LOCUS       NM_181785               3302 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens solute carrier family 46 member 3 (SLC46A3),
            transcript variant 1, mRNA.
ACCESSION   NM_181785
VERSION     NM_181785.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Hamblett,K.J., Jacob,A.P., Gurgel,J.L., Tometsko,M.E., Rock,B.M.,
            Patel,S.K., Milburn,R.R., Siu,S., Ragan,S.P., Rock,D.A.,
            Borths,C.J., O'Neill,J.W., Chang,W.S., Weidner,M.F., Bio,M.M.,
            Quon,K.C. and Fanslow,W.C.
  TITLE     SLC46A3 Is Required to Transport Catabolites of Noncleavable
            Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
  JOURNAL   Cancer Res 75 (24), 5329-5340 (2015)
   PUBMED   26631267
  REMARK    GeneRIF: our results establish SLC46A3 as a direct transporter of
            maytansine-based catabolites from the lysosome to the cytoplasm
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Chalasani,N., Guo,X., Loomba,R., Goodarzi,M.O., Haritunians,T.,
            Kwon,S., Cui,J., Taylor,K.D., Wilson,L., Cummings,O.W., Chen,Y.D.
            and Rotter,J.I.
  CONSRTM   Nonalcoholic Steatohepatitis Clinical Research Network
  TITLE     Genome-wide association study identifies variants associated with
            histologic features of nonalcoholic Fatty liver disease
  JOURNAL   Gastroenterology 139 (5), 1567-1576 (2010)
   PUBMED   20708005
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Ma,Y., Qi,X., Du,J., Song,S., Feng,D., Qi,J., Zhu,Z., Zhang,X.,
            Xiao,H., Han,Z. and Hao,X.
  TITLE     Identification of candidate genes for human pituitary development
            by EST analysis
  JOURNAL   BMC Genomics 10, 109 (2009)
   PUBMED   19284880
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359454.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_181785.3.
            
            Summary: The protein encoded by this gene is a member of a
            transmembrane protein family that transports small molecules across
            membranes. The encoded protein has been found in lysosomal
            membranes, where it can transport catabolites from the lysosomes to
            the cytoplasm. This protein has been shown to be an effective
            transporter of the cytotoxic drug maytansine, which is used in
            antibody-based targeting of cancer cells. [provided by RefSeq, Dec
            2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript yet it encodes the shorter isoform (a). Variants 1 and 3
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036662.1, BX537565.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266943.11/ ENSP00000266943.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               AL359454.7         93369-93843         c
            476-688             AL359454.7         92683-92895         c
            689-1559            AL359454.7         87553-88423         c
            1560-1643           AL359454.7         85633-85716         c
            1644-1800           AL359454.7         78816-78972         c
            1801-3302           AL359454.7         74953-76454         c
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..3302
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /note="solute carrier family 46 member 3"
                     /db_xref="GeneID:283537"
                     /db_xref="HGNC:HGNC:27501"
                     /db_xref="MIM:616764"
     exon            1..475
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /inference="alignment:Splign:2.1.0"
     exon            476..688
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..1885
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; lysosomal proton-coupled steroid conjugate and
                     bile acid symporter SLC46A3"
                     /codon_start=1
                     /product="lysosomal proton-coupled steroid conjugate and
                     bile acid symporter SLC46A3 isoform a precursor"
                     /protein_id="NP_861450.1"
                     /db_xref="CCDS:CCDS9332.1"
                     /db_xref="GeneID:283537"
                     /db_xref="HGNC:HGNC:27501"
                     /db_xref="MIM:616764"
                     /translation="MKILFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSD
                     SNISECEKNKSSPIFAFQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKF
                     PMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCK
                     EHKQKTIRIAIIDFLLGLVTGLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFL
                     GDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFLLCLLLFTVITYFFVVIG
                     IAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFT
                     TMTGMAMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLE
                     TLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLLPAISLCVVKCTSWNEGSYELLI
                     QEESSEDASDR"
     exon            689..1559
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1643
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1800
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..3302
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /note="hexamer: AATAAA"
     polyA_site      3302
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /note="major polyA site"
ORIGIN      
        1 ggacagcgat gctcagctgg ctgcggccga gtcatcgcct agcgctggca gggccgctga
       61 ccgaccgacg gaggcgccga ttggccgatt gtccactgcg cagaaggagc agctgctccg
      121 cgccccgccg cgccgcgctg aggccgaggt ccgcagggcc gcggggaagc cgagggctgc
      181 cggagaaccc tgcaggtgtc actcgggacg cggaagtgcg cttgccgagg tttgctttac
      241 aatacgcttg agactccccg acaagcgtaa tttggtcgag ttcgacggga aagtactctc
      301 cccaccccag cgccggccgc gtagtccgag gttactgtcc ccggcgcgtc ctctgttgcc
      361 ccagtccaga ggctgccctt gaacccgggc gcgcacgagc gcagggcatc cgaggcgaca
      421 gcccctggca cggcccgacc tgtacccagc ctggcaggaa gactgtaatc gtgggaatac
      481 agctacctac ccaggcaata tgaagatttt atttgtagaa cctgccattt tccttagtgc
      541 atttgctatg actttgaccg gtccactgac aacgcaatat gtttatcgga gaatatggga
      601 agaaactggc aactacactt tttcatctga tagcaatatt tctgagtgtg aaaaaaacaa
      661 aagcagccca atttttgcat tccaggagga agttcagaaa aaagtgtcac gttttaatct
      721 gcagatggac ataagtggat taattcctgg tctagtgtct acattcatac ttttgtctat
      781 tagtgatcac tacggacgaa aattccctat gattttgtct tccgttggtg ctcttgcaac
      841 cagcgtttgg ctctgtttgc tttgctattt tgcctttcca ttccagcttt tgattgcatc
      901 taccttcatt ggtgcatttt gtggcaatta taccacattt tggggagctt gctttgccta
      961 tatagttgat cagtgtaaag aacacaaaca aaaaacaatt cgaatagcta tcattgactt
     1021 tctacttgga cttgttactg gactaacagg actgtcatct ggctatttta ttagagagct
     1081 aggttttgag tggtcgtttc taattattgc tgtgtctctt gctgttaatt tgatctatat
     1141 tttatttttt ctcggagatc cagtgaaaga gtgttcatct cagaatgtta ctatgtcatg
     1201 tagtgaaggc ttcaaaaacc tattttaccg aacttacatg ctttttaaga atgcttctgg
     1261 taagagacga tttttgctct gtttgttact ttttacagta atcacttatt tttttgtggt
     1321 aattggcatt gccccaattt ttatccttta tgaattggat tcaccactct gctggaatga
     1381 agtttttata ggttatggat cagctttggg tagtgcctct tttttgacta gtttcctagg
     1441 aatatggctt ttttcttatt gtatggaaga tattcatatg gccttcattg ggatttttac
     1501 cacgatgaca ggaatggcta tgaccgcgtt tgccagtaca acactgatga tgtttttagc
     1561 cagggtgccg ttccttttca ctattgtgcc attctctgtt ctacggtcca tgttgtcaaa
     1621 agtggttcgt tcgactgaac aaggtaccct gtttgcttgt attgctttct tagaaacact
     1681 tggaggagtc actgcagttt ctacttttaa tggaatttac tcagccactg ttgcttggta
     1741 ccctggcttc actttcctgc tgtctgctgg tctgttacta cttccagcca tcagtctatg
     1801 tgttgtcaag tgtaccagct ggaatgaggg aagctatgaa cttcttatac aagaagaatc
     1861 cagtgaagat gcttcagaca ggtgactgtg atttaaacaa acaaaaaaaa tctatgaatg
     1921 cacatatcat ataccatgac ttctgaagac tataaatgaa ttccacaatc agtgcttcac
     1981 tgagaaccaa ttttacctat cttttcttct aaactgaaca gtcagagaga cagctcctgg
     2041 ctttagcttc ttgtggtacc acgcactttg agcactttgt gcgtatcatg caatatactt
     2101 gcaatacaca gaacaaattt caaatacgcc tcacttttag acttagaaga gaaacattaa
     2161 aacttaaggg tgtaaggagg gatcaagaaa cttgataagg tcaaaagcaa taatctctct
     2221 gacatattcc aggctcttac actgagacca aagagaaatc tttacctcag tttcttcatc
     2281 agcagaatgg gtttctggcc tctctcaggg ataattttga aggcataatg aaaattatga
     2341 tgaatcactc attggtagga aaataatgat ataagtttca aatatgtatg attttaccta
     2401 tacttggtaa tgctttattt tatagagcct gttaagctgc tattgatagt cggagcttat
     2461 atactgtgac ttctgaagac tatacatgaa ttccacaatc agtgctttgt tgatacaaaa
     2521 tccttaaaag ggaggcactt taaagaatat gtatttttca cttttcttaa tatgtttcat
     2581 cggtgacagg catgataata tttctatatg taatgggtaa ttgggaaaaa atagatgata
     2641 aataaaattg ctctaaagaa gttaaaaaac tgaatgaaca gctaatactg gtataaagta
     2701 actaatgttt ggagccaaca tttgttcctt gtgtcagcaa aaggatattc acattccatg
     2761 atccctggct gagaattctg cctctagtct ttcttaccca gctgttgtct atccttgttc
     2821 aattataaat actgctaagg gcatttttaa aatacgatct tgtactcctt aaatttgaat
     2881 ccgtcaacac ggtcactcat aggaaaatga tcaaacaagc aagccagtca tgatttgact
     2941 ccttcccatc tcatttctta ctgccttacg ctcatcctga ggtccacctt ggtctctaaa
     3001 aacaccatgt gttctcatgc ctccatgtct tttcacacac tgttccattt gctcttcctc
     3061 ccacattaca ttgaaacttt caagcctcag tcgaaacatt gcttcttctg gatagcagcc
     3121 ttcttgacat ccctcctcac tccccagtcc ctacagggct tccatagctc tttgtgtgca
     3181 cttcgatccc agcattttcc atcgacttgt aattgtttct gctacctgac aatcatcgcc
     3241 ttgagtactg ggacaacctt tgattactca ttatatcctc aataaatatt tgttgaacta
     3301 aa
//
