaatt ttttatacca gggtctaccc
     2641 tttgtttccc aggctggtct tgaattcctg ggatcaagca atccttccac cttgccctcc
     2701 caaagtgttg ggattatagg catgagccac cacgactggc cagaggacaa aattttaata
     2761 aaggtcttag cttaagcagt aatcctactt cattaagcct tcctggggtg cggtacacac
     2821 cgttaattca gcaaccctca gtacatacta agtatgctca gtgctgtgaa agtggattac
     2881 accaaattaa gtcattctta tcacacccaa tcaaaagtca agaagccagg gataaaagca
     2941 cctcaggcac ataacattaa tctagtaatg taattctctg cacatccagc tggtgaaact
     3001 gcgtgctgta agctgggacc agctttgtcc ataactgctg agagaacttg ctgaagctct
     3061 aggaataatt ttgcctgccc ggttgctcac cagttgtagc ttgccagctc ccaacaccct
     3121 tcctggtgcc aataaacttt ctcaaagagc aatactgaca tttcttttga taaaacctcc
     3181 agccttctct gtgttgttcc gacataccga ggaccaactg gtctacatgg atgccctgaa
     3241 catgcaattc tttcttccaa aataaaacat taaatagaga
//
