LOCUS       NM_001286646            7418 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 45 member 4 (SLC45A4),
            transcript variant 1, mRNA.
ACCESSION   NM_001286646 XM_011517169
VERSION     NM_001286646.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7418)
  AUTHORS   Brito,S., Heo,H., Cha,B., Lee,S.H., Park,G., Kwak,B.M., Seong,J.K.,
            Lee,H., Park,J.H., Weon,B.M. and Bin,B.H.
  TITLE     The Slc45a4 Gene Regulates Pigmentation in a Manner Distinct from
            that of the OCA4 Gene Slc45a2
  JOURNAL   J Invest Dermatol 144 (3), 720-722 (2024)
   PUBMED   37775036
  REMARK    GeneRIF: The Slc45a4 Gene Regulates Pigmentation in a Manner
            Distinct from that of the OCA4 Gene Slc45a2.
REFERENCE   2  (bases 1 to 7418)
  AUTHORS   Chen,W., Huang,F., Huang,J., Li,Y., Peng,J., Zhuang,Y., Huang,X.,
            Lu,L., Zhu,Z. and Zhang,S.
  TITLE     SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced
            autophagy in TP53 mutant pancreatic ductal adenocarcinoma
  JOURNAL   J Gene Med 23 (9), e3364 (2021)
   PUBMED   34010493
  REMARK    GeneRIF: SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced
            autophagy in TP53 mutant pancreatic ductal adenocarcinoma.
REFERENCE   3  (bases 1 to 7418)
  AUTHORS   Bartolke,R., Heinisch,J.J., Wieczorek,H. and Vitavska,O.
  TITLE     Proton-associated sucrose transport of mammalian solute carrier
            family 45: an analysis in Saccharomyces cerevisiae
  JOURNAL   Biochem J 464 (2), 193-201 (2014)
   PUBMED   25164149
REFERENCE   4  (bases 1 to 7418)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011676.10.
            
            On or before Feb 27, 2020 this sequence version replaced
            XM_011517169.2, NM_001286646.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC171836.1, ERR4368410.121628.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000517878.6/ ENSP00000428137.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC011676.10        172280-172472       c
            194-834             AC011676.10        118173-118813       c
            835-1023            AC011676.10        85761-85949         c
            1024-1203           AC011676.10        83834-84013         c
            1204-2222           AC011676.10        82195-83213         c
            2223-2322           AC011676.10        81274-81373         c
            2323-2534           AC011676.10        79943-80154         c
            2535-2894           AC011676.10        76381-76740         c
            2895-7418           AC011676.10        71358-75881         c
FEATURES             Location/Qualifiers
     source          1..7418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..7418
                     /gene="SLC45A4"
                     /note="solute carrier family 45 member 4"
                     /db_xref="GeneID:57210"
                     /db_xref="HGNC:HGNC:29196"
                     /db_xref="MIM:619581"
     exon            1..193
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     exon            194..834
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..3020
                     /gene="SLC45A4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="solute carrier family 45 member 4 isoform 1"
                     /protein_id="NP_001273575.1"
                     /db_xref="CCDS:CCDS75795.1"
                     /db_xref="GeneID:57210"
                     /db_xref="HGNC:HGNC:29196"
                     /db_xref="MIM:619581"
                     /translation="MKMAPQNADPESMQVQELSVPLPDPQKAGGAEAENCETISEGSI
                     DRIPMRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFT
                     PLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPNRQPIGIVL
                     TVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDW
                     TQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGALDGGE
                     PHGVPAFPDEVQSEHELALDYPDVDIMRSKSDSALHVPDTALDLEPELLFLHDIEPSI
                     FHDASYPATPRSTSQELAKTKLPRLATFLKEAAKEDETLLDNHLNEAKVPNGSGSPTK
                     DALGGYTRVDTKPSATSSSMRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIK
                     PSRSMSDLYDMQKRQRQHRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPREL
                     MRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNAGVKMGCWGLV
                     IYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTM
                     GIVSMSISYCPYALLGQYHDIKQYIHHSPGNSKRGFGIDCAILSCQVYISQILVASAL
                     GGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAGEGRA
                     GGNSEKPTVLKLTRKEGLQGPVETESVTPAGIDVCQISSHWLVPQLLESIFLYDYFRK
                     KIFFSTMWFS"
     exon            835..1023
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1203
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..2222
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2322
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2534
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2894
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..7418
                     /gene="SLC45A4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3852..3857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC45A4"
                     /note="hexamer: AATAAA"
     polyA_site      3872
                     /gene="SLC45A4"
     regulatory      7400..7405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC45A4"
                     /note="hexamer: AATAAA"
     polyA_site      7418
                     /gene="SLC45A4"
                     /note="major polyA site"
ORIGIN      
        1 gcagcctcgc agcgctctct ccgcgcccgc gtcgctgact gaccgcccgg ccggccggcc
       61 gagggagcag cccccgcccg gacccgcagc cgcctcccga ccccggtgcg cccggggctc
      121 cgcgcccccg tagcccctgc ccggcccggc ccggccgccc cgccgccccc gcggccccgg
      181 ccggaggaga cagatcatcc agtcactcga tggggattac cagcggacca cctgtttgta
      241 tcaccttccc acctctctgt agcaagaaaa atcacttcag cacctcttca gtaataatga
      301 tgaaactggt attaactgaa tggcaattat ggatttttaa ctctaattca cagtaaacca
      361 gcaagccata tgtttaaaat ccaaccaaaa atcgttctgt gttgctgcat gtctcatacc
      421 gttgtgagaa gttgtgagat agccacttgt gcaaagagga atgtaagtgt tacctgcccg
      481 aggaacacag cagaagcaga aagagaagac gtcttaattt atcattacag atatatgaaa
      541 gcattattta tatagataga atatatagat aaatacatat atttttggtg gtaatgaaaa
      601 tggctccgca gaatgccgac ccggaatcta tgcaagttca agagttatcc gtgcccctgc
      661 cggacccgca gaaagccgga ggcgcagagg ccgagaactg cgagaccatc agcgaggggt
      721 ccatagaccg aatccccatg cgcctgtggg tgatgcacgg ggcggtgatg tttggcaggg
      781 agttctgtta cgccatggaa accgctctgg tcacaccaat actgttgcag attggccttc
      841 cggagcagta ctacagcctc acctggttcc tgagccccat ccttggcctc atcttcacac
      901 ctctcattgg gtctgcgagt gaccggtgca ccctgagctg gggccgccgg cggcccttca
      961 tcctcgccct ctgcgttggc gtcctctttg gcgttgcact tttccttaac ggctctgcca
     1021 tcggtctggc cctcggcgat gtccccaacc ggcagcccat tggcatcgtg ctcacggtgc
     1081 tgggagtggt ggtcctggac ttcagcgccg atgccaccga ggggcccatc cgtgcctatc
     1141 tgctggacgt ggtggacagc gaggagcagg acatggccct caacatccac gccttctctg
     1201 ccggcctcgg cggagccatc ggctacgtgc tgggtgggct ggactggacc cagaccttcc
     1261 tgggcagctg gttccggacc cagaaccagg tgctcttctt ctttgccgcc atcatcttca
     1321 cggtgtccgt ggccctgcac ctgttcagca tcgacgagga gcagtacagc ccgcagcagg
     1381 agcgcagcgc tgaggagccc ggcgccctgg atgggggcga gccgcacggc gtccctgcct
     1441 tcccagacga ggtacagtcg gagcacgagc tggccctgga ctacccggac gtggacatca
     1501 tgcgcagcaa aagcgactcg gcattgcacg tgccggacac cgcgctggac ctggagcccg
     1561 agctgctgtt cctgcacgac atcgagccct ccatcttcca cgacgcctcc taccccgcca
     1621 ccccccgcag caccagccag gagctcgcca agaccaagct gccccgcctg gccaccttcc
     1681 tcaaggaagc cgccaaggag gacgagacct tgctggataa tcacttgaat gaagctaaag
     1741 tcccaaacgg aagtggctcc cccacaaaag acgccctcgg cggctacacc agggtggaca
     1801 cgaagccctc ggccacgtcg agctccatgc ggcggcggcg gcacgcgttc cgcaggcagg
     1861 cctccagcac cttctcctac tacggcaagc ttgggtccca ctgctaccgc taccggcgcg
     1921 ccaacgccgt ggtgctgatc aagccgtcgc gcagcatgag cgacctgtac gacatgcaga
     1981 agcggcagcg gcagcaccgg caccggaacc agagcggggc caccacctcc agcggggaca
     2041 ccgagagtga ggagggggag ggcgagacca cggtgcgcct gctgtggctc tccatgctga
     2101 agatgcccag ggagctgatg cggctgtgcc tctgccacct cctcacctgg ttctctgtca
     2161 tcgccgaggc cgtgttctac accgacttca tgggccaggt catcttcgaa ggcgacccca
     2221 aggccccctc gaactcgacc gcctggcaag cctacaacgc cggggtcaag atgggctgct
     2281 ggggcctggt catttatgcc gccactggtg ctatttgttc agccctgtta cagaagtact
     2341 tggacaacta cgacctgagc gtcagggtga tctacgtgct ggggacgctg ggcttctctg
     2401 tcggcacagc cgtgatggcc atgtttccca acgtctacgt cgccatggtc accatcagca
     2461 ccatgggcat cgtctccatg agcatctcct actgcccgta cgccctgctg ggccagtacc
     2521 atgacatcaa gcagtacatc caccacagcc ccgggaactc caagcgaggg tttggcatag
     2581 attgtgccat cctgtcctgc caagtgtaca tctcgcagat cctggtggcc tctgcccttg
     2641 ggggcgtggt cgacgccgtg gggactgtcc gcgtcatccc catggtggcc tctgtgggct
     2701 ctttcctggg cttcctgacg gccacattcc tggtgatcta tcccaacgtg tcagaggagg
     2761 ccaaggagga gcagaaaggc ctgtcttccc cgttggccgg cgaaggcagg gccggtggga
     2821 acagcgaaaa gcccaccgtg ctgaagctca cgcggaagga gggcctgcag ggaccggtgg
     2881 agacagagtc cgtgacgcct gcaggtattg acgtctgtca gatctcgtca cattggctgg
     2941 tgccgcagct gttggagagt atttttcttt atgattattt tagaaaaaaa attttctttt
     3001 ccacaatgtg gttctcttag aagaatgacg tatcttcttt tcctcagcga gttggacaca
     3061 ttgtgcccag ggcagccctg tccttgggca gcgaccgcac accaaagctg ggaggaggct
     3121 ggtccggggg gcctgggcag aagacagtga tttgcagggg tggctcccag acaccctgcc
     3181 cagggatggg ctgggcacca cctgggggcg gagcgtgagc tccagacgag ctcctgcgtg
     3241 cgcgtgtgag tgtgtctgcg cccagccatg tgaccccgct cgtcccgtct gaaggactct
     3301 cctaggaggc caggttgccc ctccagaccg ctcccaacgt cagggggaag gaaacgttga
     3361 ctttcactgc actttgattc gtctctaaac catttgctgg ggattcctga gagcagagct
     3421 cccagcgggc cctgcctccc aagtcccgcc gcaaggctac ctcgggtgtg tggatgtgcg
     3481 agggcctccc ccgcttgcga aggggacatg cgtgctggaa cctgtcggaa ctccatgcct
     3541 tcctcgcctg ctcacctgct cgacgctgga atcgggacag gtgcaaaggg acgcagacgt
     3601 ctgggacagc taaggcccgt gtcaccggag ggctccgcac agtcgttctg gtttcaacga
     3661 ataagcaaaa ctcgggcaag tactgcagct atttggaaat gttttccaaa ccacagtctc
     3721 tttagaacta agcctatttg aaacggtcgg tgtaggctta ctgagatcag gagacaggga
     3781 ggccccgcac atcacacaga taaagtcaga caattgtaat taatactttt gctgcctcaa
     3841 gttgtttttt aaataaagta ctttgaaatg catgagaatc atgctgcaat atgatcattc
     3901 tagagcaaat atatatatac acgtatatat atttcaagat gaaactaaag cagtttttaa
     3961 ataaattact tgaattttct gtgtatttaa aggaacgact gtttaatgta cttgatgggc
     4021 ctctggtctt gccgtgtctc ctgccgctgg tggcactttg tagattgtgt gtttgtgtcc
     4081 gggtggcagt tgggtacctg ctcacgcacg gtgtgtctgc caggccacgg tgtcccagga
     4141 tcgcagaggg ctgactttca agacttcaag aacattttct ggatgtgtgg aaacttgaga
     4201 atggccttgt gaatctcgtg cttggacagg gcaagtccga ctactgaaag tgctgccagc
     4261 tttgctgcga gccctccggc cagcgggagc cccgtgggct gggcactgtg gcccttcttc
     4321 tctgggggac ggcacccctg gcttcctcac ctcggccggg cgtccgtggc agctcactct
     4381 atgcaacttg atcctctagc ggctttaaga ctgtagatcc cctctctgag acctggctgt
     4441 acttgtcagg atctcgaggc gcagctcccg tcttagctgg tttctccggc ttctcgtcct
     4501 gacgactata aaacagttgg aggcaagaaa gcagcggatg tggggtggca gtggcctgac
     4561 ccgaatcaag atccgaccca aaccacacca aatgtgggtt catctggggg ccaccccttg
     4621 cctgaggctt cccaccctca tctgaaggcc caggggccgg atccagggct caccaaagcc
     4681 gattcctcgc cagctgggag tgcagaagtc tcagggcctg gctgcgactt gatttttagg
     4741 aggaagaggg gcttcgcaac ccccctctga atagtgtgtt aacccttgag atcccagcct
     4801 cgactaatct gaagtaagga caacaaaggc cattcagtgc cctccacatg gccttgccac
     4861 agtcactgtc agggtatgaa cgtgccggaa gccagtgcca gccagggaca ggcgtgactg
     4921 ttgtgtgctc ctcggtgaca ggagtcggtg gctgcacact ttgtagactc gtcaagctgt
     4981 cagcacttca ggtgtttgca agcaaagccc ttcttagtgt gcaggtcagt gtgcagagcc
     5041 caaatgaggg gaccgcaggg gctggggtcc agggtcagta gagtcggttt ctggagctgc
     5101 cttcctggga ggcaggtgtg ggtgaccggg gctctggcgg tgcgtgtggg cccggcctgg
     5161 ccacagcggg gaccaggtca cgacatcttt ggcctcaacc cctcccctgc actgagatta
     5221 tttccagatt gcactcactt gaaaccgtcc gtgtcgtcac cttgtgtctt aagggaagcc
     5281 gagaagaagg gcagacgggc aggctgtctt gtctgcaaag cgccattgcg cccgcagctt
     5341 gtgtgggtca ggctgcagct cgggtgtctg tggcttctaa ccttgtacct cagacggatg
     5401 cagtaacaag gcggggctgg ggacgccggt cagtgtcaaa ggggaggtgc tctggctgat
     5461 agccttgccc gagagggacg aggaggccgt gcgggtgccc cctggggaag ctggccagcc
     5521 atccagtgct gaggacgcag ctggagttgg gctcgtggca cccttggggt gtgggctgtg
     5581 caggctggtg gcctgggtgc ctctgcacac tgagtggagt gtcaggcagg gtgtgtcggt
     5641 tggtcgagtc ttgtgtaatg tgcgcagacc agttaccaaa ctaggataat gttggtctca
     5701 tttgtggtgg ttttgttccc tatacaagtc agctaagtaa agactctttt aacgagcttc
     5761 cccttaacac atggcagaag tttccaggtg caggaatgcg agctggcggg aaggggcaga
     5821 ggccgtgagc tctcagctgg gccggcctgc ctgtgtcccc tttcctgggt ctgtcggcag
     5881 actggcatca tgacgttccc tggtggctga agagctagct ttggagtgtt gtttttctca
     5941 ctctcaggca ggggccttag ctggaatcct ccaacctgcc actgaacacg tcagtgctgt
     6001 gtgctgcctc ttggacacct gcccttgaaa gcctcaggcc cctgggagaa gcactctgtc
     6061 cagtcctgtc cccggggggg aggcagggcc actgagccct cctcagatgg ttagtggctt
     6121 ccaacagcca tcaggagtgt ttcttgaatg ccccaggtgt ggaggacttg gtctgtgacc
     6181 acctagaacc ccagagctga acaggaagcc gtccctgcag caacaagagg gctggaaggg
     6241 ggagctgcag gccaccctcg gctctcccac tgctggggcg gtgatgttcg ggtgacatgt
     6301 ttgaaaaata ctcttaaaga taccaactgt tcccttatat ggctaatggt ttgtgcagcc
     6361 accagcgatg gcggccccta ttagagacca ggtttgttaa aacaccaaat attgctgtcc
     6421 acactagaca ttaaccggct tcagaaaaga tggacacctt ttcccacgct gtttcgcttc
     6481 ttaactttgg tccagcttta gccaccacac agcgtgtgag ggactgctgc tgcggagtca
     6541 gcctcgtttg tccctccgcc tcccaccagc acgcgccgct tctgagagac accagctccc
     6601 tgcctccaag cctggtgcca caggcctgtc gtgagggacc cctgcttccg agagctcctg
     6661 ggggggttct gcccttcacc acctgggaga ggtgtcagtt cagttccgag ttgaacaagg
     6721 cccgtgcaca cagcatgttg ggggcccagc ccaaagttct tgtcacctcc tcatgcaaag
     6781 ccagccatca ccctccggcc agagctcaag gtggcccctt ggccagcccc tccttgggtc
     6841 ctccaggagg actgagcacc cctcctagcg gcatcccttg ccctccacag tgctgccagg
     6901 ggcacgtcgc tctgtgccgt ggactgagac catcccctgg tgacagaatg acccgtttgt
     6961 tggaaatgcc tcgttgccag agaaactccc caggcatctc ggaacgaaac tatttagttc
     7021 cattgtgaac tggccacggg acagcttttt atcaacttat taagttggag cactgtaatc
     7081 gcgcttgctg agttagcagt ggtggtaagc gtgtgttaaa cacataatgt tacgttttag
     7141 gagagagagg tcgtaaggaa gtgtcgtgtc gctcatgact ctcttctatt agttgggtaa
     7201 cagtggcctc atgtttgtgt ctgtgtgtac acagagccct taggttctgc tctgtttctt
     7261 tgccaggtga atgtttgtgg catgcgctgc tgtccgcgcc cctctgtcct gcgcagggtt
     7321 cagctgtgcg gcgccctgat ttcctccatg cacacagaac ctccttgtgt ctgtttctct
     7381 gttcctctgt ggctgactca ataaactttt ccctctga
//
