LOCUS       NM_033102               3391 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 45 member 3 (SLC45A3), mRNA.
ACCESSION   NM_033102
VERSION     NM_033102.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3391)
  AUTHORS   Viehweger,F., Bocker,C., Weidemann,S., Freytag,M., Menz,A.,
            Buscheck,F., Luebke,A.M., Putri,D., Kluth,M., Hube-Magg,C.,
            Hinsch,A., Lennartz,M., Lutz,F., Reiswich,V., Hoflmayer,D.,
            Fraune,C., Moller,K., Bernreuther,C., Lebok,P., Sauter,G.,
            Steurer,S., Dum,D., Marx,A.H., Simon,R., Krech,T., Clauditz,T.S.,
            Jacobsen,F., Gorbokon,N., Burandt,E., Minner,S. and Kind,S.
  TITLE     Prostein expression in human tumors: a tissue microarray study on
            19,202 tumors from 152 different Tumor entities
  JOURNAL   Diagn Pathol 19 (1), 12 (2024)
   PUBMED   38218896
  REMARK    GeneRIF: Prostein expression in human tumors: a tissue microarray
            study on 19,202 tumors from 152 different Tumor entities.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3391)
  AUTHORS   Lee,B., Li,J.L., Marchica,J., Mercola,M., Patel,V. and Perera,R.J.
  TITLE     Mapping genetic variability in mature miRNAs and miRNA binding
            sites in prostate cancer
  JOURNAL   J Hum Genet 66 (11), 1127-1137 (2021)
   PUBMED   34099864
  REMARK    GeneRIF: Mapping genetic variability in mature miRNAs and miRNA
            binding sites in prostate cancer.
REFERENCE   3  (bases 1 to 3391)
  AUTHORS   Vogelezang,S., Bradfield,J.P., Ahluwalia,T.S., Curtin,J.A.,
            Lakka,T.A., Grarup,N., Scholz,M., van der Most,P.J., Monnereau,C.,
            Stergiakouli,E., Heiskala,A., Horikoshi,M., Fedko,I.O.,
            Vilor-Tejedor,N., Cousminer,D.L., Standl,M., Wang,C.A., Viikari,J.,
            Geller,F., Iniguez,C., Pitkanen,N., Chesi,A., Bacelis,J., Yengo,L.,
            Torrent,M., Ntalla,I., Helgeland,O., Selzam,S., Vonk,J.M.,
            Zafarmand,M.H., Heude,B., Farooqi,I.S., Alyass,A., Beaumont,R.N.,
            Have,C.T., Rzehak,P., Bilbao,J.R., Schnurr,T.M., Barroso,I.,
            Bonnelykke,K., Beilin,L.J., Carstensen,L., Charles,M.A., Chawes,B.,
            Clement,K., Closa-Monasterolo,R., Custovic,A., Eriksson,J.G.,
            Escribano,J., Groen-Blokhuis,M., Grote,V., Gruszfeld,D.,
            Hakonarson,H., Hansen,T., Hattersley,A.T., Hollensted,M.,
            Hottenga,J.J., Hypponen,E., Johansson,S., Joro,R., Kahonen,M.,
            Karhunen,V., Kiess,W., Knight,B.A., Koletzko,B., Kuhnapfel,A.,
            Landgraf,K., Langhendries,J.P., Lehtimaki,T., Leinonen,J.T., Li,A.,
            Lindi,V., Lowry,E., Bustamante,M., Medina-Gomez,C., Melbye,M.,
            Michaelsen,K.F., Morgen,C.S., Mori,T.A., Nielsen,T.R.H.,
            Niinikoski,H., Oldehinkel,A.J., Pahkala,K., Panoutsopoulou,K.,
            Pedersen,O., Pennell,C.E., Power,C., Reijneveld,S.A.,
            Rivadeneira,F., Simpson,A., Sly,P.D., Stokholm,J., Teo,K.K.,
            Thiering,E., Timpson,N.J., Uitterlinden,A.G., van
            Beijsterveldt,C.E.M., van Schaik,B.D.C., Vaudel,M., Verduci,E.,
            Vinding,R.K., Vogel,M., Zeggini,E., Sebert,S., Lind,M.V.,
            Brown,C.D., Santa-Marina,L., Reischl,E., Frithioff-Bojsoe,C.,
            Meyre,D., Wheeler,E., Ong,K., Nohr,E.A., Vrijkotte,T.G.M.,
            Koppelman,G.H., Plomin,R., Njolstad,P.R., Dedoussis,G.D.,
            Froguel,P., Sorensen,T.I.A., Jacobsson,B., Freathy,R.M.,
            Zemel,B.S., Raitakari,O., Vrijheid,M., Feenstra,B.,
            Lyytikainen,L.P., Snieder,H., Kirsten,H., Holt,P.G., Heinrich,J.,
            Widen,E., Sunyer,J., Boomsma,D.I., Jarvelin,M.R., Korner,A., Davey
            Smith,G., Holm,J.C., Atalay,M., Murray,C., Bisgaard,H.,
            McCarthy,M.I., Jaddoe,V.W.V., Grant,S.F.A. and Felix,J.F.
  CONSRTM   Early Growth Genetics Consortium
  TITLE     Novel loci for childhood body mass index and shared heritability
            with adult cardiometabolic traits
  JOURNAL   PLoS Genet 16 (10), e1008718 (2020)
   PUBMED   33045005
  REMARK    GeneRIF: Novel loci for childhood body mass index and shared
            heritability with adult cardiometabolic traits.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3391)
  AUTHORS   Pin,E., Henjes,F., Hong,M.G., Wiklund,F., Magnusson,P.,
            Bjartell,A., Uhlen,M., Nilsson,P. and Schwenk,J.M.
  TITLE     Identification of a Novel Autoimmune Peptide Epitope of Prostein in
            Prostate Cancer
  JOURNAL   J Proteome Res 16 (1), 204-216 (2017)
   PUBMED   27700103
  REMARK    GeneRIF: Identification of a novel autoimmune peptide epitope of
            prostein in prostate cancer has been reported.
REFERENCE   5  (bases 1 to 3391)
  AUTHORS   Qin,F., Song,Y., Zhang,Y., Facemire,L., Frierson,H. and Li,H.
  TITLE     Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA
  JOURNAL   PLoS One 11 (3), e0150382 (2016)
   PUBMED   26938874
  REMARK    GeneRIF: CTCF has a role in regulating SLC45A3-ELK4 Chimeric RNA
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3391)
  AUTHORS   Tomlins,S.A., Laxman,B., Dhanasekaran,S.M., Helgeson,B.E., Cao,X.,
            Morris,D.S., Menon,A., Jing,X., Cao,Q., Han,B., Yu,J., Wang,L.,
            Montie,J.E., Rubin,M.A., Pienta,K.J., Roulston,D., Shah,R.B.,
            Varambally,S., Mehra,R. and Chinnaiyan,A.M.
  TITLE     Distinct classes of chromosomal rearrangements create oncogenic ETS
            gene fusions in prostate cancer
  JOURNAL   Nature 448 (7153), 595-599 (2007)
   PUBMED   17671502
REFERENCE   7  (bases 1 to 3391)
  AUTHORS   Kalos,M., Askaa,J., Hylander,B.L., Repasky,E.A., Cai,F.,
            Vedvick,T., Reed,S.G., Wright,G.L. Jr. and Fanger,G.R.
  TITLE     Prostein expression is highly restricted to normal and malignant
            prostate tissues
  JOURNAL   Prostate 60 (3), 246-256 (2004)
   PUBMED   15176054
  REMARK    GeneRIF: Prostein is expressed in the vast majority of prostatic
            tissues, regardless of grade and metastatic status. No expression
            was detected in 4,700 normal and malignant tissue samples
            representing the great majority of essential tissues and tumors.
REFERENCE   8  (bases 1 to 3391)
  AUTHORS   Friedman,R.S., Spies,A.G. and Kalos,M.
  TITLE     Identification of naturally processed CD8 T cell epitopes from
            prostein, a prostate tissue-specific vaccine candidate
  JOURNAL   Eur J Immunol 34 (4), 1091-1101 (2004)
   PUBMED   15048720
  REMARK    GeneRIF: T cells that recognize naturally processed epitopes from
            prostein were expanded from healthy donors and characterized. T
            cells isolated from males were of low avidity and recognized
            subdominant epitopes while those from females were of higher
            avidity
REFERENCE   9  (bases 1 to 3391)
  AUTHORS   Kiessling,A., Stevanovic,S., Fussel,S., Weigle,B., Rieger,M.A.,
            Temme,A., Rieber,E.P. and Schmitz,M.
  TITLE     Identification of an HLA-A*0201-restricted T-cell epitope derived
            from the prostate cancer-associated protein prostein
  JOURNAL   Br J Cancer 90 (5), 1034-1040 (2004)
   PUBMED   14997204
REFERENCE   10 (bases 1 to 3391)
  AUTHORS   Xu,J., Kalos,M., Stolk,J.A., Zasloff,E.J., Zhang,X., Houghton,R.L.,
            Filho,A.M., Nolasco,M., Badaro,R. and Reed,S.G.
  TITLE     Identification and characterization of prostein, a novel
            prostate-specific protein
  JOURNAL   Cancer Res 61 (4), 1563-1568 (2001)
   PUBMED   11245466
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096533.3, DA759616.1 and BC050416.2.
            
            On Nov 22, 2018 this sequence version replaced NM_033102.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY033593.1, BC050416.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367145.4/ ENSP00000356113.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC096533.3         141913-141919       c
            8-99                DA759616.1         1-92
            100-3389            BC050416.2         1-3290
            3390-3391           AC096533.3         119261-119262       c
FEATURES             Location/Qualifiers
     source          1..3391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3391
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /note="solute carrier family 45 member 3"
                     /db_xref="GeneID:85414"
                     /db_xref="HGNC:HGNC:8642"
                     /db_xref="MIM:605097"
     exon            1..116
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /inference="alignment:Splign:2.1.0"
     exon            117..518
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..2008
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /note="prostate cancer-associated gene 2; prostate
                     cancer-associated gene 8; prostate cancer associated
                     protein 8; prostate cancer associated protein 2; prostate
                     cancer-associated gene 6; prostein; prostate cancer
                     associated protein 6"
                     /codon_start=1
                     /product="solute carrier family 45 member 3"
                     /protein_id="NP_149093.1"
                     /db_xref="CCDS:CCDS1458.1"
                     /db_xref="GeneID:85414"
                     /db_xref="HGNC:HGNC:8642"
                     /db_xref="MIM:605097"
                     /translation="MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLL
                     EVGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFL
                     IPRAGWLAGLLCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQA
                     YSVYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVA
                     EEAALGPTEPAEGLSAPSLSPHCCPCRARLAFRNLGALLPRLHQLCCRMPRTLRRLFV
                     AELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGVRMGSLGLFLQCAI
                     SLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSAL
                     QILPYTLASLYHREKQVFLPKYRGDTGGASSEDSLMTSFLPGPKPGAPFPNGHVGAGG
                     SGLLPPPPALCGASACDVSVRVVVGEPTEARVVPGRGICLDLAILDSAFLLSQVAPSL
                     FMGSIVQLSQSVTAYMVSAAGLGLVAIYFATQVVFDKSDLAKYSA"
     exon            519..1304
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1570
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..3391
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3368..3373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /note="hexamer: ATTAAA"
     polyA_site      3391
                     /gene="SLC45A3"
                     /gene_synonym="IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2;
                     PCANAP6; PCANAP8; PRST"
                     /note="major polyA site"
ORIGIN      
        1 gcggagtaac ctggagattt aaaagccgcc ggctggcgcg cgtggggggc aaggaagggg
       61 gggcggaacc agcctgcacg cgctggctcc gggtgacagc cgcgcgcctc ggccaggatc
      121 tgagtgatga gacgtgtccc cactgaggtg ccccacagca gcaggtgttg agcatgggct
      181 gagaagctgg accggcacca aagggctggc agaaatgggc gcctggctga ttcctaggca
      241 gttggcggca gcaaggagga gaggccgcag cttctggagc agagccgaga cgaagcagtt
      301 ctggagtgcc tgaacggccc cctgagccct acccgcctgg cccactatgg tccagaggct
      361 gtgggtgagc cgcctgctgc ggcaccggaa agcccagctc ttgctggtca acctgctaac
      421 ctttggcctg gaggtgtgtt tggccgcagg catcacctat gtgccgcctc tgctgctgga
      481 agtgggggta gaggagaagt tcatgaccat ggtgctgggc attggtccag tgctgggcct
      541 ggtctgtgtc ccgctcctag gctcagccag tgaccactgg cgtggacgct atggccgccg
      601 ccggcccttc atctgggcac tgtccttggg catcctgctg agcctctttc tcatcccaag
      661 ggccggctgg ctagcagggc tgctgtgccc ggatcccagg cccctggagc tggcactgct
      721 catcctgggc gtggggctgc tggacttctg tggccaggtg tgcttcactc cactggaggc
      781 cctgctctct gacctcttcc gggacccgga ccactgtcgc caggcctact ctgtctatgc
      841 cttcatgatc agtcttgggg gctgcctggg ctacctcctg cctgccattg actgggacac
      901 cagtgccctg gccccctacc tgggcaccca ggaggagtgc ctctttggcc tgctcaccct
      961 catcttcctc acctgcgtag cagccacact gctggtggct gaggaggcag cgctgggccc
     1021 caccgagcca gcagaagggc tgtcggcccc ctccttgtcg ccccactgct gtccatgccg
     1081 ggcccgcttg gctttccgga acctgggcgc cctgcttccc cggctgcacc agctgtgctg
     1141 ccgcatgccc cgcaccctgc gccggctctt cgtggctgag ctgtgcagct ggatggcact
     1201 catgaccttc acgctgtttt acacggattt cgtgggcgag gggctgtacc agggcgtgcc
     1261 cagagctgag ccgggcaccg aggcccggag acactatgat gaaggcgttc ggatgggcag
     1321 cctggggctg ttcctgcagt gcgccatctc cctggtcttc tctctggtca tggaccggct
     1381 ggtgcagcga ttcggcactc gagcagtcta tttggccagt gtggcagctt tccctgtggc
     1441 tgccggtgcc acatgcctgt cccacagtgt ggccgtggtg acagcttcag ccgccctcac
     1501 cgggttcacc ttctcagccc tgcagatcct gccctacaca ctggcctccc tctaccaccg
     1561 ggagaagcag gtgttcctgc ccaaataccg aggggacact ggaggtgcta gcagtgagga
     1621 cagcctgatg accagcttcc tgccaggccc taagcctgga gctcccttcc ctaatggaca
     1681 cgtgggtgct ggaggcagtg gcctgctccc acctccaccc gcgctctgcg gggcctctgc
     1741 ctgtgatgtc tccgtacgtg tggtggtggg tgagcccacc gaggccaggg tggttccggg
     1801 ccggggcatc tgcctggacc tcgccatcct ggatagtgcc ttcctgctgt cccaggtggc
     1861 cccatccctg tttatgggct ccattgtcca gctcagccag tctgtcactg cctatatggt
     1921 gtctgccgca ggcctgggtc tggtcgccat ttactttgct acacaggtag tatttgacaa
     1981 gagcgacttg gccaaatact cagcgtagaa aacttccagc acattggggt ggagggcctg
     2041 cctcactggg tcccagctcc ccgctcctgt tagccccatg gggctgccgg gctggccgcc
     2101 agtttctgtt gctgccaaag taatgtggct ctctgctgcc accctgtgct gctgaggtgc
     2161 gtagctgcac agctgggggc tggggcgtcc ctctcctctc tccccagtct ctagggctgc
     2221 ctgactggag gccttccaag ggggtttcag tctggactta tacagggagg ccagaagggc
     2281 tccatgcact ggaatgcggg gactctgcag gtggattacc caggctcagg gttaacagct
     2341 agcctcctag ttgagacaca cctagagaag ggtttttggg agctgaataa actcagtcac
     2401 ctggtttccc atctctaagc cccttaacct gcagcttcgt ttaatgtagc tcttgcatgg
     2461 gagtttctag gatgaaacac tcctccatgg gatttgaaca tatgaaagtt atttgtaggg
     2521 gaagagtcct gaggggcaac acacaagaac caggtcccct cagcccacag cactgtcttt
     2581 ttgctgatcc acccccctct taccttttat caggatgtgg cctgttggtc cttctgttgc
     2641 catcacagag acacaggcat ttaaatattt aacttattta tttaacaaag tagaagggaa
     2701 tccattgcta gcttttctgt gttggtgtct aatatttggg tagggtgggg gatccccaac
     2761 aatcaggtcc cctgagatag ctggtcattg ggctgatcat tgccagaatc ttcttctcct
     2821 ggggtctggc cccccaaaat gcctaaccca ggaccttgga aattctactc atcccaaatg
     2881 ataattccaa atgctgttac ccaaggttag ggtgttgaag gaaggtagag ggtggggctt
     2941 caggtctcaa cggcttccct aaccacccct cttctcttgg cccagcctgg ttccccccac
     3001 ttccactccc ctctactctc tctaggactg ggctgatgaa ggcactgccc aaaatttccc
     3061 ctacccccaa ctttccccta cccccaactt tccccaccag ctccacaacc ctgtttggag
     3121 ctactgcagg accagaagca caaagtgcgg tttcccaagc ctttgtccat ctcagccccc
     3181 agagtatatc tgtgcttggg gaatctcaca cagaaactca ggagcacccc ctgcctgagc
     3241 taagggaggt cttatctctc agggggggtt taagtgccgt ttgcaataat gtcgtcttat
     3301 ttatttagcg gggtgaatat tttatactgt aagtgagcaa tcagagtata atgtttatgg
     3361 tgacaaaatt aaaggctttc ttatatgttt a
//
