LOCUS       NM_001130058            3896 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens solute carrier family 44 member 5 (SLC44A5),
            transcript variant 2, mRNA.
ACCESSION   NM_001130058
VERSION     NM_001130058.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3896)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3896)
  AUTHORS   Peng,G.Z., Ye,Q.F., Wang,R., Li,M.X. and Yang,Z.X.
  TITLE     Knockdown by shRNA identifies SLC44A5 as a potential therapeutic
            target in hepatocellular carcinoma
  JOURNAL   Mol Med Rep 13 (6), 4845-4852 (2016)
   PUBMED   27082540
  REMARK    GeneRIF: the present study indicated the important role of SLC44A5
            as a tumor promoter in HCC through the inhibition of choline
            uptake, suggesting that SLC44A5 may be a potential target for HCC
            therapy.
REFERENCE   3  (bases 1 to 3896)
  AUTHORS   Song,P., Rekow,S.S., Singleton,C.A., Sekhon,H.S., Dissen,G.A.,
            Zhou,M., Campling,B., Lindstrom,J. and Spindel,E.R.
  TITLE     Choline transporter-like protein 4 (CTL4) links to non-neuronal
            acetylcholine synthesis
  JOURNAL   J Neurochem 126 (4), 451-461 (2013)
   PUBMED   23651124
REFERENCE   4  (bases 1 to 3896)
  AUTHORS   O'Donnell,P.H., Stark,A.L., Gamazon,E.R., Wheeler,H.E.,
            McIlwee,B.E., Gorsic,L., Im,H.K., Huang,R.S., Cox,N.J. and
            Dolan,M.E.
  TITLE     Identification of novel germline polymorphisms governing
            capecitabine sensitivity
  JOURNAL   Cancer 118 (16), 4063-4073 (2012)
   PUBMED   22864933
REFERENCE   5  (bases 1 to 3896)
  AUTHORS   Furney,S.J., Simmons,A., Breen,G., Pedroso,I., Lunnon,K.,
            Proitsi,P., Hodges,A., Powell,J., Wahlund,L.O., Kloszewska,I.,
            Mecocci,P., Soininen,H., Tsolaki,M., Vellas,B., Spenger,C.,
            Lathrop,M., Shen,L., Kim,S., Saykin,A.J., Weiner,M.W. and
            Lovestone,S.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; AddNeuroMed Consortium
  TITLE     Genome-wide association with MRI atrophy measures as a quantitative
            trait locus for Alzheimer's disease
  JOURNAL   Mol Psychiatry 16 (11), 1130-1138 (2011)
   PUBMED   21116278
REFERENCE   6  (bases 1 to 3896)
  AUTHORS   Traiffort,E., Ruat,M., O'Regan,S. and Meunier,F.M.
  TITLE     Molecular characterization of the family of choline
            transporter-like proteins and their splice variants
  JOURNAL   J Neurochem 92 (5), 1116-1125 (2005)
   PUBMED   15715662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093170.1, DC374918.1, BC051740.1, AK128063.1 and AC118550.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001130058.1.
            
            Transcript Variant: This variant (2) has a distinct 3' coding
            region and UTR, compared to variant 1, resulting in a protein
            (isoform B) with a shorter and distinct C-terminus, compared to
            isoform A.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093170.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370859.8/ ENSP00000359896.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               AK093170.1         3-460
            459-459             DC374918.1         420-420
            460-1645            AK093170.1         462-1647
            1646-2513           BC051740.1         1785-2652
            2514-3894           AK128063.1         2567-3947
            3895-3896           AC118550.2         30615-30616         c
FEATURES             Location/Qualifiers
     source          1..3896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..3896
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /note="solute carrier family 44 member 5"
                     /db_xref="GeneID:204962"
                     /db_xref="HGNC:HGNC:28524"
                     /db_xref="MIM:620329"
     exon            1..75
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            76..157
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2298
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /note="isoform B is encoded by transcript variant 2;
                     choline transporter-like protein 5"
                     /codon_start=1
                     /product="choline transporter-like protein 5 isoform B"
                     /protein_id="NP_001123530.1"
                     /db_xref="CCDS:CCDS44164.1"
                     /db_xref="GeneID:204962"
                     /db_xref="HGNC:HGNC:28524"
                     /db_xref="MIM:620329"
                     /translation="MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMI
                     FLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQKGTPNENKTILFYFNLLRCTS
                     PSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTAKPVKSLT
                     QLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAA
                     NGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLSWIFLILLRFIAGCLFWVFMI
                     GVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILCI
                     IEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTA
                     VFLATSGVPVYKVIAPGGHCIHENQTCDPEIFNTTEIAKACPGALCNFAFYGGKSLYH
                     QYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRA
                     IRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCFWCLENAI
                     KFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSI
                     GVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICF
                     LEDLERNDGSTARPYYVSQPLLKIFQEENPQTRKQ"
     exon            158..196
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            197..245
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            246..319
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            320..404
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            405..489
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            490..615
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            616..676
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            677..800
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            801..884
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            885..997
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1129
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1229
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1322
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1410
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1673
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1768
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1872
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1946
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2017
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2106
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2191
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..3896
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /note="hexamer: CATAAA"
     polyA_site      2516
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
     regulatory      3873..3878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /note="hexamer: AATAAA"
     polyA_site      3896
                     /gene="SLC44A5"
                     /gene_synonym="CTL5"
                     /note="major polyA site"
ORIGIN      
        1 agtagtgaat cgtagcatgt tagagttaga aggttcagtg ttgatggagt tattgaagaa
       61 atgatggagt aagagactct tttctaagca actcaagttt gcagtgattc aggcctactt
      121 ctgaagagac agccttttat ctcaatgaat gacacagaaa aaccagcaga tactccctct
      181 gaggaagagg actttggtga tccaaggaca tatgacccag atttcaaggg gcctgttgcc
      241 aacaggagtt gtacagatgt tctgtgctgt atgatcttcc tactgtgtat tattggctac
      301 attgttttag gacttgtggc ctgggtacat ggggacccca gaagagcagc ctatcctaca
      361 gacagccagg gccacttttg tggccagaag ggcactccca atgagaacaa gaccattttg
      421 ttttacttta acctgttacg ctgtaccagt ccctccgtgt tgctaaacct acagtgccct
      481 accacacaga tctgtgtctc caagtgccca gaaaaatttt taacctatgt ggaaatgcaa
      541 cttttgtaca caaaagacaa aagctactgg gaagactacc gtcagttctg taagaccact
      601 gctaagcctg tgaagtctct cacacagctt ttactggatg atgattgtcc aacagcgatt
      661 tttcccagca aaccttttct ccagagatgt ttccctgact tctctaccaa aaatggcact
      721 ttaacaatag gaagtaagat gatgtttcaa gatggaaatg gagggacaag aagtgttgta
      781 gaactcggga ttgctgcaaa tggtatcaat aaacttcttg atgcaaagtc acttggattg
      841 aaagtgtttg aagactatgc aagaacttgg tattggattc tcattggcct gacgattgcc
      901 atggtcctta gttggatatt tttgatactt ctgaggttca tagctggatg cctcttctgg
      961 gtcttcatga ttggtgtgat tggaattata ggttatggaa tatggcactg ttaccagcag
     1021 tacaccaatc ttcaggaacg cccaagttct gtattaacta tctatgacat cgggattcag
     1081 actaacataa gcatgtactt tgaactgcaa caaacatggt tcacatttat gataatactc
     1141 tgcatcattg aagtgattgt catcctcatg ctgatcttcc tcaggaatcg aatccgagtc
     1201 gccattatcc tgctgaagga aggaagcaaa gccattggat atgttcctag tacattagtc
     1261 tatccagctt taactttcat tttgctctca atctgcattt gctactgggt cgtgacagca
     1321 gttttcttgg cgacatcggg ggtacctgta tacaaagtca tagctccagg ggggcattgt
     1381 atacatgaaa atcaaacctg tgacccagag atttttaata caactgaaat tgccaaagct
     1441 tgccctgggg ctctgtgtaa ctttgctttc tatggtggaa agagcttgta ccatcagtac
     1501 atccctacct tccatgtata caacttattt gtctttctct ggcttataaa cttcgtcatt
     1561 gcattaggtc agtgcgccct tgctggtgca ttcgctactt attactgggc catgaaaaaa
     1621 cctgatgaca tcccacgata tccacttttt actgcatttg gacgagccat acgatatcac
     1681 acaggatccc tagcatttgg atctttaatt attgcattaa ttcaaatgtt taaaattgta
     1741 ctagaatact tggaccaccg tcttaaacgt acccagaaca cattgtctaa attcctacaa
     1801 tgctgcctga gatgctgctt ctggtgtttg gaaaatgcaa taaagttttt aaacagaaat
     1861 gcctatatta tgattgcaat atatggcaga aacttctgca ggtcagcaaa agatgctttc
     1921 aatctgctga tgagaaatgt tttgaaagtt gcagttacag atgaagttac atactttgta
     1981 ttattcctgg ggaaacttct agttgctgga agtataggtg ttctggcctt cctattcttc
     2041 acacaaagac tgccagtgat tgcacaagga ccagcatctt taaattacta ctgggtacct
     2101 ttgctgacag tcatttttgg gtcttacctg attgcacatg ggttcttcag cgtctatgca
     2161 atgtgtgttg aaacaatttt catctgcttc ttggaagatt tagaaagaaa tgatggttct
     2221 actgcaagac cttattatgt gagtcaacct ttgctgaaga ttttccagga ggaaaatcca
     2281 caaactagga agcagtagaa gagcaaactg gtcgtcctac agctgtgtgt taccttttct
     2341 ccatctgctg tgtctgtgca acatttgttt cataagtgct ttgtgtttag caacactgta
     2401 ttcacgacct tgttggcttg catttgcatg ttttatacca aagcttatac tgtactatgt
     2461 gaagccatca gaagtcgcaa gggaattgtt aataacataa aacattttta tactaagatc
     2521 atttgttttg taattcgttt ttaaagagtg gcttggatgt tttgaaaata ctactgaata
     2581 tgttaatatt cttttaaatc ttagattgaa aaatgataca ttacttaaat tgatagctcc
     2641 taatatattt ttaaaattac aactaaaaga agacttcttc tgcagggaaa attggtcagc
     2701 aaagtgaaat taaaaatttt aaagtttttc ccactctcgt tggacagtaa atcagtgaaa
     2761 ggactgcccc agttgagagt ttgctctctt taagtataga atgtttcctc ttaaacaaat
     2821 tgccaatcat ccagccttta ctacttagcc ctctgacaaa gtgccttact ggctatttaa
     2881 tattacccag cttttatggg caagtttaca aacattgttt tttaaaaaat taaaacctgc
     2941 aatgtttcgt gattaaaaca agtcttattg catttgtttc actcttagct cactgattgg
     3001 aaaacatttg tcattttgct ctgtttgata tcctcactat tatggaatac attgtgcagc
     3061 taaacaattt cccttgcgcc tagtggacat tcatgaatgt gtactacacg caagaagaaa
     3121 caaaccccga aagaacactt gttggatttc tttgtttttt tttttactaa aagagaagtt
     3181 ttaaaatgaa atgttttcta tagtagatct ttgaaaatac aataggtata atactgcatt
     3241 tctcagtgtt ttacaaagat cagaaagaga aacttctagg aattgcaaag ggaaacttta
     3301 ctcctcgaaa gggtgctcac agatgtcatg tactgaatag ctccctttta aatgatcatt
     3361 tattttcatc aaagcctgtt ctatatatgc cacttcattt tctaactttt ggtatgaaaa
     3421 aatcagttta cttacagtat gttaattgta ttgtactact ataaacagga acataatttc
     3481 caattcagtt ttaaataatt ttaccagtac tactaacttt taaggaaatt aattcagttg
     3541 gttactcagt gtttgttaca gaaagagtcc agaaaagtat tcaccctaag agaatgtcaa
     3601 tcatataatg ataatttgtg aaagctttga gaatcaatca tcagtaagtt actatcagtt
     3661 tataaaatat tatcacattt gtttaaatgt gactttagat acttttatgc caaaaataaa
     3721 ctcacatgag cacatgacag tctgagctct ataatcagtg tgcttctgct gtgcagaaat
     3781 gttagaaacg tattgtctaa atatctttga taattaaaat gtttaatatt taatgaaatt
     3841 tgttgttact tgttttaaat cttttttctt ttaataaaga tttaaataag aaataa
//
