LOCUS       NM_033051               2465 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 46 member 2 (SLC46A2), mRNA.
ACCESSION   NM_033051
VERSION     NM_033051.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2465)
  AUTHORS   Wang,X. and Lai,Y.
  TITLE     When SLC46A2 delivers cargo into keratinocytes
  JOURNAL   Immunity 56 (5), 897-900 (2023)
   PUBMED   37163988
  REMARK    GeneRIF: When SLC46A2 delivers cargo into keratinocytes.
REFERENCE   2  (bases 1 to 2465)
  AUTHORS   Cordova,A.F., Ritchie,C., Bohnert,V. and Li,L.
  TITLE     Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular
            cGAMP-Sensing Macrophages and Monocytes
  JOURNAL   ACS Cent Sci 7 (6), 1073-1088 (2021)
   PUBMED   34235268
REFERENCE   3  (bases 1 to 2465)
  AUTHORS   Paik,D., Monahan,A., Caffrey,D.R., Elling,R., Goldman,W.E. and
            Silverman,N.
  TITLE     SLC46 Family Transporters Facilitate Cytosolic Innate Immune
            Recognition of Monomeric Peptidoglycans
  JOURNAL   J Immunol 199 (1), 263-270 (2017)
   PUBMED   28539433
  REMARK    GeneRIF: Mammalian SLC46A2s promote tracheal cytotoxin -triggered
            NOD1 activation in human epithelial cell lines, indicating that
            SLC46As is a conserved group of peptidoglycan transporter
            contributing to cytosolic immune recognition
REFERENCE   4  (bases 1 to 2465)
  AUTHORS   Engelmark,M.T., Ivansson,E.L., Magnusson,J.J., Gustavsson,I.M.,
            Wyoni,P.I., Ingman,M., Magnusson,P.K. and Gyllensten,U.B.
  TITLE     Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in
            affected sib-pairs with high mean age at diagnosis
  JOURNAL   Hum Genet 123 (5), 437-443 (2008)
   PUBMED   18392855
  REMARK    GeneRIF: Affected sib-pairs with cervical cancer susceptibility and
            high mean age at diagnosis show increased sharing at all
            microsatellite markers at 9q31.1-33.1 and linkage signals of up to
            maximum lod-score of 2.74 for TSCOT single nucleotide
            polymorphisms.
REFERENCE   5  (bases 1 to 2465)
  AUTHORS   Obermann,H., Wingbermuhle,A., Munz,S. and Kirchhoff,C.
  TITLE     A putative 12-transmembrane domain cotransporter associated with
            apical membranes of the epididymal duct
  JOURNAL   J Androl 24 (4), 542-556 (2003)
   PUBMED   12826694
REFERENCE   6  (bases 1 to 2465)
  AUTHORS   Chen,C., Kim,M.G., Soo Lyu,M., Kozak,C.A., Schwartz,R.H. and
            Flomerfelt,F.A.
  TITLE     Characterization of the mouse gene, human promoter and human cDNA
            of TSCOT reveals strong interspecies homology
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 159-169 (2000)
   PUBMED   10978518
REFERENCE   7  (bases 1 to 2465)
  AUTHORS   Kim,M.G., Flomerfelt,F.A., Lee,K.N., Chen,C. and Schwartz,R.H.
  TITLE     A putative 12 transmembrane domain cotransporter expressed in
            thymic cortical epithelial cells
  JOURNAL   J Immunol 164 (6), 3185-3192 (2000)
   PUBMED   10706709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF242557.1, DA593062.1 and BC048285.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033051.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048285.1, SRR1803612.46078.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374228.5/ ENSP00000363345.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AF242557.1         38-307
            271-320             DA593062.1         271-320
            321-1901            AF242557.1         358-1938
            1902-2465           BC048285.1         1791-2354
FEATURES             Location/Qualifiers
     source          1..2465
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2465
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /note="solute carrier family 46 member 2"
                     /db_xref="GeneID:57864"
                     /db_xref="HGNC:HGNC:16055"
                     /db_xref="MIM:608956"
     exon            1..1324
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1623
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /note="thymic stromal co-transporter; thymic stromal
                     cotransporter homolog"
                     /codon_start=1
                     /product="solute carrier family 46 member 2"
                     /protein_id="NP_149040.3"
                     /db_xref="CCDS:CCDS6786.1"
                     /db_xref="GeneID:57864"
                     /db_xref="HGNC:HGNC:16055"
                     /db_xref="MIM:608956"
                     /translation="MSPEVTCPRRGHLPRFHPRTWVEPVVASSQVAASLYDAGLLLVV
                     KASYGTGGSSNHSASPSPRGALEDQQQRAISNFYIIYNLVVGLSPLLSAYGLGWLSDR
                     YHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGAAALNGLFGGFSAFWSGVMALG
                     SLGSSEGRRSVRLILIDLMLGLAGFCGSMASGHLFKQMAGHSGQGLILTACSVSCASF
                     ALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPDQLDQQYAVGHPPSPGKA
                     KPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAGYTIFITS
                     FLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAVMLFALIPVTTIR
                     SAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSFLSF
                     LAIIPISIVAYKQVPLSPYGDIIEK"
     exon            1325..1408
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1565
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..2465
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /note="hexamer: AATAAA"
     polyA_site      2169
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /note="major polyA site"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
                     /note="hexamer: AATAAA"
     polyA_site      2465
                     /gene="SLC46A2"
                     /gene_synonym="Ly110; TSCOT"
ORIGIN      
        1 acaggcgctg cgtgccctgg ctctgctcgc cactggccgg cgcgctcccg gcgcacggag
       61 cacactcgcg ctcccggcgc acggagcaca ctcgcgctcc gggactgaaa cctgagcagc
      121 cgtagcagcc gaatttggga gcatatcctt gtcactgcag ccagaaagcc cttcgatccc
      181 catcagagag gtcacatgag ccccgaggtc acctgcccgc ggaggggcca cctgcctcgc
      241 ttccacccga ggacctgggt tgagcccgtg gtggcctcgt cccaggtggc tgcctccctc
      301 tacgatgcgg ggctactcct cgtggtgaag gcgtcctacg gaaccggagg ctcctccaac
      361 cacagtgcca gcccatcgcc ccggggggct ctagaggacc aacagcagag agccatctcc
      421 aatttctaca ttatctacaa ccttgtggtg ggcctgtccc ccctgctgtc cgcctacggg
      481 ctgggatggc tcagcgaccg ctaccaccga aagatctcca tctgcatgtc gctgctgggc
      541 ttcctgctct cccgcctcgg gctgctgctc aaggtgctgc tggactggcc agtggaggtg
      601 ctgtacgggg cggcggcgct gaacgggcta ttcggcggct tctccgcctt ctggtccggg
      661 gtcatggcgc tgggatcgct gggctcctcc gagggccgcc gctctgtgcg cctcatcctc
      721 attgacctga tgctgggctt ggcggggttc tgcgggagca tggcttccgg gcatctcttc
      781 aagcagatgg ctgggcactc tgggcagggc ctgatactga cggcctgcag cgtgagctgt
      841 gcctcgtttg ccctgctcta cagccttttg gtgctaaagg tccctgagtc ggtggccaaa
      901 cccagccagg agctccccgc cgtggatacc gtgtctggca cggttggcac ataccgcact
      961 ctggatcctg atcagttgga ccaacagtat gcagtggggc accctccatc tcctggaaaa
     1021 gcaaaacccc ataaaaccac cattgccttg ctctttgtgg gtgctatcat atatgacctg
     1081 gcggtggtgg gcacagtgga cgtgatccct ctttttgtgc tgagggagcc tctcggttgg
     1141 aaccaagtgc aggtgggcta tggtatggct gcagggtaca ccatcttcat caccagcttc
     1201 ctgggtgtcc tggtcttctc ccgctgcttt cgggacacca ccatgatcat gattgggatg
     1261 gtctcctttg ggtcaggagc cctcctcttg gcttttgtga aagagacata catgttctat
     1321 attgctcgag ccgtcatgct gtttgctctc atccccgtca caaccatccg atcagctatg
     1381 tccaaactca taaagggctc ctcttatgga aaggtgttcg tcatactgca gctgtccttg
     1441 gctctgaccg gcgtggtgac atccaccttg tacaacaaga tctaccagct caccatggac
     1501 atgtttgtgg gctcctgctt tgctctctcc tcctttctct ccttcctggc catcattcca
     1561 attagcatcg tggcctataa acaagtccca ttgtcaccat atggagacat catagagaaa
     1621 tgaagatgct tacctgcagg aactgaaaac atcagccatg gccaggcccc cagaagacaa
     1681 aagaagggac cagggaactg gtgacctaag caacccactg cttaagaaac ctgcgttcca
     1741 gccagagttg gcctcagaat gacctgctct ggctcaggga tccctggtgg atggggaaaa
     1801 gcactttcct ggtgatggaa aaacgttctc agctttaaga cacccccatt aggcagacac
     1861 tgggttctgt gacagcagag catgacctta agggttacag gcaggctgca cacagcagtc
     1921 ccaggccctg tgaggggctt cagactccag ctacagcgag cctgcccctt ttcttcaagg
     1981 gactgtcttg agggctccaa agtatagcta actagtcacc tgggtgctgt gctgaaagtc
     2041 ccatgggaga actcaaagcg tgcattatca cagcctgagg ggaatgtgga agggatgttt
     2101 tgtaagaact accaacagtt ttgcacgaac aatgtctttt aaattaaaat aaaaccttga
     2161 aaaaagtcag ctttctttcc tgagtcttcc ttacctacaa acactcagga gggggatgga
     2221 gctcaggccc ttgtcttctg ggtagttttg ttactactgt tgcttttaag aagcaaatgt
     2281 cacaaggctt tcttcaatgg gatgttcaat tgagtacttc cagtcaacag tgcttcccaa
     2341 agtgggtggt gtgaaggaag aggaggtaca ttaagagcta ttttatttga ggtagtcatt
     2401 tttataacct tgtttacttg gatttataaa agcagactca cctaataaaa tcaacattca
     2461 ttgta
//
